Alternative titles; symbols
HGNC Approved Gene Symbol: ILRUN
Cytogenetic location: 6p21.31 Genomic coordinates (GRCh38): 6:34,587,288-34,696,767 (from NCBI)
ILRUN is an inhibitor of the interferon regulatory factor-3 (IRF3)-dependent innate antiviral response (Ambrose et al., 2018).
During their manual annotation of chromosome 6, Mungall et al. (2003) identified ILRUN, or C6ORF106.
Gross (2021) mapped the ILRUN gene to chromosome 6p21.31 based on an alignment of the ILRUN sequence (GenBank BC002328) with the genomic sequence (GRCh38).
Ambrose et al. (2018) identified ILRUN as an inhibitor of the innate antiviral response. Knockdown of ILRUN significantly enhanced IFN-alpha (IFNA1; 147660), IFN-beta (IFNB1; 147640), and TNF-alpha (TNF; 191160) transcription in response to viral RNA in HeLa cells, whereas overexpression of ILRUN had the opposite effects. ILRUN impaired cytokine transcription primarily by differentially modulating the antiviral transcription factors IRF3 (603734) and NFKB (see 164011), which control IFN-alpha, IFN-beta, and TNF-alpha transcription. ILRUN did not impair activation or nuclear translocation of IRF3 and NFKB, nor did it alter cellular protein levels of IRF3 and NFKB. Instead, ILRUN interacted with IRF3 and inhibited its binding to type I IFN promoter sequences, and it also reduced nuclear levels of the coactivator proteins p300 (EP300; 602700) and CBP (CREBBP; 600140).
Ambrose, R. L., Liu, Y. C., Adams, T. E., Bean, A. G. D., Stewart, C. R. C6orf106 is a novel inhibitor of the interferon-regulatory factor 3-dependent innate antiviral response. J. Biol. Chem. 293: 10561-10573, 2018. [PubMed: 29802199] [Full Text: https://doi.org/10.1074/jbc.RA117.001491]
Gross, M. B. Personal Communication. Baltimore, Md. 6/10/2021.
Mungall, A. J., Palmer, S. A., Sims, S. K., Edwards, C. A., Ashurst, J. L., Wilming, L., Jones, M. C., Horton, R., Hunt, S. E., Scott, C. E., Gilbert, J. G. R., Clamp, M. E., and 158 others. The DNA sequence and analysis of human chromosome 6. Nature 425: 805-811, 2003. [PubMed: 14574404] [Full Text: https://doi.org/10.1038/nature02055]