HGNC Approved Gene Symbol: SLC22A24
Cytogenetic location: 11q12.3 Genomic coordinates (GRCh38): 11:63,079,940-63,144,221 (from NCBI)
SLC22A24 belongs to a large family of transmembrane proteins that function as uniporters, symporters, and antiporters to transport organic ions across cell membranes (Jacobsson et al., 2007).
By searching a human database for SLC22 family members, Jacobsson et al. (2007) identified SLC22A24. The deduced 322-amino acid protein has 12 putative transmembrane domains. Quantitative real-time PCR detected high expression of rat Slc22a24 in liver and skeletal muscle and in coronal sections taken from the olfactory bulb and forebrain. Expression was weaker in other cortical sections, and none was detected in other specific brain regions or in peripheral tissues.
Jacobsson et al. (2007) determined that the SLC22A24 gene contains 4 exons.
Jacobsson et al. (2007) stated that the SLC22A24 gene maps to chromosome 11q12.3; the mouse Slc22a24 gene maps to chromosome 19qA.
Jacobsson, J. A., Haitina, T., Lindblom, J., Fredriksson, R. Identification of six putative human transporters with structural similarity to the drug transporter SLC22 family. Genomics 90: 595-609, 2007. [PubMed: 17714910] [Full Text: https://doi.org/10.1016/j.ygeno.2007.03.017]