Alternative titles; symbols
HGNC Approved Gene Symbol: INTS10
Cytogenetic location: 8p21.3 Genomic coordinates (GRCh38): 8:19,817,416-19,852,067 (from NCBI)
INTS10 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; 180680) and U2 (RNU2; 180690) (Baillat et al., 2005).
By SDS-PAGE of proteins that copurified with INTS11 (CPSF3L; 611354) in HEK293 cells, Baillat et al. (2005) identified INTS10 as a subunit of the Integrator complex.
Li et al. (2016) observed decreased levels of hepatitis B virus (HBV; see 610424) markers in human hepatocytes transfected with HBV and INTS10 compared with those transfected with HBV and control vectors. Knockdown of INTS10 via small interfering RNA resulted in increased HBV marker expression. Suppression of HBV replication by INTS10 occurred in an IRF3 (603734)-dependent manner. INTS10 expression was lower in patients persistently infected with HBV compared with patients who spontaneously recovered. Li et al. (2016) proposed that insufficient INTS10 may contribute to persistence of HBV infection.
Li et al. (2016) stated that the INTS10 gene maps to chromosome 8p21.3.
Baillat, D., Hakimi, M.-A., Naar, A. M., Shilatifard, A., Cooch, N., Shiekhattar, R. Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II. Cell 123: 265-276, 2005. [PubMed: 16239144] [Full Text: https://doi.org/10.1016/j.cell.2005.08.019]
Li, Y., Si, L., Zhai, Y., Hu, Y., Hu, Z., Bei, J.-X., Xie, B., Ren, Q., Cao, P., Yang, F., Song, Q., Bao, Z., and 38 others. Genome-wide association study identifies 8p21.3 associated with persistent hepatitis B virus infection among Chinese. Nature Commun. 7: 11664, 2016. Note: Electronic Article. [PubMed: 27244555] [Full Text: https://doi.org/10.1038/ncomms11664]