Alternative titles; symbols
HGNC Approved Gene Symbol: TRIM31
Cytogenetic location: 6p22.1 Genomic coordinates (GRCh38): 6:30,102,897-30,113,090 (from NCBI)
By screening a duodenal mucosa cDNA library with a fragment of a YAC containing the HLA-A gene (142800), El Kahloun et al. (1993) cloned TRIM31, which they designated HCGI. Northern blot analysis of several tissues detected a 1.2-kb TRIM31 transcript in duodenal mucosa only.
Using a B-box domain consensus sequence to screen EST databases for novel TRIM family members, Reymond et al. (2001) identified and cloned mouse and human TRIM31. The deduced protein contains an N-terminal RING domain, a B-box-2 domain, and a coiled-coil region.
By yeast 2-hybrid analysis, Reymond et al. (2001) found that TRIM31 forms homodimers. Mutation analysis of other TRIM proteins suggested that the coiled-coil region mediates complex formation.
By YAC analysis, El Kahloun et al. (1993) mapped the TRIM31 gene to chromosome 6p23-p21. TRIM31 is a single-copy gene about 170 kb centromeric to HLA-A.
By radiation hybrid analysis, Reymond et al. (2001) mapped the TRIM31 gene to chromosome 6p23-p21, where it resides within a TRIM gene cluster that includes TRIM10 (605701), TRIM26 (600830), and TRIM27 (602165).
El Kahloun, A., Chauvel, B., Mauvieux, V., Dorval, I., Jouanolle, A.-M., Gicquel, I., Le Gall, J.-Y., David, V. Localization of seven new genes around the HLA-A locus. Hum. Molec. Genet. 2: 55-60, 1993. [PubMed: 8490624] [Full Text: https://doi.org/10.1093/hmg/2.1.55]
Reymond, A., Meroni, G., Fantozzi, A., Merla, G., Cairo, S., Luzi, L., Riganelli, D., Zanaria, E., Messali, S., Cainarca, S., Guffanti, A., Minucci, S., Pelicci, P. G., Ballabio, A. The tripartite motif family identifies cell compartments. EMBO J. 20: 2140-2151, 2001. [PubMed: 11331580] [Full Text: https://doi.org/10.1093/emboj/20.9.2140]