Entry - *300508 - UTP14A SMALL SUBUNIT PROCESSOME COMPONENT; UTP14A - OMIM

 
 
* 300508

UTP14A SMALL SUBUNIT PROCESSOME COMPONENT; UTP14A


Alternative titles; symbols

UTP14, S. CEREVISIAE, HOMOLOG OF, A
NY-CO-16


HGNC Approved Gene Symbol: UTP14A

Cytogenetic location: Xq26.1     Genomic coordinates (GRCh38): X:129,906,164-129,929,752 (from NCBI)


TEXT

▼ Cloning and Expression

Using SEREX (serologic analysis of recombinant cDNA expression libraries), Scanlan et al. (1998) cloned UTP14A, which they called NY-CO-16, from a colon cancer cDNA library. The deduced 286-amino acid protein has a nuclear targeting signal.

Rohozinski and Bishop (2004) identified mouse and human UTP14A and UTP14B (UTP14C; 608969). The deduced UTP14A protein shares 77% amino acid identity with mouse Utp14a and 90% identity with human UTP14B. RT-PCR showed that the mouse Utp14a gene was ubiquitously expressed, and the authors found that human UTP14A was also ubiquitously expressed.


▼ Gene Structure

Rohozinski and Bishop (2004) determined that the UTP14A gene contains 14 coding exons. The mouse Utp14a gene contains 15 coding exons.


▼ Mapping

By genomic sequence analysis, Rohozinski and Bishop (2004) mapped the UTP14A gene to the X chromosome. They also mapped the mouse Utp14a gene to the X chromosome.


▼ REFERENCES

  1. Rohozinski, J., Bishop, C. E. The mouse juvenile spermatogonial depletion (jsd) phenotype is due to a mutation in the X-derived retrogene, mUtp14b. Proc. Nat. Acad. Sci. 101: 11695-11700, 2004. [PubMed: 15289605, images, related citations] [Full Text]

  2. Scanlan, M. J., Chen, Y.-T., Williamson, B., Gure, A. O., Stockert, E., Gordan, J. D., Tureci, O., Sahin, U., Pfreundschuh, M., Old, L. J. Characterization of human colon cancer antigens recognized by autologous antibodies. Int. J. Cancer 76: 652-658, 1998. [PubMed: 9610721, related citations] [Full Text]


Creation Date:
Patricia A. Hartz : 10/14/2004
Edit History:
carol : 11/06/2020
mgross : 10/14/2004

* 300508

UTP14A SMALL SUBUNIT PROCESSOME COMPONENT; UTP14A


Alternative titles; symbols

UTP14, S. CEREVISIAE, HOMOLOG OF, A
NY-CO-16


HGNC Approved Gene Symbol: UTP14A

Cytogenetic location: Xq26.1     Genomic coordinates (GRCh38): X:129,906,164-129,929,752 (from NCBI)


TEXT

Cloning and Expression

Using SEREX (serologic analysis of recombinant cDNA expression libraries), Scanlan et al. (1998) cloned UTP14A, which they called NY-CO-16, from a colon cancer cDNA library. The deduced 286-amino acid protein has a nuclear targeting signal.

Rohozinski and Bishop (2004) identified mouse and human UTP14A and UTP14B (UTP14C; 608969). The deduced UTP14A protein shares 77% amino acid identity with mouse Utp14a and 90% identity with human UTP14B. RT-PCR showed that the mouse Utp14a gene was ubiquitously expressed, and the authors found that human UTP14A was also ubiquitously expressed.


Gene Structure

Rohozinski and Bishop (2004) determined that the UTP14A gene contains 14 coding exons. The mouse Utp14a gene contains 15 coding exons.


Mapping

By genomic sequence analysis, Rohozinski and Bishop (2004) mapped the UTP14A gene to the X chromosome. They also mapped the mouse Utp14a gene to the X chromosome.


REFERENCES

  1. Rohozinski, J., Bishop, C. E. The mouse juvenile spermatogonial depletion (jsd) phenotype is due to a mutation in the X-derived retrogene, mUtp14b. Proc. Nat. Acad. Sci. 101: 11695-11700, 2004. [PubMed: 15289605] [Full Text: https://doi.org/10.1073/pnas.0401130101]

  2. Scanlan, M. J., Chen, Y.-T., Williamson, B., Gure, A. O., Stockert, E., Gordan, J. D., Tureci, O., Sahin, U., Pfreundschuh, M., Old, L. J. Characterization of human colon cancer antigens recognized by autologous antibodies. Int. J. Cancer 76: 652-658, 1998. [PubMed: 9610721] [Full Text: https://doi.org/10.1002/(sici)1097-0215(19980529)76:5<652::aid-ijc7>3.0.co;2-p]


Creation Date:
Patricia A. Hartz : 10/14/2004

Edit History:
carol : 11/06/2020
mgross : 10/14/2004



NOTE: OMIM is intended for use primarily by physicians and other professionals concerned with genetic disorders, by genetics researchers, and by advanced students in science and medicine. While the OMIM database is open to the public, users seeking information about a personal medical or genetic condition are urged to consult with a qualified physician for diagnosis and for answers to personal questions.
OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.

NOTE: OMIM is intended for use primarily by physicians and other professionals concerned with genetic disorders, by genetics researchers, and by advanced students in science and medicine. While the OMIM database is open to the public, users seeking information about a personal medical or genetic condition are urged to consult with a qualified physician for diagnosis and for answers to personal questions.
OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.
Printed: June 11, 2024