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Melioidosis, susceptibility to

MedGen UID:
816255
Concept ID:
C3809925
Finding
Synonym: MELIOIDOSIS, SUSCEPTIBILITY TO
 
Gene (location): TLR5 (1q41)
 
Monarch Initiative: MONDO:0014251
OMIM®: 615557

Definition

Melioidosis is infection caused by the gram-negative, flagellated soil saprophyte Burkholderia pseudomallei, which is endemic in parts of southeast Asia and northern Australia. Sepsis is a common clinical presentation of disease, and lung is the organ most commonly involved. In northern Thailand, where B. pseudomallei is the most common bloodstream isolate, the overall melioidosis mortality rate exceeds 40%, and pneumonia confers more than 2-fold increased risk of death (summary by West et al., 2013). [from OMIM]

Professional guidelines

PubMed

Hussin A, Nor Rahim MY, Dalusim F, Shahidan MA, Nathan S, Ibrahim N
PLoS Negl Trop Dis 2023 Oct;17(10):e0011696. Epub 2023 Oct 16 doi: 10.1371/journal.pntd.0011696. PMID: 37844130Free PMC Article
Shaw T, Tellapragada C, Eshwara VK, Bhat HV, Mukhopadhyay C
Indian J Med Microbiol 2016 Jul-Sep;34(3):353-4. doi: 10.4103/0255-0857.188340. PMID: 27514960
Lipsitz R, Garges S, Aurigemma R, Baccam P, Blaney DD, Cheng AC, Currie BJ, Dance D, Gee JE, Larsen J, Limmathurotsakul D, Morrow MG, Norton R, O'Mara E, Peacock SJ, Pesik N, Rogers LP, Schweizer HP, Steinmetz I, Tan G, Tan P, Wiersinga WJ, Wuthiekanun V, Smith TL
Emerg Infect Dis 2012 Dec;18(12):e2. doi: 10.3201/eid1812.120638. PMID: 23171644Free PMC Article

Recent clinical studies

Etiology

Hussin A, Nor Rahim MY, Dalusim F, Shahidan MA, Nathan S, Ibrahim N
PLoS Negl Trop Dis 2023 Oct;17(10):e0011696. Epub 2023 Oct 16 doi: 10.1371/journal.pntd.0011696. PMID: 37844130Free PMC Article
Medhasi S, Chantratita N
J Immunol Res 2022;2022:9710376. Epub 2022 May 26 doi: 10.1155/2022/9710376. PMID: 35664353Free PMC Article
Wu H, Wang X, Zhou X, Wu Z, Wang Y, Pan M, Lu B
PLoS Negl Trop Dis 2020 Aug;14(8):e0008525. Epub 2020 Aug 12 doi: 10.1371/journal.pntd.0008525. PMID: 32785225Free PMC Article
Mahikul W, White LJ, Poovorawan K, Soonthornworasiri N, Sukontamarn P, Chanthavilay P, Medley GF, Pan-Ngum W
PLoS Negl Trop Dis 2019 May;13(5):e0007380. Epub 2019 May 9 doi: 10.1371/journal.pntd.0007380. PMID: 31071094Free PMC Article
Watson AK, Ellington S, Nelson C, Treadwell T, Jamieson DJ, Meaney-Delman DM
Birth Defects Res 2017 Mar 15;109(5):391-398. doi: 10.1002/bdr2.1016. PMID: 28398677

Diagnosis

Hussin A, Nor Rahim MY, Dalusim F, Shahidan MA, Nathan S, Ibrahim N
PLoS Negl Trop Dis 2023 Oct;17(10):e0011696. Epub 2023 Oct 16 doi: 10.1371/journal.pntd.0011696. PMID: 37844130Free PMC Article
Purushotham P, Mohanty S, Chappity P, Mishra TS, Mahapatra A
Am J Trop Med Hyg 2021 Feb 1;104(4):1252-1259. doi: 10.4269/ajtmh.20-1386. PMID: 33534740Free PMC Article
Wu H, Wang X, Zhou X, Wu Z, Wang Y, Pan M, Lu B
PLoS Negl Trop Dis 2020 Aug;14(8):e0008525. Epub 2020 Aug 12 doi: 10.1371/journal.pntd.0008525. PMID: 32785225Free PMC Article
Lipsitz R, Garges S, Aurigemma R, Baccam P, Blaney DD, Cheng AC, Currie BJ, Dance D, Gee JE, Larsen J, Limmathurotsakul D, Morrow MG, Norton R, O'Mara E, Peacock SJ, Pesik N, Rogers LP, Schweizer HP, Steinmetz I, Tan G, Tan P, Wiersinga WJ, Wuthiekanun V, Smith TL
Emerg Infect Dis 2012 Dec;18(12):e2. doi: 10.3201/eid1812.120638. PMID: 23171644Free PMC Article
Choy JL, Mayo M, Janmaat A, Currie BJ
Acta Trop 2000 Feb 5;74(2-3):153-8. doi: 10.1016/s0001-706x(99)00065-0. PMID: 10674644

Therapy

Hussin A, Nor Rahim MY, Dalusim F, Shahidan MA, Nathan S, Ibrahim N
PLoS Negl Trop Dis 2023 Oct;17(10):e0011696. Epub 2023 Oct 16 doi: 10.1371/journal.pntd.0011696. PMID: 37844130Free PMC Article
Sribenjalux W, Wonglakorn L, Meesing A
J Glob Antimicrob Resist 2022 Mar;28:8-11. Epub 2021 Dec 16 doi: 10.1016/j.jgar.2021.11.015. PMID: 34922057
Purushotham P, Mohanty S, Chappity P, Mishra TS, Mahapatra A
Am J Trop Med Hyg 2021 Feb 1;104(4):1252-1259. doi: 10.4269/ajtmh.20-1386. PMID: 33534740Free PMC Article
Nhung PH, Van VH, Anh NQ, Phuong DM
J Glob Antimicrob Resist 2019 Sep;18:34-36. Epub 2019 Jan 24 doi: 10.1016/j.jgar.2019.01.024. PMID: 30685463
Lipsitz R, Garges S, Aurigemma R, Baccam P, Blaney DD, Cheng AC, Currie BJ, Dance D, Gee JE, Larsen J, Limmathurotsakul D, Morrow MG, Norton R, O'Mara E, Peacock SJ, Pesik N, Rogers LP, Schweizer HP, Steinmetz I, Tan G, Tan P, Wiersinga WJ, Wuthiekanun V, Smith TL
Emerg Infect Dis 2012 Dec;18(12):e2. doi: 10.3201/eid1812.120638. PMID: 23171644Free PMC Article

Prognosis

Hussin A, Nor Rahim MY, Dalusim F, Shahidan MA, Nathan S, Ibrahim N
PLoS Negl Trop Dis 2023 Oct;17(10):e0011696. Epub 2023 Oct 16 doi: 10.1371/journal.pntd.0011696. PMID: 37844130Free PMC Article
Medhasi S, Chantratita N
J Immunol Res 2022;2022:9710376. Epub 2022 May 26 doi: 10.1155/2022/9710376. PMID: 35664353Free PMC Article
Liu N, Pang X, Zhang H, Ji P
Front Immunol 2021;12:814709. Epub 2022 Jan 13 doi: 10.3389/fimmu.2021.814709. PMID: 35095914Free PMC Article
Mahikul W, White LJ, Poovorawan K, Soonthornworasiri N, Sukontamarn P, Chanthavilay P, Medley GF, Pan-Ngum W
PLoS Negl Trop Dis 2019 May;13(5):e0007380. Epub 2019 May 9 doi: 10.1371/journal.pntd.0007380. PMID: 31071094Free PMC Article
Török ME, Chantratita N, Peacock SJ
Curr Opin Microbiol 2012 Oct;15(5):583-7. Epub 2012 Sep 27 doi: 10.1016/j.mib.2012.07.008. PMID: 23022568Free PMC Article

Clinical prediction guides

Medhasi S, Chantratita N
J Immunol Res 2022;2022:9710376. Epub 2022 May 26 doi: 10.1155/2022/9710376. PMID: 35664353Free PMC Article
Purushotham P, Mohanty S, Chappity P, Mishra TS, Mahapatra A
Am J Trop Med Hyg 2021 Feb 1;104(4):1252-1259. doi: 10.4269/ajtmh.20-1386. PMID: 33534740Free PMC Article
Wu H, Wang X, Zhou X, Wu Z, Wang Y, Pan M, Lu B
PLoS Negl Trop Dis 2020 Aug;14(8):e0008525. Epub 2020 Aug 12 doi: 10.1371/journal.pntd.0008525. PMID: 32785225Free PMC Article
Mahikul W, White LJ, Poovorawan K, Soonthornworasiri N, Sukontamarn P, Chanthavilay P, Medley GF, Pan-Ngum W
PLoS Negl Trop Dis 2019 May;13(5):e0007380. Epub 2019 May 9 doi: 10.1371/journal.pntd.0007380. PMID: 31071094Free PMC Article
Mohan A, Podin Y, Tai N, Chieng CH, Rigas V, Machunter B, Mayo M, Wong D, Chien SL, Tan LS, Goh C, Bantin R, Mijen A, Chua WY, Hii KC, Wong SC, Ngian HU, Wong JS, Hashim J, Currie BJ, Ooi MH
PLoS Negl Trop Dis 2017 Jun;11(6):e0005650. Epub 2017 Jun 9 doi: 10.1371/journal.pntd.0005650. PMID: 28599008Free PMC Article

Recent systematic reviews

Dunachie S, Chamnan P
Trans R Soc Trop Med Hyg 2019 Feb 1;113(2):56-64. doi: 10.1093/trstmh/try124. PMID: 30517697Free PMC Article

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