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Hemorrhage, intracerebral, susceptibility to(ICH)

MedGen UID:
482735
•Concept ID:
C3281105
•
Finding
Synonyms: ICH; Stroke, hemorrhagic, susceptibility to
 
Genes (locations): ACE (17q23.3); COL4A1 (13q34); COL4A2 (13q34)
 
Monarch Initiative: MONDO:0100533
OMIM®: 614519

Definition

An inherited susceptibility or predisposition to developing intracerebral hemorrhage. [from MONDO]

Professional guidelines

PubMed

Risk and Management of Intracerebral Hemorrhage in Patients with Bleeding Disorders.
Dorgalaleh A, Farshi Y, Haeri K, Ghanbari OB, Ahmadi A
Semin Thromb Hemost 2022 Apr;48(3):344-355. Epub 2022 Jan 6 doi: 10.1055/s-0041-1740566. PMID: 34991167
Management of intracerebral hemorrhage.
Thabet AM, Kottapally M, Hemphill JC 3rd
Handb Clin Neurol 2017;140:177-194. doi: 10.1016/B978-0-444-63600-3.00011-8. PMID: 28187799
The clinical utility of QSM: disease diagnosis, medical management, and surgical planning.
Eskreis-Winkler S, Zhang Y, Zhang J, Liu Z, Dimov A, Gupta A, Wang Y
NMR Biomed 2017 Apr;30(4) Epub 2016 Dec 1 doi: 10.1002/nbm.3668. PMID: 27906525

Recent clinical studies

Etiology

Association between gut microbiome and intracerebral hemorrhage based on genome-wide association study data.
Lin D, Liu X, Li Q, Qin J, Xiong Z, Wu X
Zhong Nan Da Xue Xue Bao Yi Xue Ban 2023 Aug 28;48(8):1176-1184. doi: 10.11817/j.issn.1672-7347.2023.230107. PMID: 37875357Free PMC Article
Intracerebral Hemorrhage Among Blood Donors and Their Transfusion Recipients.
Zhao J, Rostgaard K, Lauwers E, Dahlén T, Ostrowski SR, Erikstrup C, Pedersen OB, de Strooper B, Lemmens R, Hjalgrim H, Edgren G
JAMA 2023 Sep 12;330(10):941-950. doi: 10.1001/jama.2023.14445. PMID: 37698562Free PMC Article
Diabetes Mellitus, Glycemic Traits, and Cerebrovascular Disease: A Mendelian Randomization Study.
Georgakis MK, Harshfield EL, Malik R, Franceschini N, Langenberg C, Wareham NJ, Markus HS, Dichgans M
Neurology 2021 Mar 30;96(13):e1732-e1742. Epub 2021 Jan 25 doi: 10.1212/WNL.0000000000011555. PMID: 33495378Free PMC Article
Genetic risk, incident stroke, and the benefits of adhering to a healthy lifestyle: cohort study of 306 473 UK Biobank participants.
Rutten-Jacobs LC, Larsson SC, Malik R, Rannikmäe K; MEGASTROKE consortium; International Stroke Genetics Consortium, Sudlow CL, Dichgans M, Markus HS, Traylor M
BMJ 2018 Oct 24;363:k4168. doi: 10.1136/bmj.k4168. PMID: 30355576Free PMC Article
Management of intracerebral hemorrhage.
Thabet AM, Kottapally M, Hemphill JC 3rd
Handb Clin Neurol 2017;140:177-194. doi: 10.1016/B978-0-444-63600-3.00011-8. PMID: 28187799

Diagnosis

Cerebral Amyloid Angiopathy.
Szidonya L, Nickerson JP
Radiol Clin North Am 2023 May;61(3):551-562. Epub 2023 Feb 20 doi: 10.1016/j.rcl.2023.01.009. PMID: 36931769
The Genetic Basis of Moyamoya Disease.
Mertens R, Graupera M, Gerhardt H, Bersano A, Tournier-Lasserve E, Mensah MA, Mundlos S, Vajkoczy P
Transl Stroke Res 2022 Feb;13(1):25-45. Epub 2021 Sep 16 doi: 10.1007/s12975-021-00940-2. PMID: 34529262Free PMC Article
Modifiable Lifestyle Factors and Risk of Stroke: A Mendelian Randomization Analysis.
Harshfield EL, Georgakis MK, Malik R, Dichgans M, Markus HS
Stroke 2021 Mar;52(3):931-936. Epub 2021 Feb 4 doi: 10.1161/STROKEAHA.120.031710. PMID: 33535786Free PMC Article
Novel Drug Targets for Ischemic Stroke Identified Through Mendelian Randomization Analysis of the Blood Proteome.
Chong M, Sjaarda J, Pigeyre M, Mohammadi-Shemirani P, Lali R, Shoamanesh A, Gerstein HC, Paré G
Circulation 2019 Sep 9;140(10):819-830. Epub 2019 Jun 18 doi: 10.1161/CIRCULATIONAHA.119.040180. PMID: 31208196
Genetically Determined Levels of Circulating Cytokines and Risk of Stroke.
Georgakis MK, Gill D, Rannikmäe K, Traylor M, Anderson CD, Lee JM, Kamatani Y, Hopewell JC, Worrall BB, Bernhagen J, Sudlow CLM, Malik R, Dichgans M
Circulation 2019 Jan 8;139(2):256-268. doi: 10.1161/CIRCULATIONAHA.118.035905. PMID: 30586705Free PMC Article

Therapy

Intracerebral Hemorrhage Among Blood Donors and Their Transfusion Recipients.
Zhao J, Rostgaard K, Lauwers E, Dahlén T, Ostrowski SR, Erikstrup C, Pedersen OB, de Strooper B, Lemmens R, Hjalgrim H, Edgren G
JAMA 2023 Sep 12;330(10):941-950. doi: 10.1001/jama.2023.14445. PMID: 37698562Free PMC Article
Coffee Consumption and Cardiovascular Diseases: A Mendelian Randomization Study.
Yuan S, Carter P, Mason AM, Burgess S, Larsson SC
Nutrients 2021 Jun 28;13(7) doi: 10.3390/nu13072218. PMID: 34203356Free PMC Article
Modifiable Lifestyle Factors and Risk of Stroke: A Mendelian Randomization Analysis.
Harshfield EL, Georgakis MK, Malik R, Dichgans M, Markus HS
Stroke 2021 Mar;52(3):931-936. Epub 2021 Feb 4 doi: 10.1161/STROKEAHA.120.031710. PMID: 33535786Free PMC Article
Diabetes Mellitus, Glycemic Traits, and Cerebrovascular Disease: A Mendelian Randomization Study.
Georgakis MK, Harshfield EL, Malik R, Franceschini N, Langenberg C, Wareham NJ, Markus HS, Dichgans M
Neurology 2021 Mar 30;96(13):e1732-e1742. Epub 2021 Jan 25 doi: 10.1212/WNL.0000000000011555. PMID: 33495378Free PMC Article
Smoking and stroke: A mendelian randomization study.
Larsson SC, Burgess S, Michaëlsson K
Ann Neurol 2019 Sep;86(3):468-471. Epub 2019 Jul 3 doi: 10.1002/ana.25534. PMID: 31237718Free PMC Article

Prognosis

Coffee Consumption and Cardiovascular Diseases: A Mendelian Randomization Study.
Yuan S, Carter P, Mason AM, Burgess S, Larsson SC
Nutrients 2021 Jun 28;13(7) doi: 10.3390/nu13072218. PMID: 34203356Free PMC Article
Modifiable Lifestyle Factors and Risk of Stroke: A Mendelian Randomization Analysis.
Harshfield EL, Georgakis MK, Malik R, Dichgans M, Markus HS
Stroke 2021 Mar;52(3):931-936. Epub 2021 Feb 4 doi: 10.1161/STROKEAHA.120.031710. PMID: 33535786Free PMC Article
Diabetes Mellitus, Glycemic Traits, and Cerebrovascular Disease: A Mendelian Randomization Study.
Georgakis MK, Harshfield EL, Malik R, Franceschini N, Langenberg C, Wareham NJ, Markus HS, Dichgans M
Neurology 2021 Mar 30;96(13):e1732-e1742. Epub 2021 Jan 25 doi: 10.1212/WNL.0000000000011555. PMID: 33495378Free PMC Article
Novel Drug Targets for Ischemic Stroke Identified Through Mendelian Randomization Analysis of the Blood Proteome.
Chong M, Sjaarda J, Pigeyre M, Mohammadi-Shemirani P, Lali R, Shoamanesh A, Gerstein HC, Paré G
Circulation 2019 Sep 9;140(10):819-830. Epub 2019 Jun 18 doi: 10.1161/CIRCULATIONAHA.119.040180. PMID: 31208196
Intracranial Aneurysms: Pathology, Genetics, and Molecular Mechanisms.
Xu Z, Rui YN, Hagan JP, Kim DH
Neuromolecular Med 2019 Dec;21(4):325-343. Epub 2019 May 4 doi: 10.1007/s12017-019-08537-7. PMID: 31055715Free PMC Article

Clinical prediction guides

Genetic Liability to Rheumatoid Arthritis in Relation to Coronary Artery Disease and Stroke Risk.
Yuan S, Carter P, Mason AM, Yang F, Burgess S, Larsson SC
Arthritis Rheumatol 2022 Oct;74(10):1638-1647. Epub 2022 Aug 17 doi: 10.1002/art.42239. PMID: 35583917Free PMC Article
Coffee Consumption and Cardiovascular Diseases: A Mendelian Randomization Study.
Yuan S, Carter P, Mason AM, Burgess S, Larsson SC
Nutrients 2021 Jun 28;13(7) doi: 10.3390/nu13072218. PMID: 34203356Free PMC Article
Modifiable Lifestyle Factors and Risk of Stroke: A Mendelian Randomization Analysis.
Harshfield EL, Georgakis MK, Malik R, Dichgans M, Markus HS
Stroke 2021 Mar;52(3):931-936. Epub 2021 Feb 4 doi: 10.1161/STROKEAHA.120.031710. PMID: 33535786Free PMC Article
Diabetes Mellitus, Glycemic Traits, and Cerebrovascular Disease: A Mendelian Randomization Study.
Georgakis MK, Harshfield EL, Malik R, Franceschini N, Langenberg C, Wareham NJ, Markus HS, Dichgans M
Neurology 2021 Mar 30;96(13):e1732-e1742. Epub 2021 Jan 25 doi: 10.1212/WNL.0000000000011555. PMID: 33495378Free PMC Article
Novel Drug Targets for Ischemic Stroke Identified Through Mendelian Randomization Analysis of the Blood Proteome.
Chong M, Sjaarda J, Pigeyre M, Mohammadi-Shemirani P, Lali R, Shoamanesh A, Gerstein HC, Paré G
Circulation 2019 Sep 9;140(10):819-830. Epub 2019 Jun 18 doi: 10.1161/CIRCULATIONAHA.119.040180. PMID: 31208196

Recent systematic reviews

A systematic review on intracranial aneurysm and hemorrhage detection using machine learning and deep learning techniques.
Nafees Ahmed S, Prakasam P
Prog Biophys Mol Biol 2023 Oct;183:1-16. Epub 2023 Jul 25 doi: 10.1016/j.pbiomolbio.2023.07.001. PMID: 37499766
Neuroimaging features of FOXR2-activated CNS neuroblastoma: A case series and systematic review.
Shimazaki K, Kurokawa R, Franson A, Kurokawa M, Baba A, Bou-Maroun L, Kim J, Moritani T
J Neuroimaging 2023 May-Jun;33(3):359-367. Epub 2023 Feb 20 doi: 10.1111/jon.13095. PMID: 36806312
Association between Apolipoprotein E Polymorphism and Clinical Outcome after Ischemic Stroke, Intracerebral Hemorrhage, and Subarachnoid Hemorrhage.
Pan W, Zhang M, Guo Z, Xiao W, You C, Xue L
Cerebrovasc Dis 2022;51(3):313-322. Epub 2021 Dec 15 doi: 10.1159/000520053. PMID: 34915479
Genetic risk of Spontaneous intracerebral hemorrhage: Systematic review and future directions.
Wahab KW, Tiwari HK, Ovbiagele B, Sarfo F, Akinyemi R, Traylor M, Rotimi C, Markus HS, Owolabi M
J Neurol Sci 2019 Dec 15;407:116526. Epub 2019 Oct 13 doi: 10.1016/j.jns.2019.116526. PMID: 31669726Free PMC Article
Genetic susceptibility to cerebrovascular disease: A systematic review.
Griessenauer CJ, Farrell S, Sarkar A, Zand R, Abedi V, Holland N, Michael A, Cummings CL, Metpally R, Carey DJ, Goren O, Martin N, Hendrix P, Schirmer CM
J Cereb Blood Flow Metab 2018 Nov;38(11):1853-1871. Epub 2018 Sep 5 doi: 10.1177/0271678X18797958. PMID: 30182779Free PMC Article

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      OMIM records containing genes associated with phenotypes registered in MedGen
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