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Macular hyperpigmented dermopathy

MedGen UID:
870439
•Concept ID:
C4024885
•
Anatomical Abnormality
HPO: HP:0007412

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMacular hyperpigmented dermopathy

Conditions with this feature

Epidermolysis bullosa, junctional 4, intermediate
MedGen UID:
382015
•Concept ID:
C2608084
•
Disease or Syndrome
See: Condition Record
Epidermolysis bullosa, junctional 4, intermediate

Professional guidelines

PubMed

Clinical and instrumental evaluation of the efficacy of a new depigmenting agent containing a combination of a retinoid, a phenolic agent and an antioxidant for the treatment of solar lentigines.
Cameli N, Abril E, Agozzino M, Mariano M
Dermatology 2015;230(4):360-6. Epub 2015 Apr 9 doi: 10.1159/000379746. PMID: 25871836

Recent clinical studies

Etiology

The use of radio-wave surgery: An underestimated method for small hyperpigmented flat or macular lesions on face.
Pekmezci E
J Cosmet Dermatol 2022 Oct;21(10):4691-4696. Epub 2022 May 10 doi: 10.1111/jocd.14995. PMID: 35427435
Comparison of the efficacy and safety of intralesional injection of tranexamic acid and the topical application of Kligman combination drug in the treatment of macular amyloidosis.
Ghassemi M, Roohaninasab M, Kamani SA, Sadeghzadeh-Bazargan A, Goodarzi A
Dermatol Ther 2022 Jan;35(1):e15213. Epub 2021 Nov 30 doi: 10.1111/dth.15213. PMID: 34797597
Primary Localized Cutaneous Amyloidosis of Keratinocyte Origin: An Update with Emphasis on Atypical Clinical Variants.
Hamie L, Haddad I, Nasser N, Kurban M, Abbas O
Am J Clin Dermatol 2021 Sep;22(5):667-680. Epub 2021 Jul 21 doi: 10.1007/s40257-021-00620-9. PMID: 34286474
Hyperpigmented spots after treatment for submacular hemorrhage secondary to polypoidal choroidal vasculopathy.
Kim JH, Chang YS, Kim CG, Lee DW, Han JI
Graefes Arch Clin Exp Ophthalmol 2018 Mar;256(3):469-477. Epub 2018 Jan 4 doi: 10.1007/s00417-017-3877-5. PMID: 29302789
An unusual presentation of primary cutaneous amyloidosis.
Garg T, Marak A, Ahmed R, Chander R, Jain M
Dermatol Online J 2017 Aug 15;23(8) PMID: 29469741

Diagnosis

Vulvar Melanoma.
Pye IM, Saw RPM, Saunderson RB
JAMA Dermatol 2023 Jan 1;159(1):96. doi: 10.1001/jamadermatol.2022.4550. PMID: 36449308
An intertriginous hyperpigmented macular eruption.
Harnett C, Meah N, Low SE, Eustace K
Clin Exp Dermatol 2022 Dec;47(12):2327-2329. Epub 2022 Oct 14 doi: 10.1111/ced.15363. PMID: 36239333
Cutaneous lymphocytic thrombophilic (macular) arteritis.
Kolivras A, Thompson C
Clin Dermatol 2021 Mar-Apr;39(2):278-282. Epub 2020 Oct 16 doi: 10.1016/j.clindermatol.2020.10.011. PMID: 34272022
Biological processes in solar lentigo: insights brought by experimental models.
Goorochurn R, Viennet C, Granger C, Fanian F, Varin-Blank N, Roy CL, Humbert P
Exp Dermatol 2016 Mar;25(3):174-7. doi: 10.1111/exd.12937. PMID: 26739821
Verrucous and macular sarcoidosis.
DeFelice T, Fischer M, Kamino H, Cohen D, Latkowski JA
Dermatol Online J 2012 Dec 15;18(12):10. PMID: 23286800

Therapy

Comparison of the efficacy and safety of intralesional injection of tranexamic acid and the topical application of Kligman combination drug in the treatment of macular amyloidosis.
Ghassemi M, Roohaninasab M, Kamani SA, Sadeghzadeh-Bazargan A, Goodarzi A
Dermatol Ther 2022 Jan;35(1):e15213. Epub 2021 Nov 30 doi: 10.1111/dth.15213. PMID: 34797597
Gefitinib-associated lichen planus pigmentosus-like eruption.
Chuenwipasakul D, Wititsuwannakul J, Asawanonda P, Rerknimitr P
Dermatol Online J 2021 May 15;27(5) doi: 10.5070/D327553616. PMID: 34118816
Hyperpigmented spots after treatment for submacular hemorrhage secondary to polypoidal choroidal vasculopathy.
Kim JH, Chang YS, Kim CG, Lee DW, Han JI
Graefes Arch Clin Exp Ophthalmol 2018 Mar;256(3):469-477. Epub 2018 Jan 4 doi: 10.1007/s00417-017-3877-5. PMID: 29302789
Biological processes in solar lentigo: insights brought by experimental models.
Goorochurn R, Viennet C, Granger C, Fanian F, Varin-Blank N, Roy CL, Humbert P
Exp Dermatol 2016 Mar;25(3):174-7. doi: 10.1111/exd.12937. PMID: 26739821
Macular amyloidosis complicating macroprolactinoma--a novel clinical association.
Dutta D, Ahuja A, Sharma L, Bhardwaj M, Kulshreshtha B
Endokrynol Pol 2015;66(6):555-8. doi: 10.5603/EP.2015.0068. PMID: 26662655

Prognosis

Cutaneous lymphocytic thrombophilic (macular) arteritis.
Kolivras A, Thompson C
Clin Dermatol 2021 Mar-Apr;39(2):278-282. Epub 2020 Oct 16 doi: 10.1016/j.clindermatol.2020.10.011. PMID: 34272022
Is macular lymphocytic arteritis limited to the skin? Long-term follow-up of seven patients.
Morita TCAB, Trés GFS, Criado PR
An Bras Dermatol 2020 Jan-Feb;95(1):32-39. Epub 2019 Nov 22 doi: 10.1016/j.abd.2019.05.001. PMID: 31889596Free PMC Article
Hyperpigmented spots after treatment for submacular hemorrhage secondary to polypoidal choroidal vasculopathy.
Kim JH, Chang YS, Kim CG, Lee DW, Han JI
Graefes Arch Clin Exp Ophthalmol 2018 Mar;256(3):469-477. Epub 2018 Jan 4 doi: 10.1007/s00417-017-3877-5. PMID: 29302789
Analysis of 36 cases of Blaschkoid dyspigmentation: reading between the lines of Blaschko.
Cohen J 3rd, Shahrokh K, Cohen B
Pediatr Dermatol 2014 Jul-Aug;31(4):471-6. doi: 10.1111/pde.12346. PMID: 25039703
Hyperpigmented macules on the face of young children: a series of 25 cases.
Hernández-Martín A, Gilliam AE, Baselga E, Vicente A, Lam J, González-Enseñat M, Azorín D, Torrelo A
J Am Acad Dermatol 2014 Feb;70(2):288-90. Epub 2013 Dec 15 doi: 10.1016/j.jaad.2013.10.045. PMID: 24342755

Clinical prediction guides

Hypotrichosis with Juvenile Macular Dystrophy in a Patient with Cadherin 3 (CDH3) Mutation.
Rishi E, Goel S, Bassi S, Rishi P
Nepal J Ophthalmol 2022 Jan;14(27):168-172. doi: 10.3126/nepjoph.v14i1.37258. PMID: 35996915
The use of radio-wave surgery: An underestimated method for small hyperpigmented flat or macular lesions on face.
Pekmezci E
J Cosmet Dermatol 2022 Oct;21(10):4691-4696. Epub 2022 May 10 doi: 10.1111/jocd.14995. PMID: 35427435
Comparison of the efficacy and safety of intralesional injection of tranexamic acid and the topical application of Kligman combination drug in the treatment of macular amyloidosis.
Ghassemi M, Roohaninasab M, Kamani SA, Sadeghzadeh-Bazargan A, Goodarzi A
Dermatol Ther 2022 Jan;35(1):e15213. Epub 2021 Nov 30 doi: 10.1111/dth.15213. PMID: 34797597
Hyperpigmented spots after treatment for submacular hemorrhage secondary to polypoidal choroidal vasculopathy.
Kim JH, Chang YS, Kim CG, Lee DW, Han JI
Graefes Arch Clin Exp Ophthalmol 2018 Mar;256(3):469-477. Epub 2018 Jan 4 doi: 10.1007/s00417-017-3877-5. PMID: 29302789
Primary macular amyloidosis: an ultrastructural approach to diagnosis.
Schepis C, Siragusa M, Gagliardi ME, Torre V, Cicciarello R, Albiero F, Cavallari V
Ultrastruct Pathol 1999 Sep-Oct;23(5):279-84. doi: 10.1080/019131299281428. PMID: 10582265

Recent systematic reviews

Macular amyloidosis diagnostic outcomes of skin biopsy: A systematic review.
Alhawas F, Obaid SB, Alfawzan O, Fathaddin A, Alsuwaidan S, Alajlan A
J Cutan Pathol 2024 May;51(5):393-397. Epub 2024 Feb 8 doi: 10.1111/cup.14592. PMID: 38328942

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