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Agenesis of permanent molar

MedGen UID:
869143
•Concept ID:
C4023563
•
Finding
Synonyms: Absence of adult molar; Absence of permanent molar; Agenesis of secondary molar; Failure of development of permanent molar; Failure of development of secondary molar; Missing adult molar; Missing permanent molar
 
HPO: HP:0011055

Definition

Agenesis of secondary molar tooth. [from HPO]

Conditions with this feature

Tooth agenesis, selective, 3
MedGen UID:
410035
•Concept ID:
C1970291
•
Disease or Syndrome
Any tooth agenesis in which the cause of the disease is a mutation in the PAX9 gene.
See: Condition Record
Tooth agenesis, selective, 3

Professional guidelines

PubMed

Diagnosis, Management and Follow-Up of a Rare Regional Developmental Disorder: Segmental Odontomaxillary Dysplasia.
Heggie C, Gartshore L
J Dent Child (Chic) 2020 Jan 15;87(1):39-43. PMID: 32151309
Hypodontia: An Update on Its Etiology, Classification, and Clinical Management.
Al-Ani AH, Antoun JS, Thomson WM, Merriman TR, Farella M
Biomed Res Int 2017;2017:9378325. Epub 2017 Mar 19 doi: 10.1155/2017/9378325. PMID: 28401166Free PMC Article
Molar incisor hypomineralization: review and recommendations for clinical management.
William V, Messer LB, Burrow MF
Pediatr Dent 2006 May-Jun;28(3):224-32. PMID: 16805354

Recent clinical studies

Etiology

Patterns of nonsyndromic tooth agenesis and sexual dimorphism.
Kanchanasevee C, Chantarangsu S, Pittayapat P, Porntaveetus T
BMC Oral Health 2023 Jan 23;23(1):37. doi: 10.1186/s12903-023-02753-1. PMID: 36691053Free PMC Article
Association Between Autism Spectrum Disorder and Dental Anomalies of the Permanent Dentition.
Gandhi R, Ruxmohan S, Puranik CP
Pediatr Dent 2021 Jul 15;43(4):307-312. PMID: 34467849
On the Etiology of Molar-Incisor Hypomineralization.
Vieira AR, Kup E
Caries Res 2016;50(2):166-9. Epub 2016 Apr 26 doi: 10.1159/000445128. PMID: 27111773
Preterm infants--odontological aspects.
Rythén M
Swed Dent J Suppl 2012;(224):2p preceding i-vi, 1-106. PMID: 22755470
Molar incisor hypomineralization: review and recommendations for clinical management.
William V, Messer LB, Burrow MF
Pediatr Dent 2006 May-Jun;28(3):224-32. PMID: 16805354

Diagnosis

Prevalence and patterns of permanent tooth agenesis in individuals with Down syndrome: a meta-analysis.
Palaska PK, Antonarakis GS
Eur J Oral Sci 2016 Aug;124(4):317-28. Epub 2016 Jun 17 doi: 10.1111/eos.12282. PMID: 27311636
Taurodontism.
Mohan RP, Verma S, Agarwal N, Singh U
BMJ Case Rep 2013 Apr 17;2013 doi: 10.1136/bcr-2012-008490. PMID: 23598931Free PMC Article
Prevalence and Diagnosis of Molar-Incisor- Hypomineralisation (MIH): A systematic review.
Jälevik B
Eur Arch Paediatr Dent 2010 Apr;11(2):59-64. doi: 10.1007/BF03262714. PMID: 20403299
Molar incisor hypomineralization: review and recommendations for clinical management.
William V, Messer LB, Burrow MF
Pediatr Dent 2006 May-Jun;28(3):224-32. PMID: 16805354
Otodental syndrome.
Bloch-Zupan A, Goodman JR
Orphanet J Rare Dis 2006 Mar 21;1:5. doi: 10.1186/1750-1172-1-5. PMID: 16722606Free PMC Article

Therapy

Middle distal canal of mandibular first molar: A case report and literature review.
Kirici DO, Koc S
Niger J Clin Pract 2019 Feb;22(2):285-288. doi: 10.4103/njcp.njcp_315_18. PMID: 30729957
Prevalence and aetiology of Molar-Incisor Hypomineralisation among children aged 8-10 years in Tirana, Albania.
Hysi D, Kuscu OO, Droboniku E, Toti C, Xhemnica L, Caglar E
Eur J Paediatr Dent 2016 Mar;17(1):75-9. PMID: 26949245
C-shaped maxillary permanent first molar: a case report and literature review.
Martins JN, Quaresma S, Quaresma MC, Frisbie-Teel J
J Endod 2013 Dec;39(12):1649-53. Epub 2013 Aug 31 doi: 10.1016/j.joen.2013.06.032. PMID: 24238466
Microdontia and hypodontia of premolars and permanent molars in childhood cancer survivors after chemotherapy.
Pedersen LB, Clausen N, Schrøder H, Schmidt M, Poulsen S
Int J Paediatr Dent 2012 Jul;22(4):239-43. Epub 2011 Nov 17 doi: 10.1111/j.1365-263X.2011.01199.x. PMID: 22092748
Patterns of third-molar agenesis and associated dental anomalies in an orthodontic population.
Celikoglu M, Bayram M, Nur M
Am J Orthod Dentofacial Orthop 2011 Dec;140(6):856-60. doi: 10.1016/j.ajodo.2011.05.021. PMID: 22133951

Prognosis

Self-correction of the ectopic eruption of the maxillary first permanent molar and its predictive factors: A systematic review.
Bastos RTDRM, Dos Santos CCO, Bellini-Pereira SA, Normando D
Int J Paediatr Dent 2024 Jul;34(4):348-359. Epub 2023 Oct 24 doi: 10.1111/ipd.13131. PMID: 37876132
Hypodontia: An Update on Its Etiology, Classification, and Clinical Management.
Al-Ani AH, Antoun JS, Thomson WM, Merriman TR, Farella M
Biomed Res Int 2017;2017:9378325. Epub 2017 Mar 19 doi: 10.1155/2017/9378325. PMID: 28401166Free PMC Article
Prevalence and patterns of permanent tooth agenesis in individuals with Down syndrome: a meta-analysis.
Palaska PK, Antonarakis GS
Eur J Oral Sci 2016 Aug;124(4):317-28. Epub 2016 Jun 17 doi: 10.1111/eos.12282. PMID: 27311636
Aetiology, incidence and morphology of the C-shaped root canal system and its impact on clinical endodontics.
Kato A, Ziegler A, Higuchi N, Nakata K, Nakamura H, Ohno N
Int Endod J 2014 Nov;47(11):1012-33. Epub 2014 Mar 31 doi: 10.1111/iej.12256. PMID: 24483229Free PMC Article
Incidence and features of three-rooted permanent mandibular molars.
Loh HS
Aust Dent J 1990 Oct;35(5):434-7. doi: 10.1111/j.1834-7819.1990.tb05426.x. PMID: 2073191

Clinical prediction guides

Patterns of nonsyndromic tooth agenesis and sexual dimorphism.
Kanchanasevee C, Chantarangsu S, Pittayapat P, Porntaveetus T
BMC Oral Health 2023 Jan 23;23(1):37. doi: 10.1186/s12903-023-02753-1. PMID: 36691053Free PMC Article
Association of tooth agenesis with dental anomalies in young subjects.
Marra PM, Iorio B, Itro A, Santoro R, Itro A
Oral Maxillofac Surg 2021 Mar;25(1):35-39. Epub 2020 Jul 16 doi: 10.1007/s10006-020-00879-y. PMID: 32676748
Molar incisor hypomineralization: Analysis of asymmetry of lesions.
Biondi AM, Córtese SG, Babino L, Toscano MA
Acta Odontol Latinoam 2019 Apr 1;32(1):44-48. PMID: 31206574
Molar Incisor Hypomineralization: paediatricians should be involved as well!
Paglia L
Eur J Paediatr Dent 2018 Sep;19(3):173. doi: 10.23804/ejpd.2018.19.03.1. PMID: 30063146
Hypodontia: An Update on Its Etiology, Classification, and Clinical Management.
Al-Ani AH, Antoun JS, Thomson WM, Merriman TR, Farella M
Biomed Res Int 2017;2017:9378325. Epub 2017 Mar 19 doi: 10.1155/2017/9378325. PMID: 28401166Free PMC Article

Recent systematic reviews

Self-correction of the ectopic eruption of the maxillary first permanent molar and its predictive factors: A systematic review.
Bastos RTDRM, Dos Santos CCO, Bellini-Pereira SA, Normando D
Int J Paediatr Dent 2024 Jul;34(4):348-359. Epub 2023 Oct 24 doi: 10.1111/ipd.13131. PMID: 37876132
Molar-root incisor malformation - a systematic review of case reports and case series.
Jensen ED, Smart G, Poirier BF, Sethi S
BMC Oral Health 2023 Aug 18;23(1):576. doi: 10.1186/s12903-023-03275-6. PMID: 37596569Free PMC Article
Patterns of Dental Agenesis Highlight the Nature of the Causative Mutated Genes.
Fournier BP, Bruneau MH, Toupenay S, Kerner S, Berdal A, Cormier-Daire V, Hadj-Rabia S, Coudert AE, de La Dure-Molla M
J Dent Res 2018 Nov;97(12):1306-1316. Epub 2018 Jun 7 doi: 10.1177/0022034518777460. PMID: 29879364
Permanent tooth agenesis in individuals with non-syndromic Robin sequence: a systematic review and meta-analysis.
Antonarakis GS, Palaska PK, Suri S
Orthod Craniofac Res 2017 Nov;20(4):216-226. Epub 2017 Oct 13 doi: 10.1111/ocr.12204. PMID: 29027749
Prevalence and Diagnosis of Molar-Incisor- Hypomineralisation (MIH): A systematic review.
Jälevik B
Eur Arch Paediatr Dent 2010 Apr;11(2):59-64. doi: 10.1007/BF03262714. PMID: 20403299

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