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Absence of memory B cells

MedGen UID:
868167
•Concept ID:
C4022559
•
Finding
HPO: HP:0030251

Definition

Complete lack of memory B cells, that is, of mature B cell type that is long-lived, readily activated upon re-encounter of its antigenic determinant, and has been selected for expression of higher affinity immunoglobulin. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbsence of memory B cells

Professional guidelines

PubMed

The Euroflow PID Orientation Tube in the diagnostic workup of primary immunodeficiency: Daily practice performance in a tertiary university hospital.
Neirinck J, Emmaneel A, Buysse M, Philippé J, Van Gassen S, Saeys Y, Bossuyt X, De Buyser S, van der Burg M, Pérez-Andrés M, Orfao A, van Dongen JJM, Lambrecht BN, Kerre T, Hofmans M, Haerynck F, Bonroy C
Front Immunol 2022;13:937738. Epub 2022 Sep 13 doi: 10.3389/fimmu.2022.937738. PMID: 36177024Free PMC Article
Clinical impact and a prognostic marker of early rituximab treatment after rituximab reimbursement in Korean pemphigus patients.
Song A, Jang J, Lee A, Min SY, Lee SG, Kim SC, Shin J, Kim JH
Front Immunol 2022;13:932909. Epub 2022 Aug 2 doi: 10.3389/fimmu.2022.932909. PMID: 35983042Free PMC Article
Diagnosis and prognosis models for hepatocellular carcinoma patient's management based on tumor mutation burden.
Tang B, Zhu J, Zhao Z, Lu C, Liu S, Fang S, Zheng L, Zhang N, Chen M, Xu M, Yu R, Ji J
J Adv Res 2021 Nov;33:153-165. Epub 2021 Feb 9 doi: 10.1016/j.jare.2021.01.018. PMID: 34603786Free PMC Article

Recent clinical studies

Etiology

The immune factors have complex causal regulation effects on bone mineral density.
Cao RR, Yu XH, Xiong MF, Li XT, Deng FY, Lei SF
Front Immunol 2022;13:959417. Epub 2022 Oct 20 doi: 10.3389/fimmu.2022.959417. PMID: 36341399Free PMC Article
Asplenia and spleen hypofunction.
Lenti MV, Luu S, Carsetti R, Osier F, Ogwang R, Nnodu OE, Wiedermann U, Spencer J, Locatelli F, Corazza GR, Di Sabatino A
Nat Rev Dis Primers 2022 Nov 3;8(1):71. doi: 10.1038/s41572-022-00399-x. PMID: 36329079
Seeking Relevant Biomarkers in Common Variable Immunodeficiency.
Ho HE, Cunningham-Rundles C
Front Immunol 2022;13:857050. Epub 2022 Mar 11 doi: 10.3389/fimmu.2022.857050. PMID: 35359997Free PMC Article
The Spectrum of the Deficiency of Adenosine Deaminase 2: An Observational Analysis of a 60 Patient Cohort.
Barron KS, Aksentijevich I, Deuitch NT, Stone DL, Hoffmann P, Videgar-Laird R, Soldatos A, Bergerson J, Toro C, Cudrici C, Nehrebecky M, Romeo T, Jones A, Boehm M, Kanakry JA, Dimitrova D, Calvo KR, Alao H, Kapuria D, Ben-Yakov G, Pichard DC, Hathaway L, Brofferio A, McRae E, Moura NS, Schnappauf O, Rosenzweig S, Heller T, Cowen EW, Kastner DL, Ombrello AK
Front Immunol 2021;12:811473. Epub 2022 Jan 10 doi: 10.3389/fimmu.2021.811473. PMID: 35095905Free PMC Article
The Multifaceted Roles of B Cells in the Thymus: From Immune Tolerance to Autoimmunity.
Castañeda J, Hidalgo Y, Sauma D, Rosemblatt M, Bono MR, Núñez S
Front Immunol 2021;12:766698. Epub 2021 Nov 1 doi: 10.3389/fimmu.2021.766698. PMID: 34790201Free PMC Article

Diagnosis

The immune factors have complex causal regulation effects on bone mineral density.
Cao RR, Yu XH, Xiong MF, Li XT, Deng FY, Lei SF
Front Immunol 2022;13:959417. Epub 2022 Oct 20 doi: 10.3389/fimmu.2022.959417. PMID: 36341399Free PMC Article
Asplenia and spleen hypofunction.
Lenti MV, Luu S, Carsetti R, Osier F, Ogwang R, Nnodu OE, Wiedermann U, Spencer J, Locatelli F, Corazza GR, Di Sabatino A
Nat Rev Dis Primers 2022 Nov 3;8(1):71. doi: 10.1038/s41572-022-00399-x. PMID: 36329079
Machine-Learning Algorithm-Based Prediction of Diagnostic Gene Biomarkers Related to Immune Infiltration in Patients With Chronic Obstructive Pulmonary Disease.
Zhang Y, Xia R, Lv M, Li Z, Jin L, Chen X, Han Y, Shi C, Jiang Y, Jin S
Front Immunol 2022;13:740513. Epub 2022 Mar 8 doi: 10.3389/fimmu.2022.740513. PMID: 35350787Free PMC Article
Good's Syndrome: Time to Move on From Reviewing the Past.
Kabir A, Alizadehfar R, Tsoukas CM
Front Immunol 2021;12:815710. Epub 2022 Jan 12 doi: 10.3389/fimmu.2021.815710. PMID: 35095915Free PMC Article
Identification of Diagnostic Signatures and Immune Cell Infiltration Characteristics in Rheumatoid Arthritis by Integrating Bioinformatic Analysis and Machine-Learning Strategies.
Yu R, Zhang J, Zhuo Y, Hong X, Ye J, Tang S, Zhang Y
Front Immunol 2021;12:724934. Epub 2021 Oct 6 doi: 10.3389/fimmu.2021.724934. PMID: 34691030Free PMC Article

Therapy

The immune factors have complex causal regulation effects on bone mineral density.
Cao RR, Yu XH, Xiong MF, Li XT, Deng FY, Lei SF
Front Immunol 2022;13:959417. Epub 2022 Oct 20 doi: 10.3389/fimmu.2022.959417. PMID: 36341399Free PMC Article
Asplenia and spleen hypofunction.
Lenti MV, Luu S, Carsetti R, Osier F, Ogwang R, Nnodu OE, Wiedermann U, Spencer J, Locatelli F, Corazza GR, Di Sabatino A
Nat Rev Dis Primers 2022 Nov 3;8(1):71. doi: 10.1038/s41572-022-00399-x. PMID: 36329079
Evolution of Human Memory B Cells From Childhood to Old Age.
Ciocca M, Zaffina S, Fernandez Salinas A, Bocci C, Palomba P, Conti MG, Terreri S, Frisullo G, Giorda E, Scarsella M, Brugaletta R, Vinci MR, Magnavita N, Carsetti R, Piano Mortari E
Front Immunol 2021;12:690534. Epub 2021 Jul 23 doi: 10.3389/fimmu.2021.690534. PMID: 34367150Free PMC Article
Short- and Long-Lived Autoantibody-Secreting Cells in Autoimmune Neurological Disorders.
Zografou C, Vakrakou AG, Stathopoulos P
Front Immunol 2021;12:686466. Epub 2021 Jun 17 doi: 10.3389/fimmu.2021.686466. PMID: 34220839Free PMC Article
Memory B Cells in Multiple Sclerosis: Emerging Players in Disease Pathogenesis.
DiSano KD, Gilli F, Pachner AR
Front Immunol 2021;12:676686. Epub 2021 Jun 8 doi: 10.3389/fimmu.2021.676686. PMID: 34168647Free PMC Article

Prognosis

Immunosuppressive landscape in hepatocellular carcinoma revealed by single-cell sequencing.
Bai Y, Chen D, Cheng C, Li Z, Chi H, Zhang Y, Zhang X, Tang S, Zhao Q, Ang B, Zhang Y
Front Immunol 2022;13:950536. Epub 2022 Jul 28 doi: 10.3389/fimmu.2022.950536. PMID: 35967424Free PMC Article
Role of IgM Memory B Cells and Spleen Function in COVID-19.
Rossi CM, Lenti MV, Merli S, Di Sabatino A
Front Immunol 2022;13:889876. Epub 2022 Jun 30 doi: 10.3389/fimmu.2022.889876. PMID: 35844543Free PMC Article
Machine-Learning Algorithm-Based Prediction of Diagnostic Gene Biomarkers Related to Immune Infiltration in Patients With Chronic Obstructive Pulmonary Disease.
Zhang Y, Xia R, Lv M, Li Z, Jin L, Chen X, Han Y, Shi C, Jiang Y, Jin S
Front Immunol 2022;13:740513. Epub 2022 Mar 8 doi: 10.3389/fimmu.2022.740513. PMID: 35350787Free PMC Article
Recent Metabolic Advances for Preventing and Treating Acute and Chronic Graft Versus Host Disease.
Mohamed FA, Thangavelu G, Rhee SY, Sage PT, O'Connor RS, Rathmell JC, Blazar BR
Front Immunol 2021;12:757836. Epub 2021 Oct 12 doi: 10.3389/fimmu.2021.757836. PMID: 34712243Free PMC Article
Memory B Cells in Pregnancy Sensitization.
Nellore A, Killian JT Jr, Porrett PM
Front Immunol 2021;12:688987. Epub 2021 Jun 30 doi: 10.3389/fimmu.2021.688987. PMID: 34276679Free PMC Article

Clinical prediction guides

The immune factors have complex causal regulation effects on bone mineral density.
Cao RR, Yu XH, Xiong MF, Li XT, Deng FY, Lei SF
Front Immunol 2022;13:959417. Epub 2022 Oct 20 doi: 10.3389/fimmu.2022.959417. PMID: 36341399Free PMC Article
Role of IgM Memory B Cells and Spleen Function in COVID-19.
Rossi CM, Lenti MV, Merli S, Di Sabatino A
Front Immunol 2022;13:889876. Epub 2022 Jun 30 doi: 10.3389/fimmu.2022.889876. PMID: 35844543Free PMC Article
Machine-Learning Algorithm-Based Prediction of Diagnostic Gene Biomarkers Related to Immune Infiltration in Patients With Chronic Obstructive Pulmonary Disease.
Zhang Y, Xia R, Lv M, Li Z, Jin L, Chen X, Han Y, Shi C, Jiang Y, Jin S
Front Immunol 2022;13:740513. Epub 2022 Mar 8 doi: 10.3389/fimmu.2022.740513. PMID: 35350787Free PMC Article
Evolution of Human Memory B Cells From Childhood to Old Age.
Ciocca M, Zaffina S, Fernandez Salinas A, Bocci C, Palomba P, Conti MG, Terreri S, Frisullo G, Giorda E, Scarsella M, Brugaletta R, Vinci MR, Magnavita N, Carsetti R, Piano Mortari E
Front Immunol 2021;12:690534. Epub 2021 Jul 23 doi: 10.3389/fimmu.2021.690534. PMID: 34367150Free PMC Article
Short- and Long-Lived Autoantibody-Secreting Cells in Autoimmune Neurological Disorders.
Zografou C, Vakrakou AG, Stathopoulos P
Front Immunol 2021;12:686466. Epub 2021 Jun 17 doi: 10.3389/fimmu.2021.686466. PMID: 34220839Free PMC Article

Recent systematic reviews

B-Cell Immunophenotyping to Predict Vaccination Outcome in the Immunocompromised - A Systematic Review.
Diks AM, Overduin LA, van Leenen LD, Slobbe L, Jolink H, Visser LG, van Dongen JJM, Berkowska MA
Front Immunol 2021;12:690328. Epub 2021 Sep 7 doi: 10.3389/fimmu.2021.690328. PMID: 34557188Free PMC Article

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