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Increased T cell count

MedGen UID:
867575
Concept ID:
C4021960
Finding
Synonyms: Increase in T cell count; Increase in T cell number
 
HPO: HP:0100828

Definition

An abnormal increase in the total number of T cells detected in the blood. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIncreased T cell count

Conditions with this feature

Autoinflammatory disease, systemic, with vasculitis
MedGen UID:
1841161
Concept ID:
C5830525
Disease or Syndrome
Systemic autoinflammatory disease with vasculitis (SAIDV) is an autosomal dominant disorder that manifests soon after birth with features such as purpuric skin rash, fever, hepatosplenomegaly, and elevated C-reactive protein (CRP; 123260). Laboratory studies may show leukocytosis, thrombocytopenia, and autoantibodies. A subset of patients develop progressive liver involvement that may result in fibrosis. Other systemic features, such as periorbital edema, conjunctivitis, infections, abdominal pain, and arthralgia are usually observed. Mutations occur de novo. De Jesus et al. (2023) referred to this disorder as LAVLI (LYN kinase-associated vasculopathy and liver fibrosis).
Immunodeficiency 112
MedGen UID:
1841269
Concept ID:
C5830633
Disease or Syndrome
Immunodeficiency-112 (IMD112) is an autosomal recessive primary immunologic disorder with variable manifestations beginning in early childhood. Some patients have recurrent bacterial, viral, and fungal infections, including disseminated bacillus Calmette-Guerin (BCG)-related infections, whereas at least 1 patient only presented with BCG-related infections. Immunologic workup shows variable abnormalities affecting lymphoid immunity, including hypogammaglobulinemia, lymphopenia or paradoxical lymphocytosis, and defects in B, T, and NK cell differentiation and function mainly due to disruption of the noncanonical NFKB (see 164011) signaling pathway (Willmann et al., 2014; Schlechter et al., 2017).

Professional guidelines

PubMed

Zhong M, Li M, Qi M, Su Y, Yu N, Lv R, Ye Z, Zhang X, Xu X, Cheng C, Chen C, Wei H
Front Immunol 2022;13:1033098. Epub 2023 Jan 9 doi: 10.3389/fimmu.2022.1033098. PMID: 36700216Free PMC Article
Wu Y, Zhu W, Sun C, Yue X, Zheng M, Fu G, Gong X
Front Public Health 2022;10:1002342. Epub 2022 Oct 17 doi: 10.3389/fpubh.2022.1002342. PMID: 36324449Free PMC Article
Bhebhe AT, Chongwe G, Moonga G
Pan Afr Med J 2021;40:231. Epub 2021 Dec 16 doi: 10.11604/pamj.2021.40.231.25149. PMID: 35178142Free PMC Article

Recent clinical studies

Etiology

Zahran WA, Ghonaim MM, Koura BA, El-Banna H, Ali SM, El-Sheikh N
Egypt J Immunol 2006;13(1):67-78. PMID: 17974151
Balfour EM, Glusac EJ, Heald P, Talley LL, Smoller BR
J Cutan Pathol 2003 Aug;30(7):437-42. doi: 10.1034/j.1600-0560.2003.00059.x. PMID: 12859741

Diagnosis

Zahran WA, Ghonaim MM, Koura BA, El-Banna H, Ali SM, El-Sheikh N
Egypt J Immunol 2006;13(1):67-78. PMID: 17974151
Balfour EM, Glusac EJ, Heald P, Talley LL, Smoller BR
J Cutan Pathol 2003 Aug;30(7):437-42. doi: 10.1034/j.1600-0560.2003.00059.x. PMID: 12859741

Therapy

Fujimi A, Matsunaga T, Kogawa K, Ohnuma T, Takahira N, Abe T, Kitaoka K, Kogawa T, Tanaka I, Morii K, Terui T, Sakamaki S, Kato J, Kura T, Maeda T, Niitsu Y
Br J Haematol 2002 Dec;119(3):858-62. doi: 10.1046/j.1365-2141.2002.03914.x. PMID: 12437672

Prognosis

Zahran WA, Ghonaim MM, Koura BA, El-Banna H, Ali SM, El-Sheikh N
Egypt J Immunol 2006;13(1):67-78. PMID: 17974151

Clinical prediction guides

Lu L, Li T, Feng X, Liu Z, Liu Y, Chao T, Gu Y, Huang R, Zhang F, He L, Zhou B, Kong E, Liu Z, Wang X, Chen Z, Wang H, Malissen M, Malissen B, Zhang L, Liang Y
PLoS Pathog 2022 Jun;18(6):e1010596. Epub 2022 Jun 6 doi: 10.1371/journal.ppat.1010596. PMID: 35666747Free PMC Article
Zahran WA, Ghonaim MM, Koura BA, El-Banna H, Ali SM, El-Sheikh N
Egypt J Immunol 2006;13(1):67-78. PMID: 17974151

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