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Recurrent infantile hypoglycemia

MedGen UID:
867283
•Concept ID:
C4021644
•
Disease or Syndrome
Synonyms: Episodic infantile hypoglycemia; Recurrent low blood sugar in infant
 
HPO: HP:0004914

Definition

Recurrent episodes of decreased concentration of glucose in the blood occurring during the infantile period. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRecurrent infantile hypoglycemia

Professional guidelines

PubMed

Retrospective analysis of beta-blocker instituted for treatment of hemangiomas (RABBIT study).
Chu DH, Castelo-Soccio L, Wan J, Gelfand JM, Shaddy RE, Shah KN, Perman MJ, Treat JR, Yan AC
Clin Pediatr (Phila) 2014 Oct;53(11):1084-90. Epub 2014 May 21 doi: 10.1177/0009922814535660. PMID: 24849505Free PMC Article
Cardiovascular and blood glucose parameters in infants during propranolol initiation for treatment of symptomatic infantile hemangiomas.
Puttgen KB, Summerer B, Schneider J, Cohen BA, Boss EF, Bauman NM
Ann Otol Rhinol Laryngol 2013 Sep;122(9):550-4. doi: 10.1177/000348941312200903. PMID: 24224397
Long-term treatment of persistent hyperinsulinaemic hypoglycaemia of infancy with diazoxide: a retrospective review of 77 cases and analysis of efficacy-predicting criteria.
Touati G, Poggi-Travert F, Ogier de Baulny H, Rahier J, Brunelle F, Nihoul-Fekete C, Czernichow P, Saudubray JM
Eur J Pediatr 1998 Aug;157(8):628-33. doi: 10.1007/s004310050900. PMID: 9727845

Recent clinical studies

Etiology

Case Report: Neurodevelopmental Outcome in a Small-for-Gestational-Age Infant With Symptomatic Hyperinsulinemic Hypoglycemia, Gaze Preference, and Infantile Spasms.
Chandran S, Teoh KW, Janardhan K, Yap F
Front Endocrinol (Lausanne) 2022;13:818252. Epub 2022 Jun 3 doi: 10.3389/fendo.2022.818252. PMID: 35721755Free PMC Article
Evaluating the Clinical Outcomes of Parotid Hemangiomas in the Pediatric Patient Population.
Harris J, Phillips JD
Ear Nose Throat J 2021 Jun;100(5):NP242-NP245. Epub 2019 Sep 29 doi: 10.1177/0145561319877760. PMID: 31565986
Retrospective analysis of beta-blocker instituted for treatment of hemangiomas (RABBIT study).
Chu DH, Castelo-Soccio L, Wan J, Gelfand JM, Shaddy RE, Shah KN, Perman MJ, Treat JR, Yan AC
Clin Pediatr (Phila) 2014 Oct;53(11):1084-90. Epub 2014 May 21 doi: 10.1177/0009922814535660. PMID: 24849505Free PMC Article
Carnitine palmitoyltransferases 1 and 2: biochemical, molecular and medical aspects.
Bonnefont JP, Djouadi F, Prip-Buus C, Gobin S, Munnich A, Bastin J
Mol Aspects Med 2004 Oct-Dec;25(5-6):495-520. doi: 10.1016/j.mam.2004.06.004. PMID: 15363638
Carnitine palmitoyltransferase deficiencies.
Bonnefont JP, Demaugre F, Prip-Buus C, Saudubray JM, Brivet M, Abadi N, Thuillier L
Mol Genet Metab 1999 Dec;68(4):424-40. doi: 10.1006/mgme.1999.2938. PMID: 10607472

Diagnosis

Case Report: Neurodevelopmental Outcome in a Small-for-Gestational-Age Infant With Symptomatic Hyperinsulinemic Hypoglycemia, Gaze Preference, and Infantile Spasms.
Chandran S, Teoh KW, Janardhan K, Yap F
Front Endocrinol (Lausanne) 2022;13:818252. Epub 2022 Jun 3 doi: 10.3389/fendo.2022.818252. PMID: 35721755Free PMC Article
Phosphoglucomutase-1 deficiency: Early presentation, metabolic management and detection in neonatal blood spots.
Conte F, Morava E, Bakar NA, Wortmann SB, Poerink AJ, Grunewald S, Crushell E, Al-Gazali L, de Vries MC, Mørkrid L, Hertecant J, Brocke Holmefjord KS, Kronn D, Feigenbaum A, Fingerhut R, Wong SY, van Scherpenzeel M, Voermans NC, Lefeber DJ
Mol Genet Metab 2020 Sep-Oct;131(1-2):135-146. Epub 2020 Sep 17 doi: 10.1016/j.ymgme.2020.08.003. PMID: 33342467
Recurrent hypoglycemia due to growth hormone deficiency in an infant with Turner syndrome.
Bonfig W, Salem NJ, Heiliger K, Hempel M, Lederer G, Bornkamm M, Wieland K, Lohse P, Burdach S, Oexle K
J Pediatr Endocrinol Metab 2012;25(9-10):991-5. doi: 10.1515/jpem-2012-0103. PMID: 23426831
Carnitine palmitoyltransferases 1 and 2: biochemical, molecular and medical aspects.
Bonnefont JP, Djouadi F, Prip-Buus C, Gobin S, Munnich A, Bastin J
Mol Aspects Med 2004 Oct-Dec;25(5-6):495-520. doi: 10.1016/j.mam.2004.06.004. PMID: 15363638
Carnitine palmitoyltransferase deficiencies.
Bonnefont JP, Demaugre F, Prip-Buus C, Saudubray JM, Brivet M, Abadi N, Thuillier L
Mol Genet Metab 1999 Dec;68(4):424-40. doi: 10.1006/mgme.1999.2938. PMID: 10607472

Therapy

Case Report: Neurodevelopmental Outcome in a Small-for-Gestational-Age Infant With Symptomatic Hyperinsulinemic Hypoglycemia, Gaze Preference, and Infantile Spasms.
Chandran S, Teoh KW, Janardhan K, Yap F
Front Endocrinol (Lausanne) 2022;13:818252. Epub 2022 Jun 3 doi: 10.3389/fendo.2022.818252. PMID: 35721755Free PMC Article
Evaluating the Clinical Outcomes of Parotid Hemangiomas in the Pediatric Patient Population.
Harris J, Phillips JD
Ear Nose Throat J 2021 Jun;100(5):NP242-NP245. Epub 2019 Sep 29 doi: 10.1177/0145561319877760. PMID: 31565986
Propranolol therapy for infantile hemangioma.
Gunturi N, Ramgopal S, Balagopal S, Scott JX
Indian Pediatr 2013 Mar;50(3):307-13. doi: 10.1007/s13312-013-0098-9. PMID: 23680605
Recurrent hypoglycemia due to growth hormone deficiency in an infant with Turner syndrome.
Bonfig W, Salem NJ, Heiliger K, Hempel M, Lederer G, Bornkamm M, Wieland K, Lohse P, Burdach S, Oexle K
J Pediatr Endocrinol Metab 2012;25(9-10):991-5. doi: 10.1515/jpem-2012-0103. PMID: 23426831
Propranolol vs corticosteroids for infantile hemangiomas: a multicenter retrospective analysis.
Price CJ, Lattouf C, Baum B, McLeod M, Schachner LA, Duarte AM, Connelly EA
Arch Dermatol 2011 Dec;147(12):1371-6. Epub 2011 Aug 15 doi: 10.1001/archdermatol.2011.203. PMID: 21844428

Prognosis

EIF2B2 gene mutation causing early onset vanishing white matter disease: a case report.
Filareto I, Cinelli G, Scalabrini I, Caramaschi E, Bergonzini P, Spezia E, Todeschini A, Iughetti L
Ital J Pediatr 2022 Jul 27;48(1):128. doi: 10.1186/s13052-022-01325-3. PMID: 35897042Free PMC Article
Case Report: Neurodevelopmental Outcome in a Small-for-Gestational-Age Infant With Symptomatic Hyperinsulinemic Hypoglycemia, Gaze Preference, and Infantile Spasms.
Chandran S, Teoh KW, Janardhan K, Yap F
Front Endocrinol (Lausanne) 2022;13:818252. Epub 2022 Jun 3 doi: 10.3389/fendo.2022.818252. PMID: 35721755Free PMC Article
Topical Timolol for Infantile Haemangioma of the Orbit.
Hildebrand GD, Sipkova Z
Klin Monbl Augenheilkd 2021 Oct;238(10):1069-1076. Epub 2021 Oct 18 doi: 10.1055/a-1645-1665. PMID: 34662921
Retrospective analysis of beta-blocker instituted for treatment of hemangiomas (RABBIT study).
Chu DH, Castelo-Soccio L, Wan J, Gelfand JM, Shaddy RE, Shah KN, Perman MJ, Treat JR, Yan AC
Clin Pediatr (Phila) 2014 Oct;53(11):1084-90. Epub 2014 May 21 doi: 10.1177/0009922814535660. PMID: 24849505Free PMC Article
Recurrent hypoglycemia due to growth hormone deficiency in an infant with Turner syndrome.
Bonfig W, Salem NJ, Heiliger K, Hempel M, Lederer G, Bornkamm M, Wieland K, Lohse P, Burdach S, Oexle K
J Pediatr Endocrinol Metab 2012;25(9-10):991-5. doi: 10.1515/jpem-2012-0103. PMID: 23426831

Clinical prediction guides

Evaluating the Clinical Outcomes of Parotid Hemangiomas in the Pediatric Patient Population.
Harris J, Phillips JD
Ear Nose Throat J 2021 Jun;100(5):NP242-NP245. Epub 2019 Sep 29 doi: 10.1177/0145561319877760. PMID: 31565986
Cardiovascular and blood glucose parameters in infants during propranolol initiation for treatment of symptomatic infantile hemangiomas.
Puttgen KB, Summerer B, Schneider J, Cohen BA, Boss EF, Bauman NM
Ann Otol Rhinol Laryngol 2013 Sep;122(9):550-4. doi: 10.1177/000348941312200903. PMID: 24224397
Recurrent hypoglycemia due to growth hormone deficiency in an infant with Turner syndrome.
Bonfig W, Salem NJ, Heiliger K, Hempel M, Lederer G, Bornkamm M, Wieland K, Lohse P, Burdach S, Oexle K
J Pediatr Endocrinol Metab 2012;25(9-10):991-5. doi: 10.1515/jpem-2012-0103. PMID: 23426831
Intermittent and recurrent hepatomegaly due to glycogen storage in a patient with type 1 diabetes: genetic analysis of the liver glycogen phosphorylase gene (PYGL).
Tomihira M, Kawasaki E, Nakajima H, Imamura Y, Sato Y, Sata M, Kage M, Sugie H, Nunoi K
Diabetes Res Clin Pract 2004 Aug;65(2):175-82. doi: 10.1016/j.diabres.2003.12.004. PMID: 15223230
Long-term treatment of persistent hyperinsulinaemic hypoglycaemia of infancy with diazoxide: a retrospective review of 77 cases and analysis of efficacy-predicting criteria.
Touati G, Poggi-Travert F, Ogier de Baulny H, Rahier J, Brunelle F, Nihoul-Fekete C, Czernichow P, Saudubray JM
Eur J Pediatr 1998 Aug;157(8):628-33. doi: 10.1007/s004310050900. PMID: 9727845

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