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Adult Acute Myeloid Leukemia with Maturation

MedGen UID:
83534
Concept ID:
C0279624
Neoplastic Process
Synonyms: Adult Acute Granulocytic Leukemia with Maturation; Adult Acute M2 Leukemia; Adult Acute Myeloblastic Leukemia with Maturation; Adult Acute Myeloblastic Leukemia with Maturation (M2); Adult Acute Myelocytic Leukemia with Maturation; Adult Acute Myelogenous Leukemia with Maturation; M2 Adult Acute Granulocytic Leukemia; M2 Adult Acute Granulocytic Leukemia with Maturation; M2 Adult Acute Myeloblastic Leukemia; M2 Adult Acute Myeloblastic Leukemia with Maturation; M2 Adult Acute Myelocytic Leukemia; M2 Adult Acute Myelocytic Leukemia with Maturation; M2 Adult Acute Myelogenous Leukemia; M2 Adult Acute Myelogenous Leukemia with Maturation; M2 Adult Acute Myeloid Leukemia; M2 Adult Acute Myeloid Leukemia with Maturation

Definition

An acute myeloid leukemia with maturation occurring in adults. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdult Acute Myeloid Leukemia with Maturation

Professional guidelines

PubMed

Garcia-Manero G
Am J Hematol 2023 Aug;98(8):1307-1325. Epub 2023 Jun 8 doi: 10.1002/ajh.26984. PMID: 37288607
Döhner H, Wei AH, Appelbaum FR, Craddock C, DiNardo CD, Dombret H, Ebert BL, Fenaux P, Godley LA, Hasserjian RP, Larson RA, Levine RL, Miyazaki Y, Niederwieser D, Ossenkoppele G, Röllig C, Sierra J, Stein EM, Tallman MS, Tien HF, Wang J, Wierzbowska A, Löwenberg B
Blood 2022 Sep 22;140(12):1345-1377. doi: 10.1182/blood.2022016867. PMID: 35797463
Döhner H, Estey E, Grimwade D, Amadori S, Appelbaum FR, Büchner T, Dombret H, Ebert BL, Fenaux P, Larson RA, Levine RL, Lo-Coco F, Naoe T, Niederwieser D, Ossenkoppele GJ, Sanz M, Sierra J, Tallman MS, Tien HF, Wei AH, Löwenberg B, Bloomfield CD
Blood 2017 Jan 26;129(4):424-447. Epub 2016 Nov 28 doi: 10.1182/blood-2016-08-733196. PMID: 27895058Free PMC Article

Recent clinical studies

Etiology

Bhansali RS, Pratz KW, Lai C
J Hematol Oncol 2023 Mar 25;16(1):29. doi: 10.1186/s13045-023-01424-6. PMID: 36966300Free PMC Article
Stubbins RJ, Francis A, Kuchenbauer F, Sanford D
Curr Oncol 2022 Aug 30;29(9):6245-6259. doi: 10.3390/curroncol29090491. PMID: 36135060Free PMC Article
Pollyea DA, Bixby D, Perl A, Bhatt VR, Altman JK, Appelbaum FR, de Lima M, Fathi AT, Foran JM, Gojo I, Hall AC, Jacoby M, Lancet J, Mannis G, Marcucci G, Martin MG, Mims A, Neff J, Nejati R, Olin R, Percival ME, Prebet T, Przespolewski A, Rao D, Ravandi-Kashani F, Shami PJ, Stone RM, Strickland SA, Sweet K, Vachhani P, Wieduwilt M, Gregory KM, Ogba N, Tallman MS
J Natl Compr Canc Netw 2021 Jan 6;19(1):16-27. doi: 10.6004/jnccn.2021.0002. PMID: 33406488
Döhner H, Estey E, Grimwade D, Amadori S, Appelbaum FR, Büchner T, Dombret H, Ebert BL, Fenaux P, Larson RA, Levine RL, Lo-Coco F, Naoe T, Niederwieser D, Ossenkoppele GJ, Sanz M, Sierra J, Tallman MS, Tien HF, Wei AH, Löwenberg B, Bloomfield CD
Blood 2017 Jan 26;129(4):424-447. Epub 2016 Nov 28 doi: 10.1182/blood-2016-08-733196. PMID: 27895058Free PMC Article
Döhner H, Estey EH, Amadori S, Appelbaum FR, Büchner T, Burnett AK, Dombret H, Fenaux P, Grimwade D, Larson RA, Lo-Coco F, Naoe T, Niederwieser D, Ossenkoppele GJ, Sanz MA, Sierra J, Tallman MS, Löwenberg B, Bloomfield CD; European LeukemiaNet
Blood 2010 Jan 21;115(3):453-74. Epub 2009 Oct 30 doi: 10.1182/blood-2009-07-235358. PMID: 19880497

Diagnosis

Pollyea DA, Altman JK, Assi R, Bixby D, Fathi AT, Foran JM, Gojo I, Hall AC, Jonas BA, Kishtagari A, Lancet J, Maness L, Mangan J, Mannis G, Marcucci G, Mims A, Moriarty K, Mustafa Ali M, Neff J, Nejati R, Olin R, Percival ME, Perl A, Przespolewski A, Rao D, Ravandi F, Shallis R, Shami PJ, Stein E, Stone RM, Sweet K, Thota S, Uy G, Vachhani P, Cassara CJ, Freedman-Cass DA, Stehman K
J Natl Compr Canc Netw 2023 May;21(5):503-513. doi: 10.6004/jnccn.2023.0025. PMID: 37156478
Pollyea DA, Bixby D, Perl A, Bhatt VR, Altman JK, Appelbaum FR, de Lima M, Fathi AT, Foran JM, Gojo I, Hall AC, Jacoby M, Lancet J, Mannis G, Marcucci G, Martin MG, Mims A, Neff J, Nejati R, Olin R, Percival ME, Prebet T, Przespolewski A, Rao D, Ravandi-Kashani F, Shami PJ, Stone RM, Strickland SA, Sweet K, Vachhani P, Wieduwilt M, Gregory KM, Ogba N, Tallman MS
J Natl Compr Canc Netw 2021 Jan 6;19(1):16-27. doi: 10.6004/jnccn.2021.0002. PMID: 33406488
Narayanan D, Weinberg OK
Int J Lab Hematol 2020 Feb;42(1):3-15. Epub 2019 Dec 10 doi: 10.1111/ijlh.13135. PMID: 31820579
Döhner H, Estey E, Grimwade D, Amadori S, Appelbaum FR, Büchner T, Dombret H, Ebert BL, Fenaux P, Larson RA, Levine RL, Lo-Coco F, Naoe T, Niederwieser D, Ossenkoppele GJ, Sanz M, Sierra J, Tallman MS, Tien HF, Wei AH, Löwenberg B, Bloomfield CD
Blood 2017 Jan 26;129(4):424-447. Epub 2016 Nov 28 doi: 10.1182/blood-2016-08-733196. PMID: 27895058Free PMC Article
Döhner H, Estey EH, Amadori S, Appelbaum FR, Büchner T, Burnett AK, Dombret H, Fenaux P, Grimwade D, Larson RA, Lo-Coco F, Naoe T, Niederwieser D, Ossenkoppele GJ, Sanz MA, Sierra J, Tallman MS, Löwenberg B, Bloomfield CD; European LeukemiaNet
Blood 2010 Jan 21;115(3):453-74. Epub 2009 Oct 30 doi: 10.1182/blood-2009-07-235358. PMID: 19880497

Therapy

Garcia-Manero G
Am J Hematol 2023 Aug;98(8):1307-1325. Epub 2023 Jun 8 doi: 10.1002/ajh.26984. PMID: 37288607
Bhansali RS, Pratz KW, Lai C
J Hematol Oncol 2023 Mar 25;16(1):29. doi: 10.1186/s13045-023-01424-6. PMID: 36966300Free PMC Article
Alfayez M, Kantarjian H, Kadia T, Ravandi-Kashani F, Daver N
Leuk Lymphoma 2020 Feb;61(2):288-297. Epub 2019 Sep 24 doi: 10.1080/10428194.2019.1660970. PMID: 31547736
Guerra VA, DiNardo C, Konopleva M
Best Pract Res Clin Haematol 2019 Jun;32(2):145-153. Epub 2019 May 24 doi: 10.1016/j.beha.2019.05.008. PMID: 31203996Free PMC Article
Hills RK, Castaigne S, Appelbaum FR, Delaunay J, Petersdorf S, Othus M, Estey EH, Dombret H, Chevret S, Ifrah N, Cahn JY, Récher C, Chilton L, Moorman AV, Burnett AK
Lancet Oncol 2014 Aug;15(9):986-96. Epub 2014 Jul 6 doi: 10.1016/S1470-2045(14)70281-5. PMID: 25008258Free PMC Article

Prognosis

Uy GL, Aldoss I, Foster MC, Sayre PH, Wieduwilt MJ, Advani AS, Godwin JE, Arellano ML, Sweet KL, Emadi A, Ravandi F, Erba HP, Byrne M, Michaelis L, Topp MS, Vey N, Ciceri F, Carrabba MG, Paolini S, Huls GA, Jongen-Lavrencic M, Wermke M, Chevallier P, Gyan E, Récher C, Stiff PJ, Pettit KM, Löwenberg B, Church SE, Anderson E, Vadakekolathu J, Santaguida M, Rettig MP, Muth J, Curtis T, Fehr E, Guo K, Zhao J, Bakkacha O, Jacobs K, Tran K, Kaminker P, Kostova M, Bonvini E, Walter RB, Davidson-Moncada JK, Rutella S, DiPersio JF
Blood 2021 Feb 11;137(6):751-762. doi: 10.1182/blood.2020007732. PMID: 32929488Free PMC Article
Heuser M, Ofran Y, Boissel N, Brunet Mauri S, Craddock C, Janssen J, Wierzbowska A, Buske C; ESMO Guidelines Committee. Electronic address: clinicalguidelines@esmo.org
Ann Oncol 2020 Jun;31(6):697-712. Epub 2020 Mar 17 doi: 10.1016/j.annonc.2020.02.018. PMID: 32171751
Winer ES
Hematol Oncol Clin North Am 2020 Apr;34(2):449-463. Epub 2020 Jan 7 doi: 10.1016/j.hoc.2019.11.003. PMID: 32089222
Webster JA, Pratz KW
Leuk Lymphoma 2018 Feb;59(2):274-287. Epub 2017 Jun 2 doi: 10.1080/10428194.2017.1330956. PMID: 28573892Free PMC Article
Huang L, Wang SA, DiNardo C, Li S, Hu S, Xu J, Zhou W, Goswami M, Medeiros LJ, Tang G
Leuk Res 2017 Feb;53:20-27. Epub 2016 Dec 2 doi: 10.1016/j.leukres.2016.11.016. PMID: 27951415

Clinical prediction guides

Khanal N, Upadhyay Banskota S, Bhatt VR
Clin Pharmacol Ther 2020 Sep;108(3):506-514. Epub 2020 Aug 11 doi: 10.1002/cpt.1962. PMID: 32572947Free PMC Article
Horibata S, Gui G, Lack J, DeStefano CB, Gottesman MM, Hourigan CS
Proc Natl Acad Sci U S A 2019 May 21;116(21):10494-10503. Epub 2019 May 7 doi: 10.1073/pnas.1902375116. PMID: 31064876Free PMC Article
Craddock C, Raghavan M
Curr Opin Hematol 2019 Mar;26(2):58-64. doi: 10.1097/MOH.0000000000000482. PMID: 30585893
Benetatos L, Vartholomatos G
Cell Mol Life Sci 2018 Jun;75(11):1999-2009. Epub 2018 Feb 26 doi: 10.1007/s00018-018-2783-2. PMID: 29484447
Grimwade D, Ivey A, Huntly BJ
Blood 2016 Jan 7;127(1):29-41. Epub 2015 Dec 10 doi: 10.1182/blood-2015-07-604496. PMID: 26660431Free PMC Article

Recent systematic reviews

Luo C, Wu G, Huang X, Ding Y, Huang Y, Song Q, Hou Y, Chen J, Li X, Xu S
Bone Marrow Transplant 2023 Feb;58(2):175-185. Epub 2022 Nov 10 doi: 10.1038/s41409-022-01865-6. PMID: 36357773
de Baat EC, Mulder RL, Armenian S, Feijen EA, Grotenhuis H, Hudson MM, Mavinkurve-Groothuis AM, Kremer LC, van Dalen EC
Cochrane Database Syst Rev 2022 Sep 27;9(9):CD014638. doi: 10.1002/14651858.CD014638.pub2. PMID: 36162822Free PMC Article
Stemler J, de Jonge N, Skoetz N, Sinkó J, Brüggemann RJ, Busca A, Ben-Ami R, Ráčil Z, Piechotta V, Lewis R, Cornely OA
Lancet Haematol 2022 May;9(5):e361-e373. doi: 10.1016/S2352-3026(22)00073-4. PMID: 35483397
Wang J, Zhou M, Xu JY, Zhou RF, Chen B, Wan Y
JAMA Netw Open 2020 Oct 1;3(10):e2017652. doi: 10.1001/jamanetworkopen.2020.17652. PMID: 33030550Free PMC Article
Smith TJ, Bohlke K, Lyman GH, Carson KR, Crawford J, Cross SJ, Goldberg JM, Khatcheressian JL, Leighl NB, Perkins CL, Somlo G, Wade JL, Wozniak AJ, Armitage JO; American Society of Clinical Oncology
J Clin Oncol 2015 Oct 1;33(28):3199-212. Epub 2015 Jul 13 doi: 10.1200/JCO.2015.62.3488. PMID: 26169616

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