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Abulia

MedGen UID:
776735
•Concept ID:
C0919974
•
Mental or Behavioral Dysfunction
Synonym: Aboulia
SNOMED CT: Abulia (737585009); Aboulia (737585009)
 
HPO: HP:0012671

Definition

Abulia is a severe form of apathy, characterized by difficulty in initiating and sustaining spontaneous movements, as well as reductions in emotional responsiveness, spontaneous speech, and social interaction. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbulia

Conditions with this feature

Cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 1
MedGen UID:
1634330
•Concept ID:
C4551768
•
Disease or Syndrome
CADASIL (cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy) is characterized by mid-adult onset of recurrent ischemic stroke, cognitive decline progressing to dementia, a history of migraine with aura, mood disturbance, apathy, and diffuse white matter lesions and subcortical infarcts on neuroimaging.
See: Condition Record
Cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 1

Professional guidelines

PubMed

Differential diagnosis and classification of apathy.
Marin RS
Am J Psychiatry 1990 Jan;147(1):22-30. doi: 10.1176/ajp.147.1.22. PMID: 2403472
Case report: behavioral treatment of clinical abulia.
Rosenthal TL, Meyer V
Cond Reflex 1971 Jan-Mar;6(1):22-9. doi: 10.1007/BF03000263. PMID: 5095172

Recent clinical studies

Etiology

Neurocovid: Pharmacological Recommendations for Delirium Associated With COVID-19.
Baller EB, Hogan CS, Fusunyan MA, Ivkovic A, Luccarelli JW, Madva E, Nisavic M, Praschan N, Quijije NV, Beach SR, Smith FA
Psychosomatics 2020 Nov-Dec;61(6):585-596. Epub 2020 May 21 doi: 10.1016/j.psym.2020.05.013. PMID: 32828569Free PMC Article
An evidence-based review of the psychopathology of frontotemporal dementia: a report of the ANPA Committee on Research.
Mendez MF, Lauterbach EC, Sampson SM; ANPA Committee on Research
J Neuropsychiatry Clin Neurosci 2008 Spring;20(2):130-49. doi: 10.1176/jnp.2008.20.2.130. PMID: 18451185
Complications of cerebral vein and sinus thrombosis.
Ferro JM, Canhâo P
Front Neurol Neurosci 2008;23:161-71. doi: 10.1159/000111377. PMID: 18004061
Abulia: a delphi survey of British neurologists and psychiatrists.
Vijayaraghavan L, Krishnamoorthy ES, Brown RG, Trimble MR
Mov Disord 2002 Sep;17(5):1052-7. doi: 10.1002/mds.10194. PMID: 12360558
Caudate infarcts.
Caplan LR, Schmahmann JD, Kase CS, Feldmann E, Baquis G, Greenberg JP, Gorelick PB, Helgason C, Hier DB
Arch Neurol 1990 Feb;47(2):133-43. doi: 10.1001/archneur.1990.00530020029011. PMID: 2405818

Diagnosis

Frontal lobe motor syndromes.
Thompson AE, Thompson PD
Handb Clin Neurol 2023;196:443-455. doi: 10.1016/B978-0-323-98817-9.00008-9. PMID: 37620084
Noticing in neurology.
Lees AJ
Pract Neurol 2019 Oct;19(5):427-430. Epub 2019 Apr 4 doi: 10.1136/practneurol-2018-002176. PMID: 30948556
Frontotemporal Dementia.
Kelley RE, El-Khoury R
Neurol Clin 2016 Feb;34(1):171-81. doi: 10.1016/j.ncl.2015.08.007. PMID: 26613998Free PMC Article
Apathy following stroke.
Jorge RE, Starkstein SE, Robinson RG
Can J Psychiatry 2010 Jun;55(6):350-4. doi: 10.1177/070674371005500603. PMID: 20540829
Disorders of diminished motivation.
Marin RS, Wilkosz PA
J Head Trauma Rehabil 2005 Jul-Aug;20(4):377-88. doi: 10.1097/00001199-200507000-00009. PMID: 16030444

Therapy

Neurocovid: Pharmacological Recommendations for Delirium Associated With COVID-19.
Baller EB, Hogan CS, Fusunyan MA, Ivkovic A, Luccarelli JW, Madva E, Nisavic M, Praschan N, Quijije NV, Beach SR, Smith FA
Psychosomatics 2020 Nov-Dec;61(6):585-596. Epub 2020 May 21 doi: 10.1016/j.psym.2020.05.013. PMID: 32828569Free PMC Article
Anteromedial thalamic infarct: a rare presentation.
Shabbir SH, Nadeem F, Labovitz D
BMJ Case Rep 2018 May 2;2018 doi: 10.1136/bcr-2017-223404. PMID: 29724871Free PMC Article
Agomelatine: an agent against anhedonia and abulia?
Thome J, Foley P
J Neural Transm (Vienna) 2015 Aug;122 Suppl 1:S3-7. Epub 2013 Dec 6 doi: 10.1007/s00702-013-1126-6. PMID: 24311062
Apathy following stroke.
Jorge RE, Starkstein SE, Robinson RG
Can J Psychiatry 2010 Jun;55(6):350-4. doi: 10.1177/070674371005500603. PMID: 20540829
Disorders of diminished motivation.
Marin RS, Wilkosz PA
J Head Trauma Rehabil 2005 Jul-Aug;20(4):377-88. doi: 10.1097/00001199-200507000-00009. PMID: 16030444

Prognosis

Integrated Genomic Characterization of a Pineal Parenchymal Tumor of Intermediate Differentiation.
Kang YJ, Bi WL, Dubuc AM, Martineau L, Ligon AH, Berkowitz AL, Aizer AA, Lee EQ, Ligon KL, Ramkissoon SH, Dunn IF
World Neurosurg 2016 Jan;85:96-105. Epub 2015 Jul 28 doi: 10.1016/j.wneu.2015.07.032. PMID: 26226092
Apathy following stroke.
Jorge RE, Starkstein SE, Robinson RG
Can J Psychiatry 2010 Jun;55(6):350-4. doi: 10.1177/070674371005500603. PMID: 20540829
Complications of cerebral vein and sinus thrombosis.
Ferro JM, Canhâo P
Front Neurol Neurosci 2008;23:161-71. doi: 10.1159/000111377. PMID: 18004061
Functional anatomy of thalamus and basal ganglia.
Herrero MT, Barcia C, Navarro JM
Childs Nerv Syst 2002 Aug;18(8):386-404. Epub 2002 Jul 26 doi: 10.1007/s00381-002-0604-1. PMID: 12192499
Hyperacute cognitive stroke syndromes.
Ferro JM
J Neurol 2001 Oct;248(10):841-9. doi: 10.1007/s004150170067. PMID: 11697519

Clinical prediction guides

Frontal lobe motor syndromes.
Thompson AE, Thompson PD
Handb Clin Neurol 2023;196:443-455. doi: 10.1016/B978-0-323-98817-9.00008-9. PMID: 37620084
A 45-year follow-up study of juvenile schizophrenia. Part III: Clinical picture and effect of the first hospitalization in the context of disease course and long-term social functioning of patients.
Ślosarczyk M, Ślosarczyk K, Furgał M
Psychiatr Pol 2022 Apr 30;56(2):229-244. doi: 10.12740/PP/125937. PMID: 35988071
Noticing in neurology.
Lees AJ
Pract Neurol 2019 Oct;19(5):427-430. Epub 2019 Apr 4 doi: 10.1136/practneurol-2018-002176. PMID: 30948556
Functional anatomy of thalamus and basal ganglia.
Herrero MT, Barcia C, Navarro JM
Childs Nerv Syst 2002 Aug;18(8):386-404. Epub 2002 Jul 26 doi: 10.1007/s00381-002-0604-1. PMID: 12192499
Honored guest presentation: abulia minor vs. agitated behavior.
Fisher CM
Clin Neurosurg 1983;31:9-31. doi: 10.1093/neurosurgery/31.cn_suppl_1.9. PMID: 6149834

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