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Acute Myeloid Leukemia with a Variant RARA Translocation

MedGen UID:
442905
Concept ID:
C2825128
Neoplastic Process

Definition

A term referring to acute myeloid leukemias which show variant translocations involving the RARA gene. The variant fusion partners include NUMA1, ZBTB16, STAT5B, and NPM1. These leukemias often have the morphologic features of acute promyelocytic leukemia. [from NCI]

Recent clinical studies

Etiology

Kárai B, Habók M, Reményi G, Rejtő L, Ujfalusi A, Kappelmayer J, Hevessy Z
Ann Hematol 2019 Jun;98(6):1413-1420. Epub 2019 Mar 4 doi: 10.1007/s00277-019-03642-w. PMID: 30830246Free PMC Article
Zhao J, Liang JW, Xue HL, Shen SH, Chen J, Tang YJ, Yu LS, Liang HH, Gu LJ, Tang JY, Li BS
Leukemia 2019 Jun;33(6):1387-1399. Epub 2018 Dec 21 doi: 10.1038/s41375-018-0338-z. PMID: 30575821
Nagendra S, Meyerson H, Skallerud G, Rosenthal N
Am J Clin Pathol 2002 Apr;117(4):651-7. doi: 10.1309/KD1G-NUR1-J75P-HQ28. PMID: 11939742
Jansen JH, Löwenberg B
Semin Hematol 2001 Jan;38(1):37-41. doi: 10.1016/s0037-1963(01)90004-6. PMID: 11172538
Lo Coco F, Pelicci PG, Biondi A
Leuk Lymphoma 1994 Feb;12(5-6):327-32. doi: 10.3109/10428199409073773. PMID: 8180596

Diagnosis

Liu G, Liu L, Bartolo DD, Li KY, Li X
Genes (Basel) 2022 Dec 23;14(1) doi: 10.3390/genes14010046. PMID: 36672788Free PMC Article
Cho Y, Hyun J, Kim M, Han B, Lee YK
Lab Med 2022 May 5;53(3):326-329. doi: 10.1093/labmed/lmab097. PMID: 34725711
Adams J, Nassiri M
Arch Pathol Lab Med 2015 Oct;139(10):1308-13. doi: 10.5858/arpa.2013-0345-RS. PMID: 26414475
Foucar K, Anastasi J
Am J Clin Pathol 2015 Jul;144(1):6-18. doi: 10.1309/AJCPI9C8UILYQTNS. PMID: 26071458
Brunel V, Lafage-Pochitaloff M, Alcalay M, Pelicci PG, Birg F
Leuk Lymphoma 1996 Jul;22(3-4):221-8. doi: 10.3109/10428199609051752. PMID: 8819070

Therapy

Kirkham JK, Liu YC, Foy SG, Ma J, Gheorghe G, Furtado LV, Popescu MI, Klco JM, Karol SE, Blackburn PR
Genes Chromosomes Cancer 2023 Oct;62(10):617-623. Epub 2023 Jun 7 doi: 10.1002/gcc.23180. PMID: 37283355
Lauricella C, Greco R, Mancini V, Motta V, Ciraolo A, De Canal G, De Paoli E, Paglino G, Guido V, Bonoldi E, Veronese S, Soriani S
Acta Haematol 2023;146(1):58-64. Epub 2022 Oct 5 doi: 10.1159/000527316. PMID: 36198282
Liu G, Liu L, Bartolo DD, Li KY, Li X
Genes (Basel) 2022 Dec 23;14(1) doi: 10.3390/genes14010046. PMID: 36672788Free PMC Article
Pardo Gambarte L, Franganillo Suárez A, Cornago Navascués J, Soto de Ozaeta C, Blas López C, Atance Pasarisas M, Salgado Sánchez RN, Serrano Del Castillo C, Mata Serna R, Velasco Rodríguez D, López-Lorenzo JL, Llamas-Sillero P, Solán Blanco L
Medicina (Kaunas) 2022 Apr 6;58(4) doi: 10.3390/medicina58040520. PMID: 35454359Free PMC Article
Adams J, Nassiri M
Arch Pathol Lab Med 2015 Oct;139(10):1308-13. doi: 10.5858/arpa.2013-0345-RS. PMID: 26414475

Prognosis

Liu G, Liu L, Bartolo DD, Li KY, Li X
Genes (Basel) 2022 Dec 23;14(1) doi: 10.3390/genes14010046. PMID: 36672788Free PMC Article
Pardo Gambarte L, Franganillo Suárez A, Cornago Navascués J, Soto de Ozaeta C, Blas López C, Atance Pasarisas M, Salgado Sánchez RN, Serrano Del Castillo C, Mata Serna R, Velasco Rodríguez D, López-Lorenzo JL, Llamas-Sillero P, Solán Blanco L
Medicina (Kaunas) 2022 Apr 6;58(4) doi: 10.3390/medicina58040520. PMID: 35454359Free PMC Article
Arumugam JR, Karthik Bommannan BK, Kalaiyarasi JP, Sundersingh S
Indian J Pathol Microbiol 2021 Apr-Jun;64(2):406-409. doi: 10.4103/IJPM.IJPM_409_20. PMID: 33851647
Balbuena-Merle RI, Tormey CA, DiAdamo A, Rinder HM, Siddon AJ
Lab Med 2021 May 4;52(3):290-296. doi: 10.1093/labmed/lmaa078. PMID: 32984885
Kárai B, Habók M, Reményi G, Rejtő L, Ujfalusi A, Kappelmayer J, Hevessy Z
Ann Hematol 2019 Jun;98(6):1413-1420. Epub 2019 Mar 4 doi: 10.1007/s00277-019-03642-w. PMID: 30830246Free PMC Article

Clinical prediction guides

Kirkham JK, Liu YC, Foy SG, Ma J, Gheorghe G, Furtado LV, Popescu MI, Klco JM, Karol SE, Blackburn PR
Genes Chromosomes Cancer 2023 Oct;62(10):617-623. Epub 2023 Jun 7 doi: 10.1002/gcc.23180. PMID: 37283355
Pardo Gambarte L, Franganillo Suárez A, Cornago Navascués J, Soto de Ozaeta C, Blas López C, Atance Pasarisas M, Salgado Sánchez RN, Serrano Del Castillo C, Mata Serna R, Velasco Rodríguez D, López-Lorenzo JL, Llamas-Sillero P, Solán Blanco L
Medicina (Kaunas) 2022 Apr 6;58(4) doi: 10.3390/medicina58040520. PMID: 35454359Free PMC Article
Kárai B, Habók M, Reményi G, Rejtő L, Ujfalusi A, Kappelmayer J, Hevessy Z
Ann Hematol 2019 Jun;98(6):1413-1420. Epub 2019 Mar 4 doi: 10.1007/s00277-019-03642-w. PMID: 30830246Free PMC Article
Rahman K, Gupta R, Singh MK, Sarkar MK, Gupta A, Nityanand S
Int J Lab Hematol 2018 Apr;40(2):144-151. Epub 2017 Oct 6 doi: 10.1111/ijlh.12754. PMID: 28984423
Lo Coco F, Pelicci PG, Biondi A
Leuk Lymphoma 1994 Feb;12(5-6):327-32. doi: 10.3109/10428199409073773. PMID: 8180596

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