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Pre-B Acute Lymphoblastic Leukemia

MedGen UID:
44126
•Concept ID:
C0023485
•
Neoplastic Process
Synonyms: Leukemia, Pre B Cell; Leukemia, Pre-B-Cell; Leukemias, Pre-B-Cell; Pre B ALL; Pre B Cell Leukemia; Pre B-ALL; Pre-B ALL; Pre-B-Cell Leukemia; Pre-B-Cell Leukemias; Precursor B Cell Lymphoblastic Leukemia; Precursor B Cell Lymphoblastic Leukemia Lymphoma; Precursor B Cell Lymphoblastic Lymphoma; Precursor B-Cell Lymphoblastic Leukemia; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; Precursor B-Cell Lymphoblastic Lymphoma

Definition

An acute lymphoblastic leukemia that originates from pre-B lymphocytes. The pre-B lymphoblasts contain cytoplasmic immunoglobulin. [from NCI]

Professional guidelines

PubMed

A Pediatric Case of Treatment-related Myelodysplastic Syndrome While on Therapy for Pre-B Acute Lymphoblastic Leukemia.
McElroy S, Myers GD, Flatt T
J Pediatr Hematol Oncol 2023 May 1;45(4):e518-e521. Epub 2023 Jan 10 doi: 10.1097/MPH.0000000000002613. PMID: 36706304
Induction of a central memory and stem cell memory phenotype in functionally active CD4(+) and CD8(+) CAR T cells produced in an automated good manufacturing practice system for the treatment of CD19(+) acute lymphoblastic leukemia.
Blaeschke F, Stenger D, Kaeuferle T, Willier S, Lotfi R, Kaiser AD, Assenmacher M, Döring M, Feucht J, Feuchtinger T
Cancer Immunol Immunother 2018 Jul;67(7):1053-1066. Epub 2018 Mar 31 doi: 10.1007/s00262-018-2155-7. PMID: 29605883Free PMC Article
Treatment of human pre-B acute lymphoblastic leukemia with the Aurora kinase inhibitor PHA-739358 (Danusertib).
Fei F, Lim M, Schmidhuber S, Moll J, Groffen J, Heisterkamp N
Mol Cancer 2012 Jun 21;11:42. doi: 10.1186/1476-4598-11-42. PMID: 22721004Free PMC Article

Recent clinical studies

Etiology

Increased Incidence of TdT-negative Pre-B Acute Lymphoblastic Leukemia Associated With Poor Prognostic Features Among Mexican Children in Central Mexico.
Vacek M, Zárraga Vargas LC, González Domínguez E, Garcia Rodriguez L, Tello Teran OA, Mojica Cardoso C, Ocampo Roosens LV, Acevedo Fernandez JJ, Li W, Lee B, Olalla Tapia JS, Flatt T
J Pediatr Hematol Oncol 2024 Mar 1;46(2):e131-e136. Epub 2023 Dec 22 doi: 10.1097/MPH.0000000000002802. PMID: 38132672
Frequency and Correlation of Common Genes Copy Number Alterations in Childhood Acute Lymphoblastic Leukemia with Prognosis.
Hosein Pour Feizi A, Zeinali S, Toporski J, Sheervalilou R, Mehranfar S
Asian Pac J Cancer Prev 2020 Dec 1;21(12):3493-3500. doi: 10.31557/APJCP.2020.21.12.3493. PMID: 33369444Free PMC Article
Childhood Pre-B acute lymphoblastic leukemia and glutathione S-transferase omega 1 and 2 polymorphisms.
Rezazadeh D, Moradi MT, Kazemi A, Mansouri K
Int J Lab Hematol 2015 Aug;37(4):530-5. Epub 2015 Feb 27 doi: 10.1111/ijlh.12332. PMID: 25726706
Targeting the B-cell receptor signaling pathway in B lymphoid malignancies.
Buchner M, Müschen M
Curr Opin Hematol 2014 Jul;21(4):341-9. doi: 10.1097/MOH.0000000000000048. PMID: 24811161Free PMC Article
CD10- pre-B acute lymphoblastic leukemia (ALL) is a distinct high-risk subgroup of adult ALL associated with a high frequency of MLL aberrations: results of the German Multicenter Trials for Adult ALL (GMALL).
Gleissner B, Goekbuget N, Rieder H, Arnold R, Schwartz S, Diedrich H, Schoch C, Heinze B, Fonatsch C, Bartram CR, Hoelzer D, Thiel E; GMALL Study Group
Blood 2005 Dec 15;106(13):4054-6. Epub 2005 Aug 25 doi: 10.1182/blood-2005-05-1866. PMID: 16123216

Diagnosis

Triple Trouble.
Diwan A, Barsode S
J Assoc Physicians India 2024 Mar;72(3):97-99. doi: 10.59556/japi.72.0446. PMID: 38736127
1,5-Anhydroglucitol promotes pre-B acute lymphocytic leukemia progression by driving glycolysis and reactive oxygen species formation.
Zhu H, Ma H, Dong N, Wu M, Li D, Liu L, Shi Q, Ju X
BMC Cancer 2023 Feb 6;23(1):122. doi: 10.1186/s12885-023-10589-9. PMID: 36747147Free PMC Article
Characterization of Philadelphia-like Pre-B Acute Lymphoblastic Leukemia: Experiences in Mexican Pediatric Patients.
Martínez-Anaya D, Moreno-Lorenzana D, Reyes-León A, Juárez-Figueroa U, Dean M, Aguilar-Hernández MM, Rivera-Sánchez N, García-Islas J, Vieyra-Fuentes V, Zapata-Tarrés M, Juárez-Villegas L, Paredes-Aguilera R, Vega-Vega L, Rivera-Luna R, Juárez-Velázquez MDR, Pérez-Vera P
Int J Mol Sci 2022 Aug 24;23(17) doi: 10.3390/ijms23179587. PMID: 36076986Free PMC Article
An Adult Patient with Early Pre-B Acute Lymphoblastic Leukemia with t(12;17)(p13;q21)/ZNF384-TAF15.
Georgakopoulos N, Diamantopoulos P, Micci F, Giannakopoulou N, Zervakis K, Dimitrakopoulou A, Viniou NA
In Vivo 2018 Sep-Oct;32(5):1241-1245. doi: 10.21873/invivo.11371. PMID: 30150451Free PMC Article
Childhood Pre-B acute lymphoblastic leukemia and glutathione S-transferase omega 1 and 2 polymorphisms.
Rezazadeh D, Moradi MT, Kazemi A, Mansouri K
Int J Lab Hematol 2015 Aug;37(4):530-5. Epub 2015 Feb 27 doi: 10.1111/ijlh.12332. PMID: 25726706

Therapy

Results of salvage therapy with mini-hyper-CVD and inotuzumab ozogamicin with or without blinatumomab in pre-B acute lymphoblastic leukemia.
Kantarjian H, Haddad FG, Jain N, Sasaki K, Short NJ, Loghavi S, Kanagal-Shamanna R, Jorgensen J, Khouri I, Kebriaei P, Alvarado Y, Kadia T, Paul S, Garcia-Manero G, Dabaja B, Yilmaz M, Jacob J, Garris R, O'Brien S, Ravandi F, Jabbour E
J Hematol Oncol 2023 May 2;16(1):44. doi: 10.1186/s13045-023-01444-2. PMID: 37131217Free PMC Article
Evaluation and Management of Acute-Onset Hemiparesis in an Adolescent With Leukemia.
Subrahmanian KN, Shim YH, Shah MD, Tran BH, Stevens AM, Cruz AT
Pediatr Emerg Care 2018 Mar;34(3):e47-e50. doi: 10.1097/PEC.0000000000000837. PMID: 27668914
EphA3 as a target for antibody immunotherapy in acute lymphoblastic leukemia.
Charmsaz S, Al-Ejeh F, Yeadon TM, Miller KJ, Smith FM, Stringer BW, Moore AS, Lee FT, Cooper LT, Stylianou C, Yarranton GT, Woronicz J, Scott AM, Lackmann M, Boyd AW
Leukemia 2017 Aug;31(8):1779-1787. Epub 2016 Dec 6 doi: 10.1038/leu.2016.371. PMID: 27922598
Immunotherapy in Tumors.
Kobold S, Duewell P, Schnurr M, Subklewe M, Rothenfusser S, Endres S
Dtsch Arztebl Int 2015 Nov 27;112(48):809-15. doi: 10.3238/arztebl.2015.0809. PMID: 26667979Free PMC Article
Antibodies: Immunoconjugates and autologous cellular therapy in acute lymphoblastic leukemia.
Advani A
Best Pract Res Clin Haematol 2015 Jun-Sep;28(2-3):116-23. Epub 2015 Oct 22 doi: 10.1016/j.beha.2015.10.008. PMID: 26590768

Prognosis

Results of salvage therapy with mini-hyper-CVD and inotuzumab ozogamicin with or without blinatumomab in pre-B acute lymphoblastic leukemia.
Kantarjian H, Haddad FG, Jain N, Sasaki K, Short NJ, Loghavi S, Kanagal-Shamanna R, Jorgensen J, Khouri I, Kebriaei P, Alvarado Y, Kadia T, Paul S, Garcia-Manero G, Dabaja B, Yilmaz M, Jacob J, Garris R, O'Brien S, Ravandi F, Jabbour E
J Hematol Oncol 2023 May 2;16(1):44. doi: 10.1186/s13045-023-01444-2. PMID: 37131217Free PMC Article
Frequency and Correlation of Common Genes Copy Number Alterations in Childhood Acute Lymphoblastic Leukemia with Prognosis.
Hosein Pour Feizi A, Zeinali S, Toporski J, Sheervalilou R, Mehranfar S
Asian Pac J Cancer Prev 2020 Dec 1;21(12):3493-3500. doi: 10.31557/APJCP.2020.21.12.3493. PMID: 33369444Free PMC Article
An Adult Patient with Early Pre-B Acute Lymphoblastic Leukemia with t(12;17)(p13;q21)/ZNF384-TAF15.
Georgakopoulos N, Diamantopoulos P, Micci F, Giannakopoulou N, Zervakis K, Dimitrakopoulou A, Viniou NA
In Vivo 2018 Sep-Oct;32(5):1241-1245. doi: 10.21873/invivo.11371. PMID: 30150451Free PMC Article
Immunotherapy in Tumors.
Kobold S, Duewell P, Schnurr M, Subklewe M, Rothenfusser S, Endres S
Dtsch Arztebl Int 2015 Nov 27;112(48):809-15. doi: 10.3238/arztebl.2015.0809. PMID: 26667979Free PMC Article
Targeting the B-cell receptor signaling pathway in B lymphoid malignancies.
Buchner M, Müschen M
Curr Opin Hematol 2014 Jul;21(4):341-9. doi: 10.1097/MOH.0000000000000048. PMID: 24811161Free PMC Article

Clinical prediction guides

C/EBPβ induces B-cell acute lymphoblastic leukemia and cooperates with BLNK mutations.
Kurata M, Onishi I, Takahara T, Yamazaki Y, Ishibashi S, Goitsuka R, Kitamura D, Takita J, Hayashi Y, Largaesapda DA, Kitagawa M, Nakamura T
Cancer Sci 2021 Dec;112(12):4920-4930. Epub 2021 Oct 23 doi: 10.1111/cas.15164. PMID: 34653294Free PMC Article
Curcumin Induces Apoptosis in Pre-B Acute Lymphoblastic Leukemia Cell Lines Via PARP-1 Cleavage.
Mishra D, Singh S, Narayan G
Asian Pac J Cancer Prev 2016;17(8):3865-9. PMID: 27644631
Mixed Phenotype Acute Leukemia with t(12;17)(p13;q21)/TAF15-ZNF384 and Other Chromosome Abnormalities.
Yamamoto K, Kawamoto S, Mizutani Y, Yakushijin K, Yamashita T, Nakamachi Y, Kawano S, Hayashi Y, Matsuoka H, Minami H
Cytogenet Genome Res 2016;149(3):165-170. Epub 2016 Sep 9 doi: 10.1159/000448447. PMID: 27607436
Immunotherapy in Tumors.
Kobold S, Duewell P, Schnurr M, Subklewe M, Rothenfusser S, Endres S
Dtsch Arztebl Int 2015 Nov 27;112(48):809-15. doi: 10.3238/arztebl.2015.0809. PMID: 26667979Free PMC Article
Targeting the B-cell receptor signaling pathway in B lymphoid malignancies.
Buchner M, Müschen M
Curr Opin Hematol 2014 Jul;21(4):341-9. doi: 10.1097/MOH.0000000000000048. PMID: 24811161Free PMC Article

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