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Familial febrile seizures 9(FEB9)

MedGen UID:
369868
•Concept ID:
C1968846
•
Disease or Syndrome
Synonyms: FEB9; FEBRILE CONVULSIONS, FAMILIAL, 9
 
Monarch Initiative: MONDO:0012707
OMIM®: 611634

Clinical features

From HPO
Febrile seizure (within the age range of 3 months to 6 years)
MedGen UID:
3232
•Concept ID:
C0009952
•
Disease or Syndrome
A febrile seizure is any type of seizure (most often a generalized tonic-clonic seizure) occurring with fever (at least 38 degrees Celsius) but in the absence of central nervous system infection, severe metabolic disturbance or other alternative precipitant in children between the ages of 3 months and 6 years.
See: Feature record | Search on this feature
EEG with spike-wave complexes (>3.5 Hz)
MedGen UID:
892339
•Concept ID:
C4023684
•
Finding
The presence of complexes of spikes and waves (>3.5 Hz) in electroencephalography (EEG).
See: Feature record | Search on this feature
Generalized non-motor (absence) seizure
MedGen UID:
1385688
•Concept ID:
C4316903
•
Disease or Syndrome
A generalized non-motor (absence) seizure is a type of a type of dialeptic seizure that is of electrographically generalized onset. It is a generalized seizure characterized by an interruption of activities, a blank stare, and usually the person will be unresponsive when spoken to. Any ictal motor phenomena are minor in comparison to these non-motor features.
See: Feature record | Search on this feature

Professional guidelines

PubMed

Evaluation of the feasibility, diagnostic yield, and clinical utility of rapid genome sequencing in infantile epilepsy (Gene-STEPS): an international, multicentre, pilot cohort study.
D'Gama AM, Mulhern S, Sheidley BR, Boodhoo F, Buts S, Chandler NJ, Cobb J, Curtis M, Higginbotham EJ, Holland J, Khan T, Koh J, Liang NSY, McRae L, Nesbitt SE, Oby BT, Paternoster B, Patton A, Rose G, Scotchman E, Valentine R, Wiltrout KN; Gene-STEPS Study Group; IPCHiP Executive Committee, Hayeems RZ, Jain P, Lunke S, Marshall CR, Rockowitz S, Sebire NJ, Stark Z, White SM, Chitty LS, Cross JH, Scheffer IE, Chau V, Costain G, Poduri A, Howell KB, McTague A
Lancet Neurol 2023 Sep;22(9):812-825. doi: 10.1016/S1474-4422(23)00246-6. PMID: 37596007
Knowledge, beliefs and management of childhood fever among nurses and other health professionals: A cross-sectional survey.
Gaffney GR, Bereznicki LR, Bereznicki BJ
Nurse Educ Today 2021 Feb;97:104731. Epub 2020 Dec 29 doi: 10.1016/j.nedt.2020.104731. PMID: 33385941
The assessment of risk factors for febrile seizures in children.
Gontko-Romanowska K, Żaba Z, Panieński P, Steinborn B, Szemień M, Łukasik-Głębocka M, Ratajczak K, Chrobak A, Mitkowska J, Górny J
Neurol Neurochir Pol 2017 Nov-Dec;51(6):454-458. Epub 2017 Jul 31 doi: 10.1016/j.pjnns.2017.07.011. PMID: 28803641

Recent clinical studies

Etiology

Febrile seizures: perceptions and knowledge of parents of affected and unaffected children.
Rice SA, Müller RM, Jeschke S, Herziger B, Bertsche T, Neininger MP, Bertsche A
Eur J Pediatr 2022 Apr;181(4):1487-1495. Epub 2021 Dec 7 doi: 10.1007/s00431-021-04335-1. PMID: 34873647Free PMC Article
Neurological and neurodevelopmental symptoms in children with familial Mediterranean fever and their siblings.
Biro O, Gileles-Hillel A, Dor-Wollman T, Eisenstein EM, Berkun Y
Eur J Pediatr 2022 Mar;181(3):973-978. Epub 2021 Oct 15 doi: 10.1007/s00431-021-04286-7. PMID: 34652509
First-ever convulsive seizures in children presenting to the emergency department: risk factors for seizure recurrence and diagnosis of epilepsy.
Sartori S, Nosadini M, Tessarin G, Boniver C, Frigo AC, Toldo I, Bressan S, Da Dalt L
Dev Med Child Neurol 2019 Jan;61(1):82-90. Epub 2018 Sep 7 doi: 10.1111/dmcn.14015. PMID: 30191957
Individualised prediction model of seizure recurrence and long-term outcomes after withdrawal of antiepileptic drugs in seizure-free patients: a systematic review and individual participant data meta-analysis.
Lamberink HJ, Otte WM, Geerts AT, Pavlovic M, Ramos-Lizana J, Marson AG, Overweg J, Sauma L, Specchio LM, Tennison M, Cardoso TMO, Shinnar S, Schmidt D, Geleijns K, Braun KPJ
Lancet Neurol 2017 Jul;16(7):523-531. Epub 2017 May 5 doi: 10.1016/S1474-4422(17)30114-X. PMID: 28483337
Recent advances in febrile seizures.
Mittal R
Indian J Pediatr 2014 Sep;81(9):909-16. Epub 2014 Aug 8 doi: 10.1007/s12098-014-1532-2. PMID: 25103013

Diagnosis

Phenotypic and Genotypic Spectrum of Early-Onset Developmental and Epileptic Encephalopathies-Data from a Romanian Cohort.
Riza AL, Streață I, Roza E, Budișteanu M, Iliescu C, Burloiu C, Dobrescu MA, Dorobanțu S, Dragoș A, Grigorescu A, Tătaru T, Ioana M, Teleanu R
Genes (Basel) 2022 Jul 15;13(7) doi: 10.3390/genes13071253. PMID: 35886038Free PMC Article
Neurological and neurodevelopmental symptoms in children with familial Mediterranean fever and their siblings.
Biro O, Gileles-Hillel A, Dor-Wollman T, Eisenstein EM, Berkun Y
Eur J Pediatr 2022 Mar;181(3):973-978. Epub 2021 Oct 15 doi: 10.1007/s00431-021-04286-7. PMID: 34652509
First-ever convulsive seizures in children presenting to the emergency department: risk factors for seizure recurrence and diagnosis of epilepsy.
Sartori S, Nosadini M, Tessarin G, Boniver C, Frigo AC, Toldo I, Bressan S, Da Dalt L
Dev Med Child Neurol 2019 Jan;61(1):82-90. Epub 2018 Sep 7 doi: 10.1111/dmcn.14015. PMID: 30191957
Long-term prognosis of childhood absence epilepsy.
Martínez-Ferrández C, Martínez-Salcedo E, Casas-Fernández C, Alarcón-Martínez H, Ibáñez-Micó S, Domingo-Jiménez R
Neurologia (Engl Ed) 2019 May;34(4):224-228. Epub 2017 Mar 18 doi: 10.1016/j.nrl.2016.12.005. PMID: 28325560
Recent advances in febrile seizures.
Mittal R
Indian J Pediatr 2014 Sep;81(9):909-16. Epub 2014 Aug 8 doi: 10.1007/s12098-014-1532-2. PMID: 25103013

Therapy

Neurological and neurodevelopmental symptoms in children with familial Mediterranean fever and their siblings.
Biro O, Gileles-Hillel A, Dor-Wollman T, Eisenstein EM, Berkun Y
Eur J Pediatr 2022 Mar;181(3):973-978. Epub 2021 Oct 15 doi: 10.1007/s00431-021-04286-7. PMID: 34652509
Long-term prognosis of childhood absence epilepsy.
Martínez-Ferrández C, Martínez-Salcedo E, Casas-Fernández C, Alarcón-Martínez H, Ibáñez-Micó S, Domingo-Jiménez R
Neurologia (Engl Ed) 2019 May;34(4):224-228. Epub 2017 Mar 18 doi: 10.1016/j.nrl.2016.12.005. PMID: 28325560
Individualised prediction model of seizure recurrence and long-term outcomes after withdrawal of antiepileptic drugs in seizure-free patients: a systematic review and individual participant data meta-analysis.
Lamberink HJ, Otte WM, Geerts AT, Pavlovic M, Ramos-Lizana J, Marson AG, Overweg J, Sauma L, Specchio LM, Tennison M, Cardoso TMO, Shinnar S, Schmidt D, Geleijns K, Braun KPJ
Lancet Neurol 2017 Jul;16(7):523-531. Epub 2017 May 5 doi: 10.1016/S1474-4422(17)30114-X. PMID: 28483337
Doose syndrome (myoclonic-astatic epilepsy): 40 years of progress.
Kelley SA, Kossoff EH
Dev Med Child Neurol 2010 Nov;52(11):988-93. Epub 2010 Aug 16 doi: 10.1111/j.1469-8749.2010.03744.x. PMID: 20722665
Placing the risk of seizures with pediatric vaccines in a clinical context.
Davis RL, Barlow W
Paediatr Drugs 2003;5(11):717-22. doi: 10.2165/00148581-200305110-00001. PMID: 14580221

Prognosis

Febrile seizures: perceptions and knowledge of parents of affected and unaffected children.
Rice SA, Müller RM, Jeschke S, Herziger B, Bertsche T, Neininger MP, Bertsche A
Eur J Pediatr 2022 Apr;181(4):1487-1495. Epub 2021 Dec 7 doi: 10.1007/s00431-021-04335-1. PMID: 34873647Free PMC Article
Neurological and neurodevelopmental symptoms in children with familial Mediterranean fever and their siblings.
Biro O, Gileles-Hillel A, Dor-Wollman T, Eisenstein EM, Berkun Y
Eur J Pediatr 2022 Mar;181(3):973-978. Epub 2021 Oct 15 doi: 10.1007/s00431-021-04286-7. PMID: 34652509
First-ever convulsive seizures in children presenting to the emergency department: risk factors for seizure recurrence and diagnosis of epilepsy.
Sartori S, Nosadini M, Tessarin G, Boniver C, Frigo AC, Toldo I, Bressan S, Da Dalt L
Dev Med Child Neurol 2019 Jan;61(1):82-90. Epub 2018 Sep 7 doi: 10.1111/dmcn.14015. PMID: 30191957
Individualised prediction model of seizure recurrence and long-term outcomes after withdrawal of antiepileptic drugs in seizure-free patients: a systematic review and individual participant data meta-analysis.
Lamberink HJ, Otte WM, Geerts AT, Pavlovic M, Ramos-Lizana J, Marson AG, Overweg J, Sauma L, Specchio LM, Tennison M, Cardoso TMO, Shinnar S, Schmidt D, Geleijns K, Braun KPJ
Lancet Neurol 2017 Jul;16(7):523-531. Epub 2017 May 5 doi: 10.1016/S1474-4422(17)30114-X. PMID: 28483337
Doose syndrome (myoclonic-astatic epilepsy): 40 years of progress.
Kelley SA, Kossoff EH
Dev Med Child Neurol 2010 Nov;52(11):988-93. Epub 2010 Aug 16 doi: 10.1111/j.1469-8749.2010.03744.x. PMID: 20722665

Clinical prediction guides

Febrile seizures: perceptions and knowledge of parents of affected and unaffected children.
Rice SA, Müller RM, Jeschke S, Herziger B, Bertsche T, Neininger MP, Bertsche A
Eur J Pediatr 2022 Apr;181(4):1487-1495. Epub 2021 Dec 7 doi: 10.1007/s00431-021-04335-1. PMID: 34873647Free PMC Article
Individualised prediction model of seizure recurrence and long-term outcomes after withdrawal of antiepileptic drugs in seizure-free patients: a systematic review and individual participant data meta-analysis.
Lamberink HJ, Otte WM, Geerts AT, Pavlovic M, Ramos-Lizana J, Marson AG, Overweg J, Sauma L, Specchio LM, Tennison M, Cardoso TMO, Shinnar S, Schmidt D, Geleijns K, Braun KPJ
Lancet Neurol 2017 Jul;16(7):523-531. Epub 2017 May 5 doi: 10.1016/S1474-4422(17)30114-X. PMID: 28483337
Clinical Epidemiology and Treatment of Febrile and Afebrile Convulsions With Mild Gastroenteritis: A Multicenter Study.
Higuchi Y, Kubo T, Mitsuhashi T, Nakamura N, Yokota I, Komiyama O, Kamimaki I, Yamamoto S, Uchida Y, Watanabe K, Yamashita H, Tanaka S, Iguchi K, Ichimi R, Miyagawa S, Takayanagi T, Koga H, Shukuya A, Saito A, Horibe K
Pediatr Neurol 2017 Feb;67:78-84. Epub 2016 Aug 3 doi: 10.1016/j.pediatrneurol.2016.05.011. PMID: 28094168
Familial epilepsy in Algeria: Clinical features and inheritance profiles.
Chentouf A, Dahdouh A, Guipponi M, Oubaiche ML, Chaouch M, Hamamy H, Antonarakis SE
Seizure 2015 Sep;31:12-8. Epub 2015 Jul 3 doi: 10.1016/j.seizure.2015.06.015. PMID: 26362371
Placing the risk of seizures with pediatric vaccines in a clinical context.
Davis RL, Barlow W
Paediatr Drugs 2003;5(11):717-22. doi: 10.2165/00148581-200305110-00001. PMID: 14580221

Recent systematic reviews

Defining the Clinicoradiologic Syndrome of SARS-CoV-2 Acute Necrotizing Encephalopathy: A Systematic Review and 3 New Pediatric Cases.
Lee VW, Kam KQ, Mohamed AR, Musa H, Anandakrishnan P, Shen Q, Palazzo AF, Dale RC, Lim M, Thomas T
Neurol Neuroimmunol Neuroinflamm 2024 Jan;11(1):e200186. Epub 2023 Dec 7 doi: 10.1212/NXI.0000000000200186. PMID: 38086061Free PMC Article
Association between high-mobility group box 1 levels and febrile seizures in children: a systematic review and meta-analysis.
Li S, Zhao Q, Sun J, Yan W, Wang J, Gao X, Li X, Ren C, Hao L
Sci Rep 2023 Mar 3;13(1):3619. doi: 10.1038/s41598-023-30713-w. PMID: 36869074Free PMC Article
Epilepsy in hemiplegic migraine: Genetic mutations and clinical implications.
Prontera P, Sarchielli P, Caproni S, Bedetti C, Cupini LM, Calabresi P, Costa C
Cephalalgia 2018 Feb;38(2):361-373. Epub 2017 Jan 6 doi: 10.1177/0333102416686347. PMID: 28058944
Individualised prediction model of seizure recurrence and long-term outcomes after withdrawal of antiepileptic drugs in seizure-free patients: a systematic review and individual participant data meta-analysis.
Lamberink HJ, Otte WM, Geerts AT, Pavlovic M, Ramos-Lizana J, Marson AG, Overweg J, Sauma L, Specchio LM, Tennison M, Cardoso TMO, Shinnar S, Schmidt D, Geleijns K, Braun KPJ
Lancet Neurol 2017 Jul;16(7):523-531. Epub 2017 May 5 doi: 10.1016/S1474-4422(17)30114-X. PMID: 28483337

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