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Chronic Myelomonocytic Leukemia-2

MedGen UID:
232363
•Concept ID:
C1333044
•
Neoplastic Process

Definition

A chronic myelomonocytic leukemia characterized by the presence of 10-19 percent blasts in the bone marrow and 5-19 percent blasts in the peripheral blood or by the presence of Auer rods regardless of the blasts count. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVChronic Myelomonocytic Leukemia-2

Recent clinical studies

Etiology

Haploidentical Hematopoietic Stem Cell Transplantation with Post-Transplantation Cyclophosphamide in Children with High-Risk Leukemia Using a Reduced-Intensity Conditioning Regimen and Peripheral Blood as the Stem Cell Source.
Trujillo ÁM, Karduss AJ, Suarez G, Pérez R, Ruiz G, Cardona A, Ramírez M, Betancur J
Transplant Cell Ther 2021 May;27(5):427.e1-427.e7. Epub 2021 Feb 12 doi: 10.1016/j.jtct.2021.02.010. PMID: 33965184
Prevalence, breakpoint distribution, and clinical correlates of t(5;12).
Greipp PT, Dewald GW, Tefferi A
Cancer Genet Cytogenet 2004 Sep;153(2):170-2. doi: 10.1016/j.cancergencyto.2004.01.013. PMID: 15350308
Clinical significance of Y chromosome loss in hematologic disease.
Wiktor A, Rybicki BA, Piao ZS, Shurafa M, Barthel B, Maeda K, Van Dyke DL
Genes Chromosomes Cancer 2000 Jan;27(1):11-6. PMID: 10564581

Diagnosis

Study of the Utility of Myeloid Cell Nuclear Differentiation Antigen (MNDA) in the Diagnosis of Marginal Zone Lymphoma.
Gupta N, Roychoudry S, Sticco KL, Hsu P, Zhang X, Sheikh-Fayyaz S
Appl Immunohistochem Mol Morphol 2023 Apr 1;31(4):217-223. Epub 2023 Mar 6 doi: 10.1097/PAI.0000000000001115. PMID: 36867739Free PMC Article
Clinical significance of Y chromosome loss in hematologic disease.
Wiktor A, Rybicki BA, Piao ZS, Shurafa M, Barthel B, Maeda K, Van Dyke DL
Genes Chromosomes Cancer 2000 Jan;27(1):11-6. PMID: 10564581
A comparative analysis of FISH, RT-PCR, and cytogenetics for the diagnosis of bcr-abl-positive leukemias.
Cox MC, Maffei L, Buffolino S, Del Poeta G, Venditti A, Cantonetti M, Aronica G, Aquilina P, Masi M, Amadori S
Am J Clin Pathol 1998 Jan;109(1):24-31. doi: 10.1093/ajcp/109.1.24. PMID: 9426514

Therapy

Haploidentical Hematopoietic Stem Cell Transplantation with Post-Transplantation Cyclophosphamide in Children with High-Risk Leukemia Using a Reduced-Intensity Conditioning Regimen and Peripheral Blood as the Stem Cell Source.
Trujillo ÁM, Karduss AJ, Suarez G, Pérez R, Ruiz G, Cardona A, Ramírez M, Betancur J
Transplant Cell Ther 2021 May;27(5):427.e1-427.e7. Epub 2021 Feb 12 doi: 10.1016/j.jtct.2021.02.010. PMID: 33965184
A study of leukemic cell migration by an agarose plate method.
Yamada Y, Pinkston JA, Neriishi S, Ikeda S, Kinoshita K, Ichimaru M, Finch SC
Jpn J Clin Oncol 1983 Jun;13(2):343-52. PMID: 6887555

Prognosis

Nodal and extranodal tumor-forming accumulation of plasmacytoid monocytes/interferon-producing cells associated with myeloid disorders.
Vermi W, Facchetti F, Rosati S, Vergoni F, Rossi E, Festa S, Remotti D, Grigolato P, Massarelli G, Frizzera G
Am J Surg Pathol 2004 May;28(5):585-95. doi: 10.1097/00000478-200405000-00004. PMID: 15105645
Clinical significance of Y chromosome loss in hematologic disease.
Wiktor A, Rybicki BA, Piao ZS, Shurafa M, Barthel B, Maeda K, Van Dyke DL
Genes Chromosomes Cancer 2000 Jan;27(1):11-6. PMID: 10564581
A comparative analysis of FISH, RT-PCR, and cytogenetics for the diagnosis of bcr-abl-positive leukemias.
Cox MC, Maffei L, Buffolino S, Del Poeta G, Venditti A, Cantonetti M, Aronica G, Aquilina P, Masi M, Amadori S
Am J Clin Pathol 1998 Jan;109(1):24-31. doi: 10.1093/ajcp/109.1.24. PMID: 9426514

Clinical prediction guides

Clinical significance of Y chromosome loss in hematologic disease.
Wiktor A, Rybicki BA, Piao ZS, Shurafa M, Barthel B, Maeda K, Van Dyke DL
Genes Chromosomes Cancer 2000 Jan;27(1):11-6. PMID: 10564581

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