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Paranoid schizophrenia

MedGen UID:
20664
•Concept ID:
C0036349
•
Mental or Behavioral Dysfunction
Synonyms: Paranoid Schizophrenia; Paranoid Schizophrenias; Schizophrenia, Paranoid; Schizophrenias, Paranoid
SNOMED CT: Paranoid schizophrenia (64905009); Paraphrenic schizophrenia (64905009)
 
Monarch Initiative: MONDO:0001484

Definition

A subtype of schizophrenia characterized by prominent delusions (typically persecutory or grandiose) or hallucinations in the context of a relative preservation of cognitive functioning and affect. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVParanoid schizophrenia

Professional guidelines

PubMed

Clinical predictors of response to clozapine in Tunisian patients with treatment resistant schizophrenia.
Aissa A, Jouini R, Ouali U, Zgueb Y, Nacef F, El Hechmi Z
Compr Psychiatry 2022 Jan;112:152280. Epub 2021 Oct 21 doi: 10.1016/j.comppsych.2021.152280. PMID: 34763293
Assessment of cardiovascular disease risk factors in patients treated for schizophrenia.
Tylec A, Skałecki M, Ziemecki P, Brzozowska A, Dubas-Ślemp H, Kucharska K
Psychiatr Pol 2019 Dec 31;53(6):1305-1319. doi: 10.12740/PP/OnlineFirst/95123. PMID: 32017819
Clinical and biological outcomes of prolonged treatment with haloperidol in schizophrenia.
Mutică M, Marinescu I, Militaru F, Pîrlog MC, Udriştoiu I
Rom J Morphol Embryol 2016;57(2):477-81. PMID: 27516021

Recent clinical studies

Etiology

SOCIAL COGNITION AND OXIDATIVE STRESS IN SCHIZOPHRENIA PATIENTS AND FIRST-DEGREE RELATIVES OF PATIENTS.
Çilem Kızılpınar S, Çiğdem Aydemır M, Doğan Ö, Bahar Atak-Akkus F, Baran Z
Psychiatr Danub 2023 Winter;35(4):523-534. doi: 10.24869/psyd.2023.523. PMID: 37992097
Lexical indicators of anxiety in schizophrenia.
Obrębska M, Kleka P
Anxiety Stress Coping 2023 May;36(3):382-397. Epub 2022 May 13 doi: 10.1080/10615806.2022.2076081. PMID: 35561064
Facial Emotion Recognition and Persecutory Ideation in Paranoid Schizophrenia.
Mitrovic M, Ristic M, Dimitrijevic B, Hadzi Pesic M
Psychol Rep 2020 Aug;123(4):1099-1116. Epub 2019 May 15 doi: 10.1177/0033294119849016. PMID: 31092137
Psychotic disorders in DSM-5 and ICD-11.
Biedermann F, Fleischhacker WW
CNS Spectr 2016 Aug;21(4):349-54. Epub 2016 Jul 15 doi: 10.1017/S1092852916000316. PMID: 27418328
Delusional (paranoid) disorders.
Munro A
Can J Psychiatry 1988 Jun;33(5):399-404. doi: 10.1177/070674378803300516. PMID: 3044569

Diagnosis

Conceptualizing a less paranoid schizophrenia.
Long J, Hull R
Philos Ethics Humanit Med 2023 Nov 8;18(1):14. doi: 10.1186/s13010-023-00142-8. PMID: 37936219Free PMC Article
Lexical indicators of anxiety in schizophrenia.
Obrębska M, Kleka P
Anxiety Stress Coping 2023 May;36(3):382-397. Epub 2022 May 13 doi: 10.1080/10615806.2022.2076081. PMID: 35561064
Delusional misidentification.
Feinberg TE, Roane DM
Psychiatr Clin North Am 2005 Sep;28(3):665-83, 678-9. doi: 10.1016/j.psc.2005.05.002. PMID: 16122573
Paraphrenia redefined.
Ravindran AV, Yatham LN, Munro A
Can J Psychiatry 1999 Mar;44(2):133-7. doi: 10.1177/070674379904400202. PMID: 10097832
Delusional (paranoid) disorders.
Munro A
Can J Psychiatry 1988 Jun;33(5):399-404. doi: 10.1177/070674378803300516. PMID: 3044569

Therapy

CLINICAL AND GENETIC FEATURES OF PERSONALIZED ANTIPSYCHOTIC THERAPY OF PATIENTS WITH PARANOID SCHIZOPHRENIA OF THE KAZAKH ETHNIC GROUP IN THE REPUBLIC OF KAZAKHSTAN.
Abetova A, Raspopova N, Yessimov N, Prilutskaya M, Cherchenko N, Kachiyeva Z
Georgian Med News 2023 Sep;(342):80-90. PMID: 37991961
Schizophrenia and Homoeopathy: A Review.
Gupta G
Altern Ther Health Med 2023 Jul;29(5):164-169. PMID: 34453506
Psychoeducational therapy with families of paranoid schizophrenia patients.
Mubin MF, Riwanto I, Soewadi, Sakti H, Erawati E
Enferm Clin (Engl Ed) 2020 Sep-Oct;30(5):326-332. Epub 2019 Feb 10 doi: 10.1016/j.enfcli.2018.12.006. PMID: 30745183
Potentially fatal outcomes associated with clozapine.
Li KJ, Gurrera RJ, Delisi LE
Schizophr Res 2018 Sep;199:386-389. Epub 2018 Mar 2 doi: 10.1016/j.schres.2018.02.058. PMID: 29503232
Treatments for delusional disorder.
Skelton M, Khokhar WA, Thacker SP
Cochrane Database Syst Rev 2015 May 22;2015(5):CD009785. doi: 10.1002/14651858.CD009785.pub2. PMID: 25997589Free PMC Article

Prognosis

Conceptualizing a less paranoid schizophrenia.
Long J, Hull R
Philos Ethics Humanit Med 2023 Nov 8;18(1):14. doi: 10.1186/s13010-023-00142-8. PMID: 37936219Free PMC Article
Lexical indicators of anxiety in schizophrenia.
Obrębska M, Kleka P
Anxiety Stress Coping 2023 May;36(3):382-397. Epub 2022 May 13 doi: 10.1080/10615806.2022.2076081. PMID: 35561064
Narcissistic Equilibrium in Paranoid Schizophrenia.
Canta GR, Miranda FL, Paixão R, Dias CA
Psychodyn Psychiatry 2019 Winter;47(4):373-401. doi: 10.1521/pdps.2019.47.4.373. PMID: 31913789
Adherence, insight and disability in paranoid schizophrenia.
García-Cabeza I, Díaz-Caneja CM, Ovejero M, de Portugal E
Psychiatry Res 2018 Dec;270:274-280. Epub 2018 Sep 23 doi: 10.1016/j.psychres.2018.09.021. PMID: 30278408
Heterogeneity of schizophrenia.
Tsuang MT
Biol Psychiatry 1975 Aug;10(4):465-74. PMID: 1100126

Clinical prediction guides

Lexical indicators of anxiety in schizophrenia.
Obrębska M, Kleka P
Anxiety Stress Coping 2023 May;36(3):382-397. Epub 2022 May 13 doi: 10.1080/10615806.2022.2076081. PMID: 35561064
Schizophrenia and Homoeopathy: A Review.
Gupta G
Altern Ther Health Med 2023 Jul;29(5):164-169. PMID: 34453506
Adherence, insight and disability in paranoid schizophrenia.
García-Cabeza I, Díaz-Caneja CM, Ovejero M, de Portugal E
Psychiatry Res 2018 Dec;270:274-280. Epub 2018 Sep 23 doi: 10.1016/j.psychres.2018.09.021. PMID: 30278408
Demographic and clinical features related to perceived discrimination in schizophrenia.
Fresán A, Robles-García R, Madrigal E, Tovilla-Zarate CA, Martínez-López N, Arango de Montis I
Psychiatry Res 2018 Apr;262:427-430. Epub 2017 Sep 9 doi: 10.1016/j.psychres.2017.09.019. PMID: 28939391
Anhedonia and schizophrenia.
Harrow M, Grinker RR, Holzman PS, Kayton L
Am J Psychiatry 1977 Jul;134(7):794-7. doi: 10.1176/ajp.134.7.794. PMID: 869058

Recent systematic reviews

Clinical Characterization, Course, and Treatment of Othello Syndrome: A Case Series and Systematic Review of the Literature.
Park JH, Sarwar S, Hassett LC, Staab JP, Fipps DC
J Acad Consult Liaison Psychiatry 2024 Jan-Feb;65(1):89-105. Epub 2023 Oct 11 doi: 10.1016/j.jaclp.2023.09.006. PMID: 37832650
Demographic and clinical features as predictors of clozapine response in patients with schizophrenia spectrum disorders: A systematic review and meta-analysis.
Okhuijsen-Pfeifer C, Sterk AY, Horn IM, Terstappen J, Kahn RS, Luykx JJ
Neurosci Biobehav Rev 2020 Apr;111:246-252. Epub 2020 Jan 23 doi: 10.1016/j.neubiorev.2020.01.017. PMID: 31982601
Treatments for primary delusional infestation.
Assalman I, Ahmed A, Alhajjar R, Bewley AP, Taylor R
Cochrane Database Syst Rev 2019 Dec 10;12(12):CD011326. doi: 10.1002/14651858.CD011326.pub2. PMID: 31821546Free PMC Article
Sixty Years of Placebo-Controlled Antipsychotic Drug Trials in Acute Schizophrenia: Systematic Review, Bayesian Meta-Analysis, and Meta-Regression of Efficacy Predictors.
Leucht S, Leucht C, Huhn M, Chaimani A, Mavridis D, Helfer B, Samara M, Rabaioli M, Bächer S, Cipriani A, Geddes JR, Salanti G, Davis JM
Am J Psychiatry 2017 Oct 1;174(10):927-942. Epub 2017 May 25 doi: 10.1176/appi.ajp.2017.16121358. PMID: 28541090
Treatments for delusional disorder.
Skelton M, Khokhar WA, Thacker SP
Cochrane Database Syst Rev 2015 May 22;2015(5):CD009785. doi: 10.1002/14651858.CD009785.pub2. PMID: 25997589Free PMC Article

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