U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Recurrent Primary Myelofibrosis

MedGen UID:
1791967
•Concept ID:
C5555526
•
Neoplastic Process

Definition

The reemergence of primary myelofibrosis after a period of remission. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRecurrent Primary Myelofibrosis

Professional guidelines

PubMed

Blast phase myeloproliferative neoplasm: contemporary review and 2024 treatment algorithm.
Tefferi A, Alkhateeb H, Gangat N
Blood Cancer J 2023 Jul 18;13(1):108. doi: 10.1038/s41408-023-00878-8. PMID: 37460550Free PMC Article
Thrombotic complications of myeloproliferative neoplasms: risk assessment and risk-guided management.
Casini A, Fontana P, Lecompte TP
J Thromb Haemost 2013 Jul;11(7):1215-27. doi: 10.1111/jth.12265. PMID: 23601811
Primary myelofibrosis: update on definition, pathogenesis, and treatment.
Abdel-Wahab OI, Levine RL
Annu Rev Med 2009;60:233-45. doi: 10.1146/annurev.med.60.041707.160528. PMID: 18947294

Recent clinical studies

Etiology

Blast phase myeloproliferative neoplasm: contemporary review and 2024 treatment algorithm.
Tefferi A, Alkhateeb H, Gangat N
Blood Cancer J 2023 Jul 18;13(1):108. doi: 10.1038/s41408-023-00878-8. PMID: 37460550Free PMC Article
Molecular pathogenesis of the myeloproliferative neoplasms.
Greenfield G, McMullin MF, Mills K
J Hematol Oncol 2021 Jun 30;14(1):103. doi: 10.1186/s13045-021-01116-z. PMID: 34193229Free PMC Article
The Genetic Basis of Primary Myelofibrosis and Its Clinical Relevance.
Rumi E, Trotti C, Vanni D, Casetti IC, Pietra D, Sant'Antonio E
Int J Mol Sci 2020 Nov 24;21(23) doi: 10.3390/ijms21238885. PMID: 33255170Free PMC Article
Pathogenesis and Management of Thrombotic Disease in Myeloproliferative Neoplasms.
Arachchillage DR, Laffan M
Semin Thromb Hemost 2019 Sep;45(6):604-611. Epub 2019 Aug 5 doi: 10.1055/s-0039-1693477. PMID: 31382304
JAK2 mutation-related disease and thrombosis.
Vannucchi AM, Guglielmelli P
Semin Thromb Hemost 2013 Jul;39(5):496-506. Epub 2013 Apr 30 doi: 10.1055/s-0033-1343890. PMID: 23633193

Diagnosis

Blast phase myeloproliferative neoplasm: contemporary review and 2024 treatment algorithm.
Tefferi A, Alkhateeb H, Gangat N
Blood Cancer J 2023 Jul 18;13(1):108. doi: 10.1038/s41408-023-00878-8. PMID: 37460550Free PMC Article
Molecular pathogenesis of the myeloproliferative neoplasms.
Greenfield G, McMullin MF, Mills K
J Hematol Oncol 2021 Jun 30;14(1):103. doi: 10.1186/s13045-021-01116-z. PMID: 34193229Free PMC Article
The Calreticulin gene and myeloproliferative neoplasms.
Clinton A, McMullin MF
J Clin Pathol 2016 Oct;69(10):841-5. Epub 2016 Jun 28 doi: 10.1136/jclinpath-2016-203899. PMID: 27354406
Clinical and molecular genetic characterization of myelofibrosis.
Hobbs GS, Rampal RK
Curr Opin Hematol 2015 Mar;22(2):177-83. doi: 10.1097/MOH.0000000000000122. PMID: 25635755
JAK2 mutation-related disease and thrombosis.
Vannucchi AM, Guglielmelli P
Semin Thromb Hemost 2013 Jul;39(5):496-506. Epub 2013 Apr 30 doi: 10.1055/s-0033-1343890. PMID: 23633193

Therapy

Improving allogeneic stem cell transplantation in myelofibrosis.
Gagelmann N, Kröger N
Int J Hematol 2022 May;115(5):619-625. Epub 2022 Apr 13 doi: 10.1007/s12185-022-03340-w. PMID: 35419771
Allogeneic haematopoietic cell transplantation for myelofibrosis: a real-life perspective.
Savani M, Dulery R, Bazarbachi AH, Mohty R, Brissot E, Malard F, Bazarbachi A, Nagler A, Mohty M
Br J Haematol 2021 Nov;195(4):495-506. Epub 2021 Apr 21 doi: 10.1111/bjh.17469. PMID: 33881169
Current treatment of myeloproliferative neoplasias: three scenarios.
Xicoy B, Zamora L
Med Clin (Barc) 2020 Feb 28;154(4):131-133. Epub 2019 Jul 24 doi: 10.1016/j.medcli.2019.05.009. PMID: 31351663
Pathogenesis and Management of Thrombotic Disease in Myeloproliferative Neoplasms.
Arachchillage DR, Laffan M
Semin Thromb Hemost 2019 Sep;45(6):604-611. Epub 2019 Aug 5 doi: 10.1055/s-0039-1693477. PMID: 31382304
JAK-mutant myeloproliferative neoplasms.
Levine RL
Curr Top Microbiol Immunol 2012;355:119-33. doi: 10.1007/82_2011_170. PMID: 21823028

Prognosis

Blast phase myeloproliferative neoplasm: contemporary review and 2024 treatment algorithm.
Tefferi A, Alkhateeb H, Gangat N
Blood Cancer J 2023 Jul 18;13(1):108. doi: 10.1038/s41408-023-00878-8. PMID: 37460550Free PMC Article
Molecular pathogenesis of the myeloproliferative neoplasms.
Greenfield G, McMullin MF, Mills K
J Hematol Oncol 2021 Jun 30;14(1):103. doi: 10.1186/s13045-021-01116-z. PMID: 34193229Free PMC Article
The Genetic Basis of Primary Myelofibrosis and Its Clinical Relevance.
Rumi E, Trotti C, Vanni D, Casetti IC, Pietra D, Sant'Antonio E
Int J Mol Sci 2020 Nov 24;21(23) doi: 10.3390/ijms21238885. PMID: 33255170Free PMC Article
Clinical and molecular genetic characterization of myelofibrosis.
Hobbs GS, Rampal RK
Curr Opin Hematol 2015 Mar;22(2):177-83. doi: 10.1097/MOH.0000000000000122. PMID: 25635755
JAK2 mutation-related disease and thrombosis.
Vannucchi AM, Guglielmelli P
Semin Thromb Hemost 2013 Jul;39(5):496-506. Epub 2013 Apr 30 doi: 10.1055/s-0033-1343890. PMID: 23633193

Clinical prediction guides

Haploidentical bone marrow transplants with post transplant cyclophosphamide on day + 3 + 5: The Genova protocol.
Raiola AM, Angelucci E, Sica S, Bacigalupo A
Blood Rev 2023 Nov;62:101031. Epub 2022 Nov 11 doi: 10.1016/j.blre.2022.101031. PMID: 36435691
The Genetic Basis of Primary Myelofibrosis and Its Clinical Relevance.
Rumi E, Trotti C, Vanni D, Casetti IC, Pietra D, Sant'Antonio E
Int J Mol Sci 2020 Nov 24;21(23) doi: 10.3390/ijms21238885. PMID: 33255170Free PMC Article
Detection of driver and subclonal mutations in myelofibrosis: clinical impact on pharmacologic and transplant based treatment strategies.
Finazzi MC, Lussana F, Salmoiraghi S, Spinelli O, Rambaldi A
Expert Rev Hematol 2017 Jul;10(7):627-636. Epub 2017 May 25 doi: 10.1080/17474086.2017.1331125. PMID: 28504024
Clinical and molecular genetic characterization of myelofibrosis.
Hobbs GS, Rampal RK
Curr Opin Hematol 2015 Mar;22(2):177-83. doi: 10.1097/MOH.0000000000000122. PMID: 25635755
JAK2 mutation-related disease and thrombosis.
Vannucchi AM, Guglielmelli P
Semin Thromb Hemost 2013 Jul;39(5):496-506. Epub 2013 Apr 30 doi: 10.1055/s-0033-1343890. PMID: 23633193

Recent systematic reviews

A systematic review of antithrombotic treatment of venous thromboembolism in patients with myeloproliferative neoplasms.
Hamulyák EN, Daams JG, Leebeek FWG, Biemond BJ, Te Boekhorst PAW, Middeldorp S, Lauw MN
Blood Adv 2021 Jan 12;5(1):113-121. doi: 10.1182/bloodadvances.2020003628. PMID: 33570633Free PMC Article
Leukocytosis and thrombosis in essential thrombocythemia and polycythemia vera: a systematic review and meta-analysis.
Carobbio A, Ferrari A, Masciulli A, Ghirardi A, Barosi G, Barbui T
Blood Adv 2019 Jun 11;3(11):1729-1737. doi: 10.1182/bloodadvances.2019000211. PMID: 31175128Free PMC Article
State-of-the-art review: allogeneic stem cell transplantation for myelofibrosis in 2019.
McLornan DP, Yakoub-Agha I, Robin M, Chalandon Y, Harrison CN, Kroger N
Haematologica 2019 Apr;104(4):659-668. Epub 2019 Mar 14 doi: 10.3324/haematol.2018.206151. PMID: 30872371Free PMC Article

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...