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Mesangial Immune complex deposition

MedGen UID:
1784789
•Concept ID:
C5539490
•
Finding
HPO: HP:0033295

Definition

Extracellular meangial accumulation of finely granular material corresponding to immunoglobulin and/or complement by immunofluorescence/immunohistochemistry; most typically electron-dense although this may decrease with resorption of the deposit. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMesangial Immune complex deposition

Conditions with this feature

Immunodeficiency, common variable, 6
MedGen UID:
462091
•Concept ID:
C3150741
•
Disease or Syndrome
Any common variable immunodeficiency in which the cause of the disease is a mutation in the CD81 gene.
See: Condition Record
Immunodeficiency, common variable, 6

Professional guidelines

PubMed

The role of fish oil/omega-3 fatty acids in the treatment of IgA nephropathy.
Donadio JV, Grande JP
Semin Nephrol 2004 May;24(3):225-43. doi: 10.1016/j.semnephrol.2004.01.004. PMID: 15156528

Recent clinical studies

Etiology

De novo immune complex deposition in kidney allografts: a series of 32 patients.
Lloyd IE, Ahmed F, Revelo MP, Khalighi MA
Hum Pathol 2018 Jan;71:109-116. Epub 2017 Oct 24 doi: 10.1016/j.humpath.2017.10.012. PMID: 29079181
The role of fish oil/omega-3 fatty acids in the treatment of IgA nephropathy.
Donadio JV, Grande JP
Semin Nephrol 2004 May;24(3):225-43. doi: 10.1016/j.semnephrol.2004.01.004. PMID: 15156528

Diagnosis

Recurrent or persistent hematuria. Sign of mesangial immune-complex deposition.
van de Putte LB, de la Riviere GB, van Breda Vriesman PJ
N Engl J Med 1974 May 23;290(21):1165-70. doi: 10.1056/NEJM197405232902104. PMID: 4596116

Therapy

The role of fish oil/omega-3 fatty acids in the treatment of IgA nephropathy.
Donadio JV, Grande JP
Semin Nephrol 2004 May;24(3):225-43. doi: 10.1016/j.semnephrol.2004.01.004. PMID: 15156528

Clinical prediction guides

De novo immune complex deposition in kidney allografts: a series of 32 patients.
Lloyd IE, Ahmed F, Revelo MP, Khalighi MA
Hum Pathol 2018 Jan;71:109-116. Epub 2017 Oct 24 doi: 10.1016/j.humpath.2017.10.012. PMID: 29079181

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