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Neuroinflammation

MedGen UID:
1718373
Concept ID:
C5394393
Finding
Synonym: Neuroinflammations
 
HPO: HP:0033429

Definition

Activation of the brain's innate immune system in response to an inflammatory challenge and is characterized by a host of cellular and molecular changes within the brain. [from HPO]

Professional guidelines

PubMed

Twarowski B, Herbet M
Int J Mol Sci 2023 Mar 30;24(7) doi: 10.3390/ijms24076518. PMID: 37047492Free PMC Article
Koninckx PR, Fernandes R, Ussia A, Schindler L, Wattiez A, Al-Suwaidi S, Amro B, Al-Maamari B, Hakim Z, Tahlak M
Front Endocrinol (Lausanne) 2021;12:745548. Epub 2021 Nov 25 doi: 10.3389/fendo.2021.745548. PMID: 34899597Free PMC Article
Jankovic J, Tan EK
J Neurol Neurosurg Psychiatry 2020 Aug;91(8):795-808. Epub 2020 Jun 23 doi: 10.1136/jnnp-2019-322338. PMID: 32576618

Recent clinical studies

Etiology

Hughes HK, R J Moreno, Ashwood P
Brain Behav Immun 2023 Feb;108:245-254. Epub 2022 Dec 6 doi: 10.1016/j.bbi.2022.12.001. PMID: 36494048
Koutsodendris N, Nelson MR, Rao A, Huang Y
Annu Rev Pathol 2022 Jan 24;17:73-99. Epub 2021 Aug 30 doi: 10.1146/annurev-pathmechdis-030421-112756. PMID: 34460318
Jurcau A, Simion A
Int J Mol Sci 2021 Dec 21;23(1) doi: 10.3390/ijms23010014. PMID: 35008440Free PMC Article
Leng F, Edison P
Nat Rev Neurol 2021 Mar;17(3):157-172. Epub 2020 Dec 14 doi: 10.1038/s41582-020-00435-y. PMID: 33318676
Guerreiro S, Privat AL, Bressac L, Toulorge D
Cells 2020 Feb 18;9(2) doi: 10.3390/cells9020471. PMID: 32085567Free PMC Article

Diagnosis

Twarowski B, Herbet M
Int J Mol Sci 2023 Mar 30;24(7) doi: 10.3390/ijms24076518. PMID: 37047492Free PMC Article
Al-Ghraiybah NF, Wang J, Alkhalifa AE, Roberts AB, Raj R, Yang E, Kaddoumi A
Int J Mol Sci 2022 Sep 12;23(18) doi: 10.3390/ijms231810572. PMID: 36142483Free PMC Article
Candelario-Jalil E, Dijkhuizen RM, Magnus T
Stroke 2022 May;53(5):1473-1486. Epub 2022 Apr 7 doi: 10.1161/STROKEAHA.122.036946. PMID: 35387495Free PMC Article
Kwon HS, Koh SH
Transl Neurodegener 2020 Nov 26;9(1):42. doi: 10.1186/s40035-020-00221-2. PMID: 33239064Free PMC Article
Calsolaro V, Edison P
Alzheimers Dement 2016 Jun;12(6):719-32. Epub 2016 May 11 doi: 10.1016/j.jalz.2016.02.010. PMID: 27179961

Therapy

Thakur S, Dhapola R, Sarma P, Medhi B, Reddy DH
Inflammation 2023 Feb;46(1):1-17. Epub 2022 Aug 20 doi: 10.1007/s10753-022-01721-1. PMID: 35986874
Athar T, Al Balushi K, Khan SA
Mol Biol Rep 2021 Jul;48(7):5629-5645. Epub 2021 Jun 28 doi: 10.1007/s11033-021-06512-9. PMID: 34181171Free PMC Article
Paul S, Candelario-Jalil E
Exp Neurol 2021 Jan;335:113518. Epub 2020 Nov 2 doi: 10.1016/j.expneurol.2020.113518. PMID: 33144066Free PMC Article
Ji RR, Nackley A, Huh Y, Terrando N, Maixner W
Anesthesiology 2018 Aug;129(2):343-366. doi: 10.1097/ALN.0000000000002130. PMID: 29462012Free PMC Article
Heneka MT, Carson MJ, El Khoury J, Landreth GE, Brosseron F, Feinstein DL, Jacobs AH, Wyss-Coray T, Vitorica J, Ransohoff RM, Herrup K, Frautschy SA, Finsen B, Brown GC, Verkhratsky A, Yamanaka K, Koistinaho J, Latz E, Halle A, Petzold GC, Town T, Morgan D, Shinohara ML, Perry VH, Holmes C, Bazan NG, Brooks DJ, Hunot S, Joseph B, Deigendesch N, Garaschuk O, Boddeke E, Dinarello CA, Breitner JC, Cole GM, Golenbock DT, Kummer MP
Lancet Neurol 2015 Apr;14(4):388-405. doi: 10.1016/S1474-4422(15)70016-5. PMID: 25792098Free PMC Article

Prognosis

Rantala MJ, Luoto S, Borráz-León JI, Krams I
Neurosci Biobehav Rev 2022 Nov;142:104894. Epub 2022 Sep 28 doi: 10.1016/j.neubiorev.2022.104894. PMID: 36181926
Jayaraj RL, Azimullah S, Beiram R, Jalal FY, Rosenberg GA
J Neuroinflammation 2019 Jul 10;16(1):142. doi: 10.1186/s12974-019-1516-2. PMID: 31291966Free PMC Article
Yang QQ, Zhou JW
Glia 2019 Jun;67(6):1017-1035. Epub 2018 Dec 11 doi: 10.1002/glia.23571. PMID: 30548343
McCauley ME, Baloh RH
Acta Neuropathol 2019 May;137(5):715-730. Epub 2018 Nov 21 doi: 10.1007/s00401-018-1933-9. PMID: 30465257Free PMC Article
DiSabato DJ, Quan N, Godbout JP
J Neurochem 2016 Oct;139 Suppl 2(Suppl 2):136-153. Epub 2016 May 4 doi: 10.1111/jnc.13607. PMID: 26990767Free PMC Article

Clinical prediction guides

Rantala MJ, Luoto S, Borráz-León JI, Krams I
Neurosci Biobehav Rev 2022 Nov;142:104894. Epub 2022 Sep 28 doi: 10.1016/j.neubiorev.2022.104894. PMID: 36181926
Chan KH, Lee CY
Int J Mol Sci 2021 Aug 11;22(16) doi: 10.3390/ijms22168638. PMID: 34445343Free PMC Article
Leng F, Edison P
Nat Rev Neurol 2021 Mar;17(3):157-172. Epub 2020 Dec 14 doi: 10.1038/s41582-020-00435-y. PMID: 33318676
Guerreiro S, Privat AL, Bressac L, Toulorge D
Cells 2020 Feb 18;9(2) doi: 10.3390/cells9020471. PMID: 32085567Free PMC Article
Liu CC, Liu CC, Kanekiyo T, Xu H, Bu G
Nat Rev Neurol 2013 Feb;9(2):106-18. Epub 2013 Jan 8 doi: 10.1038/nrneurol.2012.263. PMID: 23296339Free PMC Article

Recent systematic reviews

Lawrence JM, Schardien K, Wigdahl B, Nonnemacher MR
Acta Neuropathol Commun 2023 Mar 13;11(1):42. doi: 10.1186/s40478-023-01526-9. PMID: 36915214Free PMC Article
Chang CH, Lin CH, Lane HY
Int J Mol Sci 2021 Mar 9;22(5) doi: 10.3390/ijms22052761. PMID: 33803217Free PMC Article
Kim PS, Fishman MA
Curr Pain Headache Rep 2020 Aug 26;24(10):64. doi: 10.1007/s11916-020-00898-0. PMID: 32845365
Calcia MA, Bonsall DR, Bloomfield PS, Selvaraj S, Barichello T, Howes OD
Psychopharmacology (Berl) 2016 May;233(9):1637-50. Epub 2016 Feb 5 doi: 10.1007/s00213-016-4218-9. PMID: 26847047Free PMC Article
Deepmala, Slattery J, Kumar N, Delhey L, Berk M, Dean O, Spielholz C, Frye R
Neurosci Biobehav Rev 2015 Aug;55:294-321. Epub 2015 May 6 doi: 10.1016/j.neubiorev.2015.04.015. PMID: 25957927

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