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Abnormal plasmablast proportion

MedGen UID:
1697630
•Concept ID:
C5139147
•
Finding
HPO: HP:0032127

Definition

A deviation from the normal proportion of plasmablasts in circulation relative to total number of B cells. Plasmablasts are antibody-secreting cells that originate after infection or vaccination. [from HPO]

Recent clinical studies

Etiology

Comprehensive immunophenotypic analysis reveals the pathological involvement of Th17 cells in Graves' disease.
Torimoto K, Okada Y, Nakayamada S, Kubo S, Kurozumi A, Narisawa M, Tanaka Y
Sci Rep 2022 Oct 7;12(1):16880. doi: 10.1038/s41598-022-19556-z. PMID: 36207336Free PMC Article
Abnormal Shift in B Memory Cell Profile Is Associated With the Expansion of Circulating T Follicular Helper Cells via ICOS Signaling During Acute HIV-1 Infection.
Lu X, Zhang X, Cheung AKL, Moog C, Xia H, Li Z, Wang R, Ji Y, Xia W, Liu Z, Yuan L, Wang X, Wu H, Zhang T, Su B
Front Immunol 2022;13:837921. Epub 2022 Feb 10 doi: 10.3389/fimmu.2022.837921. PMID: 35222430Free PMC Article
B-cell compartment abnormalities are associated with ACLF and mortality in patients with liver cirrhosis.
Cardoso CC, Matiollo C, Pereira CHJ, Fonseca JS, Alves HEL, Silva OMD, Menegassi VS, Schiavon LL, Santos-Silva MC
Clin Res Hepatol Gastroenterol 2021 Jul;45(4):101698. Epub 2021 Apr 20 doi: 10.1016/j.clinre.2021.101698. PMID: 33852953
Distinctive association of peripheral immune cell phenotypes with capillaroscopic microvascular patterns in systemic sclerosis.
Kubo S, Nakayamada S, Miyazaki Y, Yoshikawa M, Yoshinari H, Satoh Y, Todoroki Y, Nakano K, Satoh M, Smith V, Cutolo M, Tanaka Y
Rheumatology (Oxford) 2019 Dec 1;58(12):2273-2283. doi: 10.1093/rheumatology/kez244. PMID: 31230071
Peripheral Immunophenotyping Identifies Three Subgroups Based on T Cell Heterogeneity in Lupus Patients.
Kubo S, Nakayamada S, Yoshikawa M, Miyazaki Y, Sakata K, Nakano K, Hanami K, Iwata S, Miyagawa I, Saito K, Tanaka Y
Arthritis Rheumatol 2017 Oct;69(10):2029-2037. Epub 2017 Aug 25 doi: 10.1002/art.40180. PMID: 28605137

Diagnosis

Expansion of extrafollicular B and T cell subsets in childhood-onset systemic lupus erythematosus.
Baxter RM, Wang CS, Garcia-Perez JE, Kong DS, Coleman BM, Larchenko V, Schuyler RP, Jackson C, Ghosh T, Rudra P, Paul D, Claassen M, Rochford R, Cambier JC, Ghosh D, Cooper JC, Smith MJ, Hsieh EWY
Front Immunol 2023;14:1208282. Epub 2023 Oct 27 doi: 10.3389/fimmu.2023.1208282. PMID: 37965329Free PMC Article
Correlation of T follicular helper cells and plasmablasts with the development of organ involvement in patients with IgG4-related disease.
Kubo S, Nakayamada S, Zhao J, Yoshikawa M, Miyazaki Y, Nawata A, Hirata S, Nakano K, Saito K, Tanaka Y
Rheumatology (Oxford) 2018 Mar 1;57(3):514-524. doi: 10.1093/rheumatology/kex455. PMID: 29253269
The B-cell compartment in antibody-deficient infants and young children - developing common variable immunodeficiency or transient immune maturation?
Szczawinska-Poplonyk A, Tapolska-Jozwiak K, Samara H
Ital J Pediatr 2016 Jul 26;42(1):71. doi: 10.1186/s13052-016-0279-y. PMID: 27461226Free PMC Article
Plasmablastic morphology is an independent predictor of poor survival after autologous stem-cell transplantation for multiple myeloma.
Rajkumar SV, Fonseca R, Lacy MQ, Witzig TE, Therneau TM, Kyle RA, Litzow MR, Gertz MA, Greipp PR
J Clin Oncol 1999 May;17(5):1551-7. doi: 10.1200/JCO.1999.17.5.1551. PMID: 10334543

Therapy

Comprehensive immunophenotypic analysis reveals the pathological involvement of Th17 cells in Graves' disease.
Torimoto K, Okada Y, Nakayamada S, Kubo S, Kurozumi A, Narisawa M, Tanaka Y
Sci Rep 2022 Oct 7;12(1):16880. doi: 10.1038/s41598-022-19556-z. PMID: 36207336Free PMC Article
Abnormal Shift in B Memory Cell Profile Is Associated With the Expansion of Circulating T Follicular Helper Cells via ICOS Signaling During Acute HIV-1 Infection.
Lu X, Zhang X, Cheung AKL, Moog C, Xia H, Li Z, Wang R, Ji Y, Xia W, Liu Z, Yuan L, Wang X, Wu H, Zhang T, Su B
Front Immunol 2022;13:837921. Epub 2022 Feb 10 doi: 10.3389/fimmu.2022.837921. PMID: 35222430Free PMC Article
Effect of Antiretroviral Therapy on the Memory and Activation Profiles of B Cells in HIV-Infected African Women.
Tanko RF, Soares AP, Müller TL, Garrett NJ, Samsunder N, Abdool Karim Q, Abdool Karim SS, Riou C, Burgers WA
J Immunol 2017 Feb 1;198(3):1220-1228. Epub 2016 Dec 30 doi: 10.4049/jimmunol.1601560. PMID: 28039305Free PMC Article

Prognosis

Expansion of extrafollicular B and T cell subsets in childhood-onset systemic lupus erythematosus.
Baxter RM, Wang CS, Garcia-Perez JE, Kong DS, Coleman BM, Larchenko V, Schuyler RP, Jackson C, Ghosh T, Rudra P, Paul D, Claassen M, Rochford R, Cambier JC, Ghosh D, Cooper JC, Smith MJ, Hsieh EWY
Front Immunol 2023;14:1208282. Epub 2023 Oct 27 doi: 10.3389/fimmu.2023.1208282. PMID: 37965329Free PMC Article
Regulatory T and B cells in transient hypogammaglobulinemia of infancy.
Emsen A, Uçaryılmaz H, Güler T, Artaç H
Turk J Pediatr 2022;64(2):228-238. doi: 10.24953/turkjped.2021.83. PMID: 35611411
B-cell compartment abnormalities are associated with ACLF and mortality in patients with liver cirrhosis.
Cardoso CC, Matiollo C, Pereira CHJ, Fonseca JS, Alves HEL, Silva OMD, Menegassi VS, Schiavon LL, Santos-Silva MC
Clin Res Hepatol Gastroenterol 2021 Jul;45(4):101698. Epub 2021 Apr 20 doi: 10.1016/j.clinre.2021.101698. PMID: 33852953
The B-cell compartment in antibody-deficient infants and young children - developing common variable immunodeficiency or transient immune maturation?
Szczawinska-Poplonyk A, Tapolska-Jozwiak K, Samara H
Ital J Pediatr 2016 Jul 26;42(1):71. doi: 10.1186/s13052-016-0279-y. PMID: 27461226Free PMC Article
A comprehensive investigation on the distribution of circulating follicular T helper cells and B cell subsets in primary Sjögren's syndrome and systemic lupus erythematosus.
Szabó K, Papp G, Szántó A, Tarr T, Zeher M
Clin Exp Immunol 2016 Jan;183(1):76-89. Epub 2015 Oct 21 doi: 10.1111/cei.12703. PMID: 26358223Free PMC Article

Clinical prediction guides

Comprehensive immunophenotypic analysis reveals the pathological involvement of Th17 cells in Graves' disease.
Torimoto K, Okada Y, Nakayamada S, Kubo S, Kurozumi A, Narisawa M, Tanaka Y
Sci Rep 2022 Oct 7;12(1):16880. doi: 10.1038/s41598-022-19556-z. PMID: 36207336Free PMC Article
Regulatory T and B cells in transient hypogammaglobulinemia of infancy.
Emsen A, Uçaryılmaz H, Güler T, Artaç H
Turk J Pediatr 2022;64(2):228-238. doi: 10.24953/turkjped.2021.83. PMID: 35611411
Abnormalities of bone marrow B cells and plasma cells in primary immune thrombocytopenia.
Yu TS, Wang HY, Zhao YJ, Yu YF, Hou Y, Liu S, Han PP, Ni XF, Ji XB, Peng J, Liu XG, Hou M
Blood Adv 2021 Oct 26;5(20):4087-4101. doi: 10.1182/bloodadvances.2020003860. PMID: 34507351Free PMC Article
Peripheral Immunophenotyping Identifies Three Subgroups Based on T Cell Heterogeneity in Lupus Patients.
Kubo S, Nakayamada S, Yoshikawa M, Miyazaki Y, Sakata K, Nakano K, Hanami K, Iwata S, Miyagawa I, Saito K, Tanaka Y
Arthritis Rheumatol 2017 Oct;69(10):2029-2037. Epub 2017 Aug 25 doi: 10.1002/art.40180. PMID: 28605137
Increased expression of B cell activation factor supports the abnormal expansion of transitional B cells in systemic lupus erythematosus.
Landolt-Marticorena C, Wither R, Reich H, Herzenberg A, Scholey J, Gladman DD, Urowitz MB, Fortin PR, Wither J
J Rheumatol 2011 Apr;38(4):642-51. Epub 2011 Jan 15 doi: 10.3899/jrheum.100214. PMID: 21239754

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