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Anterior blepharitis

MedGen UID:
1632973
•Concept ID:
C4703414
•
Disease or Syndrome
Synonym: Inflammation of anterior lid margin
SNOMED CT: Inflammation of anterior lid margin (1236987000); Anterior blepharitis (1236987000)
 
HPO: HP:0025609

Definition

A type of blepharitis that affects the eyelid skin, base of the eyelashes, and the eyelash follicles. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAnterior blepharitis

Professional guidelines

PubMed

In vitro evaluation of multiple antibacterial agents for the treatment of chronic staphylococcal anterior blepharitis.
Fernández-Engroba J, Ferragut-Alegre Á, Oliva-Albaladejo G, de la Paz MF
Arch Soc Esp Oftalmol (Engl Ed) 2023 Jun;98(6):338-343. Epub 2023 May 18 doi: 10.1016/j.oftale.2023.05.003. PMID: 37209719
Antibiotic treatment for dry eye disease related to meibomian gland dysfunction and blepharitis - A review.
Vernhardsdottir RR, Magno MS, Hynnekleiv L, Lagali N, Dartt DA, Vehof J, Jackson CJ, Utheim TP
Ocul Surf 2022 Oct;26:211-221. Epub 2022 Sep 20 doi: 10.1016/j.jtos.2022.08.010. PMID: 36210626
Treatment of blepharitis: recent clinical trials.
Pflugfelder SC, Karpecki PM, Perez VL
Ocul Surf 2014 Oct;12(4):273-84. Epub 2014 Jul 22 doi: 10.1016/j.jtos.2014.05.005. PMID: 25284773

Recent clinical studies

Etiology

Diagnostic Challenges of Ocular Rosacea.
Motešická S
Cesk Slov Oftalmol 2024;80(2):76-86. doi: 10.31348/2024/3. PMID: 38413227
Dry eye disease in the young: A narrative review.
Stapleton F, Velez FG, Lau C, Wolffsohn JS
Ocul Surf 2024 Jan;31:11-20. Epub 2023 Dec 7 doi: 10.1016/j.jtos.2023.12.001. PMID: 38070708
Clinical features of anterior blepharitis after cataract surgery.
Sakimoto T, Sugiura T
Sci Rep 2023 Apr 24;13(1):6615. doi: 10.1038/s41598-023-33956-9. PMID: 37095268Free PMC Article
Blepharitis: always remember demodex.
Bhandari V, Reddy JK
Middle East Afr J Ophthalmol 2014 Oct-Dec;21(4):317-20. doi: 10.4103/0974-9233.142268. PMID: 25371637Free PMC Article
Interventions for chronic blepharitis.
Lindsley K, Matsumura S, Hatef E, Akpek EK
Cochrane Database Syst Rev 2012 May 16;2012(5):CD005556. doi: 10.1002/14651858.CD005556.pub2. PMID: 22592706Free PMC Article

Diagnosis

Diagnostic Challenges of Ocular Rosacea.
Motešická S
Cesk Slov Oftalmol 2024;80(2):76-86. doi: 10.31348/2024/3. PMID: 38413227
Dry eye disease in the young: A narrative review.
Stapleton F, Velez FG, Lau C, Wolffsohn JS
Ocul Surf 2024 Jan;31:11-20. Epub 2023 Dec 7 doi: 10.1016/j.jtos.2023.12.001. PMID: 38070708
Recent advances on ocular Demodex infestation.
Cheng AM, Sheha H, Tseng SC
Curr Opin Ophthalmol 2015 Jul;26(4):295-300. doi: 10.1097/ICU.0000000000000168. PMID: 26058028
Blepharitis: always remember demodex.
Bhandari V, Reddy JK
Middle East Afr J Ophthalmol 2014 Oct-Dec;21(4):317-20. doi: 10.4103/0974-9233.142268. PMID: 25371637Free PMC Article
Interventions for chronic blepharitis.
Lindsley K, Matsumura S, Hatef E, Akpek EK
Cochrane Database Syst Rev 2012 May 16;2012(5):CD005556. doi: 10.1002/14651858.CD005556.pub2. PMID: 22592706Free PMC Article

Therapy

Clinical features of anterior blepharitis after cataract surgery.
Sakimoto T, Sugiura T
Sci Rep 2023 Apr 24;13(1):6615. doi: 10.1038/s41598-023-33956-9. PMID: 37095268Free PMC Article
Recent advances on ocular Demodex infestation.
Cheng AM, Sheha H, Tseng SC
Curr Opin Ophthalmol 2015 Jul;26(4):295-300. doi: 10.1097/ICU.0000000000000168. PMID: 26058028
Treatment of blepharitis: recent clinical trials.
Pflugfelder SC, Karpecki PM, Perez VL
Ocul Surf 2014 Oct;12(4):273-84. Epub 2014 Jul 22 doi: 10.1016/j.jtos.2014.05.005. PMID: 25284773
Interventions for chronic blepharitis.
Lindsley K, Matsumura S, Hatef E, Akpek EK
Cochrane Database Syst Rev 2012 May 16;2012(5):CD005556. doi: 10.1002/14651858.CD005556.pub2. PMID: 22592706Free PMC Article
Pathogenic role of Demodex mites in blepharitis.
Liu J, Sheha H, Tseng SC
Curr Opin Allergy Clin Immunol 2010 Oct;10(5):505-10. doi: 10.1097/ACI.0b013e32833df9f4. PMID: 20689407Free PMC Article

Prognosis

Ocular surface microbiome in meibomian gland dysfunction.
Watters GA, Turnbull PR, Swift S, Petty A, Craig JP
Clin Exp Ophthalmol 2017 Mar;45(2):105-111. Epub 2016 Sep 7 doi: 10.1111/ceo.12810. PMID: 27473509
Functional and Morphologic Changes of Meibomian Glands in an Asymptomatic Adult Population.
Yeotikar NS, Zhu H, Markoulli M, Nichols KK, Naduvilath T, Papas EB
Invest Ophthalmol Vis Sci 2016 Aug 1;57(10):3996-4007. doi: 10.1167/iovs.15-18467. PMID: 27490319
Blepharitis: always remember demodex.
Bhandari V, Reddy JK
Middle East Afr J Ophthalmol 2014 Oct-Dec;21(4):317-20. doi: 10.4103/0974-9233.142268. PMID: 25371637Free PMC Article
Clinical spectrum of pediatric blepharokeratoconjunctivitis.
Gupta N, Dhawan A, Beri S, D'souza P
J AAPOS 2010 Dec;14(6):527-9. Epub 2010 Nov 19 doi: 10.1016/j.jaapos.2010.09.013. PMID: 21093331
Surface keratopathy after penetrating keratoplasty.
Feiz V, Mannis MJ, Kandavel G, McCarthy M, Izquierdo L, Eckert M, Schwab IR, Torabian S, Wang JL, Wang W
Trans Am Ophthalmol Soc 2001;99:159-68; discussion 168-70. PMID: 11797303Free PMC Article

Clinical prediction guides

Diagnostic Challenges of Ocular Rosacea.
Motešická S
Cesk Slov Oftalmol 2024;80(2):76-86. doi: 10.31348/2024/3. PMID: 38413227
Anterior blepharitis is associated with elevated plectin levels consistent with a pronounced intracellular response.
Muttuvelu DV, Cehofski LJ, Muhammad MGF, Chen X, Utheim TP, Khan AM, Abduljabar AB, Kristensen K, Rasmussen MLR, Vorum H, Heegaard S, Honoré B
Ocul Surf 2023 Jul;29:444-455. Epub 2023 Jun 20 doi: 10.1016/j.jtos.2023.06.010. PMID: 37348651
Clinical characteristics of Demodex-associated recurrent hordeola: an observational, comparative study.
Jun SY, Choi YJ, Lee BR, Lee SU, Kim SC
Sci Rep 2021 Nov 1;11(1):21398. doi: 10.1038/s41598-021-00599-7. PMID: 34725365Free PMC Article
Clinical efficacy of eyelid hygiene in blepharitis and meibomian gland dysfunction after cataract surgery: a randomized controlled pilot trial.
Eom Y, Na KS, Hwang HS, Cho KJ, Chung TY, Jun RM, Ko BY, Chun YS, Kim HS, Song JS
Sci Rep 2020 Jul 16;10(1):11796. doi: 10.1038/s41598-020-67888-5. PMID: 32678131Free PMC Article
Ocular surface microbiome in meibomian gland dysfunction.
Watters GA, Turnbull PR, Swift S, Petty A, Craig JP
Clin Exp Ophthalmol 2017 Mar;45(2):105-111. Epub 2016 Sep 7 doi: 10.1111/ceo.12810. PMID: 27473509

Recent systematic reviews

Interventions for chronic blepharitis.
Lindsley K, Matsumura S, Hatef E, Akpek EK
Cochrane Database Syst Rev 2012 May 16;2012(5):CD005556. doi: 10.1002/14651858.CD005556.pub2. PMID: 22592706Free PMC Article

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