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Abnormal ocular alignment

MedGen UID:
1631352
•Concept ID:
C4703708
•
Finding
HPO: HP:0500073

Definition

Any deviation from the normal ocular alignment. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal ocular alignment

Professional guidelines

PubMed

Newborn and infant vision screening in primary care: A clinical review.
Stocks CO, Carson RA
J Spec Pediatr Nurs 2024 Jan;29(1):e12421. doi: 10.1111/jspn.12421. PMID: 38284218
Childhood Eye Examination in Primary Care.
Reedy-Cooper A, Scartozzi C, Yurkonis T
Am Fam Physician 2023 Jul;108(1):40-50. PMID: 37440736
Duane syndrome: Clinical features and surgical management.
Kalevar A, Ong Tone S, Flanders M
Can J Ophthalmol 2015 Aug;50(4):310-3. doi: 10.1016/j.jcjo.2015.05.005. PMID: 26257226

Recent clinical studies

Etiology

A Narrative Review of the Ocular Manifestations in Noonan Syndrome.
Christou EE, Zafeiropoulos P, Rallis D, Baltogianni M, Asproudis C, Stefaniotou M, Giapros V, Asproudis I
Semin Ophthalmol 2022 Feb 17;37(2):215-221. Epub 2021 Jul 19 doi: 10.1080/08820538.2021.1955134. PMID: 34280068
Congenital cranial dysinnervation disorders.
Singh A, Pandey PK, Agrawal A, Mittal SK, Rana KM, Bahuguna C
Int Ophthalmol 2017 Dec;37(6):1369-1381. Epub 2016 Nov 11 doi: 10.1007/s10792-016-0388-z. PMID: 27837354
Childhood eye examination.
Bell AL, Rodes ME, Collier Kellar L
Am Fam Physician 2013 Aug 15;88(4):241-8. PMID: 23944727
Inferior vestibular neuritis.
Kim JS, Kim HJ
J Neurol 2012 Aug;259(8):1553-60. Epub 2012 Jan 4 doi: 10.1007/s00415-011-6375-4. PMID: 22215238
HINTS to diagnose stroke in the acute vestibular syndrome: three-step bedside oculomotor examination more sensitive than early MRI diffusion-weighted imaging.
Kattah JC, Talkad AV, Wang DZ, Hsieh YH, Newman-Toker DE
Stroke 2009 Nov;40(11):3504-10. Epub 2009 Sep 17 doi: 10.1161/STROKEAHA.109.551234. PMID: 19762709Free PMC Article

Diagnosis

Orbital Disease in Neuro-Ophthalmology.
Chang JR, Gruener AM, McCulley TJ
Neurol Clin 2017 Feb;35(1):125-144. doi: 10.1016/j.ncl.2016.08.011. PMID: 27886890
Childhood eye examination.
Bell AL, Rodes ME, Collier Kellar L
Am Fam Physician 2013 Aug 15;88(4):241-8. PMID: 23944727
Functional neuro-ophthalmology.
Miller NR
Handb Clin Neurol 2011;102:493-513. doi: 10.1016/B978-0-444-52903-9.00024-8. PMID: 21601078
HINTS to diagnose stroke in the acute vestibular syndrome: three-step bedside oculomotor examination more sensitive than early MRI diffusion-weighted imaging.
Kattah JC, Talkad AV, Wang DZ, Hsieh YH, Newman-Toker DE
Stroke 2009 Nov;40(11):3504-10. Epub 2009 Sep 17 doi: 10.1161/STROKEAHA.109.551234. PMID: 19762709Free PMC Article
Duane retraction syndrome.
Alexandrakis G, Saunders RA
Ophthalmol Clin North Am 2001 Sep;14(3):407-17. doi: 10.1016/s0896-1549(05)70238-8. PMID: 11705140

Therapy

Childhood Eye Examination in Primary Care.
Reedy-Cooper A, Scartozzi C, Yurkonis T
Am Fam Physician 2023 Jul;108(1):40-50. PMID: 37440736
Newly developed abnormal head position and secondary esotropia after strabismus surgery for children with intermittent exotropia.
Shen T, Kang Y, Lin X, Wu H, Yan J
Int Ophthalmol 2022 Oct;42(10):2965-2972. Epub 2022 Jan 27 doi: 10.1007/s10792-021-02173-6. PMID: 35083599
Conventional occlusion versus pharmacologic penalization for amblyopia.
Li T, Qureshi R, Taylor K
Cochrane Database Syst Rev 2019 Aug 28;8(8):CD006460. doi: 10.1002/14651858.CD006460.pub3. PMID: 31461545Free PMC Article
Neuro-ophthalmic deficits after head trauma.
Jacobs SM, Van Stavern GP
Curr Neurol Neurosci Rep 2013 Nov;13(11):389. doi: 10.1007/s11910-013-0389-5. PMID: 24027004
Conventional occlusion versus pharmacologic penalization for amblyopia.
Li T, Shotton K
Cochrane Database Syst Rev 2009 Oct 7;(4):CD006460. doi: 10.1002/14651858.CD006460.pub2. PMID: 19821369Free PMC Article

Prognosis

A Narrative Review of the Ocular Manifestations in Noonan Syndrome.
Christou EE, Zafeiropoulos P, Rallis D, Baltogianni M, Asproudis C, Stefaniotou M, Giapros V, Asproudis I
Semin Ophthalmol 2022 Feb 17;37(2):215-221. Epub 2021 Jul 19 doi: 10.1080/08820538.2021.1955134. PMID: 34280068
Strabismus surgery in Angelman syndrome: More than ocular alignment.
Michieletto P, Pensiero S, Diplotti L, Ronfani L, Giangreco M, Danieli A, Bonanni P
PLoS One 2020;15(11):e0242366. Epub 2020 Nov 13 doi: 10.1371/journal.pone.0242366. PMID: 33186391Free PMC Article
Congenital cranial dysinnervation disorders.
Singh A, Pandey PK, Agrawal A, Mittal SK, Rana KM, Bahuguna C
Int Ophthalmol 2017 Dec;37(6):1369-1381. Epub 2016 Nov 11 doi: 10.1007/s10792-016-0388-z. PMID: 27837354
Refractive error, binocular vision and accommodation of children with Down syndrome.
Watt T, Robertson K, Jacobs RJ
Clin Exp Optom 2015 Jan;98(1):3-11. Epub 2014 Nov 13 doi: 10.1111/cxo.12232. PMID: 25395109
HINTS to diagnose stroke in the acute vestibular syndrome: three-step bedside oculomotor examination more sensitive than early MRI diffusion-weighted imaging.
Kattah JC, Talkad AV, Wang DZ, Hsieh YH, Newman-Toker DE
Stroke 2009 Nov;40(11):3504-10. Epub 2009 Sep 17 doi: 10.1161/STROKEAHA.109.551234. PMID: 19762709Free PMC Article

Clinical prediction guides

Binocular Alignment Changes Between Sitting and Supine Positions in Patients with Dizziness.
Tan MR, Serrador J, Perin J, Gimmon Y, Millar J, Brewer K, Gold D, Schubert MC
J Assoc Res Otolaryngol 2022 Jun;23(3):427-433. Epub 2022 Mar 22 doi: 10.1007/s10162-022-00845-3. PMID: 35318534Free PMC Article
Effect of Viewing Conditions on Fixation Eye Movements and Eye Alignment in Amblyopia.
Murray J, Gupta P, Dulaney C, Garg K, Shaikh AG, Ghasia FF
Invest Ophthalmol Vis Sci 2022 Feb 1;63(2):33. doi: 10.1167/iovs.63.2.33. PMID: 35212720Free PMC Article
A Narrative Review of the Ocular Manifestations in Noonan Syndrome.
Christou EE, Zafeiropoulos P, Rallis D, Baltogianni M, Asproudis C, Stefaniotou M, Giapros V, Asproudis I
Semin Ophthalmol 2022 Feb 17;37(2):215-221. Epub 2021 Jul 19 doi: 10.1080/08820538.2021.1955134. PMID: 34280068
Demographic, ocular and associated neurological findings in corpus callosum malformations.
Kızıltunç PB, Şahlı E, İdil A, Atilla H
Turk J Pediatr 2021;63(2):291-299. doi: 10.24953/turkjped.2021.02.013. PMID: 33929119
HINTS to diagnose stroke in the acute vestibular syndrome: three-step bedside oculomotor examination more sensitive than early MRI diffusion-weighted imaging.
Kattah JC, Talkad AV, Wang DZ, Hsieh YH, Newman-Toker DE
Stroke 2009 Nov;40(11):3504-10. Epub 2009 Sep 17 doi: 10.1161/STROKEAHA.109.551234. PMID: 19762709Free PMC Article

Recent systematic reviews

Concomitant Calcium Channelopathies Involving CACNA1A and CACNA1F: A Case Report and Review of the Literature.
Schaare D, Sarasua SM, Lusk L, Parthasarathy S, Wang L, Helbig I, Boccuto L
Genes (Basel) 2023 Feb 3;14(2) doi: 10.3390/genes14020400. PMID: 36833327Free PMC Article
Ophthalmic manifestations in Kabuki (make-up) syndrome: A single-center pediatric cohort and systematic review of the literature.
Merdler-Rabinowicz R, Prat D, Pode-Shakked B, Abel G, Chorin O, Somech R, Raas-Rothschild A
Eur J Med Genet 2021 Jun;64(6):104210. Epub 2021 Mar 30 doi: 10.1016/j.ejmg.2021.104210. PMID: 33794347
Conventional occlusion versus pharmacologic penalization for amblyopia.
Li T, Qureshi R, Taylor K
Cochrane Database Syst Rev 2019 Aug 28;8(8):CD006460. doi: 10.1002/14651858.CD006460.pub3. PMID: 31461545Free PMC Article
Conventional occlusion versus pharmacologic penalization for amblyopia.
Li T, Shotton K
Cochrane Database Syst Rev 2009 Oct 7;(4):CD006460. doi: 10.1002/14651858.CD006460.pub2. PMID: 19821369Free PMC Article

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