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Abnormal proportion of CD4-positive T cells

MedGen UID:
1619121
•Concept ID:
C4531156
•
Finding
Synonym: Abnormal proportion of CD4 T cells
 
HPO: HP:0031392

Definition

Any abnormality in the proportion of CD4-positive T cells relative to the total number of T cells. [from HPO]

Conditions with this feature

Predisposition to invasive fungal disease due to CARD9 deficiency
MedGen UID:
347128
•Concept ID:
C1859353
•
Disease or Syndrome
A rare genetic primary immunodeficiency with characteristics of increased susceptibility to fungal infections that typically manifest as recurrent, chronic mucocutaneous candidiasis, systemic candidiasis with meningoencephalitis and deep dermatophytosis. Dermatophytes invade skin, hair, nails, lymph nodes and brain, resulting in erythematosquamous lesions, nodular subcutaneous or ulcerative infiltrations, severe onychomycosis and lymphadenopathy.
See: Condition Record
Predisposition to invasive fungal disease due to CARD9 deficiency

Professional guidelines

PubMed

The abnormal distribution of NK cell subsets before HAART treatment may be related to the level of immune reconstitution in HIV patient.
Sun S, Kong W, Cui X, Lin Y, Lu B, Pan Y, Huang J, Hu X
Int Immunopharmacol 2021 Jul;96:107784. Epub 2021 May 24 doi: 10.1016/j.intimp.2021.107784. PMID: 34162148
Long-lasting decrease of CD4+/CD45RA+ T cells in HCL patients after 2-chlorodeoxyadenosine (2-CdA) treatment.
Raspadori D, Rondelli D, Birtolo S, Lenoci M, Nardi G, Scalia G, Sestigiani C, Tozzi M, Marotta G, Lauria F
Leukemia 1999 Aug;13(8):1254-7. doi: 10.1038/sj.leu.2401476. PMID: 10450754

Recent clinical studies

Etiology

Phenotypical changes and clinical significance of CD4(+)/CD8(+) T cells in SLE.
Yuan S, Zeng Y, Li J, Wang C, Li W, He Z, Ye J, Li F, Chen Y, Lin X, Yu N, Cai X
Lupus Sci Med 2022 Jun;9(1) doi: 10.1136/lupus-2022-000660. PMID: 35732344Free PMC Article
Accelerated Maturation, Exhaustion, and Senescence of T cells in 22q11.2 Deletion Syndrome.
Smetanova J, Milota T, Rataj M, Bloomfield M, Sediva A, Klocperk A
J Clin Immunol 2022 Feb;42(2):274-285. Epub 2021 Oct 29 doi: 10.1007/s10875-021-01154-9. PMID: 34716533
The abnormal distribution of NK cell subsets before HAART treatment may be related to the level of immune reconstitution in HIV patient.
Sun S, Kong W, Cui X, Lin Y, Lu B, Pan Y, Huang J, Hu X
Int Immunopharmacol 2021 Jul;96:107784. Epub 2021 May 24 doi: 10.1016/j.intimp.2021.107784. PMID: 34162148
Lymphocyte subset abnormalities in early diffuse cutaneous systemic sclerosis.
Fox DA, Lundy SK, Whitfield ML, Berrocal V, Campbell P, Rasmussen S, Ohara R, Stinson A, Gurrea-Rubio M, Wiewiora E, Spino C, Bush E, Furst D, Pillai S, Khanna D
Arthritis Res Ther 2021 Jan 6;23(1):10. doi: 10.1186/s13075-020-02383-w. PMID: 33407866Free PMC Article
T-cell abnormalities in common variable immunodeficiency: the hidden defect.
Wong GK, Huissoon AP
J Clin Pathol 2016 Aug;69(8):672-6. Epub 2016 May 6 doi: 10.1136/jclinpath-2015-203351. PMID: 27153873Free PMC Article

Diagnosis

Immune memory limits human longevity: the role of memory СD4+ T cells in age-related immune abnormalities.
Seledtsov VI, von Delwig AA
Expert Rev Vaccines 2020 Mar;19(3):209-215. Epub 2020 Apr 6 doi: 10.1080/14760584.2020.1745638. PMID: 32191535
Reduced activated regulatory T cells and imbalance of Th17/activated Treg cells marks renal involvement in ANCA-associated vasculitis.
Wang Y, Zhang S, Zhang N, Feng M, Liang Z, Zhao X, Gao C, Qin Y, Wu Y, Liu G, Zhao J, Guo H, Luo J
Mol Immunol 2020 Feb;118:19-29. Epub 2019 Dec 26 doi: 10.1016/j.molimm.2019.11.010. PMID: 31837507
Expanded CD4(+) Effector/Memory T Cell Subset in APECED Produces Predominantly Interferon Gamma.
Heikkilä N, Laakso SM, Mannerström H, Kekäläinen E, Saavalainen P, Jarva H, Arstila TP
J Clin Immunol 2016 Aug;36(6):555-63. Epub 2016 Jun 4 doi: 10.1007/s10875-016-0302-5. PMID: 27262317
Long-lasting decrease of CD4+/CD45RA+ T cells in HCL patients after 2-chlorodeoxyadenosine (2-CdA) treatment.
Raspadori D, Rondelli D, Birtolo S, Lenoci M, Nardi G, Scalia G, Sestigiani C, Tozzi M, Marotta G, Lauria F
Leukemia 1999 Aug;13(8):1254-7. doi: 10.1038/sj.leu.2401476. PMID: 10450754
Abnormalities within CD4 and CD8 T lymphocytes subsets in type 1 (insulin-dependent) diabetes.
Ilonen J, Surcel HM, Käär ML
Clin Exp Immunol 1991 Aug;85(2):278-81. doi: 10.1111/j.1365-2249.1991.tb05718.x. PMID: 1677834Free PMC Article

Therapy

Lymphocyte subset abnormalities in early diffuse cutaneous systemic sclerosis.
Fox DA, Lundy SK, Whitfield ML, Berrocal V, Campbell P, Rasmussen S, Ohara R, Stinson A, Gurrea-Rubio M, Wiewiora E, Spino C, Bush E, Furst D, Pillai S, Khanna D
Arthritis Res Ther 2021 Jan 6;23(1):10. doi: 10.1186/s13075-020-02383-w. PMID: 33407866Free PMC Article
Skewed T cell responses to Epstein-Barr virus in long-term asymptomatic kidney transplant recipients.
Nakid-Cordero C, Arzouk N, Gauthier N, Tarantino N, Larsen M, Choquet S, Burrel S, Autran B, Vieillard V, Guihot A
PLoS One 2019;14(10):e0224211. Epub 2019 Oct 22 doi: 10.1371/journal.pone.0224211. PMID: 31639143Free PMC Article
CD4(+) T Memory Stem Cells Correlate with Disease Progression in Chronically HIV-1-Infected Patients.
Lu X, Song B, Weng W, Xia H, Su B, Wu H, Zhang T, Li W, Gao Y
Viral Immunol 2017 Nov;30(9):642-648. Epub 2017 Oct 16 doi: 10.1089/vim.2017.0017. PMID: 29035156
CD28-negative CD4+ and CD8+ T cells in antiretroviral therapy-naive HIV-infected adults enrolled in adult clinical trials group studies.
Tassiopoulos K, Landay A, Collier AC, Connick E, Deeks SG, Hunt P, Lewis DE, Wilson C, Bosch R
J Infect Dis 2012 Jun;205(11):1730-8. Epub 2012 Mar 23 doi: 10.1093/infdis/jis260. PMID: 22448010Free PMC Article
Long-lasting decrease of CD4+/CD45RA+ T cells in HCL patients after 2-chlorodeoxyadenosine (2-CdA) treatment.
Raspadori D, Rondelli D, Birtolo S, Lenoci M, Nardi G, Scalia G, Sestigiani C, Tozzi M, Marotta G, Lauria F
Leukemia 1999 Aug;13(8):1254-7. doi: 10.1038/sj.leu.2401476. PMID: 10450754

Prognosis

Phenotypical changes and clinical significance of CD4(+)/CD8(+) T cells in SLE.
Yuan S, Zeng Y, Li J, Wang C, Li W, He Z, Ye J, Li F, Chen Y, Lin X, Yu N, Cai X
Lupus Sci Med 2022 Jun;9(1) doi: 10.1136/lupus-2022-000660. PMID: 35732344Free PMC Article
6-Mercaptopurine modifies cerebrospinal fluid T cell abnormalities in paediatric opsoclonus-myoclonus as steroid sparer.
Pranzatelli MR, Tate ED, Allison TJ
Clin Exp Immunol 2017 Nov;190(2):217-225. Epub 2017 Aug 7 doi: 10.1111/cei.13015. PMID: 28710878Free PMC Article
Decreases in colonic and systemic inflammation in chronic HIV infection after IL-7 administration.
Sereti I, Estes JD, Thompson WL, Morcock DR, Fischl MA, Croughs T, Beq S, Lafaye de Micheaux S, Yao MD, Ober A, Wilson EM, Natarajan V, Imamichi H, Boulassel MR, Lederman MM, Routy JP
PLoS Pathog 2014 Jan;10(1):e1003890. Epub 2014 Jan 30 doi: 10.1371/journal.ppat.1003890. PMID: 24497828Free PMC Article
CD28-negative CD4+ and CD8+ T cells in antiretroviral therapy-naive HIV-infected adults enrolled in adult clinical trials group studies.
Tassiopoulos K, Landay A, Collier AC, Connick E, Deeks SG, Hunt P, Lewis DE, Wilson C, Bosch R
J Infect Dis 2012 Jun;205(11):1730-8. Epub 2012 Mar 23 doi: 10.1093/infdis/jis260. PMID: 22448010Free PMC Article
T activation marker evaluation in ARC patients treated with AZT. Comparison with CD4+ lymphocyte count in non-progressors and progressors towards AIDS.
Levacher M, Tallet S, Dazza MC, Dournon E, Rouveix B, Pocidalo JJ
Clin Exp Immunol 1990 Aug;81(2):177-82. doi: 10.1111/j.1365-2249.1990.tb03314.x. PMID: 1696859Free PMC Article

Clinical prediction guides

Phenotypical changes and clinical significance of CD4(+)/CD8(+) T cells in SLE.
Yuan S, Zeng Y, Li J, Wang C, Li W, He Z, Ye J, Li F, Chen Y, Lin X, Yu N, Cai X
Lupus Sci Med 2022 Jun;9(1) doi: 10.1136/lupus-2022-000660. PMID: 35732344Free PMC Article
PD-1 blockade counteracts post-COVID-19 immune abnormalities and stimulates the anti-SARS-CoV-2 immune response.
Loretelli C, Abdelsalam A, D'Addio F, Ben Nasr M, Assi E, Usuelli V, Maestroni A, Seelam AJ, Ippolito E, Di Maggio S, Loreggian L, Radovanovic D, Vanetti C, Yang J, El Essawy B, Rossi A, Pastore I, Montefusco L, Lunati ME, Bolla AM, Biasin M, Antinori S, Santus P, Riva A, Zuccotti GV, Galli M, Rusconi S, Fiorina P
JCI Insight 2021 Dec 22;6(24) doi: 10.1172/jci.insight.146701. PMID: 34784300Free PMC Article
Lymphocyte subset abnormalities in early diffuse cutaneous systemic sclerosis.
Fox DA, Lundy SK, Whitfield ML, Berrocal V, Campbell P, Rasmussen S, Ohara R, Stinson A, Gurrea-Rubio M, Wiewiora E, Spino C, Bush E, Furst D, Pillai S, Khanna D
Arthritis Res Ther 2021 Jan 6;23(1):10. doi: 10.1186/s13075-020-02383-w. PMID: 33407866Free PMC Article
CD4(+) T Cell Profile and Activation Response in Sickle Cell Disease Patients with Osteonecrosis.
Daltro PB, Ribeiro TO, Daltro GC, Meyer RJ, Fortuna V
Mediators Inflamm 2020;2020:1747894. Epub 2020 Oct 9 doi: 10.1155/2020/1747894. PMID: 33132753Free PMC Article
Deficiency of a subset of T-cells with immunoregulatory properties in sarcoidosis.
Ho LP, Urban BC, Thickett DR, Davies RJ, McMichael AJ
Lancet 2005 Mar 19-25;365(9464):1062-72. doi: 10.1016/S0140-6736(05)71143-0. PMID: 15781102

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