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Pulmonary cryptococcosis

MedGen UID:
124445
•Concept ID:
C0276688
•
Disease or Syndrome
Synonyms: Cryptococcal Pneumonia; Cryptococcal pneumonitis
SNOMED CT: Pulmonary cryptococcosis (20953001); Cryptococcal pneumonitis (20953001)

Definition

Fungal pneumonia caused by inhalation of particles of Cryptococcus. It usually occurs in immunocompromised patients such as persons with AIDS, transplant recipients, patients receiving cytotoxic chemotherapy, and patients with hematologic malignancies. It is rare in immunocompetent individuals. Signs and symptoms include fever, cough, and dyspnea. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPulmonary cryptococcosis

Professional guidelines

PubMed

Clinical Diagnosis, Treatment, and Laboratory Detection of 50 Cases of Pulmonary Cryptococcosis.
Wang T, Liu M, Zhang F
Comput Math Methods Med 2022;2022:7981472. Epub 2022 Jul 25 doi: 10.1155/2022/7981472. PMID: 35924106Free PMC Article
Consensus guidelines for the diagnosis and management of cryptococcosis and rare yeast infections in the haematology/oncology setting, 2021.
Chang CC, Hall V, Cooper C, Grigoriadis G, Beardsley J, Sorrell TC, Heath CH; and the Australasian Antifungal Guidelines Steering Committee
Intern Med J 2021 Nov;51 Suppl 7:118-142. doi: 10.1111/imj.15590. PMID: 34937137
Clinical practice guidelines for the management of cryptococcal disease: 2010 update by the infectious diseases society of america.
Perfect JR, Dismukes WE, Dromer F, Goldman DL, Graybill JR, Hamill RJ, Harrison TS, Larsen RA, Lortholary O, Nguyen MH, Pappas PG, Powderly WG, Singh N, Sobel JD, Sorrell TC
Clin Infect Dis 2010 Feb 1;50(3):291-322. doi: 10.1086/649858. PMID: 20047480Free PMC Article

Recent clinical studies

Etiology

Glucocorticoids, COVID-19 and Cryptococcosis.
Dos Santos WM, Rogerio AP
Antiinflamm Antiallergy Agents Med Chem 2023;22(2):67-70. doi: 10.2174/1871523022666230912142540. PMID: 37702231
Update on Pulmonary Cryptococcosis.
Yamamura D, Xu J
Mycopathologia 2021 Oct;186(5):717-728. Epub 2021 Jun 28 doi: 10.1007/s11046-021-00575-9. PMID: 34181160
Pulmonary cryptococcosis: A review of pathobiology and clinical aspects.
Setianingrum F, Rautemaa-Richardson R, Denning DW
Med Mycol 2019 Feb 1;57(2):133-150. doi: 10.1093/mmy/myy086. PMID: 30329097
Pulmonary Cryptococcosis.
Chang CC, Sorrell TC, Chen SC
Semin Respir Crit Care Med 2015 Oct;36(5):681-91. Epub 2015 Sep 23 doi: 10.1055/s-0035-1562895. PMID: 26398535
Clinical practice guidelines for the management of cryptococcal disease: 2010 update by the infectious diseases society of america.
Perfect JR, Dismukes WE, Dromer F, Goldman DL, Graybill JR, Hamill RJ, Harrison TS, Larsen RA, Lortholary O, Nguyen MH, Pappas PG, Powderly WG, Singh N, Sobel JD, Sorrell TC
Clin Infect Dis 2010 Feb 1;50(3):291-322. doi: 10.1086/649858. PMID: 20047480Free PMC Article

Diagnosis

Glucocorticoids, COVID-19 and Cryptococcosis.
Dos Santos WM, Rogerio AP
Antiinflamm Antiallergy Agents Med Chem 2023;22(2):67-70. doi: 10.2174/1871523022666230912142540. PMID: 37702231
Update on Pulmonary Cryptococcosis.
Yamamura D, Xu J
Mycopathologia 2021 Oct;186(5):717-728. Epub 2021 Jun 28 doi: 10.1007/s11046-021-00575-9. PMID: 34181160
Pulmonary cryptococcosis: A review of pathobiology and clinical aspects.
Setianingrum F, Rautemaa-Richardson R, Denning DW
Med Mycol 2019 Feb 1;57(2):133-150. doi: 10.1093/mmy/myy086. PMID: 30329097
Pulmonary Cryptococcosis.
Chang CC, Sorrell TC, Chen SC
Semin Respir Crit Care Med 2015 Oct;36(5):681-91. Epub 2015 Sep 23 doi: 10.1055/s-0035-1562895. PMID: 26398535
Clinical practice guidelines for the management of cryptococcal disease: 2010 update by the infectious diseases society of america.
Perfect JR, Dismukes WE, Dromer F, Goldman DL, Graybill JR, Hamill RJ, Harrison TS, Larsen RA, Lortholary O, Nguyen MH, Pappas PG, Powderly WG, Singh N, Sobel JD, Sorrell TC
Clin Infect Dis 2010 Feb 1;50(3):291-322. doi: 10.1086/649858. PMID: 20047480Free PMC Article

Therapy

Glucocorticoids, COVID-19 and Cryptococcosis.
Dos Santos WM, Rogerio AP
Antiinflamm Antiallergy Agents Med Chem 2023;22(2):67-70. doi: 10.2174/1871523022666230912142540. PMID: 37702231
Pulmonary cryptococcosis: A review of pathobiology and clinical aspects.
Setianingrum F, Rautemaa-Richardson R, Denning DW
Med Mycol 2019 Feb 1;57(2):133-150. doi: 10.1093/mmy/myy086. PMID: 30329097
Pulmonary Cryptococcosis.
Chang CC, Sorrell TC, Chen SC
Semin Respir Crit Care Med 2015 Oct;36(5):681-91. Epub 2015 Sep 23 doi: 10.1055/s-0035-1562895. PMID: 26398535
Pulmonary cryptococcosis.
Brizendine KD, Baddley JW, Pappas PG
Semin Respir Crit Care Med 2011 Dec;32(6):727-34. Epub 2011 Dec 13 doi: 10.1055/s-0031-1295720. PMID: 22167400
Clinical practice guidelines for the management of cryptococcal disease: 2010 update by the infectious diseases society of america.
Perfect JR, Dismukes WE, Dromer F, Goldman DL, Graybill JR, Hamill RJ, Harrison TS, Larsen RA, Lortholary O, Nguyen MH, Pappas PG, Powderly WG, Singh N, Sobel JD, Sorrell TC
Clin Infect Dis 2010 Feb 1;50(3):291-322. doi: 10.1086/649858. PMID: 20047480Free PMC Article

Prognosis

Clinicopathological features of isolated pulmonary cryptococcosis in HIV-negative patients.
Wu HH, Chen YX, Fang SY
J Int Med Res 2020 Jun;48(6):300060520927877. doi: 10.1177/0300060520927877. PMID: 32527202Free PMC Article
Pulmonary Cryptococcosis: comparison of Cryptococcal antigen detection and radiography in Immunocompetent and Immunocompromised patients.
Min J, Huang K, Shi C, Li L, Li F, Zhu T, Deng H
BMC Infect Dis 2020 Jan 30;20(1):91. doi: 10.1186/s12879-020-4818-1. PMID: 32000709Free PMC Article
Concomitant lung adenocarcinoma and pulmonary cryptococcosis confirmed by pathologic examinations.
Huang J, Lan C, Li H, Chen S, Lin Q, Weng H
Medicine (Baltimore) 2019 Dec;98(50):e18316. doi: 10.1097/MD.0000000000018316. PMID: 31852116Free PMC Article
Pulmonary cryptococcosis: A review of pathobiology and clinical aspects.
Setianingrum F, Rautemaa-Richardson R, Denning DW
Med Mycol 2019 Feb 1;57(2):133-150. doi: 10.1093/mmy/myy086. PMID: 30329097
Pulmonary cryptococcosis coexisting with adenocarcinoma: a case report and review of the literature.
Li L, Zhuang L, Zhou J, Shao C
J Med Case Rep 2018 Nov 2;12(1):327. doi: 10.1186/s13256-018-1853-2. PMID: 30384858Free PMC Article

Clinical prediction guides

The management and outcome of cryptococcosis in patients with different immune statuses and treatment protocols: A multicenter real-world study in Jiangsu Province - China.
Wang Y, Gu Y, Shen K, Cui X, Min R, Sun S, Feng C, Chen Y, Wang L, Ma G, Chen B, Ni Y, Zhong H, Shi Y, Su X
J Mycol Med 2023 Aug;33(3):101389. Epub 2023 Apr 21 doi: 10.1016/j.mycmed.2023.101389. PMID: 37099991
Characterization of Clinical and CT Manifestations of Pulmonary Cryptococcosis with Consolidation.
Yang D, Yu L, Luo J, Shen J, Wang D, Kuang P, Fu G
Arch Iran Med 2021 Jun 1;24(6):508-511. doi: 10.34172/aim.2021.73. PMID: 34488315
Pulmonary Cryptococcosis: comparison of Cryptococcal antigen detection and radiography in Immunocompetent and Immunocompromised patients.
Min J, Huang K, Shi C, Li L, Li F, Zhu T, Deng H
BMC Infect Dis 2020 Jan 30;20(1):91. doi: 10.1186/s12879-020-4818-1. PMID: 32000709Free PMC Article
Pulmonary cryptococcosis.
Patz EF Jr, Goodman PC
J Thorac Imaging 1992 Sep;7(4):51-5. doi: 10.1097/00005382-199209000-00008. PMID: 1404545
Pulmonary cryptococcosis.
McDonnell JM, Hutchins GM
Hum Pathol 1985 Feb;16(2):121-8. doi: 10.1016/s0046-8177(85)80060-5. PMID: 3972394

Recent systematic reviews

Pulmonary cryptococcosis complicated with pulmonary aspergillosis: a series of studies and a literature review.
Wang X, Li S, Zhu M, Qiu Y, Hui Y, Li Y, Zhan Y, Wang Y, Ye F, Li Z
BMC Infect Dis 2024 Jan 16;24(1):92. doi: 10.1186/s12879-024-09014-8. PMID: 38229026Free PMC Article
Comparison of the clinical manifestations and chest CT findings of pulmonary cryptococcosis in immunocompetent and immunocompromised patients: a systematic review and meta-analysis.
Xiong C, Lu J, Chen T, Xu R
BMC Pulm Med 2022 Nov 11;22(1):415. doi: 10.1186/s12890-022-02175-9. PMID: 36369001Free PMC Article

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