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Splinter hemorrhages

MedGen UID:: 1052543
•Concept ID:: CN376648
•: Finding

HPO:	HP:6000139

Definition

Thin, red to reddish-brown lines of blood (hemorrhages) under the nails. Splinter hemorrhages run vertically under the nails. [from HPO]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVSplinter hemorrhages

Phenotypic abnormality
- Abnormality of the integument
  - Abnormal skin adnexa morphology
    - Abnormality of the nail
      - Splinter hemorrhages

Professional guidelines

PubMed

Microscopic polyangiitis: clinical aspects and treatment.

Lhote F, Cohen P, Généreau T, Gayraud M, Guillevin L
Ann Med Interne (Paris) 1996;147(3):165-77. PMID: 8796093

Geriatric nail disorders: diagnosis and treatment.

Cohen PR, Scher RK
J Am Acad Dermatol 1992 Apr;26(4):521-31. doi: 10.1016/0190-9622(92)70075-q. PMID: 1597537

Papilledema: clinical clues and differential diagnosis.

Whiting AS, Johnson LN
Am Fam Physician 1992 Mar;45(3):1125-34. PMID: 1543098

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Recent clinical studies

Etiology

SYMPTOMATOLOGY AND TREATMENT OF COVID-19 AFFECTING SKIN APPENDAGES: A NARRATIVE REVIEW BEYOND COVID-TOES.

Wollina U, Abdelmaksoud A, Chiriac A, Brzezinski P, Temiz S
Georgian Med News 2022 Oct;(331):78-84. PMID: 36539135

Nail Psoriasis.

Canal-García E, Bosch-Amate X, Belinchón I, Puig L
Actas Dermosifiliogr 2022 May;113(5):481-490. Epub 2022 Feb 2 doi: 10.1016/j.ad.2022.01.006. PMID: 35697407

Nailfold capillaroscopic changes of sleep apnea patients.

Arslan NG, Pancar GS
Microvasc Res 2021 Sep;137:104177. Epub 2021 May 10 doi: 10.1016/j.mvr.2021.104177. PMID: 33984340

Lupus erythematosus: Significance of dermatologic findings.

Lenormand C, Lipsker D
Ann Dermatol Venereol 2021 Mar;148(1):6-15. Epub 2021 Jan 19 doi: 10.1016/j.annder.2020.08.052. PMID: 33483145

Clinical, dermoscopic, and pathologic features of onychopapilloma: A review of 47 cases.

Tosti A, Schneider SL, Ramirez-Quizon MN, Zaiac M, Miteva M
J Am Acad Dermatol 2016 Mar;74(3):521-6. Epub 2015 Oct 27 doi: 10.1016/j.jaad.2015.08.053. PMID: 26518173

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Diagnosis

Nail Psoriasis.

Canal-García E, Bosch-Amate X, Belinchón I, Puig L
Actas Dermosifiliogr 2022 May;113(5):481-490. Epub 2022 Feb 2 doi: 10.1016/j.ad.2022.01.006. PMID: 35697407

Challenge of Nail Psoriasis: An Update Review.

Ji C, Wang H, Bao C, Zhang L, Ruan S, Zhang J, Gong T, Cheng B
Clin Rev Allergy Immunol 2021 Dec;61(3):377-402. Epub 2021 Sep 3 doi: 10.1007/s12016-021-08896-9. PMID: 34478047

Lupus erythematosus: Significance of dermatologic findings.

Lenormand C, Lipsker D
Ann Dermatol Venereol 2021 Mar;148(1):6-15. Epub 2021 Jan 19 doi: 10.1016/j.annder.2020.08.052. PMID: 33483145

Onychomatricoma.

Haneke E, Fränken J
Dermatol Surg 1995 Nov;21(11):984-7. doi: 10.1111/j.1524-4725.1995.tb00538.x. PMID: 7582839

Low-tension glaucoma.

Chumbley LC, Brubaker RF
Am J Ophthalmol 1976 Jun;81(6):761-7. doi: 10.1016/0002-9394(76)90359-7. PMID: 937430

See all (83)

Therapy

Nailfold capillaroscopic changes of sleep apnea patients.

Arslan NG, Pancar GS
Microvasc Res 2021 Sep;137:104177. Epub 2021 May 10 doi: 10.1016/j.mvr.2021.104177. PMID: 33984340

Nail psoriasis: a review.

Tan ES, Chong WS, Tey HL
Am J Clin Dermatol 2012 Dec 1;13(6):375-88. doi: 10.2165/11597000-000000000-00000. PMID: 22784035

Sunitinib: a multitargeted receptor tyrosine kinase inhibitor in the era of molecular cancer therapies.

Papaetis GS, Syrigos KN
BioDrugs 2009;23(6):377-89. doi: 10.2165/11318860-000000000-00000. PMID: 19894779

Tyrosine kinase inhibitors - a review on pharmacology, metabolism and side effects.

Hartmann JT, Haap M, Kopp HG, Lipp HP
Curr Drug Metab 2009 Jun;10(5):470-81. doi: 10.2174/138920009788897975. PMID: 19689244

Nail changes and disorders among the elderly.

Singh G, Haneef NS, Uday A
Indian J Dermatol Venereol Leprol 2005 Nov-Dec;71(6):386-92. doi: 10.4103/0378-6323.18941. PMID: 16394478

See all (38)

Prognosis

SYMPTOMATOLOGY AND TREATMENT OF COVID-19 AFFECTING SKIN APPENDAGES: A NARRATIVE REVIEW BEYOND COVID-TOES.

Wollina U, Abdelmaksoud A, Chiriac A, Brzezinski P, Temiz S
Georgian Med News 2022 Oct;(331):78-84. PMID: 36539135

Nailfold capillaroscopic changes of sleep apnea patients.

Arslan NG, Pancar GS
Microvasc Res 2021 Sep;137:104177. Epub 2021 May 10 doi: 10.1016/j.mvr.2021.104177. PMID: 33984340

Lupus erythematosus: Significance of dermatologic findings.

Lenormand C, Lipsker D
Ann Dermatol Venereol 2021 Mar;148(1):6-15. Epub 2021 Jan 19 doi: 10.1016/j.annder.2020.08.052. PMID: 33483145

Microscopic polyangiitis: clinical aspects and treatment.

Lhote F, Cohen P, Généreau T, Gayraud M, Guillevin L
Ann Med Interne (Paris) 1996;147(3):165-77. PMID: 8796093

Low-tension glaucoma.

Chumbley LC, Brubaker RF
Am J Ophthalmol 1976 Jun;81(6):761-7. doi: 10.1016/0002-9394(76)90359-7. PMID: 937430

See all (30)

Clinical prediction guides

SYMPTOMATOLOGY AND TREATMENT OF COVID-19 AFFECTING SKIN APPENDAGES: A NARRATIVE REVIEW BEYOND COVID-TOES.

Wollina U, Abdelmaksoud A, Chiriac A, Brzezinski P, Temiz S
Georgian Med News 2022 Oct;(331):78-84. PMID: 36539135

Clinical and onychoscopic features of histopathologically proven onychopapillomas and literature update.

Starace M, Alessandrini A, Ferrari T, Wong V, Baraldi C, Piraccini BM
J Cutan Pathol 2022 Feb;49(2):147-152. Epub 2021 Aug 30 doi: 10.1111/cup.14119. PMID: 34396563

Nailfold capillaroscopic changes of sleep apnea patients.

Arslan NG, Pancar GS
Microvasc Res 2021 Sep;137:104177. Epub 2021 May 10 doi: 10.1016/j.mvr.2021.104177. PMID: 33984340

Tyrosine kinase inhibitors - a review on pharmacology, metabolism and side effects.

Hartmann JT, Haap M, Kopp HG, Lipp HP
Curr Drug Metab 2009 Jun;10(5):470-81. doi: 10.2174/138920009788897975. PMID: 19689244

Antiphospholipid syndrome and the skin.

Gibson GE, Su WP, Pittelkow MR
J Am Acad Dermatol 1997 Jun;36(6 Pt 1):970-82. doi: 10.1016/s0190-9622(97)80283-6. PMID: 9204065

See all (32)