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Abnormally increased motivation

MedGen UID:
1050999
•Concept ID:
CN375719
•
Finding
Synonym: Abnormally increased energy
 
HPO: HP:5200263

Definition

An excessive increase in goal-directed behavior, that is, motivation, is the determinant of behavior and adaptation that allows individuals to get started, be energized to perform a sustained and directed action. It also includes an excessive increase in non goal-directed movement or activity. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormally increased motivation

Professional guidelines

PubMed

Obesity management as a primary treatment goal for type 2 diabetes: time to reframe the conversation.
Lingvay I, Sumithran P, Cohen RV, le Roux CW
Lancet 2022 Jan 22;399(10322):394-405. Epub 2021 Sep 30 doi: 10.1016/S0140-6736(21)01919-X. PMID: 34600604
What are the goals of prenatal genetic testing?
Dukhovny S, Norton ME
Semin Perinatol 2018 Aug;42(5):270-274. Epub 2018 Jul 26 doi: 10.1053/j.semperi.2018.07.002. PMID: 30195989
ACG clinical guidelines: diagnosis and management of celiac disease.
Rubio-Tapia A, Hill ID, Kelly CP, Calderwood AH, Murray JA; American College of Gastroenterology
Am J Gastroenterol 2013 May;108(5):656-76; quiz 677. Epub 2013 Apr 23 doi: 10.1038/ajg.2013.79. PMID: 23609613Free PMC Article

Recent clinical studies

Etiology

Mechanisms of Aortic Dilation in Patients With Bicuspid Aortic Valve: JACC State-of-the-Art Review.
Rodríguez-Palomares JF, Dux-Santoy L, Guala A, Galian-Gay L, Evangelista A
J Am Coll Cardiol 2023 Aug 1;82(5):448-464. doi: 10.1016/j.jacc.2022.10.042. PMID: 37495282
Mucopolysaccharidosis: A broad review.
Nagpal R, Goyal RB, Priyadarshini K, Kashyap S, Sharma M, Sinha R, Sharma N
Indian J Ophthalmol 2022 Jul;70(7):2249-2261. doi: 10.4103/ijo.IJO_425_22. PMID: 35791104Free PMC Article
Obesity management as a primary treatment goal for type 2 diabetes: time to reframe the conversation.
Lingvay I, Sumithran P, Cohen RV, le Roux CW
Lancet 2022 Jan 22;399(10322):394-405. Epub 2021 Sep 30 doi: 10.1016/S0140-6736(21)01919-X. PMID: 34600604
Neuropsychiatric safety and efficacy of varenicline, bupropion, and nicotine patch in smokers with and without psychiatric disorders (EAGLES): a double-blind, randomised, placebo-controlled clinical trial.
Anthenelli RM, Benowitz NL, West R, St Aubin L, McRae T, Lawrence D, Ascher J, Russ C, Krishen A, Evins AE
Lancet 2016 Jun 18;387(10037):2507-20. Epub 2016 Apr 22 doi: 10.1016/S0140-6736(16)30272-0. PMID: 27116918
A Randomized Trial of Intensive versus Standard Blood-Pressure Control.
SPRINT Research Group, Wright JT Jr, Williamson JD, Whelton PK, Snyder JK, Sink KM, Rocco MV, Reboussin DM, Rahman M, Oparil S, Lewis CE, Kimmel PL, Johnson KC, Goff DC Jr, Fine LJ, Cutler JA, Cushman WC, Cheung AK, Ambrosius WT
N Engl J Med 2015 Nov 26;373(22):2103-16. Epub 2015 Nov 9 doi: 10.1056/NEJMoa1511939. PMID: 26551272Free PMC Article

Diagnosis

Mucopolysaccharidosis: A broad review.
Nagpal R, Goyal RB, Priyadarshini K, Kashyap S, Sharma M, Sinha R, Sharma N
Indian J Ophthalmol 2022 Jul;70(7):2249-2261. doi: 10.4103/ijo.IJO_425_22. PMID: 35791104Free PMC Article
Dental-craniofacial manifestation and treatment of rare diseases.
Luo E, Liu H, Zhao Q, Shi B, Chen Q
Int J Oral Sci 2019 Feb 20;11(1):9. doi: 10.1038/s41368-018-0041-y. PMID: 30783081Free PMC Article
Diagnosing, monitoring and managing behavioural variant frontotemporal dementia.
Piguet O, Kumfor F, Hodges J
Med J Aust 2017 Sep 2;207(7):303-308. doi: 10.5694/mja16.01458. PMID: 28954617
ACG clinical guidelines: diagnosis and management of celiac disease.
Rubio-Tapia A, Hill ID, Kelly CP, Calderwood AH, Murray JA; American College of Gastroenterology
Am J Gastroenterol 2013 May;108(5):656-76; quiz 677. Epub 2013 Apr 23 doi: 10.1038/ajg.2013.79. PMID: 23609613Free PMC Article
Turner's syndrome.
Ranke MB, Saenger P
Lancet 2001 Jul 28;358(9278):309-14. doi: 10.1016/S0140-6736(01)05487-3. PMID: 11498234

Therapy

Obesity management as a primary treatment goal for type 2 diabetes: time to reframe the conversation.
Lingvay I, Sumithran P, Cohen RV, le Roux CW
Lancet 2022 Jan 22;399(10322):394-405. Epub 2021 Sep 30 doi: 10.1016/S0140-6736(21)01919-X. PMID: 34600604
Neuropsychiatric safety and efficacy of varenicline, bupropion, and nicotine patch in smokers with and without psychiatric disorders (EAGLES): a double-blind, randomised, placebo-controlled clinical trial.
Anthenelli RM, Benowitz NL, West R, St Aubin L, McRae T, Lawrence D, Ascher J, Russ C, Krishen A, Evins AE
Lancet 2016 Jun 18;387(10037):2507-20. Epub 2016 Apr 22 doi: 10.1016/S0140-6736(16)30272-0. PMID: 27116918
A Randomized Trial of Intensive versus Standard Blood-Pressure Control.
SPRINT Research Group, Wright JT Jr, Williamson JD, Whelton PK, Snyder JK, Sink KM, Rocco MV, Reboussin DM, Rahman M, Oparil S, Lewis CE, Kimmel PL, Johnson KC, Goff DC Jr, Fine LJ, Cutler JA, Cushman WC, Cheung AK, Ambrosius WT
N Engl J Med 2015 Nov 26;373(22):2103-16. Epub 2015 Nov 9 doi: 10.1056/NEJMoa1511939. PMID: 26551272Free PMC Article
Anabolic-androgenic steroid use and psychopathology in athletes. A systematic review.
Piacentino D, Kotzalidis GD, Del Casale A, Aromatario MR, Pomara C, Girardi P, Sani G
Curr Neuropharmacol 2015 Jan;13(1):101-21. doi: 10.2174/1570159X13666141210222725. PMID: 26074746Free PMC Article
ACG clinical guidelines: diagnosis and management of celiac disease.
Rubio-Tapia A, Hill ID, Kelly CP, Calderwood AH, Murray JA; American College of Gastroenterology
Am J Gastroenterol 2013 May;108(5):656-76; quiz 677. Epub 2013 Apr 23 doi: 10.1038/ajg.2013.79. PMID: 23609613Free PMC Article

Prognosis

Data-driven modeling and prediction of blood glucose dynamics: Machine learning applications in type 1 diabetes.
Woldaregay AZ, Årsand E, Walderhaug S, Albers D, Mamykina L, Botsis T, Hartvigsen G
Artif Intell Med 2019 Jul;98:109-134. Epub 2019 Jul 26 doi: 10.1016/j.artmed.2019.07.007. PMID: 31383477
To do it now or later: The cognitive mechanisms and neural substrates underlying procrastination.
Zhang S, Liu P, Feng T
Wiley Interdiscip Rev Cogn Sci 2019 Jul;10(4):e1492. Epub 2019 Jan 14 doi: 10.1002/wcs.1492. PMID: 30638308
Hyperinsulinemia: a Cause of Obesity?
Erion KA, Corkey BE
Curr Obes Rep 2017 Jun;6(2):178-186. doi: 10.1007/s13679-017-0261-z. PMID: 28466412Free PMC Article
Global, regional, and national causes of under-5 mortality in 2000-15: an updated systematic analysis with implications for the Sustainable Development Goals.
Liu L, Oza S, Hogan D, Chu Y, Perin J, Zhu J, Lawn JE, Cousens S, Mathers C, Black RE
Lancet 2016 Dec 17;388(10063):3027-3035. Epub 2016 Nov 11 doi: 10.1016/S0140-6736(16)31593-8. PMID: 27839855Free PMC Article
A Randomized Trial of Intensive versus Standard Blood-Pressure Control.
SPRINT Research Group, Wright JT Jr, Williamson JD, Whelton PK, Snyder JK, Sink KM, Rocco MV, Reboussin DM, Rahman M, Oparil S, Lewis CE, Kimmel PL, Johnson KC, Goff DC Jr, Fine LJ, Cutler JA, Cushman WC, Cheung AK, Ambrosius WT
N Engl J Med 2015 Nov 26;373(22):2103-16. Epub 2015 Nov 9 doi: 10.1056/NEJMoa1511939. PMID: 26551272Free PMC Article

Clinical prediction guides

Testosterone therapy in diabetes and pre-diabetes.
Corona G, Vena W, Pizzocaro A, Vignozzi L, Sforza A, Maggi M
Andrology 2023 Feb;11(2):204-214. Epub 2022 Dec 29 doi: 10.1111/andr.13367. PMID: 36542412
Data-driven modeling and prediction of blood glucose dynamics: Machine learning applications in type 1 diabetes.
Woldaregay AZ, Årsand E, Walderhaug S, Albers D, Mamykina L, Botsis T, Hartvigsen G
Artif Intell Med 2019 Jul;98:109-134. Epub 2019 Jul 26 doi: 10.1016/j.artmed.2019.07.007. PMID: 31383477
To do it now or later: The cognitive mechanisms and neural substrates underlying procrastination.
Zhang S, Liu P, Feng T
Wiley Interdiscip Rev Cogn Sci 2019 Jul;10(4):e1492. Epub 2019 Jan 14 doi: 10.1002/wcs.1492. PMID: 30638308
Hyperinsulinemia: a Cause of Obesity?
Erion KA, Corkey BE
Curr Obes Rep 2017 Jun;6(2):178-186. doi: 10.1007/s13679-017-0261-z. PMID: 28466412Free PMC Article
A Randomized Trial of Intensive versus Standard Blood-Pressure Control.
SPRINT Research Group, Wright JT Jr, Williamson JD, Whelton PK, Snyder JK, Sink KM, Rocco MV, Reboussin DM, Rahman M, Oparil S, Lewis CE, Kimmel PL, Johnson KC, Goff DC Jr, Fine LJ, Cutler JA, Cushman WC, Cheung AK, Ambrosius WT
N Engl J Med 2015 Nov 26;373(22):2103-16. Epub 2015 Nov 9 doi: 10.1056/NEJMoa1511939. PMID: 26551272Free PMC Article

Recent systematic reviews

Testosterone therapy in diabetes and pre-diabetes.
Corona G, Vena W, Pizzocaro A, Vignozzi L, Sforza A, Maggi M
Andrology 2023 Feb;11(2):204-214. Epub 2022 Dec 29 doi: 10.1111/andr.13367. PMID: 36542412
mHealth Interventions for Self-management of Hypertension: Framework and Systematic Review on Engagement, Interactivity, and Tailoring.
Cao W, Milks MW, Liu X, Gregory ME, Addison D, Zhang P, Li L
JMIR Mhealth Uhealth 2022 Mar 2;10(3):e29415. doi: 10.2196/29415. PMID: 35234655Free PMC Article
Exploring Patterns of Disturbed Eating in Psychosis: A Scoping Review.
Stogios N, Smith E, Asgariroozbehani R, Hamel L, Gdanski A, Selby P, Sockalingam S, Graff-Guerrero A, Taylor VH, Agarwal SM, Hahn MK
Nutrients 2020 Dec 18;12(12) doi: 10.3390/nu12123883. PMID: 33353080Free PMC Article
Intra-Renal Hemodynamic Changes After Habitual Physical Activity in Patients with Chronic Kidney Disease.
Kaltsatou A, Karatzaferi C, Mitrou GI, Poulianiti KP, Sakkas GK
Curr Pharm Des 2016;22(24):3700-14. doi: 10.2174/1381612822666160322144936. PMID: 27000827
Anabolic-androgenic steroid use and psychopathology in athletes. A systematic review.
Piacentino D, Kotzalidis GD, Del Casale A, Aromatario MR, Pomara C, Girardi P, Sani G
Curr Neuropharmacol 2015 Jan;13(1):101-21. doi: 10.2174/1570159X13666141210222725. PMID: 26074746Free PMC Article

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