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Pick disease

Synonyms
Dementia with lobar atrophy and neuronal cytoplasmic inclusions; LOBAR ATROPHY OF BRAIN; Lobar atrophy of the brain; PICK DISEASE OF BRAIN; Pick Disease of the Brain; Pick's disease

Summary

Pick disease refers to the neuropathologic finding of 'Pick bodies,' which are argyrophilic, intraneuronal inclusions, and 'Pick cells,' which are enlarged neurons. The clinical correlates of Pick disease of brain include those of frontotemporal dementia, which encompass the behavioral variant of FTD, semantic dementia, and progressive nonfluent aphasia (summary by Piguet et al., 2011). Kertesz (2003) suggested the term 'Pick complex' to represent the overlapping syndromes of FTD, primary progressive aphasia (PPA), corticobasal degeneration (CBD), progressive supranuclear palsy (601104), and FTD with motor neuron disease. He noted that frontotemporal dementia may also be referred to as 'clinical Pick disease,' and that the term 'Pick disease' should be restricted to the pathologic finding of Pick bodies. [from OMIM]

Available tests

42 tests are in the database for this condition.

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Clinical tests (42 available)

Molecular Genetics Tests

Genes See tests for all associated and related genes

  • Also known as: DDPAC, FTDP-17, MAPTL, MSTD, MTBT1, MTBT2, PPND, PPP1R103, TAU, Tau-PHF6, tau-40, MAPT
    Summary: microtubule associated protein tau

  • Also known as: ACNINV3, AD3, FAD, PS-1, PS1, PSNL1, S182, PSEN1
    Summary: presenilin 1

Clinical features

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Imported from Human Phenotype Ontology (HPO)

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