Melnick-Needles syndrome
- Synonyms
- Melnick-Needles osteodysplasty; Osteodysplasty of Melnick and Needles
- Modes of inheritance
- X-linked dominant inheritance (Orphanet)
Summary
Excerpted from the GeneReview:- Full text of GeneReview (by section):
- Summary
- GeneReview Scope
- Diagnosis
- Clinical Characteristics
- Genetically Related (Allelic) Disorders
- Differential Diagnosis
- Management
- Genetic Counseling
- Resources
- Molecular Genetics
- References
- Chapter Notes
- Authors:
- Stephen Robertson
- view full author information
Available tests
Check Related conditions for additional relevant tests.
Clinical features
Help- Abnormality of head or neck
- Cleft palate
Cleft palate
- MedGen UID: 756015
- Concept ID: C2981150
- Finding: Congenital Abnormality
Abnormality of head or neck
- Delayed eruption of teeth
Delayed eruption of teeth
- MedGen UID: 68678
- Concept ID: C0239174
- Finding: Finding
Abnormality of head or neck
- Long neck
Long neck
- MedGen UID: 333409
- Concept ID: C1839816
- Finding: Finding
Abnormality of head or neck
- Prominent supraorbital ridges
Prominent supraorbital ridges
- MedGen UID: 333982
- Concept ID: C1842060
- Finding: Finding
Abnormality of head or neck
- Small face
Small face
- MedGen UID: 343376
- Concept ID: C1855538
- Finding: Finding
Abnormality of head or neck
- Tooth malposition
Tooth malposition
- MedGen UID: 377692
- Concept ID: C1852504
- Finding: Finding
Abnormality of head or neck
- Cleft palate
- Abnormality of limbs
- Acroosteolysis
Acroosteolysis
- MedGen UID: 183017
- Concept ID: C0917990
- Finding: Disease or Syndrome
Abnormality of limbs
- Clubfoot
Clubfoot
- MedGen UID: 3130
- Concept ID: C0009081
- Finding: Congenital Abnormality
Abnormality of limbs
- Coxa valga
Coxa valga
- MedGen UID: 116080
- Concept ID: C0239137
- Finding: Finding
Abnormality of limbs
- Genu valgum
Genu valgum
- MedGen UID: 154364
- Concept ID: C0576093
- Finding: Anatomical Abnormality
Abnormality of limbs
- Limited elbow extension
Limited elbow extension
- MedGen UID: 401158
- Concept ID: C1867103
- Finding: Finding
Abnormality of limbs
- Pes planus
Pes planus
- MedGen UID: 42034
- Concept ID: C0016202
- Finding: Anatomical Abnormality
Abnormality of limbs
- Short distal phalanx of finger
Short distal phalanx of finger
- MedGen UID: 326590
- Concept ID: C1839829
- Finding: Finding
Abnormality of limbs
- Short humerus
Short humerus
- MedGen UID: 316907
- Concept ID: C1832117
- Finding: Congenital Abnormality
Abnormality of limbs
- Tibial bowing
Tibial bowing
- MedGen UID: 332360
- Concept ID: C1837081
- Finding: Finding
Abnormality of limbs
- Acroosteolysis
- Abnormality of the cardiovascular system
- Mitral valve prolapse
Mitral valve prolapse
- MedGen UID: 7671
- Concept ID: C0026267
- Finding: Disease or Syndrome
Abnormality of the cardiovascular system
- Pulmonary arterial hypertension
Pulmonary arterial hypertension
- MedGen UID: 425404
- Concept ID: C2973725
- Finding: Disease or Syndrome
Abnormality of the cardiovascular system
- Tricuspid valve prolapse
Tricuspid valve prolapse
- MedGen UID: 11912
- Concept ID: C0040962
- Finding: Disease or Syndrome
Abnormality of the cardiovascular system
- Mitral valve prolapse
- Abnormality of the eye
- Hypertelorism
Hypertelorism
- MedGen UID: 9373
- Concept ID: C0020534
- Finding: Finding
Abnormality of the eye
- Proptosis
Proptosis
- MedGen UID: 41917
- Concept ID: C0015300
- Finding: Disease or Syndrome
Abnormality of the eye
- Strabismus
Strabismus
- MedGen UID: 21337
- Concept ID: C0038379
- Finding: Disease or Syndrome
Abnormality of the eye
- Hypertelorism
- Abnormality of the genitourinary system
- Hydronephrosis
Hydronephrosis
- MedGen UID: 42531
- Concept ID: C0020295
- Finding: Disease or Syndrome
Abnormality of the genitourinary system
- Ureteral stenosis
Ureteral stenosis
- MedGen UID: 105481
- Concept ID: C0521618
- Finding: Anatomical Abnormality
Abnormality of the genitourinary system
- Hydronephrosis
- Abnormality of the immune system
- Recurrent otitis media
Recurrent otitis media
- MedGen UID: 155436
- Concept ID: C0747085
- Finding: Disease or Syndrome
Abnormality of the immune system
- Recurrent otitis media
- Abnormality of the integument
- Coarse hair
Coarse hair
- MedGen UID: 124454
- Concept ID: C0277959
- Finding: Finding
Abnormality of the integument
- Frontal hirsutism
Frontal hirsutism
- MedGen UID: 333413
- Concept ID: C1839830
- Finding: Finding
Abnormality of the integument
- Coarse hair
- Abnormality of the musculoskeletal system
- Anterior concavity of thoracic vertebrae
Anterior concavity of thoracic vertebrae
- MedGen UID: 326972
- Concept ID: C1839822
- Finding: Finding
Abnormality of the musculoskeletal system
- Cone-shaped epiphyses of the phalanges of the hand
Cone-shaped epiphyses of the phalanges of the hand
- MedGen UID: 347156
- Concept ID: C1859480
- Finding: Finding
Abnormality of the musculoskeletal system
- Congenital omphalocele
Congenital omphalocele
- MedGen UID: 162756
- Concept ID: C0795690
- Finding: Congenital Abnormality
Abnormality of the musculoskeletal system
- Delayed cranial suture closure
Delayed cranial suture closure
- MedGen UID: 75805
- Concept ID: C0277828
- Finding: Finding
Abnormality of the musculoskeletal system
- Flared metaphysis
Flared metaphysis
- MedGen UID: 337976
- Concept ID: C1850135
- Finding: Finding
Abnormality of the musculoskeletal system
- Hip dislocation
Hip dislocation
- MedGen UID: 42455
- Concept ID: C0019554
- Finding: Injury or Poisoning
Abnormality of the musculoskeletal system
- Hypoplastic scapulae
Hypoplastic scapulae
- MedGen UID: 337579
- Concept ID: C1846434
- Finding: Finding
Abnormality of the musculoskeletal system
- Kyphoscoliosis
Kyphoscoliosis
- MedGen UID: 154361
- Concept ID: C0575158
- Finding: Anatomical Abnormality
Abnormality of the musculoskeletal system
- Micrognathia
Micrognathia
- MedGen UID: 44428
- Concept ID: C0025990
- Finding: Congenital Abnormality
Abnormality of the musculoskeletal system
- Narrow chest
Narrow chest
- MedGen UID: 96528
- Concept ID: C0426790
- Finding: Finding
Abnormality of the musculoskeletal system
- Obtuse angle of mandible
Obtuse angle of mandible
- MedGen UID: 871603
- Concept ID: C4038738
- Finding: Finding
Abnormality of the musculoskeletal system
- Pectus excavatum
Pectus excavatum
- MedGen UID: 781174
- Concept ID: C2051831
- Finding: Finding
Abnormality of the musculoskeletal system
- Short clavicles
Short clavicles
- MedGen UID: 96529
- Concept ID: C0426799
- Finding: Congenital Abnormality
Abnormality of the musculoskeletal system
- Anterior concavity of thoracic vertebrae
- Abnormality of the nervous system
- Gait disturbance
Gait disturbance
- MedGen UID: 107895
- Concept ID: C0575081
- Finding: Finding
Abnormality of the nervous system
- Motor delay
Motor delay
- MedGen UID: 381392
- Concept ID: C1854301
- Finding: Finding
Abnormality of the nervous system
- Gait disturbance
- Abnormality of the respiratory system
- Recurrent respiratory infections
Recurrent respiratory infections
- MedGen UID: 812812
- Concept ID: C3806482
- Finding: Finding
Abnormality of the respiratory system
- Recurrent respiratory infections
- Abnormality of the voice
- Hoarse voice
Hoarse voice
- MedGen UID: 5602
- Concept ID: C0019825
- Finding: Sign or Symptom
Abnormality of the voice
- Hoarse voice
- Ear malformation
- Macrotia
Macrotia
- MedGen UID: 488785
- Concept ID: C0152421
- Finding: Congenital Abnormality
Ear malformation
- Macrotia
- Growth abnormality
- Failure to thrive
Failure to thrive
- MedGen UID: 746019
- Concept ID: C2315100
- Finding: Disease or Syndrome
Growth abnormality
- Failure to thrive
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