U.S. flag

An official website of the United States government

GTR Home > Conditions/Phenotypes > Legg-Calve-Perthes disease

Legg-Calve-Perthes disease

Synonyms
Avascular necrosis of the capital femoral epiphysis; Coxa plana; Osteochondritis deformans; Perthes disease
Modes of inheritance
Autosomal dominant inheritance (Orphanet)
Non-Mendelian inheritance (Orphanet)

Summary

Legg-Calve-Perthes disease (LCPD) is characterized by loss of circulation to the femoral head, resulting in avascular necrosis in a growing child. Clinical pictures of the disease vary, depending on the phase of disease progression through ischemia, revascularization, fracture and collapse, and repair and remodeling of the bone. The disease occurs more frequently in boys, and most patients tend to be shorter than their peers. Both familial and isolated cases of LCPD have been reported (summary by Chen et al., 2004). [from OMIM]

Available tests

76 tests are in the database for this condition.

Check Related conditions for additional relevant tests.

Clinical tests (76 available)

Molecular Genetics Tests

Genes See tests for all associated and related genes

  • Also known as: ANFH, AOM, COL11A3, SEDC, STL1, COL2A1
    Summary: collagen type II alpha 1 chain

Clinical features

Help
Imported from Human Phenotype Ontology (HPO)

Show allHide all

IMPORTANT NOTE: NIH does not independently verify information submitted to the GTR; it relies on submitters to provide information that is accurate and not misleading. NIH makes no endorsements of tests or laboratories listed in the GTR. GTR is not a substitute for medical advice. Patients and consumers with specific questions about a genetic test should contact a health care provider or a genetics professional.