MAPK3 mitogen-activated protein kinase 3 [Homo sapiens (human)] - Gene

Summary

Official Symbol: MAPK3provided by HGNC
Official Full Name: mitogen-activated protein kinase 3provided by HGNC
Primary source: HGNC:HGNC:6877
See related: Ensembl:ENSG00000102882 MIM:601795; AllianceGenome:HGNC:6877
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: ERK1; ERT2; ERK-1; PRKM3; P44ERK1; P44MAPK; HS44KDAP; HUMKER1A; p44-ERK1; p44-MAPK
Summary: The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act in a signaling cascade that regulates various cellular processes such as proliferation, differentiation, and cell cycle progression in response to a variety of extracellular signals. This kinase is activated by upstream kinases, resulting in its translocation to the nucleus where it phosphorylates nuclear targets. Alternatively spliced transcript variants encoding different protein isoforms have been described. [provided by RefSeq, Jul 2008]
Expression: Ubiquitous expression in small intestine (RPKM 45.8), colon (RPKM 42.8) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 16p11.2

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	16	NC_000016.10 (30114105..30123220, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	16	NC_060940.1 (30396752..30405867, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	16	NC_000016.9 (30125426..30134541, complement)

Chromosome 16 - NC_000016.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PP4R1 promotes glycolysis and gallbladder cancer progression through facilitating ERK1/2 mediated PKM2 nuclear translocation.
Title: PP4R1 promotes glycolysis and gallbladder cancer progression through facilitating ERK1/2 mediated PKM2 nuclear translocation.
AKAP2-anchored extracellular signal-regulated kinase 1 (ERK1) regulates cardiac myofibroblast migration.
Title: AKAP2-anchored extracellular signal-regulated kinase 1 (ERK1) regulates cardiac myofibroblast migration.
LncNFYB promotes the proliferation of rheumatoid arthritis fibroblast-like synoviocytes via LncNFYB/ANXA2/ERK1/2 axis.
Title: LncNFYB promotes the proliferation of rheumatoid arthritis fibroblast-like synoviocytes via LncNFYB/ANXA2/ERK1/2 axis.
Progestins and breast cancer hallmarks: The role of the ERK1/2 and JNK pathways in estrogen receptor positive breast cancer cells.
Title: Progestins and breast cancer hallmarks: The role of the ERK1/2 and JNK pathways in estrogen receptor positive breast cancer cells.
Mir-142-3P regulates MAPK protein family by inhibiting 14-3-3eta to enhance bone marrow mesenchymal stem cells osteogenesis.
Title: Mir-142-3P regulates MAPK protein family by inhibiting 14-3-3η to enhance bone marrow mesenchymal stem cells osteogenesis.
The complex impact of cancer-related missense mutations on the stability and on the biophysical and biochemical properties of MAPK1 and MAPK3 somatic variants.
Title: The complex impact of cancer-related missense mutations on the stability and on the biophysical and biochemical properties of MAPK1 and MAPK3 somatic variants.
Nuclear respiratory factor 1 drives hepatocellular carcinoma progression by activating LPCAT1-ERK1/2-CREB axis.
Title: Nuclear respiratory factor 1 drives hepatocellular carcinoma progression by activating LPCAT1-ERK1/2-CREB axis.
Redundant roles of extra-cellular signal-regulated kinase (ERK) 1 and 2 in the G1-S transition and etoposide-induced G2/M checkpoint in HCT116 cells.
Title: Redundant roles of extra-cellular signal-regulated kinase (ERK) 1 and 2 in the G1-S transition and etoposide-induced G2/M checkpoint in HCT116 cells.
A conserved arginine within the alphaC-helix of Erk1/2 is a latch of autoactivation and of oncogenic capabilities.
Title: A conserved arginine within the αC-helix of Erk1/2 is a latch of autoactivation and of oncogenic capabilities.
Pathologically high intraocular pressure induces mitochondrial dysfunction through Drp1 and leads to retinal ganglion cell PANoptosis in glaucoma.
Title: Pathologically high intraocular pressure induces mitochondrial dysfunction through Drp1 and leads to retinal ganglion cell PANoptosis in glaucoma.

Submit: New GeneRIF Correction See all GeneRIFs (1030)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Biological insights from 108 schizophrenia-associated genetic loci. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	HIV-1 gp120 induces activation of the ERK1/2 MAPK signaling pathway in polarized oral epithelial cells	PubMed
	env	HIV-1 gp120 activates AKT, ERK1/2, and p38 signaling in tonsil CD4+ T cells. Soluble CD4 inhibits AKT and ERK1/2 activation, but enhances phosphorylation of p38	PubMed
	env	HIV-1 gp120 induces nuclear localization of the phosphoinositide-specific phospholipase C (PI-PLC) beta 1 isozyme in MDMs, which requires activation of the MAPK ERK1/2 pathway	PubMed
	env	HIV-1 gp120-induced phosphatidylcholine-specific phospholipase D (PLD) activity is dependent on the activation of ERK1/2	PubMed
	env	Treatment of cells with HIV-1 gp120 induces increased levels of endogenous c-fos and c-jun mRNA and proteins, an activation of both c-fos and c-jun promoters, and a very rapid stimulation of the MAPK/ERK pathway	PubMed
	env	NHERF1 increases ERK1/2 phosphorylation levels following HIV-1 gp120 stimulation in cells	PubMed
	env	HIV-1 X4-tropic gp120 upregulates alpha-SMA (ACTA2) and collagen I alpha 1 expression via the ERK1/2 pathway in a CXCR4-dependent manner in activated human hepatic stellate cells	PubMed
	env	Stimulation of human monocyte-derived macrophages with HIV-1 gp120 results in the CCR5-mediated activation of Lyn and the concomitant Lyn-dependent activation of the mitogen-activated protein (MAP) kinase ERK-1/2, which leads to production of TNF-alpha	PubMed
	env	HIV-1 gp120 induces IL-10 expression in monocyte-derived dendritic cells via a mannose C-type lectin receptor and an ERK signaling pathway	PubMed
	env	Increased neurotoxicity mediated by cocaine and gp120 involves signaling pathways including c-jun N-terminal kinase (JNK), p38, extracellular signal-regulated kinase (ERK)/mitogen-activated protein kinases (MAPK), and nuclear factor (NF)-kappaB	PubMed
	env	HIV-1 gp120 activates c-Jun N-terminal kinase (JNK) and p42 extracellular-regulated kinase (ERK) in macrophages and primary human central nervous system (CNS) cells	PubMed
	env	Pre-treatment of endothelial cells with fibroblast growth factor 2 (FGF2) protects cells from HIV-1 gp120 angiotoxicity; this protection is regulated by crosstalk among the ERK, PI3K-AKT and PKC signaling pathways	PubMed
Envelope surface glycoprotein gp160, precursor	env	The activation of mitogen-activated protein kinases (MAPKs, including ERK, JNK, and p38MAPK) is induced by incubation of HIV-1 gp160 with CD4+complement receptor type 2 (CR2)+ cells	PubMed
Envelope transmembrane glycoprotein gp41	env	The HIV-1 gp41 transmembrane domain inhibits TLR2-induced activation of ERK1/2, and secretion of TNF-alpha, MCP-1, and IL-6	PubMed
	env	HIV-1 gp41 is able to activate the ERK/MAPK pathway by binding to CD74	PubMed
Nef	nef	HIV-1 Nef-induced strong activation of MAP kinases (p38/MAPK14, JNK/MAPK8, and ERK1/2) and NF-kappaB pathway (IKK alpha/beta) in M2-macrophages is mediated by TAK1	PubMed
	nef	HIV-1 Nef induces phosphorylation of MAPK3 (ERK1) in M2-type macrophages	PubMed
	nef	The Nef/hnRNPK/PKC-delta/Hck protein complex increases paxillin phosphorylation at Y118 and activates and secretes TACE through Erk1/2 activation	PubMed
	nef	HIV-1 Nef-induced relocalization of LCK increases phosphorylated ERK1/2 induction in infected and trasduced primary T cells	PubMed
	nef	Formation of the Nef-associated kinase complex (NAKC) is sufficient to activate LCK and ERK1/2 and causes a strong Tat-dependent increase of HIV-1 transcription in T cells	PubMed
	nef	HIV-1 Nef and ALK are capable of cumulatively influencing the MAP-K phosphorylation in astrocytic glioma cells	PubMed
	nef	HIV-1 Nef upregulates ICAM-1 expression on endothelial cells via Erk /Mapk signaling pathway	PubMed
	nef	HIV-1 Nef myristoylation is required for the rapid and transient phosphorylation of the alpha- and beta- subunits of the Ikappa-B kinase complex and activation of JNK, ERK1/2 and p38 MAPK family members	PubMed
Rev	rev	MAPK has been shown to phosphorylate Rev in vitro	PubMed
Tat	tat	HIV-1 Tat protein activates RELA (p65), MAP kinases ERK1/2 and p38, and PKC-bII in a TLR4-dependent manner in human monocytes	PubMed
	tat	HIV-1 Tat activates PRKCQ (PKC-theta) kinase activity, which leads to RELA (NFkB), NRAS, RAF1, MAP2K1 (MEK1), MAP2K2 (MEK2), MAPK3 (ERK1), and MAPK1 (ERK2) activation, in Jurkat T cells that stably express Tat	PubMed
	tat	HIV-1 Tat induces phosphorylation of MAPK3 (ERK1) in CRT-MG human astroglioma cells	PubMed
	tat	HIV-1 Tat increases phosphorylation of ERK1/2, JNK1/2, p38, AKT1, MEK-1, and STAT-1alpha in Muller glia and brain microvascular pericytes	PubMed
	tat	Phospholipase C/protein kinase C signaling pathway-dependent phosphorylation of p44/42 and JNK MAP kinases participates partially in IL-1beta induction by HIV-1 Tat	PubMed
	tat	Treatment with HIV-1 Tat induces phosphorylation of ERK1/2 and JNK in brain micro vascular endothelial cells (BMEC) and astrocytes, which mediates Tat-induced multidrug resistance-associated protein 1 (MRP1) expression	PubMed
	tat	Blocking HIV-1 Tat and cocaine-mediated Erk activation reverses ZO-1 downregulation in human pulmonary artery endothelial cells	PubMed
	tat	Treatment with HIV-1 Tat and cocaine activates Ras/Erk pathway in human pulmonary artery endothelial cells	PubMed
	tat	Treatment with HIV-Tat and morphine activates extracellular signal-regulated kinase-1/2 (ERK1/2), upregulates p53 and p21 levels, and downregulates cyclin D1 and Akt levels in human fetal brain-derived neural precursor cells	PubMed
	tat	The basic domain (49RKKRRQRRR57) of HIV-1 Tat is essential for enhancing the FGF-induced activation of ERK, Rho-A, and MLC2 and upregulates the expression of MMP-9 in human podocytes	PubMed
	tat	HIV-1 Tat induces activation of the ERK1/2 MAPK signaling pathway in polarized oral epithelial cells	PubMed
	tat	HIV-1 Tat- and oxovanadate-treated microglial cells synergistically induce release of TNF-alpha and IL-1beta proteins, which involves CD45 and ERK1/2 signaling pathways	PubMed
	tat	HIV-1 Tat induces ERK phosphorylation by the activation of the small GTPase Ras, but not the small GTPase Rac, in human endothelial cells	PubMed
	tat	HIV-1 Tat-induced upregulation of B7-H1 protein expression requires activation of the ERK/MAPK signaling pathway in human endothelial cells	PubMed
	tat	HIV-1 Tat and morphine-induced apoptosis in human neuroblastoma cells involves ERK1/2 and JNK activation	PubMed
	tat	Adhesion of endothelial cells to HIV-1 Tat triggers a signal transduction pathway, which leads to phosphorylation of VEGFR2 and pp60src and activation of ERK1/2	PubMed
	tat	HIV-1 Tat-linked intracellular third loop of the endothelin-1 type B receptor markedly enhances the endothelin-1 activation of ERK in the bone morphogenetic protein-2 receptor human pulmonary artery smooth muscle cells	PubMed
	tat	The NADPH oxidase inhibitors DPI and apocynin abrogate HIV-1 Tat-stimulated ERK1/2 activation in human microglia-like cells	PubMed
	tat	HIV-1 Tat inhibits the LPS-activation of ERK1/2 but not the p38 mitogen-activated protein kinases in primary blood monocytes/macrophages	PubMed
	tat	Cell-permeable SOD inhibits the activation of MAP kinases including ERK, JNK and p38 and the upregulation of ICAM-1 and VCAM-1 by HIV-1 Tat	PubMed
	tat	Tat-triggered PKCdelta and PKCtheta activation results in the downstream signaling through the apoptosis pathways mediated by both ERK1/2 and caspase-3	PubMed
	tat	Formation of the Nef-associated kinase complex (NAKC) is sufficient to activate LCK and ERK1/2 and causes a strong Tat-dependent increase of HIV-1 transcription in T cells	PubMed
	tat	HIV-1-Tat-mediated upregulation of platelet-derived growth factor (PDGF) B chain in astrocytes is regulated by activation of ERK1/2 and JNK MAPK signaling pathways and the downstream transcription factor early growth response 1 (Egr1)	PubMed
	tat	Tat activates at least three signaling pathways concurrently, including NF-kappaB, PKC, ERK1/2 and p38 MAP kinases and IKKalpha pathways, to promote production of IL-10	PubMed
	tat	Sulfated polymannuroguluronate (SPMG) blocks the Tat-induced extracellular-signal regulated kinase 1/2- and c-jun amino-terminal kinase-mediated signalling pathways	PubMed
	tat	HIV-1 Tat in combination with KSHV kaposin A activates the MEK/ERK, STAT3, and PI3K/Akt signals in NIH3T3 cells	PubMed
	tat	HIV-1 Tat alters the properties of human neural precursor cells via attenuation of the cell cycle regulatory unit cyclin D1 and the mitogen-activated protein kinase (MAPK) pathway, particularly extracellular signal-related kinase 1/2 (ERK1/2)	PubMed
	tat	HIV-1 Tat-induced glutamate release is mediated through p38 and p42/44 MAPK and through NADPH oxidase and the x(c)(-) cystine-glutamate antiporter (xCT)	PubMed
	tat	HIV-1 Tat is phosphorylated by MAPK in vitro	PubMed
	tat	HIV-1 Tat activates ERK1 and ERK2 through the activation of MEK1 and MEK2, leading to induction of IL-8, IL-10, IP-10, iNOS, superoxide and TNF-alpha, as well as suppression of p35 activator of cdk5, activation of CREB and increased albumin permeability	PubMed
	tat	Expression of HIV-1 Tat in human SK-N-MC cells inhibits the NGF-signaling pathway leading to suppression of MAPK and reduction of Puralpha binding to the Egr-1 promoter	PubMed
	tat	The interaction of HIV-1 Tat with KDR/VEGFR2 is implicated in the activation of ERK1 and ERK2 signaling pathways	PubMed
Vif	vif	MAPK phosphorylates HIV-1 Vif on Thr96 and Ser165 and is important in the regulation of HIV-1 infectivity by Vif	PubMed
Vpr	vpr	HIV-1 Vpr-induced caspase-8 activation causes cleavage of BID to tBID through ERK activation	PubMed
matrix	gag	HIV-1 MA natural variant S75X-mediated proliferation of both Epstein-Barr virus (EBV)-infected primary and fully transformed B-lymphocytes requires AKT, ERK1/2, and STAT3 pathways	PubMed
	gag	HIV-1 p17 variant S75X shows a similar activity to p17delta36 in modulating ERK1/2 signalling pathway in Raji and human primary B cells	PubMed
	gag	Expression of Pokeweed antiviral protein (PAP), a plant-derived N-glycosidase, activates the ERK1/2 MAPK pathway to a limited extent, resulting in increased phosphorylation of HIV-1 MA	PubMed
	gag	HIV-1 p17 induces phosphorylation of ERK1/ERK2 in human endothelial cells	PubMed
	gag	HIV-1 p17 induces capillary-like structures in human endothelial cells by binding to CXCR1 and CXCR2, which requires activation of the Akt-dependent ERK signaling pathway	PubMed
	gag	HIV-1 MA increases phosphorylation and the DNA-binding activity of CREB and c-Myc through activation of the cAMP/PKA and MEK/ERK signaling pathways. Both signaling pathways are synergistically activated upon co-stimulation through the CD19 receptor	PubMed
	gag	Phosphorylation of HIV-1 Matrix on tyrosine and serine prior to and during virus infection facilitates dissociation of Matrix from the cellular membrane, thus allowing it to translocate to the nucleus and participate in HIV-1 nuclear import	PubMed
	gag	Recombinant MAPK phosphorylates HIV-1 Matrix on serine and threonine residues, whereas immunoprecipitated MAPK predominantly phosphorylates HIV-1 Matrix on serine residues	PubMed
p6	gag	HIV-1 p6-Gag is phosphorylated by cellular kinases with ERK1 and ERK2 being the most likely kinases involved in p6 phosphorylation	PubMed
reverse transcriptase	gag-pol	MEK1 in HIV-1 producer cells is able to activate virion-associated MAPK in trans, and the activated MAPK facilitates efficient disengagement of the HIV-1 reverse transcription complex from the cell membrane and subsequent nuclear translocation	PubMed

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

MAPK3_2268 (e-PCR)
- UniSTS:280839

RH77963 (e-PCR)
- UniSTS:89158

G15873 (e-PCR)
- UniSTS:75694

SHGC-61070 (e-PCR)
- UniSTS:90564

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables MAP kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables MAP kinase activity	NAS Non-traceable Author Statement more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables phosphatase binding	IPI Inferred from Physical Interaction more info	PubMed
enables phosphotyrosine residue binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activity	TAS Traceable Author Statement more info

Process	Evidence Code	Pubs
involved_in BMP signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in Bergmann glial cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in ERBB2-ERBB3 signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in ERK1 and ERK2 cascade	IEA Inferred from Electronic Annotation more info
involved_in MAPK cascade	NAS Non-traceable Author Statement more info	PubMed
involved_in Schwann cell development	IEA Inferred from Electronic Annotation more info
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in cardiac neural crest cell development involved in heart development	IEA Inferred from Electronic Annotation more info
involved_in cartilage development	IEA Inferred from Electronic Annotation more info
involved_in caveolin-mediated endocytosis	TAS Traceable Author Statement more info	PubMed
involved_in cellular response to amino acid starvation	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to cadmium ion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to mechanical stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to reactive oxygen species	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to tumor necrosis factor	IEA Inferred from Electronic Annotation more info
involved_in face development	IEA Inferred from Electronic Annotation more info
involved_in insulin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in insulin-like growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in interleukin-1-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in lipopolysaccharide-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in lung morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in modulation of chemical synaptic transmission	IEA Inferred from Electronic Annotation more info
involved_in myelination	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of TORC1 signaling	IDA Inferred from Direct Assay more info	PubMed
involved_in outer ear morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in peptidyl-tyrosine autophosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of ERK1 and ERK2 cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cyclase activity	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of positive regulation of macrophage chemotaxis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of positive regulation of macrophage proliferation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of telomerase activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of telomere capping	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of telomere maintenance via telomerase	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of xenophagy	IEA Inferred from Electronic Annotation more info
involved_in protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of Golgi inheritance	TAS Traceable Author Statement more info	PubMed
involved_in regulation of cellular pH	IEA Inferred from Electronic Annotation more info
involved_in regulation of cytoskeleton organization	TAS Traceable Author Statement more info	PubMed
involved_in regulation of early endosome to late endosome transport	TAS Traceable Author Statement more info	PubMed
involved_in regulation of ossification	IEA Inferred from Electronic Annotation more info
involved_in regulation of stress-activated MAPK cascade	TAS Traceable Author Statement more info	PubMed
involved_in response to epidermal growth factor	IDA Inferred from Direct Assay more info	PubMed
involved_in response to exogenous dsRNA	IEA Inferred from Electronic Annotation more info
involved_in sensory perception of pain	IEA Inferred from Electronic Annotation more info
involved_in signal transduction in response to DNA damage	IDA Inferred from Direct Assay more info	PubMed
involved_in stress-activated MAPK cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in thymus development	IEA Inferred from Electronic Annotation more info
involved_in thyroid gland development	IEA Inferred from Electronic Annotation more info
involved_in trachea formation	IEA Inferred from Electronic Annotation more info
involved_in xenophagy	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	TAS Traceable Author Statement more info	PubMed
located_in caveola	ISS Inferred from Sequence or Structural Similarity more info
located_in caveola	TAS Traceable Author Statement more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoskeleton	TAS Traceable Author Statement more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info	PubMed
located_in early endosome	TAS Traceable Author Statement more info	PubMed
located_in endoplasmic reticulum lumen	TAS Traceable Author Statement more info
located_in focal adhesion	TAS Traceable Author Statement more info	PubMed
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
located_in late endosome	TAS Traceable Author Statement more info	PubMed
located_in mitochondrion	TAS Traceable Author Statement more info	PubMed
located_in nuclear envelope	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	TAS Traceable Author Statement more info	PubMed
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in pseudopodium	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: mitogen-activated protein kinase 3

Names: MAPK 1; extracellular signal-regulated kinase 1; extracellular signal-related kinase 1; insulin-stimulated MAP2 kinase; microtubule-associated protein 2 kinase

NP_001035145.1

EC 2.7.11.24

NP_001103361.1

EC 2.7.11.24

NP_002737.2

EC 2.7.11.24

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_029936.1 RefSeqGene

Range

5090..14205

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001040056.3 → NP_001035145.1 mitogen-activated protein kinase 3 isoform 2

See identical proteins and their annotated locations for NP_001035145.1

Status: REVIEWED

Description

Transcript Variant: This variant (2, also known as ERK1c) lacks several exons and its 3'-terminal exon extends past a splice site that is used in variant 1. The encoded isoform (2) has a shorter and distinct C-terminus, compared to isoform 1.

Source sequence(s)

AY033607, DA351318, DQ399291

Consensus CDS

CCDS42149.1

UniProtKB/TrEMBL

E9PQW4

Related

ENSP00000378625.3, ENST00000395199.7

Conserved Domains (1) summary

cd07849
Location:36 → 344

STKc_ERK1_2_like; Catalytic domain of Extracellular signal-Regulated Kinase 1 and 2-like Serine/Threonine Kinases
NM_001109891.2 → NP_001103361.1 mitogen-activated protein kinase 3 isoform 3

See identical proteins and their annotated locations for NP_001103361.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) lacks an in-frame exon in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 3), compared to isoform 1.

Source sequence(s)

BC000205, BC013992, DA351318, DQ399291

Consensus CDS

CCDS42148.1

UniProtKB/TrEMBL

Q8NHX0

Related

ENSP00000327293.5, ENST00000322266.9

Conserved Domains (1) summary

cd07849
Location:36 → 326

STKc_ERK1_2_like; Catalytic domain of Extracellular signal-Regulated Kinase 1 and 2-like Serine/Threonine Kinases
NM_002746.3 → NP_002737.2 mitogen-activated protein kinase 3 isoform 1

See identical proteins and their annotated locations for NP_002737.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the most common transcript and encodes isoform 1.

Source sequence(s)

AC012645, BC013992

Consensus CDS

CCDS10672.1

UniProtKB/Swiss-Prot

A8CZ58, B0LPG3, P27361, Q8NHX1

UniProtKB/TrEMBL

L7RXH5, Q8NHX0

Related

ENSP00000263025.4, ENST00000263025.9

Conserved Domains (1) summary

cd07849
Location:36 → 370

STKc_ERK1_2_like; Catalytic domain of Extracellular signal-Regulated Kinase 1 and 2-like Serine/Threonine Kinases