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    KCNK10 potassium two pore domain channel subfamily K member 10 [ Homo sapiens (human) ]

    Gene ID: 54207, updated on 5-Mar-2024

    Summary

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    Official Symbol
    KCNK10provided by HGNC
    Official Full Name
    potassium two pore domain channel subfamily K member 10provided by HGNC
    Primary source
    HGNC:HGNC:6273
    See related
    Ensembl:ENSG00000100433 MIM:605873; AllianceGenome:HGNC:6273
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TREK2; TREK-2; K2p10.1; PPP1R97
    Summary
    The protein encoded by this gene belongs to the family of potassium channel proteins containing two pore-forming P domains. This channel is an open rectifier which primarily passes outward current under physiological K+ concentrations, and is stimulated strongly by arachidonic acid and to a lesser degree by membrane stretching, intracellular acidification, and general anaesthetics. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Sep 2008]
    Expression
    Biased expression in brain (RPKM 1.7), duodenum (RPKM 1.4) and 8 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    14q31.3
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (88180108..88326912, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (82400736..82547879, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (88646452..88793256, complement)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene NANOG hESC enhancer GRCh37_chr14:88503612-88504113 Neighboring gene long intergenic non-protein coding RNA 1147 Neighboring gene HIF1A stabilizing long noncoding RNA Neighboring gene uncharacterized LOC107984699 Neighboring gene uncharacterized LOC105370612 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8835 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8836 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5989 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_38654 Neighboring gene Sharpr-MPRA regulatory region 1231 Neighboring gene ReSE screen-validated silencer GRCh37_chr14:88685623-88685838 Neighboring gene Sharpr-MPRA regulatory region 1180 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:88788959-88789618 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5990 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8837 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:88792556-88793070 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr14:88830965-88831772 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8838 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8839 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8840 Neighboring gene spermatogenesis associated 7 Neighboring gene NANOG hESC enhancer GRCh37_chr14:88948745-88949275 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8841 Neighboring gene uncharacterized LOC105370614 Neighboring gene protein tyrosine phosphatase non-receptor type 21 Neighboring gene RNA, U4 small nuclear 22, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Effects of ionic strength on gating and permeation of TREK-2 K2P channels. Conrad LJ, et al. PLoS One, 2021. PMID 34618865, Free PMC Article
    2. Polymodal activation of the TREK-2 K2P channel produces structurally distinct open states. McClenaghan C, et al. J Gen Physiol, 2016 Jun. PMID 27241700, Free PMC Article
    3. The isoforms generated by alternative translation initiation adopt similar conformation in the selectivity filter in TREK-2. Zhuo RG, et al. J Physiol Biochem, 2015 Dec. PMID 26271386
    4. Insights into the stimulatory mechanism of 2-aminoethoxydiphenyl borate on TREK-2 potassium channel. Zhuo RG, et al. Neuroscience, 2015 Aug 6. PMID 25982558
    5. K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac. Dong YY, et al. Science, 2015 Mar 13. PMID 25766236, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. beta-COP Suppresses the Surface Expression of the TREK2.
      Title: β-COP Suppresses the Surface Expression of the TREK2.
    2. Effects of ionic strength on gating and permeation of TREK-2 K2P channels.
      Title: Effects of ionic strength on gating and permeation of TREK-2 K2P channels.
    3. The M2-glycine hinge controls the macroscopic currents of TREK1 channels.
      Title: The glycine hinge of transmembrane segment 2 modulates the subcellular localization and gating properties in TREK channels.
    4. This study showed that KCNK10 gene involved in neuronal growth and cerebellum development and associated with neurological and psychological disorders.
      Title: The association of DNA methylation and brain volume in healthy individuals and schizophrenia patients.
    5. The selectivity filter conformations of alternative translation initiation isoforms and wild type human TREK-2 are similar in the S4 site and pHo position.
      Title: The isoforms generated by alternative translation initiation adopt similar conformation in the selectivity filter in TREK-2.
    6. Results suggest that the cytosolic C-terminal domain and the bottom of transmembrane segment M2 are required for the 2-aminoethoxydiphenyl borate activation on TREK-2 channels
      Title: Insights into the stimulatory mechanism of 2-aminoethoxydiphenyl borate on TREK-2 potassium channel.
    7. How ion channels sense mechanical force: insights from mechanosensitive K2P channels TRAAK, TREK1, and TREK2.
      Title: How ion channels sense mechanical force: insights from mechanosensitive K2P channels TRAAK, TREK1, and TREK2.
    8. Modulation of K2P 2.1 and K2P 10.1 K(+) channel sensitivity to carvedilol by alternative mRNA translation initiation
      Title: Modulation of K2P 2.1 and K2P 10.1 K(+) channel sensitivity to carvedilol by alternative mRNA translation initiation.
    9. PLD2, but not PLD1, directly binds to the C terminus of TREK1 and TREK2.
      Title: Phospholipase D2 specifically regulates TREK potassium channels via direct interaction and local production of phosphatidic acid.
    10. crystal structures of TREK-2 channel in 2 conformations and in complex with norfluoxetine, a state-dependent blocker of TREK channels; results provide an explanation for TREK channel mechanosensitivity, regulation by diverse stimuli and possible off-target effects of Prozac
      Title: K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac.
    Submit: New GeneRIF Correction See all GeneRIFs (14)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide genetic and transcriptomic investigation of variation in antibody response to dietary antigens.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ43399

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables outward rectifier potassium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables potassium channel activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables potassium ion leak channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in memory IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in potassium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in stabilization of membrane potential IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of monoatomic ion channel complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    potassium channel subfamily K member 10
    Names
    2P domain potassium channel TREK2
    TREK-2 K(+) channel subunit
    TWIK-related K+ channel 2
    outward rectifying potassium channel protein TREK-2
    potassium channel TREK-2
    potassium channel, subfamily K, member 10
    potassium channel, two pore domain subfamily K, member 10
    protein phosphatase 1, regulatory subunit 97

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_021161.5 → NP_066984.1  potassium channel subfamily K member 10 isoform 1 precursor

      See identical proteins and their annotated locations for NP_066984.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1, also known as TREK2 splice variant a) encodes the shortest isoform (1).
      Source sequence(s)
      AF279890, AI693366, AL049834, AL133279, U79244
      Consensus CDS
      CCDS9880.1
      UniProtKB/Swiss-Prot
      B2R8T4, B2RCT3, B5TJL4, P57789, Q6B014, Q8TDK7, Q8TDK8, Q9HB59
      UniProtKB/TrEMBL
      A8K3A3
      Related
      ENSP00000343104.5, ENST00000340700.9
      Conserved Domains (1) summary
      pfam07885
      Location:148 → 206
      Ion_trans_2; Ion channel

    2. NM_138317.3 → NP_612190.1  potassium channel subfamily K member 10 isoform 2

      See identical proteins and their annotated locations for NP_612190.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2, also known as TREK2 splice variant c) has a different 5' terminal exon compared to transcript variant 1, and encodes a slightly longer isoform (2) with a distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AF279890, AI693366, AK313499, AL049834, AL133279, EU978939, U79244
      Consensus CDS
      CCDS9881.1
      UniProtKB/TrEMBL
      A8K3A3
      Related
      ENSP00000312811.5, ENST00000319231.10
      Conserved Domains (1) summary
      pfam07885
      Location:153 → 211
      Ion_trans_2; Ion channel

    3. NM_138318.3 → NP_612191.1  potassium channel subfamily K member 10 isoform 3

      See identical proteins and their annotated locations for NP_612191.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3, also known as TREK2 splice variant b) has a different 5' terminal exon compared to transcript variant 1, and encodes a slightly longer isoform (3) with a distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AF279890, AF385399, AI693366, AL133279, BC075021, EU978940, U79244
      Consensus CDS
      CCDS9882.1
      UniProtKB/TrEMBL
      A8K3A3
      Related
      ENSP00000310568.5, ENST00000312350.9
      Conserved Domains (1) summary
      pfam07885
      Location:153 → 211
      Ion_trans_2; Ion channel

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

      Range
      88180108..88326912 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060938.1 Alternate T2T-CHM13v2.0

      Range
      82400736..82547879 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P57789.1 GenPept UniProtKB/Swiss-Prot:P57789

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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