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    OR4Q3 olfactory receptor family 4 subfamily Q member 3 [ Homo sapiens (human) ]

    Gene ID: 441669, updated on 11-Apr-2024

    Summary

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    Official Symbol
    OR4Q3provided by HGNC
    Official Full Name
    olfactory receptor family 4 subfamily Q member 3provided by HGNC
    Primary source
    HGNC:HGNC:15426
    See related
    Ensembl:ENSG00000182652 AllianceGenome:HGNC:15426
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HSA6; OR4Q4; OR14-3; C14orf13; c14_5008
    Summary
    Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
    Annotation information
    Annotation category: partial on reference assembly
    Orthologs
    mouse all
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    Genomic context

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    Location:
    14q11.2
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (19743571..19752334)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (13918508..13962426)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (20215587..20216528)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 11 subfamily H member 2 Neighboring gene olfactory receptor family 11 subfamily K member 2 pseudogene Neighboring gene small nucleolar RNA U13 Neighboring gene olfactory receptor family 4 subfamily H member 12 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. The olfactory receptor gene repertoire in primates and mouse: evidence for reduction of the functional fraction in primates. Rouquier S, et al. Proc Natl Acad Sci U S A, 2000 Mar 14. PMID 10706615, Free PMC Article
    2. The human olfactory receptor gene family. Malnic B, et al. Proc Natl Acad Sci U S A, 2004 Feb 24. PMID 14983052, Free PMC Article
    3. Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. Huttlin EL, et al. Cell, 2021 May 27. PMID 33961781, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables olfactory receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in detection of chemical stimulus involved in sensory perception of smell IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    olfactory receptor 4Q3
    Names
    olfactory receptor 4Q4
    olfactory receptor OR14-3
    olfactory receptor, family 4, subfamily Q, member 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001405963.1 → NP_001392892.1  olfactory receptor 4Q3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL512310, KF455839
      UniProtKB/TrEMBL
      A0A2U3TZU4
      Related
      ENSP00000492928.2, ENST00000642117.2

    2. NM_172194.1 → NP_751944.1  olfactory receptor 4Q3 isoform 1

      See identical proteins and their annotated locations for NP_751944.1

      Status: VALIDATED

      Source sequence(s)
      AB065609
      UniProtKB/Swiss-Prot
      Q6IEX4, Q8NH05
      UniProtKB/TrEMBL
      A0A126GW32
      Conserved Domains (2) summary
      pfam00001
      Location:41 → 288
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:35 → 302
      7tm_4; Olfactory receptor

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

      Range
      19743571..19752334
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024449618.1 → XP_024305386.1  olfactory receptor 4Q3 isoform X1

      Conserved Domains (1) summary
      cd15935
      Location:98 → 355
      7tmA_OR4Q3-like; olfactory receptor 4Q3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060938.1 Alternate T2T-CHM13v2.0

      Range
      13918508..13962426
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054376145.1 → XP_054232120.1  olfactory receptor 4Q3 isoform X2

      UniProtKB/TrEMBL
      A0A126GWJ8

    RNA

    1. XR_007085115.1 RNA Sequence

    2. XR_007085116.1 RNA Sequence

    3. XR_007085117.1 RNA Sequence

    4. XR_007085119.1 RNA Sequence

    5. XR_007085118.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8NH05.1 GenPept UniProtKB/Swiss-Prot:Q8NH05

    Gene LinkOut

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