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    ZNF26 zinc finger protein 26 [ Homo sapiens (human) ]

    Gene ID: 7574, updated on 5-May-2024

    Summary

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    Official Symbol
    ZNF26provided by HGNC
    Official Full Name
    zinc finger protein 26provided by HGNC
    Primary source
    HGNC:HGNC:13053
    See related
    Ensembl:ENSG00000198393 MIM:194537; AllianceGenome:HGNC:13053
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    KOX20; HEL-179
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in bone marrow (RPKM 2.0), lymph node (RPKM 1.7) and 25 other tissues See more
    Orthologs
    all
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    Genomic context

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    Location:
    12q24.33
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (132986367..133027102)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (133043702..133084435)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (133562953..133603688)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene zinc finger protein 605 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:133531610-133532440 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:133532441-133533269 Neighboring gene uncharacterized LOC124903064 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:133553507-133553757 Neighboring gene NANOGNB pseudogene 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7395 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:133563299-133563798 Neighboring gene RNA, U4atac small nuclear 12, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7397 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5134 Neighboring gene ZNF84 divergent transcript Neighboring gene PTP4A1 pseudogene 2 Neighboring gene zinc finger protein 84 Neighboring gene MPRA-validated peak2056 silencer

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Two human genes encoding zinc finger proteins, ZNF 12 (KOX 3) and ZNF 26 (KOX 20), map to chromosome 7p22-p21 and 12q24.33, respectively. Seite P, et al. Hum Genet, 1991 Apr. PMID 2026422
    2. Multiple genes encoding zinc finger domains are expressed in human T cells. Thiesen HJ. New Biol, 1990 Apr. PMID 2288909
    3. Microtubule-associated proteins 1 (MAP1) promote human immunodeficiency virus type I (HIV-1) intracytoplasmic routing to the nucleus. Fernandez J, et al. J Biol Chem, 2015 Feb 20. PMID 25505242, Free PMC Article
    4. POH1 contributes to hyperactivation of TGF-β signaling and facilitates hepatocellular carcinoma metastasis through deubiquitinating TGF-β receptors and caveolin-1. Wang B, et al. EBioMedicine, 2019 Mar. PMID 30745168, Free PMC Article
    5. A census of human transcription factors: function, expression and evolution. Vaquerizas JM, et al. Nat Rev Genet, 2009 Apr. PMID 19274049

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    capsid gag The interaction of HIV-1 CA with human cellular zinc finger protein 26 (ZNF26) is identified by yeast two-hybrid screen PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ20755

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 26
    Names
    epididymis luminal protein 179
    zinc finger protein KOX20

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001256279.2 → NP_001243208.1  zinc finger protein 26 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC073911
      Conserved Domains (5) summary
      smart00349
      Location:47 → 107
      KRAB; krueppel associated box
      COG5048
      Location:209 → 557
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:489 → 509
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:47 → 86
      KRAB; KRAB box
      pfam13465
      Location:501 → 526
      zf-H2C2_2; Zinc-finger double domain

    2. NM_001256280.2 → NP_001243209.1  zinc finger protein 26 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an in-frame exon in the coding region, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
      Source sequence(s)
      AC073911
      Conserved Domains (5) summary
      smart00349
      Location:14 → 54
      KRAB; krueppel associated box
      COG5048
      Location:144 → 492
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:424 → 444
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:14 → 53
      KRAB; KRAB box
      pfam13465
      Location:436 → 461
      zf-H2C2_2; Zinc-finger double domain

    3. NM_001330513.2 → NP_001317442.1  zinc finger protein 26 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in its 5' UTR and lacks an alternate exon in the 5' coding region compared to variant 1. This variant represents translation initiation at a downstream start codon compared to variant 1; the 5'-most initiation codon, as used in variant 1, is associated with a truncated ORF that would render the transcript a candidate for nonsense-mediated decay (NMD). Leaky scanning may allow translation initiation at the downstream start codon to encode an isoform (4) that has a shorter N-terminus, compared to isoform 1. Variants 4 and 5 encode the same isoform (4).
      Source sequence(s)
      AC073911, BM718210, DA022426, DA107937, DA737586, DB239332, EU668356
      UniProtKB/TrEMBL
      F5H6R4, V9HW07

    4. NM_001330514.2 → NP_001317443.1  zinc finger protein 26 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in its 5' UTR and lacks an alternate exon in the 5' coding region compared to variant 1. This variant represents translation initiation at a downstream start codon compared to variant 1; the 5'-most initiation codon, as used in variant 1, is associated with a truncated ORF that would render the transcript a candidate for nonsense-mediated decay (NMD). Leaky scanning may allow translation initiation at the downstream start codon to encode an isoform (4) that has a shorter N-terminus, compared to isoform 1. Variants 4 and 5 encode the same isoform (4).
      Source sequence(s)
      AC073911, BM718210, DA107937, DA737586, DB232386, EU668356
      UniProtKB/TrEMBL
      F5H6R4, V9HW07

    5. NM_019591.4 → NP_062537.2  zinc finger protein 26 isoform 2

      See identical proteins and their annotated locations for NP_062537.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC073911
      Consensus CDS
      CCDS31939.1
      UniProtKB/Swiss-Prot
      P17031, Q86X57, Q9NWL3
      UniProtKB/TrEMBL
      V9HW07
      Related
      ENSP00000333725.5, ENST00000328654.10
      Conserved Domains (3) summary
      smart00349
      Location:14 → 74
      KRAB; krueppel associated box
      COG5048
      Location:200 → 512
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:456 → 476
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      132986367..133027102
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047429502.1 → XP_047285458.1  zinc finger protein 26 isoform X1

    2. XM_047429503.1 → XP_047285459.1  zinc finger protein 26 isoform X2

    RNA

    1. XR_007063124.1 RNA Sequence

    2. XR_007063123.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      133043702..133084435
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054373134.1 → XP_054229109.1  zinc finger protein 26 isoform X2

    RNA

    1. XR_008488676.1 RNA Sequence

    2. XR_008488675.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P17031.3 GenPept UniProtKB/Swiss-Prot:P17031

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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