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    ARMCX5 armadillo repeat containing X-linked 5 [ Homo sapiens (human) ]

    Gene ID: 64860, updated on 5-Mar-2024

    Summary

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    Official Symbol
    ARMCX5provided by HGNC
    Official Full Name
    armadillo repeat containing X-linked 5provided by HGNC
    Primary source
    HGNC:HGNC:25772
    See related
    Ensembl:ENSG00000125962 MIM:301047; AllianceGenome:HGNC:25772
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GASP5
    Expression
    Ubiquitous expression in thyroid (RPKM 7.2), prostate (RPKM 6.6) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    Xq22.1
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (102599206..102604159)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (101044161..101049114)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (101854134..101859087)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene nuclear RNA export factor 5 pseudogene Neighboring gene forkhead box N3 pseudogene 1 Neighboring gene ARMCX5-GPRASP2 readthrough Neighboring gene nuclear RNA export factor 4 (pseudogene) Neighboring gene H3K27ac hESC enhancer GRCh37_chrX:101854489-101855260 Neighboring gene H3 histone pseudogene 45 Neighboring gene G protein-coupled receptor associated sorting protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. The Eutherian Armcx genes regulate mitochondrial trafficking in neurons and interact with Miro and Trak2. López-Doménech G, et al. Nat Commun, 2012 May 8. PMID 22569362
    2. Mammalian BEX, WEX and GASP genes: coding and non-coding chimaerism sustained by gene conversion events. Winter EE, et al. BMC Evol Biol, 2005 Oct 12. PMID 16221301, Free PMC Article
    3. A synthetic interaction screen identifies factors selectively required for proliferation and TERT transcription in p53-deficient human cancer cells. Xie L, et al. PLoS Genet, 2012. PMID 23284306, Free PMC Article
    4. ARMC5 is part of an RPB1-specific ubiquitin ligase implicated in adrenal hyperplasia. Lao L, et al. Nucleic Acids Res, 2022 Jun 24. PMID 35687106, Free PMC Article
    5. Agrin has a pathological role in the progression of oral cancer. Rivera C, et al. Br J Cancer, 2018 Jun. PMID 29872149, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Readthrough ARMCX5-GPRASP2

    Readthrough gene: ARMCX5-GPRASP2, Included gene: GPRASP1, Included gene: GPRASP3, Included gene: GPRASP2, Included gene: LINC00630

    Homology

    Clone Names

    • FLJ12969, FLJ13382, DKFZp686A22185

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    armadillo repeat-containing X-linked protein 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_016347.1 RefSeqGene

      Range
      5348..9992
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001168478.2 → NP_001161950.1  armadillo repeat-containing X-linked protein 5

      See identical proteins and their annotated locations for NP_001161950.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-6 all encode the same protein.
      Source sequence(s)
      AL537480, BC064983
      Consensus CDS
      CCDS14500.1
      UniProtKB/Swiss-Prot
      B3KU88, D3DX99, Q68DB4, Q6P1M9, Q9BVZ3, Q9H969
      Related
      ENSP00000473737.2, ENST00000473968.7
      Conserved Domains (1) summary
      pfam04826
      Location:300 → 552
      Arm_2; Armadillo-like

    2. NM_001168479.2 → NP_001161951.1  armadillo repeat-containing X-linked protein 5

      See identical proteins and their annotated locations for NP_001161951.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1-6 all encode the same protein.
      Source sequence(s)
      AK096692, BC000792, BI765968
      Consensus CDS
      CCDS14500.1
      UniProtKB/Swiss-Prot
      B3KU88, D3DX99, Q68DB4, Q6P1M9, Q9BVZ3, Q9H969
      Conserved Domains (1) summary
      pfam04826
      Location:300 → 552
      Arm_2; Armadillo-like

    3. NM_001168480.2 → NP_001161952.1  armadillo repeat-containing X-linked protein 5

      See identical proteins and their annotated locations for NP_001161952.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1-6 all encode the same protein.
      Source sequence(s)
      AK096692, BC000792
      Consensus CDS
      CCDS14500.1
      UniProtKB/Swiss-Prot
      B3KU88, D3DX99, Q68DB4, Q6P1M9, Q9BVZ3, Q9H969
      Related
      ENSP00000246174.2, ENST00000246174.6
      Conserved Domains (1) summary
      pfam04826
      Location:300 → 552
      Arm_2; Armadillo-like

    4. NM_001168482.2 → NP_001161954.1  armadillo repeat-containing X-linked protein 5

      See identical proteins and their annotated locations for NP_001161954.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 1. Variants 1-6 all encode the same protein.
      Source sequence(s)
      BC064983, BX352705
      Consensus CDS
      CCDS14500.1
      UniProtKB/Swiss-Prot
      B3KU88, D3DX99, Q68DB4, Q6P1M9, Q9BVZ3, Q9H969
      Related
      ENSP00000474484.2, ENST00000477663.6
      Conserved Domains (1) summary
      pfam04826
      Location:300 → 552
      Arm_2; Armadillo-like

    5. NM_001168485.2 → NP_001161957.1  armadillo repeat-containing X-linked protein 5

      See identical proteins and their annotated locations for NP_001161957.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1-6 all encode the same protein.
      Source sequence(s)
      AK096692, BC064983, DN991222
      Consensus CDS
      CCDS14500.1
      UniProtKB/Swiss-Prot
      B3KU88, D3DX99, Q68DB4, Q6P1M9, Q9BVZ3, Q9H969
      Conserved Domains (1) summary
      pfam04826
      Location:300 → 552
      Arm_2; Armadillo-like

    6. NM_022838.4 → NP_073749.2  armadillo repeat-containing X-linked protein 5

      See identical proteins and their annotated locations for NP_073749.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-6 all encode the same protein.
      Source sequence(s)
      BC064983
      Consensus CDS
      CCDS14500.1
      UniProtKB/Swiss-Prot
      B3KU88, D3DX99, Q68DB4, Q6P1M9, Q9BVZ3, Q9H969
      Related
      ENSP00000474470.2, ENST00000479502.2
      Conserved Domains (1) summary
      pfam04826
      Location:300 → 552
      Arm_2; Armadillo-like

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      102599206..102604159
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      101044161..101049114
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6P1M9.1 GenPept UniProtKB/Swiss-Prot:Q6P1M9

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