CAPG capping actin protein, gelsolin like [Homo sapiens (human)] - Gene

Summary

Official Symbol: CAPGprovided by HGNC
Official Full Name: capping actin protein, gelsolin likeprovided by HGNC
Primary source: HGNC:HGNC:1474
See related: Ensembl:ENSG00000042493 MIM:153615; AllianceGenome:HGNC:1474
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: MCP; AFCP; HEL-S-66
Summary: This gene encodes a member of the gelsolin/villin family of actin-regulatory proteins. The encoded protein reversibly blocks the barbed ends of F-actin filaments in a Ca2+ and phosphoinositide-regulated manner, but does not sever preformed actin filaments. By capping the barbed ends of actin filaments, the encoded protein contributes to the control of actin-based motility in non-muscle cells. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jan 2012]
Expression: Broad expression in lung (RPKM 44.7), esophagus (RPKM 37.5) and 22 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 2p11.2

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	2	NC_000002.12 (85391602..85419540, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	2	NC_060926.1 (85393613..85421559, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	2	NC_000002.11 (85621876..85641139, complement)

Chromosome 2 - NC_000002.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CAPG interference induces apoptosis and ferroptosis in colorectal cancer cells through the P53 pathway.
Title: CAPG interference induces apoptosis and ferroptosis in colorectal cancer cells through the P53 pathway.
CAPG facilitates diffuse large B-cell lymphoma cell progression through PI3K/AKT signaling pathway.
Title: CAPG facilitates diffuse large B-cell lymphoma cell progression through PI3K/AKT signaling pathway.
The Association Between Gelsolin-like Actin-capping Protein (CapG) Overexpression and Bladder Cancer Prognosis.
Title: The Association Between Gelsolin-like Actin-capping Protein (CapG) Overexpression and Bladder Cancer Prognosis.
The migration behavior of human glioblastoma cells is influenced by the redox-sensitive human macrophage capping protein CAPG.
Title: The migration behavior of human glioblastoma cells is influenced by the redox-sensitive human macrophage capping protein CAPG.
Oncogenic potential of macrophagecapping protein in clear cell renal cell carcinoma.
Title: Oncogenic potential of macrophage‑capping protein in clear cell renal cell carcinoma.
The role of CAPG in molecular communication between the embryo and the uterine endometrium: Is its function conserved in species with different implantation strategies?
Title: The role of CAPG in molecular communication between the embryo and the uterine endometrium: Is its function conserved in species with different implantation strategies?
CapG promotes resistance to paclitaxel in breast cancer through transactivation of PIK3R1/P50.
Title: CapG promotes resistance to paclitaxel in breast cancer through transactivation of PIK3R1/P50.
CAPG competes with the transcriptional repressor arginine methyltransferase 5 (PRMT5) for binding to the STC-1 promoter.
Title: CAPG enhances breast cancer metastasis by competing with PRMT5 to modulate STC-1 transcription.
Study suggested that CapG could be used as a biomarker for metastatic CRC in the clinical specimens. Moreover, our in vitro study demonstrated that CapG might contribute on tumor metastasis in human CRCs.
Title: Capping Actin Protein Overexpression in Human Colorectal Carcinoma and Its Contributed Tumor Migration.
Results revealed that CapG is a novel independent prognostic predictor for glioma patients and highlight a key role of CapG in proliferation and metastasis of glioma.
Title: Actin-capping protein CapG is associated with prognosis, proliferation and metastasis in human glioma.

Submit: New GeneRIF Correction See all GeneRIFs (36)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Tat	tat	Interaction of HIV-1 Tat with CAPG in T-cells is identified by a proteomic strategy based on affinity chromatography coupled with mass spectrometry	PubMed
Vpr	vpr	A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies downregulation of capping protein gelsolin-like (CAPG) expression by HIV-1 Vpr in Vpr transduced macrophages	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

WI-17489 (e-PCR)
- UniSTS:54046

CAPG (e-PCR)
- UniSTS:505033

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables cadherin binding	HDA more info	PubMed
enables phosphatidylinositol-4,5-bisphosphate binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in actin filament severing	IBA Inferred from Biological aspect of Ancestor more info
involved_in actin polymerization or depolymerization	IBA Inferred from Biological aspect of Ancestor more info
involved_in barbed-end actin filament capping	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell projection assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in central nervous system development	IBA Inferred from Biological aspect of Ancestor more info
NOT involved_in extracellular matrix disassembly	IMP Inferred from Mutant Phenotype more info	PubMed
NOT involved_in positive regulation of podosome assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein-containing complex assembly	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
part_of F-actin capping protein complex	TAS Traceable Author Statement more info	PubMed
located_in Flemming body	IDA Inferred from Direct Assay more info	PubMed
is_active_in actin cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in centriole	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular exosome	HDA more info	PubMed
located_in lamellipodium	IEA Inferred from Electronic Annotation more info
located_in melanosome	IEA Inferred from Electronic Annotation more info
located_in mitotic spindle	IDA Inferred from Direct Assay more info	PubMed
located_in nucleolus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in ruffle	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: macrophage-capping protein

Names: actin-regulatory protein CAP-G; capping protein (actin filament), gelsolin-like; epididymis secretory protein Li 66; gelsolin-like capping protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001256139.2 → NP_001243068.1 macrophage-capping protein isoform 1

See identical proteins and their annotated locations for NP_001243068.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 4, and 5 all encode the same isoform (1).

Source sequence(s)

AK130130, AK313898, AU099216, BU626913

Consensus CDS

CCDS1974.1

UniProtKB/Swiss-Prot

B8ZZS7, D6W5K8, P40121, Q53SA7

UniProtKB/TrEMBL

B2R9S4, V9HW69

Related

ENSP00000386965.1, ENST00000409724.5

Conserved Domains (3) summary

cd11289
Location:137 → 225

gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins

cd11290
Location:17 → 120

gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins

cd11292
Location:251 → 346

gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
NM_001256140.2 → NP_001243069.1 macrophage-capping protein isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (3) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.

Source sequence(s)

AK130130, AK225374, BU626913

Consensus CDS

CCDS58715.1

UniProtKB/TrEMBL

B2R9S4

Related

ENSP00000387063.1, ENST00000409921.5

Conserved Domains (3) summary

cd11289
Location:137 → 208

gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins

cd11290
Location:17 → 120

gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins

cd11292
Location:236 → 331

gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
NM_001320732.2 → NP_001307661.1 macrophage-capping protein isoform 1

Status: REVIEWED

Description

Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2, 4, and 5 all encode the same isoform (1).

Source sequence(s)

BG762391, FJ224312

Consensus CDS

CCDS1974.1

UniProtKB/Swiss-Prot

B8ZZS7, D6W5K8, P40121, Q53SA7

UniProtKB/TrEMBL

B2R9S4, V9HW69

Conserved Domains (3) summary

cd11289
Location:137 → 225

gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins

cd11290
Location:17 → 120

gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins

cd11292
Location:251 → 346

gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
NM_001320733.2 → NP_001307662.1 macrophage-capping protein isoform 1

Status: REVIEWED

Description

Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1, 2, 4, and 5 all encode the same isoform (1).

Source sequence(s)

BG762114, FJ224312

Consensus CDS

CCDS1974.1

UniProtKB/Swiss-Prot

B8ZZS7, D6W5K8, P40121, Q53SA7

UniProtKB/TrEMBL

B2R9S4, V9HW69

Conserved Domains (3) summary

cd11289
Location:137 → 225

gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins

cd11290
Location:17 → 120

gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins

cd11292
Location:251 → 346

gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
NM_001320734.2 → NP_001307663.1 macrophage-capping protein isoform 3

Status: REVIEWED

Description

Transcript Variant: This variant (6) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.

Source sequence(s)

AK130130, BU172582, FJ224312

UniProtKB/TrEMBL

B2R9S4

Conserved Domains (3) summary

cd11289
Location:137 → 223

gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins

cd11290
Location:17 → 120

gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins

cd11292
Location:221 → 315

gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
NM_001747.4 → NP_001738.2 macrophage-capping protein isoform 1

See identical proteins and their annotated locations for NP_001738.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Variants 1, 2, 4, and 5 all encode the same isoform (1).

Source sequence(s)

AK130130, BU626913

Consensus CDS

CCDS1974.1

UniProtKB/Swiss-Prot

B8ZZS7, D6W5K8, P40121, Q53SA7

UniProtKB/TrEMBL

B2R9S4, V9HW69

Related

ENSP00000263867.4, ENST00000263867.9

Conserved Domains (3) summary

cd11289
Location:137 → 225

gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins

cd11290
Location:17 → 120

gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins

cd11292
Location:251 → 346

gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000002.12 Reference GRCh38.p14 Primary Assembly

Range

85391602..85419540 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047445951.1 → XP_047301907.1 macrophage-capping protein isoform X1
XM_047445948.1 → XP_047301904.1 macrophage-capping protein isoform X1
XM_047445950.1 → XP_047301906.1 macrophage-capping protein isoform X1
XM_047445947.1 → XP_047301903.1 macrophage-capping protein isoform X1
XM_047445949.1 → XP_047301905.1 macrophage-capping protein isoform X1
XM_047445952.1 → XP_047301908.1 macrophage-capping protein isoform X1
XM_047445953.1 → XP_047301909.1 macrophage-capping protein isoform X2

UniProtKB/Swiss-Prot

B8ZZS7, D6W5K8, P40121, Q53SA7

UniProtKB/TrEMBL

V9HW69
XM_011533122.2 → XP_011531424.1 macrophage-capping protein isoform X2

See identical proteins and their annotated locations for XP_011531424.1

UniProtKB/Swiss-Prot

B8ZZS7, D6W5K8, P40121, Q53SA7

UniProtKB/TrEMBL

B2R9S4, V9HW69

Conserved Domains (3) summary

cd11289
Location:137 → 225

gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins

cd11290
Location:17 → 120

gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins

cd11292
Location:251 → 346

gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
XM_011533123.2 → XP_011531425.1 macrophage-capping protein isoform X2

See identical proteins and their annotated locations for XP_011531425.1

UniProtKB/Swiss-Prot

B8ZZS7, D6W5K8, P40121, Q53SA7

UniProtKB/TrEMBL

B2R9S4, V9HW69

Conserved Domains (3) summary

cd11289
Location:137 → 225

gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins

cd11290
Location:17 → 120

gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins

cd11292
Location:251 → 346

gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
XM_047445954.1 → XP_047301910.1 macrophage-capping protein isoform X2

UniProtKB/Swiss-Prot

B8ZZS7, D6W5K8, P40121, Q53SA7

UniProtKB/TrEMBL

V9HW69