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    NOL10 nucleolar protein 10 [ Homo sapiens (human) ]

    Gene ID: 79954, updated on 3-Apr-2024

    Summary

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    Official Symbol
    NOL10provided by HGNC
    Official Full Name
    nucleolar protein 10provided by HGNC
    Primary source
    HGNC:HGNC:25862
    See related
    Ensembl:ENSG00000115761 MIM:616197; AllianceGenome:HGNC:25862
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PQBP5
    Summary
    Enables RNA binding activity. Predicted to be involved in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Located in nucleolus. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis (RPKM 4.5), adrenal (RPKM 4.0) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    2p25.1
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (10570754..10689975, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (10600793..10720003, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (10710880..10830101, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:10600271-10600772 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:10600773-10601272 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:10606558-10607058 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:10607059-10607559 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:10609230-10609744 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:10609745-10610259 Neighboring gene ODC1 divergent transcript Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:10616917-10617620 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:10617621-10618324 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:10618316-10618506 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:10627262-10627772 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:10627773-10628281 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15305 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15306 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15307 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15308 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:10637679-10638211 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:10662988-10663488 Neighboring gene uncharacterized LOC105373426 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:10679827-10680338 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:10686337-10687208 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr2:10687298-10688497 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:10690693-10691562 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr2:10715723-10716922 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:10729319-10730518 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr2:10794082-10795281 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15309 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15310 Neighboring gene RNA, 7SL, cytoplasmic 832, pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr2:10877794-10877974 Neighboring gene ATPase H+ transporting V1 subunit C2 Neighboring gene RNA, U7 small nuclear 138 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. PQBP5/NOL10 maintains and anchors the nucleolus under physiological and osmotic stress conditions. Jin X, et al. Nat Commun, 2023 Jan 4. PMID 36599853, Free PMC Article
    2. Human AATF/Che-1 forms a nucleolar protein complex with NGDN and NOL10 required for 40S ribosomal subunit synthesis. Bammert L, et al. Nucleic Acids Res, 2016 Nov 16. PMID 27599843, Free PMC Article
    3. Polar amino acid-rich sequences bind to polyglutamine tracts. Imafuku I, et al. Biochem Biophys Res Commun, 1998 Dec 9. PMID 9875212
    4. A meta-analysis of 87,040 individuals identifies 23 new susceptibility loci for prostate cancer. Al Olama AA, et al. Nat Genet, 2014 Oct. PMID 25217961, Free PMC Article
    5. PHGDH Inhibits Ferroptosis and Promotes Malignant Progression by Upregulating SLC7A11 in Bladder Cancer. Shen L, et al. Int J Biol Sci, 2022. PMID 36147463, Free PMC Article

    See all (71) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PQBP5/NOL10 maintains and anchors the nucleolus under physiological and osmotic stress conditions.
      Title: PQBP5/NOL10 maintains and anchors the nucleolus under physiological and osmotic stress conditions.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    A meta-analysis of 87,040 individuals identifies 23 new susceptibility loci for prostate cancer.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ13938, FLJ14075

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    Process Evidence Code Pubs
    involved_in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		  
    part_of small-subunit processome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    nucleolar protein 10
    Names
    H_NH0074G24.1
    polyglutamine binding protein 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001261392.2 → NP_001248321.1  nucleolar protein 10 isoform 2

      See identical proteins and their annotated locations for NP_001248321.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting protein (isoform 2) is shorter compared to isoform 1.
      Source sequence(s)
      AC007314, AC092687
      Consensus CDS
      CCDS58697.1
      UniProtKB/TrEMBL
      A0A8Q3SHX7
      Related
      ENSP00000439663.1, ENST00000538384.5
      Conserved Domains (4) summary
      sd00039
      Location:154 → 189
      7WD40; WD40 repeat [structural motif]
      pfam08159
      Location:456 → 482
      NUC153; NUC153 domain
      cl25539
      Location:156 → 313
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      cl26511
      Location:381 → 642
      Neuromodulin_N; Gap junction protein N-terminal region

    2. NM_001261394.2 → NP_001248323.1  nucleolar protein 10 isoform 3

      See identical proteins and their annotated locations for NP_001248323.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon compared to variant 1. The resulting protein (isoform 3) is shorter compared to isoform 1.
      Source sequence(s)
      AC007314, AC092687
      Consensus CDS
      CCDS58698.1
      UniProtKB/TrEMBL
      A0A8Q3SHW5
      Related
      ENSP00000263837.4, ENST00000345985.7
      Conserved Domains (2) summary
      pfam08159
      Location:432 → 458
      NUC153; NUC153 domain
      cl26511
      Location:357 → 618
      Neuromodulin_N; Gap junction protein N-terminal region

    3. NM_024894.4 → NP_079170.2  nucleolar protein 10 isoform 1

      See identical proteins and their annotated locations for NP_079170.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest protein (isoform 1).
      Source sequence(s)
      AC007314, AC092687
      Consensus CDS
      CCDS1673.2
      UniProtKB/Swiss-Prot
      A8K3R5, B4DLV0, Q53RC9, Q96TA5, Q9BSC4, Q9H7Y7, Q9H855
      UniProtKB/TrEMBL
      A0A8Q3SHX7
      Related
      ENSP00000371101.5, ENST00000381685.10
      Conserved Domains (4) summary
      COG2319
      Location:24 → 312
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:55 → 95
      7WD40; WD40 repeat [structural motif]
      pfam08159
      Location:482 → 508
      NUC153; NUC153 domain
      cl26511
      Location:407 → 668
      Neuromodulin_N; Gap junction protein N-terminal region

    RNA

    1. NR_048552.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks an alternate 5' exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC007314, AC092687

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      10570754..10689975 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047445893.1 → XP_047301849.1  nucleolar protein 10 isoform X1

    2. XM_047445899.1 → XP_047301855.1  nucleolar protein 10 isoform X2

    3. XM_047445897.1 → XP_047301853.1  nucleolar protein 10 isoform X2

    4. XM_047445902.1 → XP_047301858.1  nucleolar protein 10 isoform X5

      Related
      ENSP00000511949.1, ENST00000695472.1

    5. XM_011510400.3 → XP_011508702.1  nucleolar protein 10 isoform X3

      UniProtKB/TrEMBL
      A0A8Q3SHZ5
      Related
      ENST00000695479.1
      Conserved Domains (3) summary
      COG2319
      Location:24 → 312
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:55 → 95
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:182 → 339
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    6. XM_011510402.3 → XP_011508704.1  nucleolar protein 10 isoform X4

      UniProtKB/TrEMBL
      A0A8Q3SHZ5
      Conserved Domains (3) summary
      COG2319
      Location:24 → 312
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:55 → 95
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:182 → 339
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    7. XM_024453153.2 → XP_024308921.1  nucleolar protein 10 isoform X5

      UniProtKB/TrEMBL
      A0A8Q3SHT2
      Conserved Domains (2) summary
      COG2319
      Location:24 → 302
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:55 → 95
      7WD40; WD40 repeat [structural motif]

    RNA

    1. XR_007082254.1 RNA Sequence

    2. XR_007082293.1 RNA Sequence

    3. XR_001738958.2 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      10600793..10720003 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054343998.1 → XP_054199973.1  nucleolar protein 10 isoform X1

    2. XM_054344000.1 → XP_054199975.1  nucleolar protein 10 isoform X2

    3. XM_054343999.1 → XP_054199974.1  nucleolar protein 10 isoform X2

    4. XM_054344003.1 → XP_054199978.1  nucleolar protein 10 isoform X5

    5. XM_054344001.1 → XP_054199976.1  nucleolar protein 10 isoform X3

    6. XM_054344002.1 → XP_054199977.1  nucleolar protein 10 isoform X4

    7. XM_054344004.1 → XP_054199979.1  nucleolar protein 10 isoform X5

    RNA

    1. XR_008486525.1 RNA Sequence

    2. XR_008486526.1 RNA Sequence

    3. XR_008486524.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9BSC4.1 GenPept UniProtKB/Swiss-Prot:Q9BSC4

    Gene LinkOut

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