CYP2S1 cytochrome P450 family 2 subfamily S member 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: CYP2S1provided by HGNC
Official Full Name: cytochrome P450 family 2 subfamily S member 1provided by HGNC
Primary source: HGNC:HGNC:15654
See related: Ensembl:ENSG00000167600 MIM:611529; AllianceGenome:HGNC:15654
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CYPIIS1
Summary: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. In rodents, the homologous protein has been shown to metabolize certain carcinogens; however, the specific function of the human protein has not been determined. [provided by RefSeq, Jul 2008]
Expression: Biased expression in stomach (RPKM 58.7), duodenum (RPKM 46.6) and 7 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 19q13.2

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	19	NC_000019.10 (41193219..41207539)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	19	NC_060943.1 (44013177..44028420)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	19	NC_000019.9 (41699124..41713444)

Chromosome 19 - NC_000019.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CYP2S1 and CYP2W1 expression is associated with patient survival in breast cancer.
Title: CYP2S1 and CYP2W1 expression is associated with patient survival in breast cancer.
CYP2S1 rs338599 polymorphism confers reduced risk to anti-tuberculosis drug-induced liver injury and may be a novel marker for its risk prediction.
Title: CYP2S1 rs338599 polymorphism confers reduced risk to anti-tuberculosis drug-induced liver injury and may be a novel marker for its risk prediction.
Knockdown CYP2S1 inhibits lung cancer cells proliferation and migration.
Title: Knockdown CYP2S1 inhibits lung cancer cells proliferation and migration.
CYP2S1 might regulate proliferation and immune response of keratinocyte in psoriasis.
Title: CYP2S1 might regulate proliferation and immune response of keratinocyte in psoriasis.
CYP2S1 is a synthetic lethal target in BRAF(V600E)-driven thyroid cancers.
Title: CYP2S1 is a synthetic lethal target in BRAF(V600E)-driven thyroid cancers.
Hypoxia as a modulator of cytochromes P450: Overexpression of the cytochromes CYP2S1 and CYP24A1 in human liver cancer cells in hypoxia.
Title: Hypoxia as a modulator of cytochromes P450: Overexpression of the cytochromes CYP2S1 and CYP24A1 in human liver cancer cells in hypoxia.
PPARalpha plays an important role in the migration activity, and the expression of CYP2S1 and CYP1B1 in chrysin-treated HCT116 cells.
Title: PPARα plays an important role in the migration activity, and the expression of CYP2S1 and CYP1B1 in chrysin-treated HCT116 cells.
There were 21 genetic variants identified in CYP2S1 in three Chinese populations: Han, Tibetan and Uighur.
Title: Genetic polymorphisms of CYP2S1, CYP2J2 and CYP2R1 genes in three Chinese populations: Han, Tibetan and Uighur.
Biotransformation of (+)-fenchone by Salmonella typhimurium OY1002/2A6 expressing human CYP2A6 and NADPH-P450 reductase.
Title: Biotransformation of (+)-fenchone by Salmonella typhimurium OY1002/2A6 expressing human CYP2A6 and NADPH-P450 reductase.
These results suggest that oxaliplatin exerts its inhibitory effects in human CRC cells via upregulation of CYP2S1 expression in a p53-dependent manner.
Title: Upregulation of CYP2S1 by oxaliplatin is associated with p53 status in colorectal cancer cell lines.

Submit: New GeneRIF Correction See all GeneRIFs (25)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

CYP2S1_2466 (e-PCR)
- UniSTS:471410

RH92207 (e-PCR)
- UniSTS:88435

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables 12-hydroxyheptadecatrienoic acid synthase activity	IEA Inferred from Electronic Annotation more info
enables arachidonic acid epoxygenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables heme binding	IBA Inferred from Biological aspect of Ancestor more info
enables hydro-lyase activity	IDA Inferred from Direct Assay more info	PubMed
enables hydroperoxy icosatetraenoate dehydratase activity	IEA Inferred from Electronic Annotation more info
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables monooxygenase activity	IDA Inferred from Direct Assay more info	PubMed
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables retinoic acid 4-hydroxylase activity	TAS Traceable Author Statement more info
enables thromboxane-A synthase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in cytochrome metabolic process	TAS Traceable Author Statement more info
involved_in epoxygenase P450 pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in icosanoid metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in prostaglandin metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in retinoic acid metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in xenobiotic metabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info
located_in endoplasmic reticulum membrane	TAS Traceable Author Statement more info
is_active_in intracellular membrane-bounded organelle	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: cytochrome P450 2S1

Names: cytochrome P450, family 2, subfamily S, polypeptide 1; cytochrome P540, subfamily IIS, polypeptide 1; hydroperoxy icosatetraenoate dehydratase; thromboxane-A synthase

NP_085125.1

EC 4.2.1.152

EC 5.3.99.5

XP_047294667.1

EC 4.2.1.152

EC 5.3.99.5

XP_054176735.1

EC 4.2.1.152

EC 5.3.99.5

XP_054176736.1

EC 4.2.1.152

EC 5.3.99.5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.