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    ZNF233 zinc finger protein 233 [ Homo sapiens (human) ]

    Gene ID: 353355, updated on 3-Apr-2024

    Summary

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    Official Symbol
    ZNF233provided by HGNC
    Official Full Name
    zinc finger protein 233provided by HGNC
    Primary source
    HGNC:HGNC:30946
    See related
    Ensembl:ENSG00000159915 AllianceGenome:HGNC:30946
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in testis (RPKM 6.0), brain (RPKM 0.9) and 6 other tissues See more
    Orthologs
    all
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    Genomic context

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    Location:
    19q13.31
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (44259886..44275317)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (47082752..47098164)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (44764039..44779470)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14757 Neighboring gene zinc finger protein 226 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14758 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14759 Neighboring gene zinc finger protein 227 Neighboring gene uncharacterized LOC124904726 Neighboring gene zinc finger protein 235 Neighboring gene mitochondrial ribosomal protein S15 pseudogene 2 Neighboring gene NADH:ubiquinone oxidoreductase subunit A3 pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Knockdown of ZNF233 suppresses hepatocellular carcinoma cell proliferation and tumorigenesis. Xie W, et al. Gene, 2018 Dec 30. PMID 30179682
    2. Differential expansion of zinc-finger transcription factor loci in homologous human and mouse gene clusters. Shannon M, et al. Genome Res, 2003 Jun. PMID 12743021, Free PMC Article
    3. Comparison of an expanded ataxia interactome with patient medical records reveals a relationship between macular degeneration and ataxia. Kahle JJ, et al. Hum Mol Genet, 2011 Feb 1. PMID 21078624, Free PMC Article
    4. Cullin 3 Exon 9 Deletion in Familial Hyperkalemic Hypertension Impairs Cullin3-Ring-E3 Ligase (CRL3) Dynamic Regulation and Cycling. Kouranti I, et al. Int J Mol Sci, 2022 May 5. PMID 35563538, Free PMC Article
    5. Toward a confocal subcellular atlas of the human proteome. Barbe L, et al. Mol Cell Proteomics, 2008 Mar. PMID 18029348

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ38032

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 233

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001207005.2 → NP_001193934.1  zinc finger protein 233 isoform 1

      See identical proteins and their annotated locations for NP_001193934.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has a different 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein (isoform 1).
      Source sequence(s)
      AK055310, BC136734, CR743367, DB071795
      Consensus CDS
      CCDS33047.1
      UniProtKB/Swiss-Prot
      A6NK53, B2RN78, B2RN79, Q86WL8
      Related
      ENSP00000507588.1, ENST00000683810.1
      Conserved Domains (4) summary
      smart00349
      Location:8 → 66
      KRAB; krueppel associated box
      COG5048
      Location:450 → 599
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:566 → 586
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:634 → 657
      zf-H2C2_2; Zinc-finger double domain

    2. NM_001330529.2 → NP_001317458.1  zinc finger protein 233 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) has a different 5' UTR and uses an alternate splice site which results in a frameshift, compared to variant 1. The enocoded isoform (2) is shorter and has a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC138470, AK055310, CR743367
      Consensus CDS
      CCDS82363.1
      UniProtKB/TrEMBL
      K7ER86
      Related
      ENSP00000468154.1, ENST00000592581.5

    3. NM_181756.3 → NP_861421.2  zinc finger protein 233 isoform 1

      See identical proteins and their annotated locations for NP_861421.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein (isoform 1).
      Source sequence(s)
      AC138470, AK095351, BC136734, CR743367, DA393180
      Consensus CDS
      CCDS33047.1
      UniProtKB/Swiss-Prot
      A6NK53, B2RN78, B2RN79, Q86WL8
      Related
      ENSP00000375820.1, ENST00000391958.6
      Conserved Domains (4) summary
      smart00349
      Location:8 → 66
      KRAB; krueppel associated box
      COG5048
      Location:450 → 599
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:566 → 586
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:634 → 657
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      44259886..44275317
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017026758.3 → XP_016882247.1  zinc finger protein 233 isoform X4

    2. XM_024451488.2 → XP_024307256.1  zinc finger protein 233 isoform X1

      Conserved Domains (5) summary
      smart00349
      Location:65 → 123
      KRAB; krueppel associated box
      COG5048
      Location:507 → 656
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:623 → 643
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:677 → 699
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:691 → 714
      zf-H2C2_2; Zinc-finger double domain

    3. XM_017026760.3 → XP_016882249.1  zinc finger protein 233 isoform X6

      UniProtKB/TrEMBL
      K7ER86

    4. XM_047438766.1 → XP_047294722.1  zinc finger protein 233 isoform X3

    5. XM_017026761.2 → XP_016882250.1  zinc finger protein 233 isoform X5

      UniProtKB/TrEMBL
      K7EJE5
      Related
      ENSP00000465136.1, ENST00000588489.5

    6. XM_024451489.2 → XP_024307257.1  zinc finger protein 233 isoform X2

      UniProtKB/Swiss-Prot
      A6NK53, B2RN78, B2RN79, Q86WL8
      Conserved Domains (4) summary
      smart00349
      Location:8 → 66
      KRAB; krueppel associated box
      COG5048
      Location:450 → 599
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:566 → 586
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:634 → 657
      zf-H2C2_2; Zinc-finger double domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      47082752..47098164
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054320867.1 → XP_054176842.1  zinc finger protein 233 isoform X6

      UniProtKB/TrEMBL
      K7ER86

    2. XM_054320861.1 → XP_054176836.1  zinc finger protein 233 isoform X8

    3. XM_054320860.1 → XP_054176835.1  zinc finger protein 233 isoform X8

    4. XM_054320865.1 → XP_054176840.1  zinc finger protein 233 isoform X9

    5. XM_054320859.1 → XP_054176834.1  zinc finger protein 233 isoform X7

    6. XM_054320864.1 → XP_054176839.1  zinc finger protein 233 isoform X4

    7. XM_054320866.1 → XP_054176841.1  zinc finger protein 233 isoform X5

    8. XM_054320863.1 → XP_054176838.1  zinc finger protein 233 isoform X3

    9. XM_054320862.1 → XP_054176837.1  zinc finger protein 233 isoform X8

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A6NK53.3 GenPept UniProtKB/Swiss-Prot:A6NK53

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