EIF4G1 eukaryotic translation initiation factor 4 gamma 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: EIF4G1provided by HGNC
Official Full Name: eukaryotic translation initiation factor 4 gamma 1provided by HGNC
Primary source: HGNC:HGNC:3296
See related: Ensembl:ENSG00000114867 MIM:600495; AllianceGenome:HGNC:3296
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: P220; EIF4F; EIF4G; EIF4GI; PARK18; EIF-4G1
Summary: The protein encoded by this gene is a component of the multi-subunit protein complex EIF4F. This complex facilitates the recruitment of mRNA to the ribosome, which is a rate-limiting step during the initiation phase of protein synthesis. The recognition of the mRNA cap and the ATP-dependent unwinding of 5'-terminal secondary structure is catalyzed by factors in this complex. The subunit encoded by this gene is a large scaffolding protein that contains binding sites for other members of the EIF4F complex. A domain at its N-terminus can also interact with the poly(A)-binding protein, which may mediate the circularization of mRNA during translation. Alternative splicing results in multiple transcript variants, some of which are derived from alternative promoter usage. [provided by RefSeq, Aug 2010]
Expression: Ubiquitous expression in esophagus (RPKM 48.2), skin (RPKM 39.4) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 3q27.1

Exon count:: 34

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	3	NC_000003.12 (184314606..184335358)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	3	NC_060927.1 (187123882..187144618)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	3	NC_000003.11 (184032394..184053146)

Chromosome 3 - NC_000003.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Insulin Receptor and Insulin like Growth Factor Receptor 5' UTRs Support Translation Initiation Independently of EIF4G1.
Title: The Insulin Receptor and Insulin like Growth Factor Receptor 5' UTRs Support Translation Initiation Independently of EIF4G1.
Computational inference of eIF4F complex function and structure in human cancers.
Title: Computational inference of eIF4F complex function and structure in human cancers.
Thermodynamically Favorable Interactions between eIF4E Binding Domain of eIF4GI with Structured 5'-Untranslated Regions Drive Cap-Independent Translation of Selected mRNAs.
Title: Thermodynamically Favorable Interactions between eIF4E Binding Domain of eIF4GI with Structured 5'-Untranslated Regions Drive Cap-Independent Translation of Selected mRNAs.
Prognostic and functional roles of EIF4G1 in lung squamous cell carcinoma.
Title: Prognostic and functional roles of EIF4G1 in lung squamous cell carcinoma.
EIF4G1 Is a Potential Prognostic Biomarker of Breast Cancer.
Title: EIF4G1 Is a Potential Prognostic Biomarker of Breast Cancer.
Inhibitors of eIF4G1-eIF1 uncover its regulatory role of ER/UPR stress-response genes independent of eIF2alpha-phosphorylation.
Title: Inhibitors of eIF4G1-eIF1 uncover its regulatory role of ER/UPR stress-response genes independent of eIF2α-phosphorylation.
Phosphorylation of Eukaryotic Initiation Factor 4G1 (eIF4G1) at Ser1147 Is Specific for eIF4G1 Bound to eIF4E in Delayed Neuronal Death after Ischemia.
Title: Phosphorylation of Eukaryotic Initiation Factor 4G1 (eIF4G1) at Ser1147 Is Specific for eIF4G1 Bound to eIF4E in Delayed Neuronal Death after Ischemia.
Association study of DNAJC13, UCHL1, HTRA2, GIGYF2, and EIF4G1 with Parkinson's disease.
Title: Association study of DNAJC13, UCHL1, HTRA2, GIGYF2, and EIF4G1 with Parkinson's disease.
Role of EIF4G1 network in non-small cell lung cancers (NSCLC) cell survival and disease progression.
Title: Role of EIF4G1 network in non-small cell lung cancers (NSCLC) cell survival and disease progression.
Elevation of EIF4G1 promotes non-small cell lung cancer progression by activating mTOR signalling.
Title: Elevation of EIF4G1 promotes non-small cell lung cancer progression by activating mTOR signalling.

Submit: New GeneRIF Correction See all GeneRIFs (119)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Parkinson disease 18, autosomal dominant, susceptibility to MedGen: C3280271 OMIM: 614251 GeneReviews: Not available	Compare labs

EBI GWAS Catalog

Description
Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction	Pubs
HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of EIF4G1	PubMed

Protein interactions

Protein	Gene	Interaction	Pubs
Pr55(Gag)	gag	Cellular biotinylated eukaryotic translation initiation factor 4 gamma, 1 (EIF4G1) protein is incorporated into HIV-1 Gag virus-like particles	PubMed
	gag	The initiation factor eIF4G is required for the synthesis of the Gag polyprotein by a classical cap-dependent mechanism	PubMed
Tat	tat	HIV-1 Tat co-localizes with eIF4G in cytoplasmic stress granules under stress conditions	PubMed
retropepsin	gag-pol	Purified HIV-1 protease cleaves eIF4GI at positions 678, 681, and 1086 leading to inhibition of protein synthesis directed by capped mRNAs	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

EIF4G1_3109 (e-PCR)
- UniSTS:462180

RH68199 (e-PCR)
- UniSTS:33666

GDB:593083 (e-PCR)
- UniSTS:157934

GDB:593094 (e-PCR)
- UniSTS:157935

D3S3609 (e-PCR)
- UniSTS:14067

RH79680 (e-PCR)
- UniSTS:84472

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ATP binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA binding	HDA more info	PubMed
enables RNA binding	TAS Traceable Author Statement more info	PubMed
enables eukaryotic initiation factor 4E binding	IDA Inferred from Direct Assay more info	PubMed
enables eukaryotic initiation factor 4E binding	TAS Traceable Author Statement more info	PubMed
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables mRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables molecular adaptor activity	TAS Traceable Author Statement more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables translation factor activity, RNA binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables translation initiation factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables translation initiation factor activity	IDA Inferred from Direct Assay more info	PubMed
enables translation initiation factor activity	TAS Traceable Author Statement more info	PubMed
enables translation initiation factor binding	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in behavioral fear response	IEA Inferred from Electronic Annotation more info
involved_in cap-dependent translational initiation	TAS Traceable Author Statement more info	PubMed
involved_in cellular response to nutrient levels	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in energy homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lung development	IEA Inferred from Electronic Annotation more info
involved_in macromolecule biosynthetic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in miRNA-mediated gene silencing by inhibition of translation	IDA Inferred from Direct Assay more info	PubMed
involved_in miRNA-mediated gene silencing by inhibition of translation	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of autophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of peptidyl-threonine phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron differentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of G1/S transition of mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of eukaryotic translation initiation factor 4F complex assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of eukaryotic translation initiation factor 4F complex assembly	IPI Inferred from Physical Interaction more info	PubMed
involved_in positive regulation of mRNA cap binding	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of neuron differentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of peptidyl-serine phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein localization to cell periphery	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of protein metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of translation in response to endoplasmic reticulum stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cellular response to stress	TAS Traceable Author Statement more info	PubMed
involved_in regulation of presynapse assembly	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of translational initiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of translational initiation	NAS Non-traceable Author Statement more info	PubMed
involved_in response to ethanol	IEA Inferred from Electronic Annotation more info
involved_in translation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in translation	IPI Inferred from Physical Interaction more info	PubMed
involved_in translational initiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in translational initiation	IDA Inferred from Direct Assay more info	PubMed
involved_in translational initiation	NAS Non-traceable Author Statement more info	PubMed
involved_in translational initiation	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IMP Inferred from Mutant Phenotype more info	PubMed
located_in cytoplasmic stress granule	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info
located_in cytosol	TAS Traceable Author Statement more info
part_of eukaryotic translation initiation factor 4F complex	IBA Inferred from Biological aspect of Ancestor more info
part_of eukaryotic translation initiation factor 4F complex	IDA Inferred from Direct Assay more info	PubMed
part_of eukaryotic translation initiation factor 4F complex	NAS Non-traceable Author Statement more info	PubMed
located_in membrane	HDA more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
located_in postsynapse	IEA Inferred from Electronic Annotation more info
located_in ribosome	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: eukaryotic translation initiation factor 4 gamma 1

Names: EIF4-gamma; eIF-4-gamma 1; eucaryotic translation initiation factor 4G

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_016850.2 RefSeqGene

Range

5002..25749

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001194946.2 → NP_001181875.2 eukaryotic translation initiation factor 4 gamma 1 isoform 6

Status: REVIEWED

Description

Transcript Variant: This variant (6) differs in the 5' UTR, includes an additional in-frame exon in the 5' coding region, and uses an alternate in-frame splice site in the central coding region, compared to variant 1. The resulting isoform (6) is longer than isoform 1. Both variants 6 and 7 encode the same isoform.

Source sequence(s)

AC078797

Consensus CDS

CCDS54687.1

UniProtKB/TrEMBL

B2RU10

Related

ENSP00000371767.3, ENST00000382330.7

Conserved Domains (4) summary

cd11559
Location:1445 → 1577

W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins

PHA03247
Location:21 → 583

PHA03247; large tegument protein UL36; Provisional

pfam02847
Location:1249 → 1361

MA3; MA3 domain

pfam02854
Location:768 → 993

MIF4G; MIF4G domain
NM_001194947.2 → NP_001181876.2 eukaryotic translation initiation factor 4 gamma 1 isoform 6

Status: REVIEWED

Description

Transcript Variant: This variant (7) differs in the 5' UTR, includes an additional in-frame exon in the 5' coding region, and uses an alternate in-frame splice site in the central coding region, compared to variant 1. The resulting isoform (6) is longer than isoform 1. Both variants 6 and 7 encode the same isoform.

Source sequence(s)

AC078797

Consensus CDS

CCDS54687.1

UniProtKB/TrEMBL

B2RU10

Related

ENSP00000338020.4, ENST00000352767.7

Conserved Domains (4) summary

cd11559
Location:1445 → 1577

W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins

PHA03247
Location:21 → 583

PHA03247; large tegument protein UL36; Provisional

pfam02847
Location:1249 → 1361

MA3; MA3 domain

pfam02854
Location:768 → 993

MIF4G; MIF4G domain
NM_001291157.2 → NP_001278086.2 eukaryotic translation initiation factor 4 gamma 1 isoform 7

Status: REVIEWED

Description

Transcript Variant: This variant (8) differs in the 5' UTR, includes an additional internal segment in the 5' region, which results in a downstream start codon, and uses an alternate in-frame splice site in the central coding region, compared to variant 1. The resulting isoform (7) is shorter at the N-terminus, and lacks an internal residue, compared to isoform 1.

Source sequence(s)

AC078797

Consensus CDS

CCDS77866.1

UniProtKB/TrEMBL

E7EUU4

Related

ENSP00000391935.1, ENST00000414031.5

Conserved Domains (4) summary

cd11559
Location:1398 → 1530

W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins

PHA03247
Location:13 → 536

PHA03247; large tegument protein UL36; Provisional

pfam02847
Location:1202 → 1314

MA3; MA3 domain

pfam02854
Location:721 → 949

MIF4G; MIF4G domain
NM_004953.5 → NP_004944.3 eukaryotic translation initiation factor 4 gamma 1 isoform 4

See identical proteins and their annotated locations for NP_004944.3

Status: REVIEWED

Description

Transcript Variant: This variant (5) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream start codon, compared to variant 1. The resulting isoform (4) is shorter at the N-terminus, compared to isoform 1.

Source sequence(s)

AC078797, BQ011010

Consensus CDS

CCDS46970.2

UniProtKB/TrEMBL

E7EX73

Related

ENSP00000411826.2, ENST00000434061.6

Conserved Domains (4) summary

cd11559
Location:1243 → 1375

W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins

pfam02847
Location:1047 → 1159

MA3; MA3 domain

pfam02854
Location:566 → 791

MIF4G; MIF4G domain

pfam08648
Location:952 → 1053

DUF1777; Protein of unknown function (DUF1777)
NM_182917.4 → NP_886553.3 eukaryotic translation initiation factor 4 gamma 1 isoform 1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1.

Source sequence(s)

AF002815, AK308319, AY082886, BQ011010, DC347118

Consensus CDS

CCDS54688.1

UniProtKB/TrEMBL

B2RU10

Related

ENSP00000343450.4, ENST00000342981.8

Conserved Domains (4) summary

cd11559
Location:1439 → 1571

W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins

pfam02847
Location:1243 → 1355

MA3; MA3 domain

pfam02854
Location:762 → 987

MIF4G; MIF4G domain

pfam08648
Location:1148 → 1249

DUF1777; Protein of unknown function (DUF1777)
NM_198241.3 → NP_937884.2 eukaryotic translation initiation factor 4 gamma 1 isoform 5

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate in-frame splice site in the central coding region, compared to variant 1, resulting in an isoform (5) that is 1 aa shorter than isoform 1.

Source sequence(s)

AC078797

Consensus CDS

CCDS3259.1

UniProtKB/Swiss-Prot

D3DNT2, D3DNT4, D3DNT5, E9PFM1, G5E9S1, O43177, O95066, Q04637, Q5HYG0, Q6ZN21, Q8N102

UniProtKB/TrEMBL

B2RU10

Related

ENSP00000316879.5, ENST00000346169.7

Conserved Domains (5) summary

cd11559
Location:1438 → 1570

W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins

PHA03247
Location:20 → 452

PHA03247; large tegument protein UL36; Provisional

PRK12323
Location:405 → 573

PRK12323; DNA polymerase III subunit gamma/tau

pfam02847
Location:1242 → 1354

MA3; MA3 domain

pfam02854
Location:761 → 986

MIF4G; MIF4G domain
NM_198242.3 → NP_937885.1 eukaryotic translation initiation factor 4 gamma 1 isoform 3

See identical proteins and their annotated locations for NP_937885.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, uses a downstream start codon, and uses an alternate in-frame splice site in the central coding region, compared to variant 1. The resulting isoform (3) is shorter at the N-terminus and lacks an internal residue, compared to isoform 1.

Source sequence(s)

AC078797

Consensus CDS

CCDS3261.1

UniProtKB/TrEMBL

E7EX73

Related

ENSP00000317600.8, ENST00000350481.9

Conserved Domains (4) summary

cd11559
Location:1274 → 1406

W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins

pfam02847
Location:1078 → 1190

MA3; MA3 domain

pfam02854
Location:597 → 822

MIF4G; MIF4G domain

pfam08648
Location:983 → 1084

DUF1777; Protein of unknown function (DUF1777)
NM_198244.3 → NP_937887.2 eukaryotic translation initiation factor 4 gamma 1 isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, uses a downstream start codon, and uses an alternate in-frame splice site in the central coding region, compared to variant 1. The resulting isoform (2) is shorter at the N-terminus and lacks an internal residue, compared to isoform 1.

Source sequence(s)

AC078797

Consensus CDS

CCDS3260.1

UniProtKB/TrEMBL

E9PGM1

Related

ENSP00000376320.2, ENST00000392537.6

Conserved Domains (4) summary

cd11559
Location:1351 → 1483

W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins

PHA03247
Location:28 → 489

PHA03247; large tegument protein UL36; Provisional

pfam02847
Location:1155 → 1267

MA3; MA3 domain

pfam02854
Location:674 → 902

MIF4G; MIF4G domain