Vav1 vav guanine nucleotide exchange factor 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Vav1provided by RGD
Official Full Name: vav guanine nucleotide exchange factor 1provided by RGD
Primary source: RGD:3951
See related: Ensembl:ENSRNOG00000050430 AllianceGenome:RGD:3951
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Vav
Summary: Predicted to enable guanyl-nucleotide exchange factor activity; phosphorylation-dependent protein binding activity; and phosphotyrosine residue binding activity. Involved in immune response-regulating cell surface receptor signaling pathway. Predicted to be located in cell-cell junction. Biomarker of endometriosis; hepatocellular carcinoma; lymphopenia; and type 1 diabetes mellitus. Orthologous to human VAV1 (vav guanine nucleotide exchange factor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Spleen (RPKM 181.4), Thymus (RPKM 161.6) and 6 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 9q11

Exon count:: 28

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (2248856..2295905)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (2161985..2209951)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (9617551..9675167, complement)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Klf2-Vav1-Rac1 axis promotes axon regeneration after peripheral nerve injury.
Title: Klf2-Vav1-Rac1 axis promotes axon regeneration after peripheral nerve injury.
these results highlight the importance of the signaling pathway involving epistasis between Themis1 and Vav1 in the control of Treg suppressive function and susceptibility to IBD development.
Title: An Epistatic Interaction between Themis1 and Vav1 Modulates Regulatory T Cell Function and Inflammatory Bowel Disease Development.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH94621 (e-PCR)
- UniSTS:119869

MARC_12285-12286:1005663674:1 (e-PCR)
- UniSTS:267396

MARC_12285-12286:1008002533:1 (e-PCR)
- UniSTS:267396

RH141231 (e-PCR)
- UniSTS:223227

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables guanyl-nucleotide exchange factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables guanyl-nucleotide exchange factor activity	IEA Inferred from Electronic Annotation more info
enables guanyl-nucleotide exchange factor activity	ISO Inferred from Sequence Orthology more info
enables guanyl-nucleotide exchange factor activity	TAS Traceable Author Statement more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables phosphorylation-dependent protein binding	IEA Inferred from Electronic Annotation more info
enables phosphorylation-dependent protein binding	ISO Inferred from Sequence Orthology more info
enables phosphotyrosine residue binding	IEA Inferred from Electronic Annotation more info
enables phosphotyrosine residue binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within T cell activation	ISO Inferred from Sequence Orthology more info
involved_in T cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within T cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in cell development	TAS Traceable Author Statement more info	PubMed
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell surface receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in immune response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within immune response	ISO Inferred from Sequence Orthology more info
involved_in immune response-regulating cell surface receptor signaling pathway	IEP Inferred from Expression Pattern more info	PubMed
involved_in integrin-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within integrin-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within intracellular signal transduction	ISO Inferred from Sequence Orthology more info
involved_in natural killer cell mediated cytotoxicity	ISO Inferred from Sequence Orthology more info
involved_in neutrophil chemotaxis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within neutrophil chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in phagocytosis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within phagocytosis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell adhesion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of natural killer cell mediated cytotoxicity	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of natural killer cell mediated cytotoxicity	ISO Inferred from Sequence Orthology more info
involved_in reactive oxygen species metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within reactive oxygen species metabolic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cell size	IEA Inferred from Electronic Annotation more info
NOT involved_in regulation of cell size	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell size	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell-cell junction	IEA Inferred from Electronic Annotation more info
located_in cell-cell junction	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: proto-oncogene vav

Names: p95; vav 1 guanine nucleotide exchange factor; vav 1 oncogene

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012759.2 → NP_036891.2 proto-oncogene vav

See identical proteins and their annotated locations for NP_036891.2

Status: VALIDATED

Source sequence(s)

BC091160

UniProtKB/Swiss-Prot

P54100

UniProtKB/TrEMBL

A0A8I5Y9Q8, Q5BK91

Related

ENSRNOP00000077767.1, ENSRNOT00000096076.1

Conserved Domains (8) summary

cd10405
Location:663 → 765

SH2_Vav1; Src homology 2 (SH2) domain found in the Vav1 proteins

cd11976
Location:784 → 837

SH3_VAV1_2; C-terminal (or second) Src homology 3 domain of VAV1 protein

cd11979
Location:594 → 656

SH3_VAV1_1; First Src homology 3 domain of VAV1 protein

cd00160
Location:195 → 371

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd01223
Location:385 → 508

PH_Vav; Vav pleckstrin homology (PH) domain

pfam00130
Location:516 → 564

C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

pfam00169
Location:403 → 504

PH; PH domain

pfam00307
Location:2 → 115

CH; Calponin homology (CH) domain