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    GPR87 G protein-coupled receptor 87 [ Homo sapiens (human) ]

    Gene ID: 53836, updated on 5-Mar-2024

    Summary

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    Official Symbol
    GPR87provided by HGNC
    Official Full Name
    G protein-coupled receptor 87provided by HGNC
    Primary source
    HGNC:HGNC:4538
    See related
    Ensembl:ENSG00000138271 MIM:606379; AllianceGenome:HGNC:4538
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GPR95; FKSG78; KPG_002
    Summary
    This gene encodes a G protein-coupled receptor and is located in a cluster of G protein-couple receptor genes on chromosome 3. The encoded protein has been shown to be overexpressed in lung squamous cell carcinoma (PMID:18057535) and regulated by p53 (PMID:19602589). [provided by RefSeq, Nov 2011]
    Expression
    Biased expression in skin (RPKM 16.8), esophagus (RPKM 16.5) and 4 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See GPR87 in Genome Data Viewer
    Location:
    3q25.1
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (151294086..151316820, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (154045086..154067827, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (151011874..151034608, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene mediator complex subunit 12L Neighboring gene Sharpr-MPRA regulatory region 7583 Neighboring gene G protein-coupled receptor 171 Neighboring gene purinergic receptor P2Y14 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:150959259-150959858 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:150959859-150960456 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20700 Neighboring gene Sharpr-MPRA regulatory region 3159 Neighboring gene SET pseudogene 11 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr3:151033994-151035193 Neighboring gene purinergic receptor P2Y13 Neighboring gene purinergic receptor P2Y12 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20701

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Single-cell RNA sequencing identifies G-protein coupled receptor 87 as a basal cell marker expressed in distal honeycomb cysts in idiopathic pulmonary fibrosis. Heinzelmann K, et al. Eur Respir J, 2022 Jun. PMID 35604813, Free PMC Article
    2. Engineering of siRNA loaded PLGA Nano-Particles for highly efficient silencing of GPR87 gene as a target for pancreatic cancer treatment. Ceylan S, et al. Pharm Dev Technol, 2020 Sep. PMID 32188321
    3. Overexpression of G protein-coupled receptor GPR87 promotes pancreatic cancer aggressiveness and activates NF-κB signaling pathway. Wang L, et al. Mol Cancer, 2017 Mar 14. PMID 28288630, Free PMC Article
    4. Signaling via G proteins mediates tumorigenic effects of GPR87. Niss Arfelt K, et al. Cell Signal, 2017 Jan. PMID 27865873
    5. G Protein-Coupled Receptor 87 (GPR87) Promotes Cell Proliferation in Human Bladder Cancer Cells. Zhang X, et al. Int J Mol Sci, 2015 Oct 14. PMID 26473854, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Single-cell RNA sequencing identifies G-protein coupled receptor 87 as a basal cell marker expressed in distal honeycomb cysts in idiopathic pulmonary fibrosis.
      Title: Single-cell RNA sequencing identifies G-protein coupled receptor 87 as a basal cell marker expressed in distal honeycomb cysts in idiopathic pulmonary fibrosis.
    2. Engineering of siRNA loaded PLGA Nano-Particles for highly efficient silencing of GPR87 gene as a target for pancreatic cancer treatment.
      Title: Engineering of siRNA loaded PLGA Nano-Particles for highly efficient silencing of GPR87 gene as a target for pancreatic cancer treatment.
    3. the basal activity of GPR87 was investigated.
      Title: Signaling via G proteins mediates tumorigenic effects of GPR87.
    4. we reported that GPR87 expression was significantly upregulated in pancreatic cancer, and higher GPR87 correlated with shorter overall survival of patients with pancreatic cancer.
      Title: Overexpression of G protein-coupled receptor GPR87 promotes pancreatic cancer aggressiveness and activates NF-κB signaling pathway.
    5. knockdown of GPR87 led to a p53-dependent signal transduction and caused apoptosis in the bladder cancer cells.
      Title: G Protein-Coupled Receptor 87 (GPR87) Promotes Cell Proliferation in Human Bladder Cancer Cells.
    6. This study aimed to clarify the role of GPR87 in urothelial carcinoma of the bladder.
      Title: Expression and role of GPR87 in urothelial carcinoma of the bladder.
    7. GPR87 promotes the growth and metastasis of CD133(+) cancer stem-like cells, and our findings may reveal new targets for HCC prevention or therapy
      Title: G protein-coupled receptor 87 (GPR87) promotes the growth and metastasis of CD133⁺ cancer stem-like cells in hepatocellular carcinoma.
    8. GPR87 knockdown sensitized cancer cells to DNA damage-induced growth suppression via enhanced p53 stabilization and activation.
      Title: The G protein-coupled receptor 87 is necessary for p53-dependent cell survival in response to genotoxic stress.
    9. Human GPR87 mRNA transcript was preferentially overexpressed in squamous cell carcinomas. Up-regulation of both, transcript and protein, was detected in samples of SCC of the lung, cervix, skin and head and neck (pharynx, larynx and epiglottis).
      Title: hGPR87 contributes to viability of human tumor cells.
    10. Results suggest that the GPR87 is a LPA receptor which evolved from a common ancestor of P2Y receptors.
      Title: The orphan GPCR GPR87 was deorphanized and shown to be a lysophosphatidic acid receptor.
    Submit: New GeneRIF Correction See all GeneRIFs (11)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC131898

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled purinergic nucleotide receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled purinergic nucleotide receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    G-protein coupled receptor 87
    Names
    G-protein coupled receptor 95
    orphan GPCR 87

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_023915.4 → NP_076404.3  G-protein coupled receptor 87

      See identical proteins and their annotated locations for NP_076404.3

      Status: VALIDATED

      Source sequence(s)
      AF345566, BC117565, BP226924
      Consensus CDS
      CCDS3157.1
      UniProtKB/Swiss-Prot
      Q5KU35, Q96JZ8, Q9BXC2, Q9BY21
      Related
      ENSP00000260843.4, ENST00000260843.5
      Conserved Domains (1) summary
      cd15969
      Location:43 → 325
      7tmA_GPR87; G protein-coupled receptor 87, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      151294086..151316820 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      154045086..154067827 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9BY21.1 GenPept UniProtKB/Swiss-Prot:Q9BY21

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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