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    ANK2 ankyrin 2 [ Homo sapiens (human) ]

    Gene ID: 287, updated on 5-May-2024

    Summary

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    Official Symbol
    ANK2provided by HGNC
    Official Full Name
    ankyrin 2provided by HGNC
    Primary source
    HGNC:HGNC:493
    See related
    Ensembl:ENSG00000145362 MIM:106410; AllianceGenome:HGNC:493
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LQT4; ANK-2; FAP87; CFAP87; brank-2
    Summary
    This gene encodes a member of the ankyrin family of proteins that link the integral membrane proteins to the underlying spectrin-actin cytoskeleton. Ankyrins play key roles in activities such as cell motility, activation, proliferation, contact and the maintenance of specialized membrane domains. Most ankyrins are typically composed of three structural domains: an amino-terminal domain containing multiple ankyrin repeats; a central region with a highly conserved spectrin binding domain; and a carboxy-terminal regulatory domain which is the least conserved and subject to variation. The protein encoded by this gene is required for targeting and stability of Na/Ca exchanger 1 in cardiomyocytes. Mutations in this gene cause long QT syndrome 4 and cardiac arrhythmia syndrome. Multiple transcript variants encoding different isoforms have been described. [provided by RefSeq, Dec 2011]
    Expression
    Biased expression in brain (RPKM 29.6), kidney (RPKM 21.6) and 13 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    4q25-q26
    Exon count:
    61
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (112705622..113383736)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (116013980..116692458)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (113626778..114304892)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:113625759-113626458 Neighboring gene Sharpr-MPRA regulatory region 87 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:113632589-113633089 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:113639815-113640314 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:113659291-113660232 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:113660233-113661174 Neighboring gene oligosaccharyltransferase complex subunit pseudogene 4 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:113671787-113672487 Neighboring gene GET1 pseudogene 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:113678316-113679129 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:113679943-113680756 Neighboring gene Sharpr-MPRA regulatory region 864 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:113695074-113695600 Neighboring gene ribosomal protein L32 pseudogene 13 Neighboring gene eukaryotic translation initiation factor 2 subunit gamma pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15643 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr4:113738957-113739482 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr4:113739483-113740006 Neighboring gene TATA-box binding protein associated factor 4b pseudogene Neighboring gene ribosomal protein L7a pseudogene 30 Neighboring gene uncharacterized LOC102723896 Neighboring gene Sharpr-MPRA regulatory region 8329 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:113879232-113879899 Neighboring gene uncharacterized LOC124900761 Neighboring gene NANOG hESC enhancer GRCh37_chr4:113945514-113946051 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr4:113981923-113982493 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr4:113985214-113985864 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:113987456-113987956 Neighboring gene ANK2 antisense RNA 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:114066308-114066916 Neighboring gene microRNA 1243 Neighboring gene microRNA 8082 Neighboring gene ReSE screen-validated silencer GRCh37_chr4:114158073-114158257 Neighboring gene ribosomal protein S26 pseudogene 25 Neighboring gene ReSE screen-validated silencer GRCh37_chr4:114199559-114199733 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_72140 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:114213551-114214070 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:114214071-114214590 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21836 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr4:114274931-114276130 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr4:114276560-114277759 Neighboring gene NANOG hESC enhancer GRCh37_chr4:114306634-114307363 Neighboring gene uncharacterized LOC105377374 Neighboring gene Sharpr-MPRA regulatory region 2369 Neighboring gene RNA, 7SL, cytoplasmic 184, pseudogene Neighboring gene RNA, U1 small nuclear 138, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. ANK2 loss-of-function variants are associated with epilepsy, and lead to impaired axon initial segment plasticity and hyperactive network activity in hiPSC-derived neuronal networks. Teunissen MWA, et al. Hum Mol Genet, 2023 Jul 4. PMID 37195288, Free PMC Article
    2. Established Loss-of-Function Variants in ANK2-Encoded Ankyrin-B Rarely Cause a Concerning Cardiac Phenotype in Humans. Giudicessi JR, et al. Circ Genom Precis Med, 2020 Apr. PMID 32164423
    3. Mechanisms and Alterations of Cardiac Ion Channels Leading to Disease: Role of Ankyrin-B in Cardiac Function. Sucharski HC, et al. Biomolecules, 2020 Jan 31. PMID 32023981, Free PMC Article
    4. Novel Variant in the ANK2 Membrane-Binding Domain Is Associated With Ankyrin-B Syndrome and Structural Heart Disease in a First Nations Population With a High Rate of Long QT Syndrome. Swayne LA, et al. Circ Cardiovasc Genet, 2017 Jan. PMID 28196901, Free PMC Article
    5. Rare Variants in ANK2 Associated With Various Inherited Arrhythmia Syndromes. Watanabe H, et al. Circ J, 2016 Nov 25. PMID 27818464

    See all (123) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ANK2 loss-of-function variants are associated with epilepsy, and lead to impaired axon initial segment plasticity and hyperactive network activity in hiPSC-derived neuronal networks.
      Title: ANK2 loss-of-function variants are associated with epilepsy, and lead to impaired axon initial segment plasticity and hyperactive network activity in hiPSC-derived neuronal networks.
    2. Human ankyrins and their contribution to disease biology: An update.
      Title: Human ankyrins and their contribution to disease biology: An update.
    3. lncRNA ZNF667-AS1 (NR_036521.1) inhibits the progression of colorectal cancer via regulating ANK2/JAK2 expression.
      Title: lncRNA ZNF667-AS1 (NR_036521.1) inhibits the progression of colorectal cancer via regulating ANK2/JAK2 expression.
    4. Established Loss-of-Function Variants in ANK2-Encoded Ankyrin-B Rarely Cause a Concerning Cardiac Phenotype in Humans.
      Title: Established Loss-of-Function Variants in ANK2-Encoded Ankyrin-B Rarely Cause a Concerning Cardiac Phenotype in Humans.
    5. Mechanisms and Alterations of Cardiac Ion Channels Leading to Disease: Role of Ankyrin-B in Cardiac Function.
      Title: Mechanisms and Alterations of Cardiac Ion Channels Leading to Disease: Role of Ankyrin-B in Cardiac Function.
    6. Giant ankyrin-B suppresses stochastic collateral axon branching through direct interaction with microtubules.
      Title: Giant ankyrin-B suppresses stochastic collateral axon branching through direct interaction with microtubules.
    7. ANK2 Hypermethylation in Canine Mammary Tumors and Human Breast Cancer.
      Title: ANK2 Hypermethylation in Canine Mammary Tumors and Human Breast Cancer.
    8. Genetic heterogeneity and prognostic impact of recurrent ANK2 and TP53 mutations in mantle cell lymphoma: a multi-centre cohort study.
      Title: Genetic heterogeneity and prognostic impact of recurrent ANK2 and TP53 mutations in mantle cell lymphoma: a multi-centre cohort study.
    9. These novel findings have important implications for understanding the role of AnkB and Cav2.1 in the regulation of neuronal function in health and disease.
      Title: Ankyrin B and Ankyrin B variants differentially modulate intracellular and surface Cav2.1 levels.
    10. findings introduce what we believe to be a new pathway for Arrhythmogenic cardiomyopathy, a role of ankyrin-B in cardiac structure and signaling, a molecular link between ankyrin-B and beta-catenin, and evidence for targeted activation of the WNT/beta-catenin pathway as a potential treatment for this disease.
      Title: Ankyrin-B dysfunction predisposes to arrhythmogenic cardiomyopathy and is amenable to therapy.
    Submit: New GeneRIF Correction See all GeneRIFs (51)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Cardiac arrhythmia, ankyrin-B-related
    MedGen: C1970119 OMIM: 600919 GeneReviews: Long QT Syndrome Overview
    		Compare labs

    Copy number response

    Description
    Copy number response
    Triplosensitivity

    No evidence available (Last evaluated 2019-05-22)

    ClinGen Genome Curation Page
    Haploinsufficency

    Sufficient evidence for dosage pathogenicity (Last evaluated 2019-05-22)

    ClinGen Genome Curation PagePubMed

    EBI GWAS Catalog

    Description
    A genome-wide search for loci interacting with known prostate cancer risk-associated genetic variants.
    EBI GWAS Catalog
    Fraction of exhaled nitric oxide values in childhood are associated with 17q11.2-q12 and 17q12-q21 variants.
    EBI GWAS Catalog
    Genome-wide association study identifies loci affecting blood copper, selenium and zinc.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ11832, FLJ38277, FLJ46169, DKFZp686P0948, DKFZp686M09125

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATPase binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables cytoskeletal anchor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables enzyme binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables phosphorylation-dependent protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-macromolecule adaptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables spectrin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables spectrin binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables structural constituent of cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane transporter binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane transporter binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transmembrane transporter binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in SA node cell action potential ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in SA node cell to atrial cardiac muscle cell communication IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in T-tubule organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in atrial cardiac muscle cell action potential IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in atrial cardiac muscle cell to AV node cell communication ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in atrial septum development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in endocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular calcium ion homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in membrane depolarization during SA node cell action potential TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in paranodal junction assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of calcium ion transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of calcium ion transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of cation channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of gene expression IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of potassium ion transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of potassium ion transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein localization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein localization to M-band ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein localization to T-tubule ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein localization to cell surface ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein localization to endoplasmic reticulum IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein localization to organelle IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein localization to plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization to plasma membrane IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein localization to plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in protein stabilization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of SA node cell action potential IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of atrial cardiac muscle cell action potential IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of calcium ion transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in regulation of calcium ion transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of cardiac muscle cell contraction IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of cardiac muscle contraction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cardiac muscle contraction by calcium ion signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in regulation of heart rate IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of heart rate by cardiac conduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of heart rate by cardiac conduction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of protein stability IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in regulation of release of sequestered calcium ion into cytosol IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of ventricular cardiac muscle cell membrane repolarization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to methylmercury IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sarcoplasmic reticulum calcium ion transport TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in ventricular cardiac muscle cell action potential IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in A band ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in M band ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in T-tubule ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in Z disc ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in apical plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in basolateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in costamere ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in early endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intercalated disc ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in lysosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in plasma membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in postsynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in recycling endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in sarcolemma ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    ankyrin-2
    Names
    ankyrin 2, neuronal
    ankyrin B
    ankyrin, brain
    ankyrin-2, nonerythrocytic
    non-erythroid ankyrin

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_009006.2 RefSeqGene

      Range
      5001..570658
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_327

    mRNA and Protein(s)

    1. NM_001127493.3 → NP_001120965.1  ankyrin-2 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC004057, AC017007, AC093900
      Consensus CDS
      CCDS54796.1
      UniProtKB/Swiss-Prot
      Q01484
      Related
      ENSP00000421067.1, ENST00000506722.5
      Conserved Domains (9) summary
      pfam06390
      Location:1629 → 1786
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      smart00218
      Location:957 → 1094
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      smart00248
      Location:508 → 533
      ANK; ankyrin repeats
      COG0666
      Location:285 → 483
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      cd00204
      Location:206 → 331
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd08804
      Location:1473 → 1556
      Death_ank2; Death domain of Ankyrin-2
      pfam12796
      Location:216 → 307
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:16 → 63
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:409 → 440
      ANK; ANK repeat [structural motif]

    2. NM_001148.6 → NP_001139.3  ankyrin-2 isoform 1

      See identical proteins and their annotated locations for NP_001139.3

      Status: REVIEWED

      Source sequence(s)
      AC004057, AC093879, AC093900
      Consensus CDS
      CCDS3702.1
      UniProtKB/Swiss-Prot
      Q01484, Q01485, Q08AC7, Q08AC8, Q7Z3L5
      UniProtKB/TrEMBL
      I6L894
      Related
      ENSP00000349588.4, ENST00000357077.9
      Conserved Domains (11) summary
      pfam06390
      Location:3723 → 3880
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      pfam09528
      Location:2071 → 2594
      Ehrlichia_rpt; Ehrlichia tandem repeat (Ehrlichia_rpt)
      smart00218
      Location:966 → 1103
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      smart00248
      Location:529 → 554
      ANK; ankyrin repeats
      COG0666
      Location:306 → 504
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      cd00204
      Location:227 → 352
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd08804
      Location:3567 → 3650
      Death_ank2; Death domain of Ankyrin-2
      pfam12796
      Location:237 → 328
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:37 → 84
      Ank_4; Ankyrin repeats (many copies)
      pfam15718
      Location:1877 → 2169
      DUF4673; Domain of unknown function (DUF4673)
      sd00045
      Location:430 → 461
      ANK; ANK repeat [structural motif]

    3. NM_001354225.2 → NP_001341154.1  ankyrin-2 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC004057, AC093879, AC093900
      Conserved Domains (6) summary
      pfam06390
      Location:1642 → 1799
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      smart00218
      Location:970 → 1107
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd00204
      Location:227 → 352
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd08804
      Location:1486 → 1569
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:430 → 461
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:499 → 550
      Ank_4; Ankyrin repeats (many copies)

    4. NM_001354228.2 → NP_001341157.1  ankyrin-2 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC004057, AC093879, AC093900
      Consensus CDS
      CCDS93591.1
      UniProtKB/TrEMBL
      A0A5F9ZH70
      Related
      ENSP00000500102.1, ENST00000671727.1
      Conserved Domains (6) summary
      pfam06390
      Location:1605 → 1742
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      smart00218
      Location:966 → 1070
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd00204
      Location:227 → 352
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd08804
      Location:1449 → 1532
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:430 → 461
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:499 → 550
      Ank_4; Ankyrin repeats (many copies)

    5. NM_001354230.2 → NP_001341159.1  ankyrin-2 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC004057, AC093879, AC093900
      UniProtKB/TrEMBL
      A0A994J7V8
      Conserved Domains (6) summary
      pfam06390
      Location:1631 → 1788
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      smart00218
      Location:992 → 1096
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd00204
      Location:242 → 367
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd08804
      Location:1475 → 1558
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:445 → 476
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:514 → 565
      Ank_4; Ankyrin repeats (many copies)

    6. NM_001354231.2 → NP_001341160.1  ankyrin-2 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AC004057, AC093879, AC093900
      UniProtKB/TrEMBL
      A0A994J7V8
      Conserved Domains (6) summary
      pfam06390
      Location:1652 → 1789
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      smart00218
      Location:980 → 1117
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd00204
      Location:242 → 367
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd08804
      Location:1496 → 1579
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:445 → 476
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:514 → 565
      Ank_4; Ankyrin repeats (many copies)

    7. NM_001354232.2 → NP_001341161.1  ankyrin-2 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AC004057, AC093879, AC093900
      Consensus CDS
      CCDS93590.1
      UniProtKB/TrEMBL
      A0A5F9ZI81
      Related
      ENSP00000500954.1, ENST00000671762.1
      Conserved Domains (6) summary
      pfam06390
      Location:1650 → 1787
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      smart00218
      Location:978 → 1115
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd00204
      Location:227 → 352
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd08804
      Location:1494 → 1577
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:430 → 461
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:499 → 550
      Ank_4; Ankyrin repeats (many copies)

    8. NM_001354235.2 → NP_001341164.1  ankyrin-2 isoform 9

      Status: REVIEWED

      Source sequence(s)
      AC004057, AC093879, AC093900
      Conserved Domains (6) summary
      pfam06390
      Location:1637 → 1774
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      smart00218
      Location:965 → 1102
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd00204
      Location:227 → 352
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd08804
      Location:1481 → 1564
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:430 → 461
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:499 → 550
      Ank_4; Ankyrin repeats (many copies)

    9. NM_001354236.2 → NP_001341165.1  ankyrin-2 isoform 10

      Status: REVIEWED

      Source sequence(s)
      AC004057, AC093879, AC093900
      Conserved Domains (6) summary
      pfam06390
      Location:1604 → 1761
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      smart00218
      Location:965 → 1069
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd00204
      Location:227 → 352
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd08804
      Location:1448 → 1531
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:430 → 461
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:499 → 550
      Ank_4; Ankyrin repeats (many copies)

    10. NM_001354237.2 → NP_001341166.1  ankyrin-2 isoform 11

      Status: REVIEWED

      Source sequence(s)
      AC004057, AC093879, AC093900
      UniProtKB/TrEMBL
      A0A994J7V8
      Conserved Domains (6) summary
      pfam06390
      Location:1664 → 1821
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      smart00218
      Location:992 → 1129
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd00204
      Location:242 → 367
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd08804
      Location:1508 → 1591
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:445 → 476
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:514 → 565
      Ank_4; Ankyrin repeats (many copies)

    11. NM_001354239.2 → NP_001341168.1  ankyrin-2 isoform 12

      Status: REVIEWED

      Source sequence(s)
      AC004057, AC017007, AC093900
      Conserved Domains (6) summary
      pfam06390
      Location:1628 → 1765
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      smart00218
      Location:956 → 1093
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd00204
      Location:206 → 331
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd08804
      Location:1472 → 1555
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:409 → 440
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:478 → 529
      Ank_4; Ankyrin repeats (many copies)

    12. NM_001354240.2 → NP_001341169.1  ankyrin-2 isoform 13

      Status: REVIEWED

      Source sequence(s)
      AC004057, AC093879, AC093900
      Consensus CDS
      CCDS93595.1
      UniProtKB/TrEMBL
      A0A5F9ZH39, A0A994J7V8
      Related
      ENSP00000499996.1, ENST00000673240.1
      Conserved Domains (6) summary
      pfam06390
      Location:1653 → 1810
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      smart00218
      Location:981 → 1118
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd00204
      Location:242 → 367
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd08804
      Location:1497 → 1580
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:445 → 476
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:514 → 565
      Ank_4; Ankyrin repeats (many copies)

    13. NM_001354241.2 → NP_001341170.1  ankyrin-2 isoform 14

      Status: REVIEWED

      Source sequence(s)
      AC004057, AC093617, AC093879, AC093900
      Consensus CDS
      CCDS93589.1
      UniProtKB/TrEMBL
      A0A5F9ZGY1
      Related
      ENSP00000499869.1, ENST00000672779.1
      Conserved Domains (6) summary
      pfam06390
      Location:1653 → 1810
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      smart00218
      Location:981 → 1118
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd00204
      Location:242 → 367
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd08804
      Location:1497 → 1580
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:445 → 476
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:514 → 565
      Ank_4; Ankyrin repeats (many copies)

    14. NM_001354242.2 → NP_001341171.1  ankyrin-2 isoform 15

      Status: REVIEWED

      Source sequence(s)
      AC004057, AC093879, AC093900
      UniProtKB/TrEMBL
      A0A994J7V8
      Conserved Domains (6) summary
      pfam06390
      Location:1652 → 1809
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      smart00218
      Location:980 → 1117
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd00204
      Location:242 → 367
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd08804
      Location:1496 → 1579
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:445 → 476
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:514 → 565
      Ank_4; Ankyrin repeats (many copies)

    15. NM_001354243.2 → NP_001341172.1  ankyrin-2 isoform 16

      Status: REVIEWED

      Source sequence(s)
      AC004057, AC017007, AC093900
      Consensus CDS
      CCDS93573.1
      UniProtKB/TrEMBL
      A0A5F9ZI56
      Related
      ENSP00000500881.1, ENST00000672402.1
      Conserved Domains (6) summary
      pfam06390
      Location:1617 → 1754
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      smart00218
      Location:945 → 1082
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd00204
      Location:206 → 331
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd08804
      Location:1461 → 1544
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:409 → 440
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:478 → 529
      Ank_4; Ankyrin repeats (many copies)

    16. NM_001354244.2 → NP_001341173.1  ankyrin-2 isoform 17

      Status: REVIEWED

      Source sequence(s)
      AC004057, AC017007, AC093900
      Conserved Domains (6) summary
      pfam06390
      Location:1616 → 1753
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      smart00218
      Location:944 → 1081
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd00204
      Location:206 → 331
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd08804
      Location:1460 → 1543
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:409 → 440
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:478 → 529
      Ank_4; Ankyrin repeats (many copies)

    17. NM_001354245.2 → NP_001341174.1  ankyrin-2 isoform 18

      Status: REVIEWED

      Source sequence(s)
      AC004057, AC093879, AC093900
      Consensus CDS
      CCDS93593.1
      UniProtKB/TrEMBL
      A0A5F9ZH17
      Related
      ENSP00000499959.1, ENST00000672045.1
      Conserved Domains (6) summary
      pfam06390
      Location:1584 → 1741
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      smart00218
      Location:945 → 1049
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd00204
      Location:227 → 352
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd08804
      Location:1428 → 1511
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:430 → 461
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:565 → 616
      Ank_4; Ankyrin repeats (many copies)

    18. NM_001354246.2 → NP_001341175.1  ankyrin-2 isoform 19

      Status: REVIEWED

      Source sequence(s)
      AC004057, AC093879, AC093900
      Conserved Domains (6) summary
      pfam06390
      Location:1637 → 1794
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      smart00218
      Location:965 → 1102
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd00204
      Location:227 → 352
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd08804
      Location:1481 → 1564
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:430 → 461
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:499 → 550
      Ank_4; Ankyrin repeats (many copies)

    19. NM_001354249.2 → NP_001341178.1  ankyrin-2 isoform 20

      Status: REVIEWED

      Source sequence(s)
      AC004057, AC017007, AC093900
      Consensus CDS
      CCDS93582.1
      UniProtKB/TrEMBL
      A0A5F9ZGS5
      Related
      ENSP00000499837.1, ENST00000672088.1
      Conserved Domains (6) summary
      pfam06390
      Location:1576 → 1733
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      smart00218
      Location:937 → 1041
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd00204
      Location:198 → 323
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd08804
      Location:1420 → 1503
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:401 → 432
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:470 → 521
      Ank_4; Ankyrin repeats (many copies)

    20. NM_001354252.2 → NP_001341181.1  ankyrin-2 isoform 21

      Status: REVIEWED

      Source sequence(s)
      AC004057, AC017007, AC093900
      Conserved Domains (6) summary
      pfam06390
      Location:1628 → 1785
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      smart00218
      Location:956 → 1093
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd00204
      Location:206 → 331
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd08804
      Location:1472 → 1555
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:409 → 440
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:478 → 529
      Ank_4; Ankyrin repeats (many copies)

    21. NM_001354253.2 → NP_001341182.1  ankyrin-2 isoform 22

      Status: REVIEWED

      Source sequence(s)
      AC004057, AC017007, AC093900
      Consensus CDS
      CCDS93577.1
      UniProtKB/TrEMBL
      A0A5F9ZHL3
      Related
      ENSP00000500420.1, ENST00000672350.1
      Conserved Domains (6) summary
      pfam06390
      Location:1563 → 1720
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      smart00218
      Location:924 → 1028
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd00204
      Location:206 → 331
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd08804
      Location:1407 → 1490
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:409 → 440
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:544 → 595
      Ank_4; Ankyrin repeats (many copies)

    22. NM_001354254.2 → NP_001341183.1  ankyrin-2 isoform 23

      Status: REVIEWED

      Source sequence(s)
      AC004057, AC017007, AC093900
      Conserved Domains (6) summary
      pfam06390
      Location:1621 → 1778
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      smart00218
      Location:949 → 1086
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd00204
      Location:206 → 331
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd08804
      Location:1465 → 1548
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:409 → 440
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:478 → 529
      Ank_4; Ankyrin repeats (many copies)

    23. NM_001354255.2 → NP_001341184.1  ankyrin-2 isoform 24

      Status: REVIEWED

      Source sequence(s)
      AC004057, AC017007, AC093900
      Consensus CDS
      CCDS93574.1
      UniProtKB/TrEMBL
      A0A024RDI4, A0A5F9ZHJ6
      Related
      ENSP00000500459.1, ENST00000671825.1
      Conserved Domains (6) summary
      pfam06390
      Location:1617 → 1774
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      smart00218
      Location:945 → 1082
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd00204
      Location:206 → 331
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd08804
      Location:1461 → 1544
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:409 → 440
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:478 → 529
      Ank_4; Ankyrin repeats (many copies)

    24. NM_001354256.2 → NP_001341185.1  ankyrin-2 isoform 25

      Status: REVIEWED

      Source sequence(s)
      AC004057, AC017007, AC093900
      Conserved Domains (8) summary
      pfam06390
      Location:1616 → 1773
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      smart00218
      Location:944 → 1081
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      PHA03095
      Location:383 → 668
      PHA03095; ankyrin-like protein; Provisional
      cd08804
      Location:1460 → 1543
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:409 → 440
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:740 → 792
      Ank_4; Ankyrin repeats (many copies)
      pfam17809
      Location:1302 → 1431
      UPA_2; UPA domain
      cl39094
      Location:540 → 764
      Ank_2; Ankyrin repeats (3 copies)

    25. NM_001354257.2 → NP_001341186.1  ankyrin-2 isoform 26

      Status: REVIEWED

      Source sequence(s)
      AC004057, AC017007, AC093900
      Consensus CDS
      CCDS93579.1
      UniProtKB/TrEMBL
      A0A5F9ZI36
      Related
      ENSP00000500833.1, ENST00000671854.1
      Conserved Domains (6) summary
      pfam06390
      Location:1551 → 1708
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      smart00218
      Location:912 → 1016
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd00204
      Location:206 → 331
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd08804
      Location:1395 → 1478
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:409 → 440
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:544 → 595
      Ank_4; Ankyrin repeats (many copies)

    26. NM_001354258.2 → NP_001341187.1  ankyrin-2 isoform 27

      Status: REVIEWED

      Source sequence(s)
      AC004057, AC093879, AC093900
      Consensus CDS
      CCDS93592.1
      UniProtKB/TrEMBL
      A0A5F9ZI69
      Related
      ENSP00000500937.1, ENST00000672366.1
      Conserved Domains (6) summary
      pfam06390
      Location:1605 → 1762
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      smart00218
      Location:966 → 1070
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd00204
      Location:227 → 352
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd08804
      Location:1449 → 1532
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:430 → 461
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:499 → 550
      Ank_4; Ankyrin repeats (many copies)

    27. NM_001354260.2 → NP_001341189.1  ankyrin-2 isoform 28

      Status: REVIEWED

      Source sequence(s)
      AC004057, AC017007, AC093900
      Consensus CDS
      CCDS93586.1
      UniProtKB/TrEMBL
      A0A5F9ZHQ3
      Related
      ENSP00000500544.1, ENST00000672356.1
      Conserved Domains (6) summary
      pfam06390
      Location:1543 → 1700
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      smart00218
      Location:904 → 1008
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd00204
      Location:198 → 323
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd08804
      Location:1387 → 1470
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:401 → 432
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:536 → 587
      Ank_4; Ankyrin repeats (many copies)

    28. NM_001354261.2 → NP_001341190.1  ankyrin-2 isoform 29

      Status: REVIEWED

      Source sequence(s)
      AC004057, AC017007, AC093617, AC093900
      Conserved Domains (6) summary
      pfam06390
      Location:1591 → 1748
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      smart00218
      Location:952 → 1056
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd00204
      Location:213 → 338
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd08804
      Location:1435 → 1518
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:416 → 447
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:485 → 536
      Ank_4; Ankyrin repeats (many copies)

    29. NM_001354262.2 → NP_001341191.1  ankyrin-2 isoform 30

      Status: REVIEWED

      Source sequence(s)
      AC004057, AC017007, AC093900
      Consensus CDS
      CCDS93575.1
      UniProtKB/TrEMBL
      A0A5F9ZHJ4
      Related
      ENSP00000500378.1, ENST00000672312.1
      Conserved Domains (6) summary
      pfam06390
      Location:1584 → 1741
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      smart00218
      Location:945 → 1049
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd00204
      Location:206 → 331
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd08804
      Location:1428 → 1511
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:409 → 440
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:478 → 529
      Ank_4; Ankyrin repeats (many copies)

    30. NM_001354264.2 → NP_001341193.1  ankyrin-2 isoform 31

      Status: REVIEWED

      Source sequence(s)
      AC004057, AC017007, AC093900
      Consensus CDS
      CCDS93581.1
      UniProtKB/TrEMBL
      A0A5F9ZHL9
      Related
      ENSP00000500473.1, ENST00000672221.1
      Conserved Domains (6) summary
      pfam06390
      Location:1583 → 1740
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      smart00218
      Location:937 → 1041
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd00204
      Location:198 → 323
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd08804
      Location:1427 → 1510
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:401 → 432
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:470 → 521
      Ank_4; Ankyrin repeats (many copies)

    31. NM_001354265.2 → NP_001341194.1  ankyrin-2 isoform 32

      Status: REVIEWED

      Source sequence(s)
      AC004057, AC093879, AC093900
      UniProtKB/TrEMBL
      B7Z636
      Conserved Domains (6) summary
      pfam06390
      Location:1637 → 1794
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      smart00218
      Location:965 → 1102
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd00204
      Location:227 → 352
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd08804
      Location:1481 → 1564
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:430 → 461
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:499 → 550
      Ank_4; Ankyrin repeats (many copies)

    32. NM_001354266.2 → NP_001341195.1  ankyrin-2 isoform 33

      Status: REVIEWED

      Source sequence(s)
      AC004057, AC017007, AC093900
      Consensus CDS
      CCDS93583.1
      UniProtKB/TrEMBL
      A0A5F9ZHR2
      Related
      ENSP00000500527.1, ENST00000672955.1
      Conserved Domains (6) summary
      pfam06390
      Location:1576 → 1733
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      smart00218
      Location:937 → 1041
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd00204
      Location:198 → 323
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd08804
      Location:1420 → 1503
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:401 → 432
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:470 → 521
      Ank_4; Ankyrin repeats (many copies)

    33. NM_001354267.2 → NP_001341196.1  ankyrin-2 isoform 33

      Status: REVIEWED

      Source sequence(s)
      AC004057, AC017007, AC093900
      Consensus CDS
      CCDS93583.1
      UniProtKB/TrEMBL
      A0A5F9ZHR2
      Related
      ENSP00000500926.1, ENST00000671704.1
      Conserved Domains (6) summary
      pfam06390
      Location:1576 → 1733
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      smart00218
      Location:937 → 1041
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd00204
      Location:198 → 323
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd08804
      Location:1420 → 1503
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:401 → 432
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:470 → 521
      Ank_4; Ankyrin repeats (many copies)

    34. NM_001354268.2 → NP_001341197.1  ankyrin-2 isoform 35

      Status: REVIEWED

      Source sequence(s)
      AC004057, AC093879, AC093900
      Consensus CDS
      CCDS93594.1
      UniProtKB/TrEMBL
      A0A5F9ZHE2
      Related
      ENSP00000500311.1, ENST00000672854.1
      Conserved Domains (6) summary
      pfam06390
      Location:1572 → 1729
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      smart00218
      Location:933 → 1037
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd00204
      Location:227 → 352
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd08804
      Location:1416 → 1499
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:430 → 461
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:565 → 616
      Ank_4; Ankyrin repeats (many copies)

    35. NM_001354269.3 → NP_001341198.1  ankyrin-2 isoform 36

      Status: REVIEWED

      Source sequence(s)
      AC004057, AC093900, AC106864
      Conserved Domains (7) summary
      pfam06390
      Location:1567 → 1724
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      smart00218
      Location:895 → 1032
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      COG0666
      Location:10 → 92
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      cd00204
      Location:223 → 348
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd08804
      Location:1411 → 1494
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:624 → 655
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:188 → 249
      Ank_4; Ankyrin repeats (many copies)

    36. NM_001354270.2 → NP_001341199.1  ankyrin-2 isoform 37

      Status: REVIEWED

      Source sequence(s)
      AC004057, AC017007, AC093900
      Consensus CDS
      CCDS93578.1
      UniProtKB/TrEMBL
      A0A5F9ZI08
      Related
      ENSP00000500843.1, ENST00000673546.1
      Conserved Domains (6) summary
      pfam06390
      Location:1563 → 1720
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      smart00218
      Location:924 → 1028
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd00204
      Location:206 → 331
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd08804
      Location:1407 → 1490
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:409 → 440
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:544 → 595
      Ank_4; Ankyrin repeats (many copies)

    37. NM_001354271.2 → NP_001341200.1  ankyrin-2 isoform 38

      Status: REVIEWED

      Source sequence(s)
      AC004057, AC017007, AC093900
      Consensus CDS
      CCDS93587.1
      UniProtKB/TrEMBL
      A0A5F9ZHN0
      Related
      ENSP00000500528.1, ENST00000671951.1
      Conserved Domains (6) summary
      pfam06390
      Location:1543 → 1700
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      smart00218
      Location:904 → 1008
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd00204
      Location:198 → 323
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd08804
      Location:1387 → 1470
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:401 → 432
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:536 → 587
      Ank_4; Ankyrin repeats (many copies)

    38. NM_001354272.2 → NP_001341201.1  ankyrin-2 isoform 39

      Status: REVIEWED

      Source sequence(s)
      AC004057, AC017007, AC093900
      Conserved Domains (6) summary
      pfam06390
      Location:1595 → 1752
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      smart00218
      Location:956 → 1060
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd00204
      Location:206 → 331
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd08804
      Location:1439 → 1522
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:409 → 440
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:478 → 529
      Ank_4; Ankyrin repeats (many copies)

    39. NM_001354273.2 → NP_001341202.1  ankyrin-2 isoform 40

      Status: REVIEWED

      Source sequence(s)
      AC004057, AC093879, AC093900
      Conserved Domains (6) summary
      pfam06390
      Location:1538 → 1695
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      smart00218
      Location:899 → 1003
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd00204
      Location:227 → 352
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd08804
      Location:1382 → 1465
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:628 → 659
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:192 → 253
      Ank_4; Ankyrin repeats (many copies)

    40. NM_001354274.2 → NP_001341203.1  ankyrin-2 isoform 41

      Status: REVIEWED

      Source sequence(s)
      AC004057, AC017007, AC093900
      Consensus CDS
      CCDS93585.1
      UniProtKB/TrEMBL
      A0A5F9ZH58
      Related
      ENSP00000500112.1, ENST00000673453.1
      Conserved Domains (6) summary
      pfam06390
      Location:1560 → 1697
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      smart00218
      Location:932 → 1036
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd00204
      Location:198 → 323
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd08804
      Location:1404 → 1487
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:401 → 432
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:470 → 521
      Ank_4; Ankyrin repeats (many copies)

    41. NM_001354275.2 → NP_001341204.1  ankyrin-2 isoform 42

      Status: REVIEWED

      Source sequence(s)
      AC004057, AC017007, AC093900
      Consensus CDS
      CCDS93576.1
      UniProtKB/TrEMBL
      A0A5F9ZHY6
      Related
      ENSP00000500712.1, ENST00000671756.1
      Conserved Domains (6) summary
      pfam06390
      Location:1584 → 1741
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      smart00218
      Location:945 → 1049
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd00204
      Location:206 → 331
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd08804
      Location:1428 → 1511
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:409 → 440
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:478 → 529
      Ank_4; Ankyrin repeats (many copies)

    42. NM_001354276.2 → NP_001341205.1  ankyrin-2 isoform 43

      Status: REVIEWED

      Source sequence(s)
      AC004057, AC017007, AC093900
      Consensus CDS
      CCDS93584.1
      UniProtKB/TrEMBL
      A0A5F9ZI53
      Related
      ENSP00000500908.1, ENST00000672731.1
      Conserved Domains (9) summary
      pfam06390
      Location:1576 → 1733
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      smart00218
      Location:937 → 1041
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      PHA03095
      Location:375 → 660
      PHA03095; ankyrin-like protein; Provisional
      COG0666
      Location:6 → 141
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      cd08804
      Location:1420 → 1503
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:401 → 432
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:732 → 784
      Ank_4; Ankyrin repeats (many copies)
      pfam17809
      Location:1262 → 1391
      UPA_2; UPA domain
      cl39094
      Location:532 → 756
      Ank_2; Ankyrin repeats (3 copies)

    43. NM_001354277.2 → NP_001341206.1  ankyrin-2 isoform 44

      Status: REVIEWED

      Source sequence(s)
      AC004057, AC017007, AC093900
      Consensus CDS
      CCDS93588.1
      UniProtKB/TrEMBL
      A0A5F9ZH34
      Related
      ENSP00000499986.1, ENST00000671893.1
      Conserved Domains (9) summary
      pfam06390
      Location:1510 → 1667
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      smart00218
      Location:871 → 975
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      PHA02876
      Location:219 → 559
      PHA02876; ankyrin repeat protein; Provisional
      PHA03095
      Location:8 → 327
      PHA03095; ankyrin-like protein; Provisional
      cd08804
      Location:1354 → 1437
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:599 → 630
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:666 → 718
      Ank_4; Ankyrin repeats (many copies)
      pfam17809
      Location:1196 → 1325
      UPA_2; UPA domain
      cl39094
      Location:466 → 690
      Ank_2; Ankyrin repeats (3 copies)

    44. NM_001354278.2 → NP_001341207.1  ankyrin-2 isoform 45

      Status: REVIEWED

      Source sequence(s)
      AC004057, AC093900
      Consensus CDS
      CCDS93600.1
      UniProtKB/TrEMBL
      A0A5F9ZH18, H0Y8Y2
      Related
      ENSP00000500007.1, ENST00000673353.1
      Conserved Domains (3) summary
      pfam06390
      Location:814 → 971
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      smart00218
      Location:175 → 279
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd08804
      Location:658 → 741
      Death_ank2; Death domain of Ankyrin-2

    45. NM_001354279.2 → NP_001341208.1  ankyrin-2 isoform 46

      Status: REVIEWED

      Source sequence(s)
      AC004057, AC093900
      Consensus CDS
      CCDS93597.1
      UniProtKB/TrEMBL
      A0A5F9ZH99, B7Z2H4
      Related
      ENSP00000500111.1, ENST00000673231.1
      Conserved Domains (3) summary
      pfam06390
      Location:826 → 983
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      smart00218
      Location:187 → 291
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd08804
      Location:670 → 753
      Death_ank2; Death domain of Ankyrin-2

    46. NM_001354280.2 → NP_001341209.1  ankyrin-2 isoform 47

      Status: REVIEWED

      Source sequence(s)
      AC004057, AC093900
      Consensus CDS
      CCDS93599.1
      UniProtKB/TrEMBL
      A0A5F9ZI16, B7Z2H4
      Related
      ENSP00000500832.1, ENST00000673048.1
      Conserved Domains (3) summary
      pfam06390
      Location:821 → 978
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      smart00218
      Location:175 → 279
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd08804
      Location:665 → 748
      Death_ank2; Death domain of Ankyrin-2

    47. NM_001354281.2 → NP_001341210.1  ankyrin-2 isoform 48

      Status: REVIEWED

      Source sequence(s)
      AC004057, AC093900
      Consensus CDS
      CCDS87250.1
      UniProtKB/TrEMBL
      B7Z2H4, E9PCH6
      Related
      ENSP00000426944.1, ENST00000509550.5
      Conserved Domains (3) summary
      pfam06390
      Location:814 → 971
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      smart00218
      Location:175 → 279
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd08804
      Location:658 → 741
      Death_ank2; Death domain of Ankyrin-2

    48. NM_001354282.2 → NP_001341211.1  ankyrin-2 isoform 49

      Status: REVIEWED

      Source sequence(s)
      AC004057, AC093900
      Consensus CDS
      CCDS93598.1
      UniProtKB/TrEMBL
      A0A5F9ZH10, B7Z2H4
      Related
      ENSP00000499979.1, ENST00000672411.1
      Conserved Domains (3) summary
      pfam06390
      Location:826 → 983
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      smart00218
      Location:187 → 291
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd08804
      Location:670 → 753
      Death_ank2; Death domain of Ankyrin-2

    49. NM_001386142.1 → NP_001373071.1  ankyrin-2 isoform 50

      Status: REVIEWED

      Source sequence(s)
      AC004057, AC017007, AC093900
      Related
      ENSP00000500245.1, ENST00000673298.1
      Conserved Domains (15) summary
      pfam06390
      Location:3645 → 3802
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      smart00218
      Location:932 → 1036
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      PTZ00449
      Location:1592 → 2036
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      PHA03095
      Location:375 → 660
      PHA03095; ankyrin-like protein; Provisional
      COG0666
      Location:6 → 141
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      PRK14949
      Location:3071 → 3317
      PRK14949; DNA polymerase III subunits gamma and tau; Provisional
      cd08804
      Location:3489 → 3572
      Death_ank2; Death domain of Ankyrin-2
      TIGR00600
      Location:2906 → 3440
      rad2; DNA excision repair protein (rad2)
      sd00045
      Location:401 → 432
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:732 → 784
      Ank_4; Ankyrin repeats (many copies)
      pfam15402
      Location:2368 → 2509
      Spc7_N; N-terminus of kinetochore NMS complex subunit Spc7
      pfam17809
      Location:1257 → 1386
      UPA_2; UPA domain
      NF033804
      Location:1718 → 1902
      Streccoc_I_II; antigen I/II family LPXTG-anchored adhesin
      NF033838
      Location:1424 → 1797
      PspC_subgroup_1; pneumococcal surface protein PspC, choline-binding form
      cl39094
      Location:532 → 756
      Ank_2; Ankyrin repeats (3 copies)

    50. NM_001386143.1 → NP_001373072.1  ankyrin-2 isoform 51

      Status: REVIEWED

      Source sequence(s)
      AC004057, AC017007, AC093900
      Consensus CDS
      CCDS93572.1
      UniProtKB/TrEMBL
      A0A5F9ZGZ1
      Related
      ENSP00000499928.1, ENST00000671793.1
      Conserved Domains (8) summary
      pfam06390
      Location:1617 → 1754
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      smart00218
      Location:945 → 1082
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      PHA03095
      Location:383 → 668
      PHA03095; ankyrin-like protein; Provisional
      cd08804
      Location:1461 → 1544
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:409 → 440
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:740 → 792
      Ank_4; Ankyrin repeats (many copies)
      pfam17809
      Location:1303 → 1432
      UPA_2; UPA domain
      cl39094
      Location:540 → 764
      Ank_2; Ankyrin repeats (3 copies)

    51. NM_001386144.1 → NP_001373073.1  ankyrin-2 isoform 52

      Status: REVIEWED

      Source sequence(s)
      AC004057, AC093879, AC093900
      UniProtKB/TrEMBL
      A0A994J7V8
      Conserved Domains (8) summary
      pfam06390
      Location:1653 → 1790
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      smart00218
      Location:981 → 1118
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      PHA03095
      Location:419 → 704
      PHA03095; ankyrin-like protein; Provisional
      cd08804
      Location:1497 → 1580
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:445 → 476
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:776 → 828
      Ank_4; Ankyrin repeats (many copies)
      pfam17809
      Location:1339 → 1468
      UPA_2; UPA domain
      cl39094
      Location:576 → 800
      Ank_2; Ankyrin repeats (3 copies)

    52. NM_001386146.1 → NP_001373075.1  ankyrin-2 isoform 53

      Status: REVIEWED

      Source sequence(s)
      AC004057, AC017007, AC093900
      Conserved Domains (9) summary
      pfam06390
      Location:1565 → 1702
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      smart00218
      Location:937 → 1041
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      PHA03095
      Location:375 → 660
      PHA03095; ankyrin-like protein; Provisional
      COG0666
      Location:6 → 141
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      cd08804
      Location:1409 → 1492
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:401 → 432
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:732 → 784
      Ank_4; Ankyrin repeats (many copies)
      pfam17809
      Location:1262 → 1391
      UPA_2; UPA domain
      cl39094
      Location:532 → 756
      Ank_2; Ankyrin repeats (3 copies)

    53. NM_001386147.1 → NP_001373076.1  ankyrin-2 isoform 54

      Status: REVIEWED

      Source sequence(s)
      AC004057, AC017007, AC093617, AC093900
      Conserved Domains (9) summary
      pfam06390
      Location:1580 → 1737
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      smart00218
      Location:952 → 1056
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      PHA03095
      Location:390 → 675
      PHA03095; ankyrin-like protein; Provisional
      COG0666
      Location:23 → 156
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      cd08804
      Location:1424 → 1507
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:416 → 447
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:747 → 799
      Ank_4; Ankyrin repeats (many copies)
      pfam17809
      Location:1277 → 1406
      UPA_2; UPA domain
      cl39094
      Location:547 → 771
      Ank_2; Ankyrin repeats (3 copies)

    54. NM_001386148.2 → NP_001373077.1  ankyrin-2 isoform 55

      Status: REVIEWED

      Source sequence(s)
      AC004057, AC093900, AC106864
      Conserved Domains (8) summary
      pfam06390
      Location:1633 → 1790
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      smart00218
      Location:961 → 1098
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      PHA03095
      Location:400 → 685
      PHA03095; ankyrin-like protein; Provisional
      cd08804
      Location:1477 → 1560
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:426 → 457
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:757 → 809
      Ank_4; Ankyrin repeats (many copies)
      pfam17809
      Location:1319 → 1448
      UPA_2; UPA domain
      cl39094
      Location:557 → 781
      Ank_2; Ankyrin repeats (3 copies)

    55. NM_001386149.1 → NP_001373078.1  ankyrin-2 isoform 56

      Status: REVIEWED

      Source sequence(s)
      AC004057, AC017007, AC093900
      Conserved Domains (9) summary
      pfam06390
      Location:1565 → 1722
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      smart00218
      Location:937 → 1041
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      PHA03095
      Location:375 → 660
      PHA03095; ankyrin-like protein; Provisional
      COG0666
      Location:6 → 141
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      cd08804
      Location:1409 → 1492
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:401 → 432
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:732 → 784
      Ank_4; Ankyrin repeats (many copies)
      pfam17809
      Location:1262 → 1391
      UPA_2; UPA domain
      cl39094
      Location:532 → 756
      Ank_2; Ankyrin repeats (3 copies)

    56. NM_001386150.1 → NP_001373079.1  ankyrin-2 isoform 57

      Status: REVIEWED

      Source sequence(s)
      AC004057, AC017007, AC093900
      Conserved Domains (9) summary
      pfam06390
      Location:1565 → 1702
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      smart00218
      Location:937 → 1041
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      PHA03095
      Location:375 → 660
      PHA03095; ankyrin-like protein; Provisional
      COG0666
      Location:6 → 141
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      cd08804
      Location:1409 → 1492
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:401 → 432
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:732 → 784
      Ank_4; Ankyrin repeats (many copies)
      pfam17809
      Location:1262 → 1391
      UPA_2; UPA domain
      cl39094
      Location:532 → 756
      Ank_2; Ankyrin repeats (3 copies)

    57. NM_001386151.1 → NP_001373080.1  ankyrin-2 isoform 58

      Status: REVIEWED

      Source sequence(s)
      AC004057, AC017007, AC093900
      Conserved Domains (9) summary
      pfam06390
      Location:1543 → 1680
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      smart00218
      Location:904 → 1008
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      COG0666
      Location:6 → 141
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      cd08804
      Location:1387 → 1470
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:401 → 432
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:699 → 751
      Ank_4; Ankyrin repeats (many copies)
      pfam17809
      Location:1229 → 1358
      UPA_2; UPA domain
      pfam12796
      Location:373 → 464
      Ank_2; Ankyrin repeats (3 copies)
      cl39094
      Location:448 → 723
      Ank_2; Ankyrin repeats (3 copies)

    58. NM_001386152.1 → NP_001373081.1  ankyrin-2 isoform 59

      Status: REVIEWED

      Source sequence(s)
      AC004057, AC093879, AC093900
      UniProtKB/TrEMBL
      A0A994J7V8
      Conserved Domains (8) summary
      pfam06390
      Location:1657 → 1804
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      smart00218
      Location:985 → 1122
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      PHA03095
      Location:419 → 704
      PHA03095; ankyrin-like protein; Provisional
      cd08804
      Location:1501 → 1584
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:445 → 476
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:776 → 828
      Ank_4; Ankyrin repeats (many copies)
      pfam17809
      Location:1343 → 1472
      UPA_2; UPA domain
      cl39094
      Location:576 → 800
      Ank_2; Ankyrin repeats (3 copies)

    59. NM_001386153.1 → NP_001373082.1  ankyrin-2 isoform 60

      Status: REVIEWED

      Source sequence(s)
      AC004057, AC017007, AC093900
      Conserved Domains (9) summary
      pfam06390
      Location:1565 → 1722
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      smart00218
      Location:937 → 1041
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      PHA03095
      Location:375 → 660
      PHA03095; ankyrin-like protein; Provisional
      COG0666
      Location:6 → 141
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      cd08804
      Location:1409 → 1492
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:401 → 432
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:732 → 784
      Ank_4; Ankyrin repeats (many copies)
      pfam17809
      Location:1262 → 1391
      UPA_2; UPA domain
      cl39094
      Location:532 → 756
      Ank_2; Ankyrin repeats (3 copies)

    60. NM_001386154.1 → NP_001373083.1  ankyrin-2 isoform 61

      Status: REVIEWED

      Source sequence(s)
      AC004057, AC017007, AC093900
      Conserved Domains (9) summary
      pfam06390
      Location:1560 → 1717
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      smart00218
      Location:932 → 1036
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      PHA03095
      Location:375 → 660
      PHA03095; ankyrin-like protein; Provisional
      COG0666
      Location:6 → 141
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      cd08804
      Location:1404 → 1487
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:401 → 432
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:732 → 784
      Ank_4; Ankyrin repeats (many copies)
      pfam17809
      Location:1257 → 1386
      UPA_2; UPA domain
      cl39094
      Location:532 → 756
      Ank_2; Ankyrin repeats (3 copies)

    61. NM_001386156.1 → NP_001373085.1  ankyrin-2 isoform 62

      Status: REVIEWED

      Source sequence(s)
      AC004057, AC017007, AC093900
      Consensus CDS
      CCDS93580.1
      UniProtKB/TrEMBL
      A0A5F9ZH03
      Related
      ENSP00000499943.1, ENST00000672684.1
      Conserved Domains (8) summary
      pfam06390
      Location:1551 → 1708
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      smart00218
      Location:912 → 1016
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd08804
      Location:1395 → 1478
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:409 → 440
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:707 → 759
      Ank_4; Ankyrin repeats (many copies)
      pfam17809
      Location:1237 → 1366
      UPA_2; UPA domain
      pfam12796
      Location:381 → 472
      Ank_2; Ankyrin repeats (3 copies)
      cl39094
      Location:456 → 731
      Ank_2; Ankyrin repeats (3 copies)

    62. NM_001386157.1 → NP_001373086.1  ankyrin-2 isoform 63

      Status: REVIEWED

      Source sequence(s)
      AC004057, AC017007, AC093900
      Related
      ENSP00000499967.1, ENST00000672986.1
      Conserved Domains (9) summary
      pfam06390
      Location:1510 → 1667
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      smart00218
      Location:871 → 975
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      PHA02876
      Location:219 → 559
      PHA02876; ankyrin repeat protein; Provisional
      PHA03095
      Location:8 → 327
      PHA03095; ankyrin-like protein; Provisional
      cd08804
      Location:1354 → 1437
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:599 → 630
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:666 → 718
      Ank_4; Ankyrin repeats (many copies)
      pfam17809
      Location:1196 → 1325
      UPA_2; UPA domain
      cl39094
      Location:466 → 690
      Ank_2; Ankyrin repeats (3 copies)

    63. NM_001386158.1 → NP_001373087.1  ankyrin-2 isoform 64

      Status: REVIEWED

      Source sequence(s)
      AC004057, AC017007, AC093900
      Conserved Domains (9) summary
      pfam06390
      Location:1477 → 1634
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      smart00218
      Location:838 → 942
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      PHA03095
      Location:114 → 432
      PHA03095; ankyrin-like protein; Provisional
      cd08804
      Location:1321 → 1404
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:566 → 597
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:633 → 685
      Ank_4; Ankyrin repeats (many copies)
      pfam17809
      Location:1163 → 1292
      UPA_2; UPA domain
      pfam12796
      Location:47 → 134
      Ank_2; Ankyrin repeats (3 copies)
      cl39094
      Location:382 → 657
      Ank_2; Ankyrin repeats (3 copies)

    64. NM_001386160.1 → NP_001373089.1  ankyrin-2 isoform 71

      Status: REVIEWED

      Source sequence(s)
      AC004057, AC017007, AC093617, AC093900
      Conserved Domains (9) summary
      pfam06390
      Location:1586 → 1743
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      smart00218
      Location:947 → 1051
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      PHA03095
      Location:390 → 675
      PHA03095; ankyrin-like protein; Provisional
      COG0666
      Location:23 → 156
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      cd08804
      Location:1430 → 1513
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:416 → 447
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:747 → 799
      Ank_4; Ankyrin repeats (many copies)
      pfam17809
      Location:1272 → 1401
      UPA_2; UPA domain
      cl39094
      Location:547 → 771
      Ank_2; Ankyrin repeats (3 copies)

    65. NM_001386161.1 → NP_001373090.1  ankyrin-2 isoform 25

      Status: REVIEWED

      Source sequence(s)
      AC004057, AC017007, AC093900
      Conserved Domains (8) summary
      pfam06390
      Location:1616 → 1773
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      smart00218
      Location:944 → 1081
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      PHA03095
      Location:383 → 668
      PHA03095; ankyrin-like protein; Provisional
      cd08804
      Location:1460 → 1543
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:409 → 440
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:740 → 792
      Ank_4; Ankyrin repeats (many copies)
      pfam17809
      Location:1302 → 1431
      UPA_2; UPA domain
      cl39094
      Location:540 → 764
      Ank_2; Ankyrin repeats (3 copies)

    66. NM_001386162.1 → NP_001373091.1  ankyrin-2 isoform 43

      Status: REVIEWED

      Source sequence(s)
      AC004057, AC017007, AC093900
      Consensus CDS
      CCDS93584.1
      UniProtKB/TrEMBL
      A0A5F9ZI53
      Conserved Domains (9) summary
      pfam06390
      Location:1576 → 1733
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      smart00218
      Location:937 → 1041
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      PHA03095
      Location:375 → 660
      PHA03095; ankyrin-like protein; Provisional
      COG0666
      Location:6 → 141
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      cd08804
      Location:1420 → 1503
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:401 → 432
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:732 → 784
      Ank_4; Ankyrin repeats (many copies)
      pfam17809
      Location:1262 → 1391
      UPA_2; UPA domain
      cl39094
      Location:532 → 756
      Ank_2; Ankyrin repeats (3 copies)

    67. NM_001386166.1 → NP_001373095.1  ankyrin-2 isoform 65

      Status: REVIEWED

      Source sequence(s)
      AC093900
      Related
      ENST00000683972.1
      Conserved Domains (5) summary
      PTZ00121
      Location:333 → 960
      PTZ00121; MAEBL; Provisional
      PHA03307
      Location:478 → 757
      PHA03307; transcriptional regulator ICP4; Provisional
      PRK14949
      Location:1949 → 2195
      PRK14949; DNA polymerase III subunits gamma and tau; Provisional
      cd08804
      Location:2367 → 2450
      Death_ank2; Death domain of Ankyrin-2
      pfam17809
      Location:124 → 253
      UPA_2; UPA domain

    68. NM_001386167.1 → NP_001373096.1  ankyrin-2 isoform 66

      Status: REVIEWED

      Source sequence(s)
      AC093900
      UniProtKB/TrEMBL
      B7Z678
      Conserved Domains (3) summary
      pfam06390
      Location:438 → 552
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      cd08804
      Location:282 → 365
      Death_ank2; Death domain of Ankyrin-2
      pfam17809
      Location:124 → 253
      UPA_2; UPA domain

    69. NM_001386174.1 → NP_001373103.1  ankyrin-2 isoform 67

      Status: REVIEWED

      Source sequence(s)
      AC004057, AC093617, AC093900
      Consensus CDS
      CCDS93596.1
      UniProtKB/TrEMBL
      H0Y933
      Related
      ENSP00000422888.2, ENST00000506344.6
      Conserved Domains (14) summary
      pfam06390
      Location:3770 → 3884
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      smart00218
      Location:1013 → 1150
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      PTZ00449
      Location:1717 → 2161
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      PHA03095
      Location:421 → 706
      PHA03095; ankyrin-like protein; Provisional
      PRK14949
      Location:3196 → 3442
      PRK14949; DNA polymerase III subunits gamma and tau; Provisional
      cd08804
      Location:3614 → 3697
      Death_ank2; Death domain of Ankyrin-2
      TIGR00600
      Location:3031 → 3565
      rad2; DNA excision repair protein (rad2)
      sd00045
      Location:447 → 478
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:778 → 830
      Ank_4; Ankyrin repeats (many copies)
      pfam15402
      Location:2493 → 2634
      Spc7_N; N-terminus of kinetochore NMS complex subunit Spc7
      pfam17809
      Location:1371 → 1500
      UPA_2; UPA domain
      NF033804
      Location:1843 → 2027
      Streccoc_I_II; antigen I/II family LPXTG-anchored adhesin
      NF033838
      Location:1549 → 1922
      PspC_subgroup_1; pneumococcal surface protein PspC, choline-binding form
      cl39094
      Location:578 → 802
      Ank_2; Ankyrin repeats (3 copies)

    70. NM_001386175.1 → NP_001373104.1  ankyrin-2 isoform 68

      Status: REVIEWED

      Source sequence(s)
      AC004057, AC093617, AC093900
      Conserved Domains (15) summary
      pfam06390
      Location:3762 → 3876
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      smart00218
      Location:1005 → 1142
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      PTZ00449
      Location:1709 → 2153
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      PHA03095
      Location:413 → 698
      PHA03095; ankyrin-like protein; Provisional
      COG0666
      Location:37 → 179
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      PRK14949
      Location:3188 → 3434
      PRK14949; DNA polymerase III subunits gamma and tau; Provisional
      cd08804
      Location:3606 → 3689
      Death_ank2; Death domain of Ankyrin-2
      TIGR00600
      Location:3023 → 3557
      rad2; DNA excision repair protein (rad2)
      sd00045
      Location:439 → 470
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:770 → 822
      Ank_4; Ankyrin repeats (many copies)
      pfam15402
      Location:2485 → 2626
      Spc7_N; N-terminus of kinetochore NMS complex subunit Spc7
      pfam17809
      Location:1363 → 1492
      UPA_2; UPA domain
      NF033804
      Location:1835 → 2019
      Streccoc_I_II; antigen I/II family LPXTG-anchored adhesin
      NF033838
      Location:1541 → 1914
      PspC_subgroup_1; pneumococcal surface protein PspC, choline-binding form
      cl39094
      Location:570 → 794
      Ank_2; Ankyrin repeats (3 copies)

    71. NM_001386186.2 → NP_001373115.1  ankyrin-2 isoform 69

      Status: REVIEWED

      Source sequence(s)
      AC004057, AC093900, AC106864
      Conserved Domains (8) summary
      pfam06390
      Location:1633 → 1790
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      smart00218
      Location:961 → 1098
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      PHA03095
      Location:400 → 685
      PHA03095; ankyrin-like protein; Provisional
      cd08804
      Location:1477 → 1560
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:426 → 457
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:757 → 809
      Ank_4; Ankyrin repeats (many copies)
      pfam17809
      Location:1319 → 1448
      UPA_2; UPA domain
      cl39094
      Location:557 → 781
      Ank_2; Ankyrin repeats (3 copies)

    72. NM_001386187.2 → NP_001373116.1  ankyrin-2 isoform 70

      Status: REVIEWED

      Source sequence(s)
      AC004057, AC093900, AC106864
      Conserved Domains (9) summary
      pfam06390
      Location:1593 → 1750
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      smart00218
      Location:954 → 1058
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      PHA03095
      Location:392 → 677
      PHA03095; ankyrin-like protein; Provisional
      COG0666
      Location:25 → 158
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      cd08804
      Location:1437 → 1520
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:418 → 449
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:749 → 801
      Ank_4; Ankyrin repeats (many copies)
      pfam17809
      Location:1279 → 1408
      UPA_2; UPA domain
      cl39094
      Location:549 → 773
      Ank_2; Ankyrin repeats (3 copies)

    73. NM_020977.5 → NP_066187.2  ankyrin-2 isoform 2

      See identical proteins and their annotated locations for NP_066187.2

      Status: REVIEWED

      Source sequence(s)
      AC004057, AC093879, AC093900
      Consensus CDS
      CCDS43261.1
      UniProtKB/Swiss-Prot
      Q01484
      Related
      ENSP00000378044.3, ENST00000394537.7
      Conserved Domains (8) summary
      pfam06390
      Location:1638 → 1795
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      smart00218
      Location:966 → 1103
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      smart00248
      Location:529 → 554
      ANK; ankyrin repeats
      cd00204
      Location:227 → 352
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd08804
      Location:1482 → 1565
      Death_ank2; Death domain of Ankyrin-2
      pfam12796
      Location:237 → 328
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:37 → 84
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:430 → 461
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      112705622..113383736
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      116013980..116692458
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001386173.1: Suppressed sequence

      Description
      NM_001386173.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q01484.4 GenPept UniProtKB/Swiss-Prot:Q01484

    Gene LinkOut

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