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    FRS2 phenylalanine--tRNA ligase subunit alpha [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850522, updated on 17-May-2024

    Summary

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    Gene symbol
    FRS2
    Gene description
    phenylalanine--tRNA ligase subunit alpha
    Primary source
    FungiDB:YFL022C
    Locus tag
    YFL022C
    See related
    SGD:S000001872; AllianceGenome:SGD:S000001872
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables aminoacyl-tRNA editing activity. Contributes to phenylalanine-tRNA ligase activity. Involved in phenylalanyl-tRNA aminoacylation. Located in cytoplasm. Part of phenylalanine-tRNA ligase complex. Orthologous to human FARSA (phenylalanyl-tRNA synthetase subunit alpha). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: VI
    Exon count:
    1
    Sequence:
    Chromosome: VI; NC_001138.5 (93499..95010, complement)

    Chromosome VI - NC_001138.5Genomic Context describing neighboring genes Neighboring gene Epl1p Neighboring gene Bud27p Neighboring gene Gat1p Neighboring gene seripauperin PAU5

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001138.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Multiple Quality Control Pathways Limit Non-protein Amino Acid Use by Yeast Cytoplasmic Phenylalanyl-tRNA Synthetase. Moghal A, et al. J Biol Chem, 2016 Jul 22. PMID 27226603, Free PMC Article
    2. Tailoring the substrate specificity of yeast phenylalanyl-tRNA synthetase toward a phenylalanine analog using multiple-site-specific incorporation. Kwon I, et al. ACS Synth Biol, 2015 May 15. PMID 25268049
    3. Design of a bacterial host for site-specific incorporation of p-bromophenylalanine into recombinant proteins. Kwon I, et al. J Am Chem Soc, 2006 Sep 13. PMID 16953616
    4. Expansion of the genetic code: site-directed p-fluoro-phenylalanine incorporation in Escherichia coli. Furter R. Protein Sci, 1998 Feb. PMID 9521119, Free PMC Article
    5. Conservation in evolution for a small monomeric phenylalanyl-tRNA synthetase of the tRNA(Phe) recognition nucleotides and initial aminoacylation site. Aphasizhev R, et al. Biochemistry, 1996 Jan 9. PMID 8555164

    See all (68) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aminoacyl-tRNA editing activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables aminoacyl-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables catalytic activity, acting on a tRNA IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phenylalanine-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in aminoacyl-tRNA metabolism involved in translational fidelity IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phenylalanyl-tRNA aminoacylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phenylalanyl-tRNA aminoacylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in phenylalanyl-tRNA aminoacylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA aminoacylation for protein translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of phenylalanine-tRNA ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of phenylalanine-tRNA ligase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    phenylalanine--tRNA ligase subunit alpha
    NP_116631.1
    • Alpha subunit of cytoplasmic phenylalanyl-tRNA synthetase; forms a tetramer with Frs1p to form active enzyme; evolutionarily distant from mitochondrial phenylalanyl-tRNA synthetase based on protein sequence, but substrate binding is similar

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001138.5 Reference assembly

      Range
      93499..95010 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179944.2 → NP_116631.1  TPA: phenylalanine--tRNA ligase subunit alpha [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_116631.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VTK8, P15625
      UniProtKB/TrEMBL
      A0A7I9ET35, B3LUI8, C8Z7R1, G2WDB9, N1P357
      Conserved Domains (1) summary
      PTZ00326
      Location:1 → 486
      PTZ00326; phenylalanyl-tRNA synthetase alpha chain; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P15625.3

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