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    NDST2 N-deacetylase and N-sulfotransferase 2 [ Homo sapiens (human) ]

    Gene ID: 8509, updated on 5-Mar-2024

    Summary

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    Official Symbol
    NDST2provided by HGNC
    Official Full Name
    N-deacetylase and N-sulfotransferase 2provided by HGNC
    Primary source
    HGNC:HGNC:7681
    See related
    Ensembl:ENSG00000166507 MIM:603268; AllianceGenome:HGNC:7681
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NST2; HSST2; N-HSST 2
    Summary
    This gene encodes a member of the N-deacetylase/N-sulfotransferase subfamily of the sulfotransferase 1 proteins. The encoded enzyme has dual functions in processing glucosamine and heparin polymers, including N-deacetylation and N-sulfation. The encoded protein may be localized to the Golgi. [provided by RefSeq, Feb 2009]
    Expression
    Ubiquitous expression in spleen (RPKM 13.3), bone marrow (RPKM 9.9) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    10q22.2
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (73801916..73811820, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (74673316..74683220, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (75561674..75571578, complement)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3575 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:75543706-75543880 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3576 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2488 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr10:75548316-75549515 Neighboring gene NDST2-ZSWIM8-AS1 readthrough Neighboring gene coiled-coil-helix-coiled-coil-helix domain containing 1 Neighboring gene zinc finger SWIM-type containing 8 Neighboring gene ZSWIM8 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2489 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2490 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:75574449-75574702 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:75579102-75579602 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:75579603-75580103 Neighboring gene calcium/calmodulin dependent protein kinase II gamma Neighboring gene MPRA-validated peak1013 silencer Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:75617818-75618318 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:75618319-75618819 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3577 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2491 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2492 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2493 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2494 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3578 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3579 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3580 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr10:75646944-75648143 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:75648172-75649130 Neighboring gene uncharacterized LOC124902454

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Characterization of the N-deacetylase domain from the heparan sulfate N-deacetylase/N-sulfotransferase 2. Duncan MB, et al. Biochem Biophys Res Commun, 2006 Jan 27. PMID 16343444
    2. Endothelial inflammation: the role of differential expression of N-deacetylase/N-sulphotransferase enzymes in alteration of the immunological properties of heparan sulphate. Carter NM, et al. J Cell Sci, 2003 Sep 1. PMID 12876215
    3. Influence of high glucose concentrations on the expression of glycosaminoglycans and N-deacetylase/N-sulphotransferase mRNA in cultured skin fibroblasts from diabetic patients with or without nephropathy. Yard B, et al. Nephrol Dial Transplant, 2002 Mar. PMID 11865082
    4. cDNA cloning, genomic organization and chromosomal localization of human heparan glucosaminyl N-deacetylase/N-sulphotransferase-2. Humphries DE, et al. Biochem J, 1998 Jun 1. PMID 9601056, Free PMC Article
    5. Order out of chaos: assembly of ligand binding sites in heparan sulfate. Esko JD, et al. Annu Rev Biochem, 2002. PMID 12045103

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Observational study of gene-disease association. (HuGE Navigator)
      Title: A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Readthrough NDST2-ZSWIM8-AS1

    Readthrough gene: NDST2-ZSWIM8-AS1, Included gene: ZSWIM8-AS1

    Homology

    Clone Names

    • MGC129697, MGC129705

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables N-acetylglucosamine deacetylase activity TAS
    Traceable Author Statement
    more info
    		  
    enables [heparan sulfate]-glucosamine N-sulfotransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables [heparan sulfate]-glucosamine N-sulfotransferase activity TAS
    Traceable Author Statement
    more info
    		  
    enables deacetylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables heparan sulfate N-deacetylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in heparan sulfate proteoglycan biosynthetic process, enzymatic modification TAS
    Traceable Author Statement
    more info
    		  
    involved_in heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in heparin biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mast cell mediated immunity IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of angiotensin levels in blood IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2
    Names
    N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2
    N-heparan sulfate sulfotransferase 2
    glucosaminyl N-deacetylase/N-sulfotransferase 2
    NP_001317036.1
    NP_003626.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_046905.1 RefSeqGene

      Range
      5234..14916
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001330107.2 → NP_001317036.1  bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC022400, AL045074, AU125430, BC035711, CN266932, DN999958
      Consensus CDS
      CCDS81476.1
      UniProtKB/TrEMBL
      B4E139, S4R438
      Conserved Domains (2) summary
      pfam00685
      Location:603 → 797
      Sulfotransfer_1; Sulfotransferase domain
      pfam12062
      Location:25 → 514
      HSNSD; heparan sulfate-N-deacetylase

    2. NM_003635.4 → NP_003626.1  bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2 isoform 1

      See identical proteins and their annotated locations for NP_003626.1

      Status: REVIEWED

      Source sequence(s)
      AK303648, BC035711
      Consensus CDS
      CCDS7335.1
      UniProtKB/Swiss-Prot
      P52849, Q2TB32, Q59H89
      UniProtKB/TrEMBL
      B4E139
      Related
      ENSP00000310657.6, ENST00000309979.11
      Conserved Domains (2) summary
      pfam00685
      Location:603 → 852
      Sulfotransfer_1; Sulfotransferase domain
      pfam12062
      Location:25 → 514
      HSNSD; heparan sulfate-N-deacetylase

    RNA

    1. NR_160743.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC022400

    2. NR_160744.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC022400

    3. NR_160745.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) is represented as non-coding because it lacks the coding region found in variant 1.
      Source sequence(s)
      AC022400, AK303648, BC018681
      Related
      ENST00000398701.2

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      73801916..73811820 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      74673316..74683220 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P52849.1 GenPept UniProtKB/Swiss-Prot:P52849

    Gene LinkOut

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