NFKBIB NFKB inhibitor beta [Homo sapiens (human)] - Gene

Summary

Official Symbol: NFKBIBprovided by HGNC
Official Full Name: NFKB inhibitor betaprovided by HGNC
Primary source: HGNC:HGNC:7798
See related: Ensembl:ENSG00000104825 MIM:604495; AllianceGenome:HGNC:7798
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: IKBB; TRIP9
Summary: The protein encoded by this gene belongs to the NF-kappa-B inhibitor family, which inhibit NF-kappa-B by complexing with, and trapping it in the cytoplasm. Phosphorylation of serine residues on these proteins by kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B, which translocates to the nucleus to function as a transcription factor. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jul 2011]
Expression: Ubiquitous expression in testis (RPKM 8.2), bone marrow (RPKM 7.5) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 19q13.2

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	19	NC_000019.10 (38899666..38908889)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	19	NC_060943.1 (41703721..41712860)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	19	NC_000019.9 (39390306..39399529)

Chromosome 19 - NC_000019.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The NF-kappaB regulator IkappaBbeta exhibits different molecular interactivity and phosphorylation status from IkappaBalpha in an IKK2-catalysed reaction.
Title: The NF-κB regulator IκBβ exhibits different molecular interactivity and phosphorylation status from IκBα in an IKK2-catalysed reaction.
The subcellular distributions of IkappaB and NFkappaB are indicative of carcinogenesis. Inhibition of XPO1 results in intranuclear retention of IkappaB, which inhibits NFkappaB and thereby provides a novel mechanism for drug therapy in sarcoma. This effect can be further enhanced in relatively selinexor-resistant sarcoma cell lines by pretreatment with the proteasome inhibitor carfilzomib.
Title: Selinexor (KPT-330) Induces Tumor Suppression through Nuclear Sequestration of IκB and Downregulation of Survivin.
data suggest that miRNA-4776 modulates Influenza A virus production in infected cells through NFKBIB expression, possibly through the modulation of NF-kappaB.
Title: Upregulation of miRNA-4776 in Influenza Virus Infected Bronchial Epithelial Cells Is Associated with Downregulation of NFKBIB and Increased Viral Survival.
our data establish the importance of a novel tumor suppressive IKBB gene in abrogating angiogenesis in NPC via the NF-kappaB signalling pathway.
Title: IKBB tumor suppressive role in nasopharyngeal carcinoma via NF-κB-mediated signalling.
NFKBIBrs3136641TT single nucleotide polymorphism was associated with a significantly decreased risk of developing wheezing.
Title: Genetic polymorphisms and risk of recurrent wheezing in pediatric age.
Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Observational study of gene-disease association, gene-gene interaction, gene-environment interaction, and genetic testing. (HuGE Navigator)
Title: Integrative predictive model of coronary artery calcification in atherosclerosis.
NFKBIA and NFKBIB are not likely to harbor ovarian cancer risk alleles.
Title: Polymorphisms in NF-kappaB inhibitors and risk of epithelial ovarian cancer.
increased I-kappaBbeta expression reversed NF-kappaB activation in cancer cells, compensating for the loss of I-kappaBalpha via TGase 2 polymerization.
Title: A new regulatory mechanism of NF-kappaB activation by I-kappaBbeta in cancer cells.
Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
Title: MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage head and neck cancer.

Submit: New GeneRIF Correction See all GeneRIFs (17)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	The mRNA expression levels for alpha-tubulin, TRADD, IFN-gamma R2, GAS1, MADD, NF-kappaB, I-kappa B, 14-3-3 protein, APaf1, PARP, IGF-1 receptor, RB1, Rb2/p130, ARC, and caspase 6 are upregulated in human neuronal cells after treatment with HIV-1 gp120	PubMed
Tat	tat	The gene expression of NFKBIB is significantly upregulated in both clade B and clade C Tat treated SK-N-MC neuroblastoma cells	PubMed
	tat	I kappa B potently inhibits HIV-1 Tat-mediated transactivation of the HIV-1 LTR promoter	PubMed
	tat	HIV-1 Tat induces the phosphorylation and degradation of IkappaB through a p56lck dependent mechanism, leading to the activation of NF-kappa B	PubMed
Vpr	vpr	HIV-1 Vpr induces phosphorylation of IkappaB-beta at serine positions 177 and 181	PubMed
	vpr	Overexpression of NFKBIB is induced by HIV-1 Vpr in the transfected 293T cells	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D8S2279 (e-PCR)
- UniSTS:473907

D15S1477 (e-PCR)
- UniSTS:474482

RH93707 (e-PCR)
- UniSTS:91071

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription coactivator activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA-templated transcription	TAS Traceable Author Statement more info	PubMed
involved_in cellular response to lipopolysaccharide	IBA Inferred from Biological aspect of Ancestor more info
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of canonical NF-kappaB signal transduction	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	TAS Traceable Author Statement more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: NF-kappa-B inhibitor beta

Names: I-kappa-B-beta; NF-kappa-BIB; TR-interacting protein 9; TRIP-9; ikB-B; ikB-beta; ikappaBbeta; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta; thyroid receptor-interacting protein 9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_029624.1 RefSeqGene

Range

5270..14190

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001243116.2 → NP_001230045.1 NF-kappa-B inhibitor beta isoform 2

See identical proteins and their annotated locations for NP_001230045.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) contains an alternate 5' terminal exon compared to variant 1. This results in translation initiation from an in-frame downstream AUG, and a shorter isoform (2) compared to isoform 1.

Source sequence(s)

AC011455, AI684894, BC015528, BI520169

Consensus CDS

CCDS74362.1

UniProtKB/TrEMBL

G5E9C2, I3L4X3

Related

ENSP00000375929.4, ENST00000392079.7

Conserved Domains (3) summary

cd00204
Location:2 → 175

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam12796
Location:125 → 212

Ank_2; Ankyrin repeats (3 copies)

sd00045
Location:120 → 151

ANK; ANK repeat [structural motif]
NM_001369699.1 → NP_001356628.1 NF-kappa-B inhibitor beta isoform 3

Status: REVIEWED

Source sequence(s)

AB209784, AC011455

Consensus CDS

CCDS92612.1

UniProtKB/TrEMBL

Q59EM7

Related

ENSP00000459728.1, ENST00000572515.5

Conserved Domains (3) summary

PHA03095
Location:203 → 298

PHA03095; ankyrin-like protein; Provisional

COG0666
Location:57 → 148

ANKYR; Ankyrin repeat [Signal transduction mechanisms]

sd00045
Location:206 → 237

ANK; ANK repeat [structural motif]
NM_001369700.1 → NP_001356629.1 NF-kappa-B inhibitor beta isoform 4

Status: REVIEWED

Source sequence(s)

AC011455

Conserved Domains (3) summary

PHA03095
Location:111 → 206

PHA03095; ankyrin-like protein; Provisional

sd00045
Location:114 → 145

ANK; ANK repeat [structural motif]

pfam12796
Location:52 → 142

Ank_2; Ankyrin repeats (3 copies)
NM_002503.5 → NP_002494.2 NF-kappa-B inhibitor beta isoform 1

See identical proteins and their annotated locations for NP_002494.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the predominant transcript and encodes the longest isoform (1).

Source sequence(s)

AI684894, BC015528, DA633677

Consensus CDS

CCDS12524.1

UniProtKB/Swiss-Prot

A8K3F4, Q15653, Q96BJ7

UniProtKB/TrEMBL

Q59EM7

Related

ENSP00000312988.5, ENST00000313582.6

Conserved Domains (4) summary

COG0666
Location:240 → 299

ANKYR; Ankyrin repeat [Signal transduction mechanisms]

cd00204
Location:88 → 261

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

sd00045
Location:206 → 237

ANK; ANK repeat [structural motif]

pfam12796
Location:52 → 118

Ank_2; Ankyrin repeats (3 copies)

RNA

NR_040515.2 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (3) uses an alternate acceptor splice site at the second exon, and is alternatively spliced at the 3' end compared to variant 1. It is represented as non-coding due to the presence of an upstream ORF (with a strong Kozak signal) that is predicted to interfere with the translation of the downstream longer ORF; translation of the upstream ORF renders this transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AA044256, AB209784, AK057862, BX111397, DA633677

Related

ENST00000509705.3
NR_161470.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC011455

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000019.10 Reference GRCh38.p14 Primary Assembly

Range

38899666..38908889

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006723227.4 → XP_006723290.4 NF-kappa-B inhibitor beta isoform X2

UniProtKB/TrEMBL

G5E9C2
XM_006723226.3 → XP_006723289.2 NF-kappa-B inhibitor beta isoform X1

UniProtKB/TrEMBL

Q96LS1

Conserved Domains (3) summary

cd00204
Location:56 → 229

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam12796
Location:179 → 266

Ank_2; Ankyrin repeats (3 copies)

sd00045
Location:174 → 205

ANK; ANK repeat [structural motif]

Reference GRCh38.p14 PATCHES

Genomic

NW_014040929.1 Reference GRCh38.p14 PATCHES

Range

309338..318561

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054331970.1 → XP_054187945.1 NF-kappa-B inhibitor beta isoform X2

UniProtKB/TrEMBL

G5E9C2
XM_054331969.1 → XP_054187944.1 NF-kappa-B inhibitor beta isoform X1

Alternate T2T-CHM13v2.0

Genomic

NC_060943.1 Alternate T2T-CHM13v2.0

Range

41703721..41712860

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054321077.1 → XP_054177052.1 NF-kappa-B inhibitor beta isoform X2

UniProtKB/TrEMBL

G5E9C2
XM_054321076.1 → XP_054177051.1 NF-kappa-B inhibitor beta isoform X1

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001001716.1: Suppressed sequence

Description

NM_001001716.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.