CRABP2 cellular retinoic acid binding protein 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: CRABP2provided by HGNC
Official Full Name: cellular retinoic acid binding protein 2provided by HGNC
Primary source: HGNC:HGNC:2339
See related: Ensembl:ENSG00000143320 MIM:180231; AllianceGenome:HGNC:2339
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: RBP6; CRABP-II
Summary: This gene encodes a member of the retinoic acid (RA, a form of vitamin A) binding protein family and lipocalin/cytosolic fatty-acid binding protein family. The protein is a cytosol-to-nuclear shuttling protein, which facilitates RA binding to its cognate receptor complex and transfer to the nucleus. It is involved in the retinoid signaling pathway, and is associated with increased circulating low-density lipoprotein cholesterol. Alternatively spliced transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Dec 2010]
Expression: Biased expression in esophagus (RPKM 46.7), skin (RPKM 7.1) and 2 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 1q23.1

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (156699606..156705784, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (155836009..155842185, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (156669398..156675576, complement)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CRABP2 affects chemotherapy resistance of ovarian cancer by regulating the expression of HIF1alpha.
Title: CRABP2 affects chemotherapy resistance of ovarian cancer by regulating the expression of HIF1α.
CRABP2 regulates infiltration of cancer-associated fibroblasts and immune response in melanoma.
Title: CRABP2 regulates infiltration of cancer-associated fibroblasts and immune response in melanoma.
The heterogeneity of tumour immune microenvironment revealing the CRABP2/CD69 signature discriminates distinct clinical outcomes in breast cancer.
Title: The heterogeneity of tumour immune microenvironment revealing the CRABP2/CD69 signature discriminates distinct clinical outcomes in breast cancer.
CRABP2 - A novel biomarker for high-risk endometrial cancer.
Title: CRABP2 - A novel biomarker for high-risk endometrial cancer.
The prognostic gene CRABP2 affects drug sensitivity by regulating docetaxel-induced apoptosis in breast invasive carcinoma: A pan-cancer analysis.
Title: The prognostic gene CRABP2 affects drug sensitivity by regulating docetaxel-induced apoptosis in breast invasive carcinoma: A pan-cancer analysis.
CRABP2 Is Associated With Thyroid Cancer Recurrence and Promotes Invasion via the Integrin/FAK/AKT Pathway.
Title: CRABP2 Is Associated With Thyroid Cancer Recurrence and Promotes Invasion via the Integrin/FAK/AKT Pathway.
Upregulation of CRABP2 by TET1-mediated DNA hydroxymethylation attenuates mitochondrial apoptosis and promotes oxaliplatin resistance in gastric cancer.
Title: Upregulation of CRABP2 by TET1-mediated DNA hydroxymethylation attenuates mitochondrial apoptosis and promotes oxaliplatin resistance in gastric cancer.
CRABP2 accelerates epithelial mesenchymal transition in serous ovarian cancer cells by promoting TRIM16 methylation via upregulating EZH2 expression.
Title: CRABP2 accelerates epithelial mesenchymal transition in serous ovarian cancer cells by promoting TRIM16 methylation via upregulating EZH2 expression.
Circular RNA hsa_circ_0011298 enhances Taxol resistance of non-small cell lung cancer by regulating miR-486-3p/CRABP2 axis.
Title: Circular RNA hsa_circ_0011298 enhances Taxol resistance of non-small cell lung cancer by regulating miR-486-3p/CRABP2 axis.
Targeting CRABP-II overcomes pancreatic cancer drug resistance by reversing lipid raft cholesterol accumulation and AKT survival signaling.
Title: Targeting CRABP-II overcomes pancreatic cancer drug resistance by reversing lipid raft cholesterol accumulation and AKT survival signaling.

Submit: New GeneRIF Correction See all GeneRIFs (64)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH69209 (e-PCR)
- UniSTS:47664

GDB:376729 (e-PCR)
- UniSTS:157064

RH80810 (e-PCR)
- UniSTS:89506

CRABP2 (e-PCR)
- UniSTS:519116

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables cyclin binding	IDA Inferred from Direct Assay more info	PubMed
enables fatty acid binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables retinal binding	IEA Inferred from Electronic Annotation more info
enables retinoic acid binding	IBA Inferred from Biological aspect of Ancestor more info
enables retinoid binding	TAS Traceable Author Statement more info	PubMed
enables retinol binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in embryonic forelimb morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in epidermis development	TAS Traceable Author Statement more info	PubMed
involved_in fatty acid transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of collateral sprouting	IEA Inferred from Electronic Annotation more info
involved_in regulation of DNA-templated transcription	TAS Traceable Author Statement more info	PubMed
involved_in retinoic acid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info
located_in cytosol	TAS Traceable Author Statement more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in extracellular exosome	HDA more info	PubMed
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: cellular retinoic acid-binding protein 2

Names: cellular retinoic acid-binding protein II

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001199723.2 → NP_001186652.1 cellular retinoic acid-binding protein 2

See identical proteins and their annotated locations for NP_001186652.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) has an alternate 5' UTR and encodes the same protein, as compared to variant 1.

Source sequence(s)

AU126559, BC001109

Consensus CDS

CCDS1152.1

UniProtKB/Swiss-Prot

B2R4Z8, D3DVC5, F1T098, P29373, Q6ICN6

Related

ENSP00000482841.1, ENST00000621784.4

Conserved Domains (1) summary

cd19461
Location:3 → 138

CRABP2; Cellular retinoic acid-binding protein 2
NM_001878.4 → NP_001869.1 cellular retinoic acid-binding protein 2

See identical proteins and their annotated locations for NP_001869.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) and variant 2 encode the same protein.

Source sequence(s)

AK312007, BC001109

Consensus CDS

CCDS1152.1

UniProtKB/Swiss-Prot

B2R4Z8, D3DVC5, F1T098, P29373, Q6ICN6

Related

ENSP00000357205.3, ENST00000368222.8

Conserved Domains (1) summary

cd19461
Location:3 → 138

CRABP2; Cellular retinoic acid-binding protein 2