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    CHL1 cell adhesion molecule L1 like [ Homo sapiens (human) ]

    Gene ID: 10752, updated on 3-Apr-2024

    Summary

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    Official Symbol
    CHL1provided by HGNC
    Official Full Name
    cell adhesion molecule L1 likeprovided by HGNC
    Primary source
    HGNC:HGNC:1939
    See related
    Ensembl:ENSG00000134121 MIM:607416; AllianceGenome:HGNC:1939
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CALL; L1CAM2
    Summary
    The protein encoded by this gene is a member of the L1 gene family of neural cell adhesion molecules. It is a neural recognition molecule that may be involved in signal transduction pathways. The deletion of one copy of this gene may be responsible for mental defects in patients with 3p- syndrome. This protein may also play a role in the growth of certain cancers. Alternate splicing results in both coding and non-coding variants. [provided by RefSeq, Nov 2011]
    Expression
    Biased expression in brain (RPKM 21.7), ovary (RPKM 3.5) and 12 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    3p26.3
    Exon count:
    32
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (196763..409417)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (188582..401277)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (238446..451100)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107986057 Neighboring gene uncharacterized LOC124909336 Neighboring gene CHL1 antisense RNA 2 Neighboring gene FOXA motif-containing MPRA enhancer 226 Neighboring gene RNA, U6 small nuclear 1194, pseudogene Neighboring gene ribosomal protein S8 pseudogene 6 Neighboring gene CHL1 antisense RNA 1 Neighboring gene NANOG hESC enhancer GRCh37_chr3:492506-493034 Neighboring gene uncharacterized LOC105376922 Neighboring gene uncharacterized LOC124909337

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Expression of CHL1 in Clear Cell Renal Cell Carcinoma and its Association With Prognosis. Qin M, et al. Appl Immunohistochem Mol Morphol, 2022 Mar 1. PMID 35262525
    2. Cell adhesion molecule L1 like plays a role in the pathogenesis of idiopathic hypogonadotropic hypogonadism. Chen Y, et al. J Endocrinol Invest, 2021 Aug. PMID 33453020
    3. Analysis of the functional sequences in the promoter region of the human adhesion molecule close homolog of L1. Yoo M, et al. Int J Neurosci, 2022 May. PMID 33054469
    4. Reduced Expression of Chl1 gene Impairs Insulin Secretion by Down-Regulating the Expression of Key Molecules of β-cell Function. Taneera J, et al. Exp Clin Endocrinol Diabetes, 2021 Dec. PMID 31614370
    5. Protein expression of close homologue of L1 (CHL1) is a marker for overall survival in non-small cell lung cancer (NSCLC). Hötzel J, et al. J Cancer Res Clin Oncol, 2019 Sep. PMID 31372722

    See all (57) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Analysis of the functional sequences in the promoter region of the human adhesion molecule close homolog of L1.
      Title: Analysis of the functional sequences in the promoter region of the human adhesion molecule close homolog of L1.
    2. Expression of CHL1 in Clear Cell Renal Cell Carcinoma and its Association With Prognosis.
      Title: Expression of CHL1 in Clear Cell Renal Cell Carcinoma and its Association With Prognosis.
    3. Reduced Expression of Chl1 gene Impairs Insulin Secretion by Down-Regulating the Expression of Key Molecules of beta-cell Function.
      Title: Reduced Expression of Chl1 gene Impairs Insulin Secretion by Down-Regulating the Expression of Key Molecules of β-cell Function.
    4. Exosomal miR-338-3p suppresses non-small-cell lung cancer cells metastasis by inhibiting CHL1 through the MAPK signaling pathway.
      Title: Exosomal miR-338-3p suppresses non-small-cell lung cancer cells metastasis by inhibiting CHL1 through the MAPK signaling pathway.
    5. Cell adhesion molecule L1 like plays a role in the pathogenesis of idiopathic hypogonadotropic hypogonadism.
      Title: Cell adhesion molecule L1 like plays a role in the pathogenesis of idiopathic hypogonadotropic hypogonadism.
    6. Downregulation of Adhesion Molecule CHL1 in B Cells but Not T Cells of Patients with Major Depression and in the Brain of Mice with Chronic Stress.
      Title: Downregulation of Adhesion Molecule CHL1 in B Cells but Not T Cells of Patients with Major Depression and in the Brain of Mice with Chronic Stress.
    7. Ezrin interacts with the tumor suppressor CHL1 and promotes neuronal differentiation of human neuroblastoma.
      Title: Ezrin interacts with the tumor suppressor CHL1 and promotes neuronal differentiation of human neuroblastoma.
    8. CHL1 expression levels were significantly higher in ovarian endometriosis tissue than in eutopic endometrium.
      Title: Aberrant expression of CHL1 gene and long non-coding RNA CHL1-AS1, CHL1-AS2 in ovarian endometriosis.
    9. The prognostic significance of CHL1 makes it a potential prognostic and therapeutic target and underlines its role as a tumour suppressor. Further validation studies and functional analyses are needed to investigate its potential role in tumourigenesis and dissemination.
      Title: Protein expression of close homologue of L1 (CHL1) is a marker for overall survival in non-small cell lung cancer (NSCLC).
    10. Results identified a new tumor suppressor, CHL1, located at 3p26 which was frequently deleted in esophageal squamous cells carcinoma (ESCC). Reduced expression of CHL1 correlated with poor differentiation, increased invasion, lymph-node metastasis, advanced tumor stage, and decreased overall survival. Further data support CHL1 as an important tumor suppressor with both anti-proliferation and anti-metastasis abilities.
      Title: Loss of cell adhesion molecule L1 like promotes tumor growth and metastasis in esophageal squamous cell carcinoma.
    Submit: New GeneRIF Correction See all GeneRIFs (35)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Copy number response

    Description
    Copy number response
    Triplosensitivity

    No evidence available (Last evaluated 2023-12-12)

    ClinGen Genome Curation PagePubMed
    Haploinsufficency

    No evidence available (Last evaluated 2023-12-12)

    ClinGen Genome Curation PagePubMed

    EBI GWAS Catalog

    Description
    A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance.
    EBI GWAS Catalog
    A genome-wide search for loci interacting with known prostate cancer risk-associated genetic variants.
    EBI GWAS Catalog
    Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects.
    EBI GWAS Catalog
    Genome-wide association of lipid-lowering response to statins in combined study populations.
    EBI GWAS Catalog
    Genome-wide association studies of adolescent idiopathic scoliosis suggest candidate susceptibility genes.
    EBI GWAS Catalog
    GWAS for discovery and replication of genetic loci associated with sudden cardiac arrest in patients with coronary artery disease.
    EBI GWAS Catalog
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    EBI GWAS Catalog
    Pharmacogenomic study of side-effects for antidepressant treatment options in STAR*D.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ30674, FLJ44930, MGC132578, DKFZp547L174

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protease binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in adult locomotory behavior IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in axon guidance IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cognition IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in exploration behavior IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of neuron apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in neuron migration IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in apical part of cell IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular exosome HDA PubMed 
    located_in membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    neural cell adhesion molecule L1-like protein
    Names
    L1 cell adhesion molecule 2
    cell adhesion molecule with homology to L1CAM (close homolog of L1)
    cell adhesion molecule with homology to L1CAM (close homologue of L1)
    close homolog of L1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001253387.2 → NP_001240316.1  neural cell adhesion molecule L1-like protein isoform 2 precursor

      See identical proteins and their annotated locations for NP_001240316.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, compared to variant 1. This variant encodes isoform 2, which is shorter than isoform 1.
      Source sequence(s)
      AB209329, AC011609, DA778898, R40400
      Consensus CDS
      CCDS58812.1
      UniProtKB/Swiss-Prot
      B7ZL03, O00533, Q2M3G2, Q59FY0
      UniProtKB/TrEMBL
      B3KX75
      Related
      ENSP00000380628.2, ENST00000397491.6
      Conserved Domains (9) summary
      cd00096
      Location:532 → 600
      Ig; Immunoglobulin domain
      cd04978
      Location:345 → 419
      Ig4_L1-NrCAM_like; Fourth immunoglobulin (Ig)-like domain of L1, Ng-CAM (Neuron-glia CAM cell adhesion molecule), and NrCAM (Ng-CAM-related)
      cd05731
      Location:258 → 328
      Ig3_L1-CAM_like; Third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM)
      cd05845
      Location:129 → 223
      Ig2_L1-CAM_like; Second immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM) and similar proteins
      smart00410
      Location:248 → 327
      IG_like; Immunoglobulin like
      cd00063
      Location:612 → 701
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:715 → 795
      fn3; Fibronectin type III domain
      pfam13882
      Location:1104 → 1189
      Bravo_FIGEY; Bravo-like intracellular region
      cl11960
      Location:55 → 126
      Ig; Immunoglobulin domain

    2. NM_001253388.1 → NP_001240317.1  neural cell adhesion molecule L1-like protein isoform 3 precursor

      See identical proteins and their annotated locations for NP_001240317.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an in-frame exon in the coding region, compared to variant 1. This variant encodes isoform 3, which is shorter than isoform 1.
      Source sequence(s)
      AC011609, AC026187, BC143498, R40400
      Consensus CDS
      CCDS74887.1
      UniProtKB/TrEMBL
      A0A087X0M8, B3KX75
      Related
      ENSP00000483512.1, ENST00000620033.4
      Conserved Domains (9) summary
      cd00096
      Location:548 → 616
      Ig; Immunoglobulin domain
      cd04978
      Location:361 → 435
      Ig4_L1-NrCAM_like; Fourth immunoglobulin (Ig)-like domain of L1, Ng-CAM (Neuron-glia CAM cell adhesion molecule), and NrCAM (Ng-CAM-related)
      cd05731
      Location:274 → 344
      Ig3_L1-CAM_like; Third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM)
      cd05845
      Location:129 → 223
      Ig2_L1-CAM_like; Second immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM) and similar proteins
      smart00410
      Location:264 → 343
      IG_like; Immunoglobulin like
      cd00063
      Location:628 → 717
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:731 → 811
      fn3; Fibronectin type III domain
      pfam13882
      Location:1067 → 1152
      Bravo_FIGEY; Bravo-like intracellular region
      cl11960
      Location:55 → 126
      Ig; Immunoglobulin domain

    3. NM_006614.4 → NP_006605.2  neural cell adhesion molecule L1-like protein isoform 1 precursor

      See identical proteins and their annotated locations for NP_006605.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC011609, AC066595, AF002246, DA778898, R40400
      Consensus CDS
      CCDS2556.1
      UniProtKB/TrEMBL
      B3KX75
      Related
      ENSP00000256509.2, ENST00000256509.7
      Conserved Domains (9) summary
      cd00096
      Location:548 → 616
      Ig; Immunoglobulin domain
      cd04978
      Location:361 → 435
      Ig4_L1-NrCAM_like; Fourth immunoglobulin (Ig)-like domain of L1, Ng-CAM (Neuron-glia CAM cell adhesion molecule), and NrCAM (Ng-CAM-related)
      cd05731
      Location:274 → 344
      Ig3_L1-CAM_like; Third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM)
      cd05845
      Location:129 → 223
      Ig2_L1-CAM_like; Second immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM) and similar proteins
      smart00410
      Location:264 → 343
      IG_like; Immunoglobulin like
      cd00063
      Location:628 → 717
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:731 → 811
      fn3; Fibronectin type III domain
      pfam13882
      Location:1120 → 1205
      Bravo_FIGEY; Bravo-like intracellular region
      cl11960
      Location:55 → 126
      Ig; Immunoglobulin domain

    RNA

    1. NR_045572.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) has multiple differences, compared to variant 1. This variant is represented as non-coding because it lacks the exons that contain the coding region in variant 1.
      Source sequence(s)
      AC026187, AC066595, AK055236, AL359583
      Related
      ENST00000489224.5

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      196763..409417
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017005566.2 → XP_016861055.1  neural cell adhesion molecule L1-like protein isoform X1

      UniProtKB/TrEMBL
      B3KX75
      Conserved Domains (9) summary
      cd00096
      Location:548 → 616
      Ig; Immunoglobulin domain
      cd04978
      Location:361 → 435
      Ig4_L1-NrCAM_like; Fourth immunoglobulin (Ig)-like domain of L1, Ng-CAM (Neuron-glia CAM cell adhesion molecule), and NrCAM (Ng-CAM-related)
      cd05731
      Location:274 → 344
      Ig3_L1-CAM_like; Third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM)
      cd05845
      Location:129 → 223
      Ig2_L1-CAM_like; Second immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM) and similar proteins
      smart00410
      Location:264 → 343
      IG_like; Immunoglobulin like
      cd00063
      Location:628 → 717
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:731 → 811
      fn3; Fibronectin type III domain
      pfam13882
      Location:1120 → 1205
      Bravo_FIGEY; Bravo-like intracellular region
      cl11960
      Location:55 → 126
      Ig; Immunoglobulin domain

    2. XM_017005572.2 → XP_016861061.1  neural cell adhesion molecule L1-like protein isoform X3

      UniProtKB/TrEMBL
      A0A087X0M8, B3KX75
      Conserved Domains (9) summary
      cd00096
      Location:548 → 616
      Ig; Immunoglobulin domain
      cd04978
      Location:361 → 435
      Ig4_L1-NrCAM_like; Fourth immunoglobulin (Ig)-like domain of L1, Ng-CAM (Neuron-glia CAM cell adhesion molecule), and NrCAM (Ng-CAM-related)
      cd05731
      Location:274 → 344
      Ig3_L1-CAM_like; Third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM)
      cd05845
      Location:129 → 223
      Ig2_L1-CAM_like; Second immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM) and similar proteins
      smart00410
      Location:264 → 343
      IG_like; Immunoglobulin like
      cd00063
      Location:628 → 717
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:731 → 811
      fn3; Fibronectin type III domain
      pfam13882
      Location:1067 → 1152
      Bravo_FIGEY; Bravo-like intracellular region
      cl11960
      Location:55 → 126
      Ig; Immunoglobulin domain

    3. XM_006712939.4 → XP_006713002.1  neural cell adhesion molecule L1-like protein isoform X1

      See identical proteins and their annotated locations for XP_006713002.1

      UniProtKB/TrEMBL
      B3KX75
      Conserved Domains (9) summary
      cd00096
      Location:548 → 616
      Ig; Immunoglobulin domain
      cd04978
      Location:361 → 435
      Ig4_L1-NrCAM_like; Fourth immunoglobulin (Ig)-like domain of L1, Ng-CAM (Neuron-glia CAM cell adhesion molecule), and NrCAM (Ng-CAM-related)
      cd05731
      Location:274 → 344
      Ig3_L1-CAM_like; Third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM)
      cd05845
      Location:129 → 223
      Ig2_L1-CAM_like; Second immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM) and similar proteins
      smart00410
      Location:264 → 343
      IG_like; Immunoglobulin like
      cd00063
      Location:628 → 717
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:731 → 811
      fn3; Fibronectin type III domain
      pfam13882
      Location:1120 → 1205
      Bravo_FIGEY; Bravo-like intracellular region
      cl11960
      Location:55 → 126
      Ig; Immunoglobulin domain

    4. XM_017005573.2 → XP_016861062.1  neural cell adhesion molecule L1-like protein isoform X3

      UniProtKB/TrEMBL
      A0A087X0M8, B3KX75
      Conserved Domains (9) summary
      cd00096
      Location:548 → 616
      Ig; Immunoglobulin domain
      cd04978
      Location:361 → 435
      Ig4_L1-NrCAM_like; Fourth immunoglobulin (Ig)-like domain of L1, Ng-CAM (Neuron-glia CAM cell adhesion molecule), and NrCAM (Ng-CAM-related)
      cd05731
      Location:274 → 344
      Ig3_L1-CAM_like; Third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM)
      cd05845
      Location:129 → 223
      Ig2_L1-CAM_like; Second immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM) and similar proteins
      smart00410
      Location:264 → 343
      IG_like; Immunoglobulin like
      cd00063
      Location:628 → 717
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:731 → 811
      fn3; Fibronectin type III domain
      pfam13882
      Location:1067 → 1152
      Bravo_FIGEY; Bravo-like intracellular region
      cl11960
      Location:55 → 126
      Ig; Immunoglobulin domain

    5. XM_017005569.2 → XP_016861058.1  neural cell adhesion molecule L1-like protein isoform X2

      UniProtKB/Swiss-Prot
      B7ZL03, O00533, Q2M3G2, Q59FY0
      UniProtKB/TrEMBL
      B3KX75
      Conserved Domains (9) summary
      cd00096
      Location:532 → 600
      Ig; Immunoglobulin domain
      cd04978
      Location:345 → 419
      Ig4_L1-NrCAM_like; Fourth immunoglobulin (Ig)-like domain of L1, Ng-CAM (Neuron-glia CAM cell adhesion molecule), and NrCAM (Ng-CAM-related)
      cd05731
      Location:258 → 328
      Ig3_L1-CAM_like; Third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM)
      cd05845
      Location:129 → 223
      Ig2_L1-CAM_like; Second immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM) and similar proteins
      smart00410
      Location:248 → 327
      IG_like; Immunoglobulin like
      cd00063
      Location:612 → 701
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:715 → 795
      fn3; Fibronectin type III domain
      pfam13882
      Location:1104 → 1189
      Bravo_FIGEY; Bravo-like intracellular region
      cl11960
      Location:55 → 126
      Ig; Immunoglobulin domain

    6. XM_006712938.2 → XP_006713001.1  neural cell adhesion molecule L1-like protein isoform X1

      See identical proteins and their annotated locations for XP_006713001.1

      UniProtKB/TrEMBL
      B3KX75
      Conserved Domains (9) summary
      cd00096
      Location:548 → 616
      Ig; Immunoglobulin domain
      cd04978
      Location:361 → 435
      Ig4_L1-NrCAM_like; Fourth immunoglobulin (Ig)-like domain of L1, Ng-CAM (Neuron-glia CAM cell adhesion molecule), and NrCAM (Ng-CAM-related)
      cd05731
      Location:274 → 344
      Ig3_L1-CAM_like; Third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM)
      cd05845
      Location:129 → 223
      Ig2_L1-CAM_like; Second immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM) and similar proteins
      smart00410
      Location:264 → 343
      IG_like; Immunoglobulin like
      cd00063
      Location:628 → 717
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:731 → 811
      fn3; Fibronectin type III domain
      pfam13882
      Location:1120 → 1205
      Bravo_FIGEY; Bravo-like intracellular region
      cl11960
      Location:55 → 126
      Ig; Immunoglobulin domain

    7. XM_011533296.2 → XP_011531598.1  neural cell adhesion molecule L1-like protein isoform X3

      See identical proteins and their annotated locations for XP_011531598.1

      UniProtKB/TrEMBL
      A0A087X0M8, B3KX75
      Conserved Domains (9) summary
      cd00096
      Location:548 → 616
      Ig; Immunoglobulin domain
      cd04978
      Location:361 → 435
      Ig4_L1-NrCAM_like; Fourth immunoglobulin (Ig)-like domain of L1, Ng-CAM (Neuron-glia CAM cell adhesion molecule), and NrCAM (Ng-CAM-related)
      cd05731
      Location:274 → 344
      Ig3_L1-CAM_like; Third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM)
      cd05845
      Location:129 → 223
      Ig2_L1-CAM_like; Second immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM) and similar proteins
      smart00410
      Location:264 → 343
      IG_like; Immunoglobulin like
      cd00063
      Location:628 → 717
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:731 → 811
      fn3; Fibronectin type III domain
      pfam13882
      Location:1067 → 1152
      Bravo_FIGEY; Bravo-like intracellular region
      cl11960
      Location:55 → 126
      Ig; Immunoglobulin domain

    8. XM_011533294.2 → XP_011531596.1  neural cell adhesion molecule L1-like protein isoform X2

      See identical proteins and their annotated locations for XP_011531596.1

      UniProtKB/Swiss-Prot
      B7ZL03, O00533, Q2M3G2, Q59FY0
      UniProtKB/TrEMBL
      B3KX75
      Conserved Domains (9) summary
      cd00096
      Location:532 → 600
      Ig; Immunoglobulin domain
      cd04978
      Location:345 → 419
      Ig4_L1-NrCAM_like; Fourth immunoglobulin (Ig)-like domain of L1, Ng-CAM (Neuron-glia CAM cell adhesion molecule), and NrCAM (Ng-CAM-related)
      cd05731
      Location:258 → 328
      Ig3_L1-CAM_like; Third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM)
      cd05845
      Location:129 → 223
      Ig2_L1-CAM_like; Second immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM) and similar proteins
      smart00410
      Location:248 → 327
      IG_like; Immunoglobulin like
      cd00063
      Location:612 → 701
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:715 → 795
      fn3; Fibronectin type III domain
      pfam13882
      Location:1104 → 1189
      Bravo_FIGEY; Bravo-like intracellular region
      cl11960
      Location:55 → 126
      Ig; Immunoglobulin domain

    9. XM_017005567.2 → XP_016861056.1  neural cell adhesion molecule L1-like protein isoform X1

      UniProtKB/TrEMBL
      B3KX75
      Conserved Domains (9) summary
      cd00096
      Location:548 → 616
      Ig; Immunoglobulin domain
      cd04978
      Location:361 → 435
      Ig4_L1-NrCAM_like; Fourth immunoglobulin (Ig)-like domain of L1, Ng-CAM (Neuron-glia CAM cell adhesion molecule), and NrCAM (Ng-CAM-related)
      cd05731
      Location:274 → 344
      Ig3_L1-CAM_like; Third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM)
      cd05845
      Location:129 → 223
      Ig2_L1-CAM_like; Second immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM) and similar proteins
      smart00410
      Location:264 → 343
      IG_like; Immunoglobulin like
      cd00063
      Location:628 → 717
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:731 → 811
      fn3; Fibronectin type III domain
      pfam13882
      Location:1120 → 1205
      Bravo_FIGEY; Bravo-like intracellular region
      cl11960
      Location:55 → 126
      Ig; Immunoglobulin domain

    10. XM_047447335.1 → XP_047303291.1  neural cell adhesion molecule L1-like protein isoform X3

      UniProtKB/TrEMBL
      A0A087X0M8

    11. XM_017005571.2 → XP_016861060.1  neural cell adhesion molecule L1-like protein isoform X2

      UniProtKB/Swiss-Prot
      B7ZL03, O00533, Q2M3G2, Q59FY0
      UniProtKB/TrEMBL
      B3KX75
      Conserved Domains (9) summary
      cd00096
      Location:532 → 600
      Ig; Immunoglobulin domain
      cd04978
      Location:345 → 419
      Ig4_L1-NrCAM_like; Fourth immunoglobulin (Ig)-like domain of L1, Ng-CAM (Neuron-glia CAM cell adhesion molecule), and NrCAM (Ng-CAM-related)
      cd05731
      Location:258 → 328
      Ig3_L1-CAM_like; Third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM)
      cd05845
      Location:129 → 223
      Ig2_L1-CAM_like; Second immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM) and similar proteins
      smart00410
      Location:248 → 327
      IG_like; Immunoglobulin like
      cd00063
      Location:612 → 701
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:715 → 795
      fn3; Fibronectin type III domain
      pfam13882
      Location:1104 → 1189
      Bravo_FIGEY; Bravo-like intracellular region
      cl11960
      Location:55 → 126
      Ig; Immunoglobulin domain

    12. XM_011533292.2 → XP_011531594.1  neural cell adhesion molecule L1-like protein isoform X1

      See identical proteins and their annotated locations for XP_011531594.1

      UniProtKB/TrEMBL
      B3KX75
      Conserved Domains (9) summary
      cd00096
      Location:548 → 616
      Ig; Immunoglobulin domain
      cd04978
      Location:361 → 435
      Ig4_L1-NrCAM_like; Fourth immunoglobulin (Ig)-like domain of L1, Ng-CAM (Neuron-glia CAM cell adhesion molecule), and NrCAM (Ng-CAM-related)
      cd05731
      Location:274 → 344
      Ig3_L1-CAM_like; Third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM)
      cd05845
      Location:129 → 223
      Ig2_L1-CAM_like; Second immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM) and similar proteins
      smart00410
      Location:264 → 343
      IG_like; Immunoglobulin like
      cd00063
      Location:628 → 717
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:731 → 811
      fn3; Fibronectin type III domain
      pfam13882
      Location:1120 → 1205
      Bravo_FIGEY; Bravo-like intracellular region
      cl11960
      Location:55 → 126
      Ig; Immunoglobulin domain

    13. XM_011533295.2 → XP_011531597.1  neural cell adhesion molecule L1-like protein isoform X2

      See identical proteins and their annotated locations for XP_011531597.1

      UniProtKB/Swiss-Prot
      B7ZL03, O00533, Q2M3G2, Q59FY0
      UniProtKB/TrEMBL
      B3KX75
      Conserved Domains (9) summary
      cd00096
      Location:532 → 600
      Ig; Immunoglobulin domain
      cd04978
      Location:345 → 419
      Ig4_L1-NrCAM_like; Fourth immunoglobulin (Ig)-like domain of L1, Ng-CAM (Neuron-glia CAM cell adhesion molecule), and NrCAM (Ng-CAM-related)
      cd05731
      Location:258 → 328
      Ig3_L1-CAM_like; Third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM)
      cd05845
      Location:129 → 223
      Ig2_L1-CAM_like; Second immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM) and similar proteins
      smart00410
      Location:248 → 327
      IG_like; Immunoglobulin like
      cd00063
      Location:612 → 701
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:715 → 795
      fn3; Fibronectin type III domain
      pfam13882
      Location:1104 → 1189
      Bravo_FIGEY; Bravo-like intracellular region
      cl11960
      Location:55 → 126
      Ig; Immunoglobulin domain

    14. XM_006712940.4 → XP_006713003.1  neural cell adhesion molecule L1-like protein isoform X1

      See identical proteins and their annotated locations for XP_006713003.1

      UniProtKB/TrEMBL
      B3KX75
      Conserved Domains (9) summary
      cd00096
      Location:548 → 616
      Ig; Immunoglobulin domain
      cd04978
      Location:361 → 435
      Ig4_L1-NrCAM_like; Fourth immunoglobulin (Ig)-like domain of L1, Ng-CAM (Neuron-glia CAM cell adhesion molecule), and NrCAM (Ng-CAM-related)
      cd05731
      Location:274 → 344
      Ig3_L1-CAM_like; Third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM)
      cd05845
      Location:129 → 223
      Ig2_L1-CAM_like; Second immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM) and similar proteins
      smart00410
      Location:264 → 343
      IG_like; Immunoglobulin like
      cd00063
      Location:628 → 717
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:731 → 811
      fn3; Fibronectin type III domain
      pfam13882
      Location:1120 → 1205
      Bravo_FIGEY; Bravo-like intracellular region
      cl11960
      Location:55 → 126
      Ig; Immunoglobulin domain

    15. XM_017005570.2 → XP_016861059.1  neural cell adhesion molecule L1-like protein isoform X2

      UniProtKB/Swiss-Prot
      B7ZL03, O00533, Q2M3G2, Q59FY0
      UniProtKB/TrEMBL
      B3KX75
      Conserved Domains (9) summary
      cd00096
      Location:532 → 600
      Ig; Immunoglobulin domain
      cd04978
      Location:345 → 419
      Ig4_L1-NrCAM_like; Fourth immunoglobulin (Ig)-like domain of L1, Ng-CAM (Neuron-glia CAM cell adhesion molecule), and NrCAM (Ng-CAM-related)
      cd05731
      Location:258 → 328
      Ig3_L1-CAM_like; Third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM)
      cd05845
      Location:129 → 223
      Ig2_L1-CAM_like; Second immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM) and similar proteins
      smart00410
      Location:248 → 327
      IG_like; Immunoglobulin like
      cd00063
      Location:612 → 701
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:715 → 795
      fn3; Fibronectin type III domain
      pfam13882
      Location:1104 → 1189
      Bravo_FIGEY; Bravo-like intracellular region
      cl11960
      Location:55 → 126
      Ig; Immunoglobulin domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      188582..401277
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054344997.1 → XP_054200972.1  neural cell adhesion molecule L1-like protein isoform X1

    2. XM_054345004.1 → XP_054200979.1  neural cell adhesion molecule L1-like protein isoform X3

    3. XM_054344993.1 → XP_054200968.1  neural cell adhesion molecule L1-like protein isoform X1

    4. XM_054345005.1 → XP_054200980.1  neural cell adhesion molecule L1-like protein isoform X3

    5. XM_054345000.1 → XP_054200975.1  neural cell adhesion molecule L1-like protein isoform X2

    6. XM_054344991.1 → XP_054200966.1  neural cell adhesion molecule L1-like protein isoform X1

    7. XM_054344999.1 → XP_054200974.1  neural cell adhesion molecule L1-like protein isoform X2

    8. XM_054344994.1 → XP_054200969.1  neural cell adhesion molecule L1-like protein isoform X1

    9. XM_054345002.1 → XP_054200977.1  neural cell adhesion molecule L1-like protein isoform X2

    10. XM_054345003.1 → XP_054200978.1  neural cell adhesion molecule L1-like protein isoform X3

    11. XM_054345007.1 → XP_054200982.1  neural cell adhesion molecule L1-like protein isoform X3

    12. XM_054344992.1 → XP_054200967.1  neural cell adhesion molecule L1-like protein isoform X1

    13. XM_054344998.1 → XP_054200973.1  neural cell adhesion molecule L1-like protein isoform X2

    14. XM_054344995.1 → XP_054200970.1  neural cell adhesion molecule L1-like protein isoform X1

    15. XM_054345001.1 → XP_054200976.1  neural cell adhesion molecule L1-like protein isoform X2

    16. XM_054344996.1 → XP_054200971.1  neural cell adhesion molecule L1-like protein isoform X1

    17. XM_054345006.1 → XP_054200981.1  neural cell adhesion molecule L1-like protein isoform X3

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O00533.4 GenPept UniProtKB/Swiss-Prot:O00533

    Gene LinkOut

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